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M8787

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Gabriela Sycz et al.
PloS one, 10(5), e0124058-e0124058 (2015-05-21)
Brucella is the causative agent of the zoonotic disease brucellosis, and its success as an intracellular pathogen relies on its ability to adapt to the harsh environmental conditions that it encounters inside the host. The Brucella genome encodes a sensor...
Katalin Türmer et al.
Biochimica et biophysica acta, 1850(9), 1855-1861 (2015-05-31)
Actin filament bundling proteins mediate numerous processes in cells such as the formation of cell membrane protrusions or cell adhesions and stress fiber based locomotion. Among them alpha-actinin and fascin are the most abundant ones. This work characterizes differences in...
Alexander W Gofton et al.
Parasites & vectors, 8, 345-345 (2015-06-26)
The Australian paralysis tick (Ixodes holocyclus) is of significant medical and veterinary importance as a cause of dermatological and neurological disease, yet there is currently limited information about the bacterial communities harboured by these ticks and the risk of infectious...
Joanna Korycińska et al.
Vector borne and zoonotic diseases (Larchmont, N.Y.), 21(4), 269-274 (2021-02-11)
Swimmer's itch or human cercarial dermatitis (HCD) appears as a skin rash caused by an allergic reaction to larval (cercariae) flatworm parasites of the family Schistosomatidae. In our study, two cases of HCD were analyzed; both of them were reported...
Anita Leocadio Freitas-Mesquita et al.
Experimental parasitology, 137, 8-13 (2013-12-10)
Several ecto-enzymatic activities have been described in the plasma membrane of the protozoan Leishmania amazonensis, which is the major etiological agent of diffuse cutaneous leishmaniasis in South America. These enzymes, including ecto-phosphatases, contribute to the survival of the parasite by...
Kha Tram et al.
PloS one, 10(5), e0126402-e0126402 (2015-05-07)
Many DNAzymes have been isolated from synthetic DNA pools to cleave natural RNA (D-RNA) substrates and some have been utilized for the design of aptazyme biosensors for bioanalytical applications. Even though these biosensors perform well in simple sample matrices, they...
Noria Segueni et al.
PloS one, 10(5), e0126058-e0126058 (2015-05-08)
IL-36 cytokines are members of the IL-1 family of cytokines that stimulate dendritic cells and T cells leading to enhanced T helper 1 responses in vitro and in vivo; however, their role in host defense has not been fully addressed...
Nicholas J Haley et al.
Journal of clinical microbiology, 52(9), 3237-3243 (2014-06-25)
Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of deer, elk, and moose, is the only prion disease affecting free-ranging animals. Since the disease was first identified in northern Colorado and southern Wyoming in 1967, new epidemic foci of the...
Giovanni Giurdanella et al.
Biochemical pharmacology, 96(3), 278-287 (2015-06-10)
Diabetic retinopathy, a major cause of vision loss, is currently treated with anti-VEGF agents. Here we tested two hypotheses: (i) high glucose damages retinal pericytes, the cell layer surrounding endothelial cells, via VEGF induction, which may be counteracted by anti-VEGFs...
Andrew N Gray et al.
eLife, 4 (2015-05-08)
To maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that...
H-J Kim et al.
Cell death & disease, 5, e1292-e1292 (2014-06-13)
Cisplatin (cis-diaminedichloroplatinum-II) is an extensively used chemotherapeutic agent, and one of its most adverse effects is ototoxicity. A number of studies have demonstrated that these effects are related to oxidative stress and DNA damage. However, the precise mechanism underlying cisplatin-associated...
Qin Sun et al.
Clinical drug investigation, 37(12), 1125-1136 (2017-09-14)
Drug transporters and drug-metabolizing enzymes have been linked to drug-induced hepatotoxicity. Solute carrier organic anion transporter family member 1B1 (SLCO1B1), cytochrome P450 2E1 (CYP2E1), and UDP glucuronosyltransferase 1A1 (UGT1A1) were selected as candidate genes to explore their association with susceptibility...
Madhusudhan Tarigopula et al.
Cardiovascular research, 107(2), 226-234 (2015-06-06)
Therapeutic approaches to treat familial dilated cardiomyopathy (DCM), which is characterized by depressed sarcomeric tension and susceptibility to Ca(2+)-related arrhythmias, have been generally unsuccessful. Our objective in the present work was to determine the effect of the angiotensin II type...
Heyu Chen et al.
Neurochemical research, 40(6), 1311-1318 (2015-05-23)
NADH shuttles mediate the transfer of the reducing equivalents of cytosolic NADH into mitochondria. Cumulating evidence has suggested that malate-aspartate shuttle (MAS), one of the two types of NADH shuttles, plays significant roles in such biological processes as glutamate synthesis...
Veronica Diez et al.
ACS synthetic biology, 4(7), 796-807 (2015-02-26)
A key problem in the engineering of pathways for the production of pharmaceutical compounds is the limited diversity of biosynthetic enzymes, which restricts the attainability of suitable traits such as less harmful byproducts, enhanced expression features, or different cofactor requirements....
Rumyana Ivanova Dodova et al.
BMC cancer, 15, 523-523 (2015-07-18)
About 3885 women are diagnosed with breast cancer and 1285 die from the disease each year in Bulgaria. However no genetic testing to identify the mutations in high-risk families has been provided so far. We evaluated 200 Bulgarian women with...
Christopher M Lucaj et al.
Cytoskeleton (Hoboken, N.J.), 72(5), 225-234 (2015-05-28)
Microtubule plus-end dynamics are regulated by a family of proteins called plus-end tracking proteins (+TIPs). We recently demonstrated that the transforming acidic coiled-coil (TACC) domain family member, TACC3, can function as a +TIP to regulate microtubule dynamics in Xenopus laevis...
Sajedeh Eftekhari et al.
The Journal of comparative neurology, 524(1), 90-118 (2015-06-25)
Functional imaging studies have revealed that certain brainstem areas are activated during migraine attacks. The neuropeptide calcitonin gene-related peptide (CGRP) is associated with activation of the trigeminovascular system and transmission of nociceptive information and plays a key role in migraine...
Marco Bocchio et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(13), 3015-3026 (2015-06-09)
Genetic association studies suggest that variations in the 5-hydroxytryptamine (5-HT; serotonin) transporter (5-HTT) gene are associated with susceptibility to psychiatric disorders such as anxiety or posttraumatic stress disorder. Individuals carrying high 5-HTT-expressing gene variants display low amygdala reactivity to fearful...
Camila Guerra Martinez et al.
Scientific reports, 5, 16940-16940 (2015-11-26)
Autoantibodies against the M2 receptors (M2AChR) have been associated with Dilated Cardiomyopathy (DCM). In the heart, P2×7 receptors influence electrical conduction, coronary circulation and response to ischemia. They can also trigger pro-inflammatory responses and the development of neurological, cardiac and...
Dan Gao et al.
Journal of the American Society for Mass Spectrometry, 26(4), 686-694 (2015-01-17)
The identification of drug metabolites is very important in drug development. Nowadays, the most widely used methods are isotopes and mass spectrometry. However, the commercial isotopic labeled reagents are usually very expensive, and the rapid and convenient identification of metabolites...
Teresa M Barbosa et al.
PloS one, 9(12), e115583-e115583 (2014-12-31)
A better understanding of the origin and natural reservoirs of resistance determinants is fundamental to efficiently tackle antibiotic resistance. This paper reports the identification of a novel 5.8 kb erythromycin resistance plasmid, from Bacillus sp. HS24 isolated from the marine...
Yugen Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2394-2404 (2014-07-30)
IFN-β has been implicated as an effector of oviduct pathology resulting from genital chlamydial infection in the mouse model. In this study, we investigated the role of cytosolic DNA and engagement of DNA sensors in IFN-β expression during chlamydial infection....
Célia Gasselin et al.
The Journal of physiology, 593(22), 4855-4869 (2015-09-01)
We determined the contribution of the hyperpolarization-activated cationic (h) current (Ih ) to the homeostatic regulation of CA1 pyramidal cells in vitro using chronic treatments (48 h) that either increase (picrotoxin) or decrease (kynurenate) neuronal activity. The h-conductance was found to...
Qing-Guo Ren et al.
Journal of Alzheimer's disease : JAD, 47(1), 61-71 (2015-09-25)
Here, we investigated the effect of escitalopram pretreatment on protein kinase A (PKA)-induced tau hyperphosphorylation and spatial memory deficits in rats using western blot and behavioral tests, respectively. We demonstrated that escitalopram effectively ameliorated tau hyperphosphorylation and the spatial memory...
Beth Wells et al.
Parasites & vectors, 8, 66-66 (2015-02-05)
The apicomplexan parasite Cryptosporidium represents a threat to water quality and public health. An important zoonotic species involved in human cryptosporidiosis from contaminated water is Cryptosporidium parvum (C. parvum), the main reservoirs of which are known to be farm livestock...
Xiang Ma et al.
Oncology letters, 10(1), 509-517 (2015-07-15)
The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7...
J-H La et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1730-1742 (2014-10-14)
A low-level inflammation has been hypothesized to mediate visceral hypersensitivity in functional bowel disorders that persist after or even in the absence of gut inflammation. We aimed to test the efficacy of a steroidal anti-inflammatory treatment, and identify local inflammatory...
Brandon T Gufford et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1675-1683 (2014-07-11)
Drug-metabolizing enzymes within enterocytes constitute a key barrier to xenobiotic entry into the systemic circulation. Furanocoumarins in grapefruit juice are cornerstone examples of diet-derived xenobiotics that perpetrate interactions with drugs via mechanism-based inhibition of intestinal CYP3A4. Relative to intestinal CYP3A4-mediated...
Paola B Navas et al.
Thyroid : official journal of the American Thyroid Association, 24(6), 1040-1050 (2014-04-02)
Progesterone (P4) is the main steroid secreted by the corpora lutea (CL) and is required for successful implantation and maintenance of pregnancy. Although adequate circulating levels of thyroid hormone (TH) are needed to support formation and maintenance of CL during...
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