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M90003

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Damiano Carbonari et al.
Toxicology letters, 231(2), 205-212 (2014-06-27)
This study investigated the effect of polymorphic genes GSTT1, GSTM1, GSTA1, EHPX1, NQO1, CYP2E1, CYP1A and MPO on the urinary concentrations and ratio (R) of the benzene metabolites trans,trans-muconic acid (t,t-MA) and S-phenyl mercapturic acid (S-PMA) in 301 oil refinery
G Scherer et al.
Journal of chromatography. B, Biomedical sciences and applications, 717(1-2), 179-199 (1998-12-01)
Benzene is an important industrial chemical and, due to its occurrence in mineral oil and its formation in many combustion processes, a widespread environmental pollutant. Since benzene is hematoxic and has been classified as a human carcinogen, monitoring and control
S G Carmella et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 20(5), 587-590 (1982-10-01)
A method was developed for the quantitative analysis of catechol and 4-methylcatechol in human urine. [U-14C]Catechol was used as in internal standard. Urine was treated with beta-glucuronidase and sulphatase, acidified and extracted with ether. The ether extract was silylated and
Adnan M Massadeh et al.
Journal of chromatographic science, 47(2), 170-177 (2009-02-19)
A simple, rapid, reliable, and low cost one-step extraction method is developed and validated for the determination of nicotine and cotinine in human plasma and urine in smokers using reversed-phase high-performance liquid chromatography (RP-HPLC) and gas chromatography-mass spectrometry (GC-MS). The
Hilmi Orhan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 827(1), 104-108 (2005-05-10)
We recently described an isotope dilution reversed-phase liquid chromatography-atmospheric pressure chemical ionization-ion-trap-tandem mass spectrometry (HPLC-APCI-MS/MS) method for the quantitative determination of oxidized amino acids in human urine, including o,o'-dityrosine, a specific marker of protein oxidation. In the present study, we
Selective hydrogenation of trans,trans-muconic acid to adipic acid over a titania-supported rhenium catalyst.
Xiaoyan She et al.
ChemSusChem, 4(8), 1071-1073 (2011-06-21)
Ling Zhang et al.
Journal of occupational and environmental medicine, 53(10), 1194-1198 (2011-09-15)
The work aimed to study the potential correlation between the high-level benzene exposure and its urinary metabolites S-phenylmercapturic acid (SPMA) and trans, trans-muconic acid (t,t-MA) in Chinese shoe-making workers. Individual benzene-exposed levels were determined by gas chromatography analysis, urinary t,t-MA
Sungkyoon Kim et al.
Carcinogenesis, 27(4), 772-781 (2005-12-13)
Although the toxicity of benzene has been linked to its metabolism, the dose-related production of metabolites is not well understood in humans, particularly at low levels of exposure. We investigated unmetabolized benzene in urine (UBz) and all major urinary metabolites
Adonis Michaelides et al.
Chemical communications (Cambridge, England), 49(10), 1008-1010 (2012-12-20)
Three 2D and 3D photoreactive MOFs of trans,trans-muconic acid with Er(3+) and their corresponding isomorphous Y(3+) phases were synthesized and their photoreactivity was studied as a function of the crystal environment.
Nancy B Hopf et al.
International archives of occupational and environmental health, 85(3), 261-271 (2011-06-15)
Characterize ethylbenzene and xylene air concentrations, and explore the biological exposure markers (urinary t,t-muconic acid (t,t-MA) and unmetabolized toluene) among petroleum workers offshore. Offshore workers have increased health risks due to simultaneous exposures to several hydrocarbons present in crude oil.
L G Pruneda-Álvarez et al.
Indoor air, 22(2), 140-147 (2011-10-12)
Indoor air pollution is considered to be a serious public health issue in Mexico; therefore, more studies regarding this topic are necessary. In this context, we assessed exposure to polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds in: (i) women
Kathleen A Curran et al.
Metabolic engineering, 15, 55-66 (2012-11-21)
The dicarboxylic acid muconic acid has garnered significant interest due to its potential use as a platform chemical for the production of several valuable consumer bio-plastics including nylon-6,6 and polyurethane (via an adipic acid intermediate) and polyethylene terephthalate (PET) (via
Nura A Mohamed et al.
Pulmonary circulation, 7(3), 643-653 (2017-04-28)
Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects. Nanomedicine uses nanoparticles to improve drug delivery and/or reduce side effects. We
Thomas Schettgen et al.
Rapid communications in mass spectrometry : RCM, 22(17), 2629-2638 (2008-07-31)
Mercapturic acids are highly important and specific biomarkers of exposure to carcinogenic substances in occupational and environmental medicine. We have developed and validated a reliable, specific and very sensitive method for the simultaneous determination of five mercapturic acids derived from
Ashley Tran et al.
Environmental science & technology, 51(17), 9700-9708 (2017-07-29)
The role of transition metals in the formation and aging of secondary organic aerosol (SOA) from aliphatic and aromatic precursors in heterogeneous/multiphase reactions is not well understood. The reactivity of soluble Fe(III) toward known benzene photooxidation products that include fumaric
Tanasorn Tunsaringkarn et al.
Asian Pacific journal of cancer prevention : APJCP, 12(1), 223-227 (2011-04-27)
Early warning of the potential of mutagens or carcinogens caused by benzene exposure that might occur in gasoline station workers can be achieved by examining 2 major biomarkers: sister chromatid exchange (SCE) and trans, trans-muconic acid (t,t-MA), a urinary metabolite
Francesco Marchetti et al.
Environmental health perspectives, 120(2), 229-234 (2011-11-17)
Benzene is an industrial chemical that causes blood disorders, including acute myeloid leukemia. We previously reported that occupational exposures near the U.S. Occupational Safety and Health Administration permissible exposure limit (8 hr) of 1 ppm was associated with sperm aneuploidy.
M A S Toledo et al.
Biochimica et biophysica acta, 1834(3), 697-707 (2013-01-10)
Xylella fastidiosa is a xylem-limited, Gram-negative phytopathogen responsible for economically relevant crop diseases. Its genome was thus sequenced in an effort to characterize and understand its metabolism and pathogenic mechanisms. However, the assignment of the proper functions to the identified
P Zuccaro et al.
Journal of chromatography, 621(2), 257-261 (1993-11-24)
A simple and reliable reversed-phase high-performance liquid chromatographic method with ultraviolet detection is described for the quantitation of nicotine and its metabolites cotinine, trans-3'-hydroxycotinine, norcotinine and cotinine N-oxide in human serum. The analytes and the internal standard, N-ethylnorcotinine, were extracted
Hnin Thanda Aung et al.
Bioorganic & medicinal chemistry, 19(23), 7000-7002 (2011-11-04)
Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxylic acids and substituted benzoic acids against Protobothropsflavoviridis venom-induced hemorrhage. Pyromellitic acid (1,2,4,5-benzenetetracarboxylic
Sirirat Chanvaivit et al.
Mutation research, 626(1-2), 79-87 (2006-11-11)
Exposure to benzene can cause DNA damage and the subsequent development of cancer. In this study, study subjects were 31 laboratory workers at a petrochemical factory and 31 gasoline service attendants. Control subjects were 34 workers from a mail sorting
Mariella Carrieri et al.
Toxicology letters, 213(1), 63-68 (2011-12-17)
The environmental and biological monitoring of benzene exposure is crucial to prevent the toxic effects of this solvent in workers. The degree of correlation, however, between the two and of different biomarkers among them varies, particularly at low levels of
Ning Li et al.
The Journal of nutrition, 137(12), 2717-2722 (2007-11-22)
Smoking increases the risk of several chronic diseases associated with elevated oxidative stress status. Almonds are a good source of antioxidant nutrients and may diminish smoking-related biomarkers of oxidative stress. We investigated whether almond consumption decreases biomarkers of oxidative stress
Jozef B J H van Duuren et al.
Biotechnology progress, 28(1), 85-92 (2011-09-29)
Pseudomonas putida KT2440-JD1 is able to cometabolize benzoate to cis, cis-muconate in the presence of glucose as growth substrate. P. putida KT2440-JD1 was unable to grow in the presence of concentrations above 50 mM benzoate or 600 mM cis, cis-muconate.
Manuela Ciarrocca et al.
Chemosphere, 87(7), 813-819 (2012-02-03)
This is the first research study to compare among female, non-smoker workers: (a) the exposure to benzene, toluene and xylenes (BTXs) in urban air during work in the street (traffic policewomen, TP) vs. work in vehicles (police drivers, PD); (b)
Hauh-Jyun Candy Chen et al.
Toxicology letters, 155(3), 403-410 (2005-01-15)
5-Hydroxymethyluracil (5-HMU) is derived from radiation in addition to endogenous oxidative DNA damage and it is one of the most abundant DNA adducts. Human 5-HMU-DNA-glycosylase has been shown to repair this lesion. Whether urinary levels of 5-HMU is a valid
Stephen S Hecht
Carcinogenesis, 23(6), 907-922 (2002-06-26)
Measurement of human urinary carcinogen metabolites is a practical approach for obtaining important information about tobacco and cancer. This review presents currently available methods and evaluates their utility. Carcinogens and their metabolites and related compounds that have been quantified in
Thomas P Moyer et al.
Clinical chemistry, 48(9), 1460-1471 (2002-08-27)
Assessment of nicotine metabolism and disposition has become an integral part of nicotine dependency treatment programs. Serum nicotine concentrations or urine cotinine concentrations can be used to guide nicotine patch dose to achieve biological concentrations adequate to provide the patient
P Ducos et al.
International archives of occupational and environmental health, 64(5), 309-313 (1992-01-01)
trans,trans-Muconic acid (2,4-hexadienedioic acid) (t,t-MA) is a minor benzene metabolite which can be used as a biological indicator for benzene exposure. The purpose of the study was to evaluate the limits of use of t,t-MA for detection and quantification of
J B J H van Duuren et al.
Journal of biotechnology, 156(3), 163-172 (2011-09-13)
Pseudomonas putida KT2440-JD1 was derived from P. putida KT2440 after N-methyl-N'-nitro-N-nitrosoguanidine (NTG)-mutagenesis and exposure to 3-fluorobenzoate (3-FB). The mutant was no longer able to grow using benzoate as a sole carbon source, but co-metabolized benzoate to cis, cis-muconate during growth
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