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S Bashir et al.
Alimentary pharmacology & therapeutics, 16(7), 1367-1382 (2002-07-30)
Chronic hypergastrinaemia causes gastric enterochromaffin cell proliferation and carcinoid tumours. The only reliable means to diagnose enterochromaffin cell changes/carcinoids is by biopsy. To assess whether serum histamine, chromogranin A or serotonin and urinary N-methylimidazoleacetic acid or 5-hydroxyindoleacetic acid correlate with
J Martens-Lobenhoffer et al.
Journal of chromatography. B, Biomedical sciences and applications, 721(1), 135-140 (1999-02-23)
The determination of the metabolites of histamine, 1-methylhistamine (MHIS) and 1-methylimidazoleacetic acid (MIIA), in human urine is a useful tool for the diagnosis of mastocytosis. MHIS was extracted under basic conditions with chloroform and derivatized with trifluoroacetic acid anhydride, MIIA
G D Prell et al.
Clinical neuropharmacology, 19(5), 415-419 (1996-10-01)
Concentrations of pros-methylimidazoleacetic acid (p-MIAA) were measured in cerebrospinal fluid of 30 patients with chronic schizophrenia. Levels of p-MIAA correlated negatively with mean scores of the Psychiatric Symptom Assessment Scale for positive symptoms (r = -0.48), but not negative symptoms
E Sakurai et al.
Brain research, 906(1-2), 180-183 (2001-06-30)
The effects of an H3 agonist, R-alpha-methylhistamine (alpha-MeHA), and an H3 antagonist, thioperamide, on monoamine oxidase (MAO) activity in the hypothalamus of rat, monkey and human brains were compared in vitro. The histamine H(3)-receptor ligands competitively inhibited MAO-B, but noncompetitively
D P Skoner et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 87(4), 303-306 (2001-11-01)
Although histamine is hypothesized to mediate symptoms induced by viral upper respiratory infections, elevations of this mediator have not been observed in nasal lavage fluids recovered from patients with viral upper respiratory infections. The purpose of this study was to
Bjorn van Anrooij et al.
The Journal of allergy and clinical immunology, 132(1), 125-130 (2013-03-19)
Increased basal serum tryptase (bsT) levels are a well-described risk factor for Hymenoptera venom-induced anaphylaxis (HVAn) in patients allergic to Hymenoptera venom. Increased bsT levels might also indicate the presence of mastocytosis. In this study we evaluated whether the risk
Hiroki Kawanishi et al.
Clinica chimica acta; international journal of clinical chemistry, 378(1-2), 122-127 (2007-01-02)
According to a previous study, the concentration of HA in the hair of SD rats was similar in each rat and the variation in HA concentration was not so great. However, the concentration in human hair was fairly different in
W A Fogel et al.
Journal of neurochemistry, 80(3), 375-382 (2002-03-22)
Rats with portocaval anastomosis (PCA), an animal model of hepatic encephalopathy (HE), have very high brain histamine concentrations. Our previous studies based on a biochemical approach indicated histamine accumulation in the neuronal compartment. In this study, immunohistochemical evidence is presented
Marjolein L Donker et al.
Haematologica, 93(1), 120-123 (2008-01-02)
Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up. We questioned whether bone marrow involvement could be predicted using biochemical markers. We selected patients with various symptoms suggestive of indolent systemic mastocytosis
A L Krogstad et al.
Experimental dermatology, 10(2), 118-123 (2001-03-22)
Mastocytosis represents a group of disorders characterized by the proliferation and accumulation of mast cells in tissue. The aim of the present study was to examine whether the interstitial histamine concentration in the skin is increased in mastocytosis patients and
J J van Doormaal et al.
Allergy, 67(5), 683-690 (2012-03-23)
Risk indicators of indolent systemic mastocytosis (ISM) in adults with clinical suspicion of ISM without accompanying skin lesions [urticaria pigmentosa (UP)] are lacking. This study aimed at creating a decision tree using clinical characteristics, serum tryptase, and the urinary histamine
G D Prell et al.
Journal of neurochemistry, 67(5), 1938-1944 (1996-11-01)
Levels of histamine and its major metabolites in brain, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), were measured in rat brains up to 12 h after intraperitoneal administration of L-histidine (His), the precursor of histamine. Compared with saline-treated controls, mean levels
Elia Mattarucchi et al.
Biomedical chromatography : BMC, 26(1), 89-94 (2011-04-06)
Asthma is a heterogeneous disorder and one of the most common chronic childhood diseases. An improved characterization of asthma phenotypes would be invaluable for the understanding of the pathogenic mechanisms and the correct treatment of this disease. The aim of
K Hartmann et al.
The journal of investigative dermatology. Symposium proceedings, 6(2), 143-147 (2002-01-05)
Mastcytosis is a rare disease characterized by an abnormal increase of mast cells in tissues. The skin is the organ most frequently involved, but mast cells also accumulate in the bone marrow, gastrointestinal tract, lymph nodes, spleen, and liver. Recent
Can urinary N-tele methylimidazoleacetic acid (t-MeImAA) serve as a marker of histaminergic activity in hepatic encephalopathy (HE)?
W A Fogel et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 51 Suppl 1, S63-S64 (2002-05-16)
The relationship between body size and the urinary excretion of the main histamine metabolite tele-methylimidazoleacetic acid in man.
A C Johansson et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 50 Suppl 2, S70-S71 (2001-06-20)
G Granerus et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48(2), 75-80 (1999-04-15)
To develop an HPLC method with UV detection for determination of tele-methylimidazoleacetic acid (t-MelmAA) in urine of man or animals, which is reliable, simple and less expensive than existing GC/MS techniques. The elaborated procedure enables separation of t-MelmAA from its
Day-to-day variation in urinary excretion of the histamine metabolite methylimidazoleacetic acid.
G Granerus et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 47 Suppl 1, S52-S53 (1998-04-30)
No sex difference in the urinary excretion of the histamine metabolite methylimidazoleacetic acid (MeImAA) when corrected for creatinine excretion.
G Granerus et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48 Suppl 1, S92-S93 (1999-06-01)
J H Butterfield
The British journal of dermatology, 138(3), 489-495 (1998-05-15)
Six patients with documented systemic mast cell disease were enrolled in a 1-year, phase I study to determine the possible benefits of interferon alpha-2b (IFN-alpha). IFN-alpha therapy was begun at a dosage of 0.5 million units/day (MU/day) by subcutaneous injection
Yanhua Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(22), 2023-2033 (2011-06-21)
A UPLC-MS/MS assay was developed and validated for simultaneous quantification of acetylcholine (ACh), histamine (HA), tele-methylhistamine (t-mHA), and tele-methylimidazolacetic acid (t-MIAA) in rat cerebrospinal fluid (CSF). The biological stability of ACh in rat CSF was investigated. Following fit-for-purpose validation, the
Zhaopin Wang et al.
Analytica chimica acta, 774, 1-10 (2013-04-10)
Histamine, a neurotransmitter crucially involved in a number of basic physiological functions, undergoes changes in neuropsychiatric disorders. Detection of histamine in biological samples such as cerebrospinal fluid (CSF) is thus of clinical importance. The most commonly used method for measuring
Philippe Casassus et al.
British journal of haematology, 119(4), 1090-1097 (2002-12-11)
Systemic mastocytosis (SM) is characterized by proliferation of mast cells in various organs, which may release a wide variety of mediators, thereby explaining the broad clinical spectrum of disease manifestations. The potentially life-threatening systemic symptoms and tumoral proliferation are poorly
S A Kemink et al.
Nederlands tijdschrift voor geneeskunde, 140(24), 1277-1279 (1996-06-15)
Out of 21 male patients with osteoporosis who visited an outpatient clinic for endocrine diseases in two years (1994-1995), three had systemic mastocytosis as diagnosed histopathologically. Two of these had characteristic features of urticaria pigmentosa, consisting of multiple brown nodules
G Granerus et al.
The British journal of dermatology, 139(5), 858-861 (1999-01-20)
Serum tryptase was measured with the B12 and G5 antibody-based immunoassays in 25 adult patients with mastocytosis and in 18 controls. Twelve patients had uncomplicated cutaneous mastocytosis (urticaria pigmentosa) and 13 had urticaria pigmentosa with systemic symptoms. Tryptase levels were
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