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Showing 1-30 of 98 results for "M9513" within Papers
Mingjie Chen et al.
SpringerPlus, 3, 439-439 (2014-09-04)
The goal of metabolomics data pre-processing is to eliminate systematic variation, such that biologically-related metabolite signatures are detected by statistical pattern recognition. Although several methods have been developed to tackle the issue of batch-to-batch variation, each method has its advantages
Eung Ju Kim et al.
PloS one, 9(6), e97841-e97841 (2014-06-06)
Although triglyceride accumulation in the liver causes non-alcoholic fatty liver disease (NAFLD), hypercholesterolemia is also a main cause of NAFLD as well as atherosclerosis. However, NAFLD and atherosclerosis have not been investigated simultaneously in animal models fed a high-cholesterol diet.
Si Chen et al.
Molecular bioSystems, 10(12), 3310-3321 (2014-10-16)
As a classical formula, Sini decoction (SND) has been fully proved to be clinically effective in treating doxorubicin (DOX)-induced cardiomyopathy. Current chemomics and pharmacology proved that the total alkaloids (TA), total gingerols (TG), total flavones and total saponins (TFS) are
Hao Du et al.
Journal of integrative plant biology, 57(11), 954-968 (2014-11-25)
Plant responses to abiotic stresses are coordinated by arrays of growth and developmental programs. Gibberellic acid (GA) and abscisic acid (ABA) play critical roles in the developmental programs and environmental responses, respectively, through complex signaling and metabolism networks. However, crosstalk
Núria Monfort et al.
Drug testing and analysis, 7(9), 819-830 (2015-03-03)
A fast screening method for the detection of more than 60 stimulants in urine was developed. The method consisted of a dilution of the urine (1:5 v/v) and analysis by ultra high performance liquid chromatography coupled to tandem mass spectrometry
Y Deceuninck et al.
Journal of chromatography. A, 1362, 241-249 (2014-09-10)
BPA-containing products are widely used in foodstuffs packaging as authorized within the European Union (UE no. 10/2011). Therefore, foods and beverages are in contact with BPA which can migrate from food contact material to foodstuffs. An accurate assessment of the
Ebru Uçaktürk
Journal of analytical methods in chemistry, 2015, 707414-707414 (2015-12-19)
A sensitive and selective gas chromatography-mass spectrometry (GC-MS) method was developed and fully validated for the determination of vildagliptin (VIL) in pharmaceutical formulation. Prior to GC-MS analysis, VIL was efficiently derivatized with MSTFA/NH4I/β-mercaptoethanol at 60°C for 30 min. The obtained O-TMS
Sander Koster et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 80, 163-181 (2015-03-21)
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex
Kathleen A Vermeersch et al.
PloS one, 10(2), e0118262-e0118262 (2015-02-18)
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid-derived cells displayed numerous hallmarks of cancer stem cells, which are chemo- and radioresistant cells thought to be a significant
Danilo M Daloso et al.
Plant, cell & environment, 38(11), 2353-2371 (2015-04-15)
Transcriptomic and proteomic studies have improved our knowledge of guard cell function; however, metabolic changes in guard cells remain relatively poorly understood. Here we analysed metabolic changes in guard cell-enriched epidermal fragments from tobacco during light-induced stomatal opening. Increases in
Anne Y Fennell et al.
Frontiers in plant science, 6, 834-834 (2015-11-20)
Bud dormancy in grapevine is an adaptive strategy for the survival of drought, high and low temperatures and freeze dehydration stress that limit the range of cultivar adaptation. Therefore, development of a comprehensive understanding of the biological mechanisms involved in
Thérèse Tercé-Laforgue et al.
Plant & cell physiology, 56(10), 1918-1929 (2015-08-08)
NAD-dependent glutamate dehydrogenase (NAD-GDH) of higher plants has a central position at the interface between carbon and nitrogen metabolism due to its ability to carry out the deamination of glutamate. In order to obtain a better understanding of the physiological
Cariton Kubwabo et al.
Analytical and bioanalytical chemistry, 406(18), 4381-4392 (2014-05-13)
Bisphenol A (BPA) is a widely used industrial chemical in the manufacturing of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt normal hormonal function and hence
Lucas Willmann et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 95-104 (2015-07-29)
Although the concept of aerobic glycolysis in cancer was already reported in the 1930s by Otto Warburg, the understanding of metabolic pathways remains challenging especially due to the heterogeneity of cancer. In consideration of four different time points (1, 2
Joanna Kałużna-Czaplińska et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 70-76 (2014-02-26)
There is a need to identify metabolic phenotypes in autism as they might each require unique approaches to prevention. Biological markers can help define autism subtypes and reveal potential therapeutic targets. The aim of the study was to identify alterations
Wen-Quan Zhang et al.
Biomedical chromatography : BMC, 29(6), 902-910 (2014-12-18)
Metabonomics based on GC-MS was used to study the possible anti-inflammatory mechanisms of volatile oils of Angelica sinensis (VOAS) in rats with acute inflammation. Acute inflammation was induced by subcutaneous injection of carrageenan in rats. The levels of prostaglandin E2
Scott A Harding et al.
Tree physiology, 34(11), 1240-1251 (2013-12-18)
The partitioning of carbon for growth, storage and constitutive chemical defenses is widely framed in terms of a hypothetical sink-source differential that varies with nutrient supply. According to this framework, phenolics accrual is passive and occurs in source leaves when
A Iparraguirre et al.
Journal of chromatography. A, 1360, 57-65 (2014-08-19)
In the present work, a novel analytical method for the simultaneous determination of ten polybrominated diphenyl ethers (PBDEs), eight methoxylated PBDEs (MeO-PBDEs) and seven hydroxylated PBDEs (OH-PBDEs) in soil, lettuce and carrot samples was developed. The procedure was based on
Frida Torell et al.
PloS one, 10(6), e0129260-e0129260 (2015-06-19)
Hierarchical modelling was applied in order to identify the organs that contribute to the levels of metabolites in plasma. Plasma and organ samples from gut, kidney, liver, muscle and pancreas were obtained from mice. The samples were analysed using gas
C Urrutia et al.
Bioresource technology, 200, 1044-1049 (2015-10-27)
Sewage sludge generated in municipal wastewater treatment plants was used as a feedstock for biodiesel production via esterification/transesterification in a two-step process. In the first esterification step, greasy and secondary sludge were tested using acid and enzymatic catalysts. The results
Mohammad R Nezami Ranjbar et al.
PloS one, 10(6), e0127299-e0127299 (2015-06-02)
This study evaluates changes in metabolite levels in hepatocellular carcinoma (HCC) cases vs. patients with liver cirrhosis by analysis of human blood plasma using gas chromatography coupled with mass spectrometry (GC-MS). Untargeted metabolomic analysis of plasma samples from participants recruited
Se-Hwan Joo et al.
Phytochemistry, 111, 84-90 (2014-12-01)
A crude enzyme solution was prepared from young rice seedlings, and the metabolism of C29-brassinosteroids identified from the seedlings was examined. When 28-homoteasterone was added as a substrate, 28-homotyphasterol, teasterone, and 26-nor-28-homoteasterone were characterized as enzyme products by GC-MS/SIM analysis.
Claudia Vignali et al.
Forensic science international, 242, e48-e51 (2014-08-05)
Venlafaxine is an extensively used antidepressant drug; it is considered to be quite safe and only a few pure cases of fatal poisoning have been reported. Here we describe a fatal case of venlafaxine self-poisoning including detailed tissue distribution of
Kristina B Jäpelt et al.
Microbial cell factories, 14, 132-132 (2015-09-05)
Quenching in cold buffered methanol at -40 °C has long been the preferred method for sub-second inactivation of cell metabolism during metabolic fingerprinting. However, methanol is known to cause intracellular metabolite leakage of microbial cells, making the distinction between intra-
Christoph H Weinert et al.
Journal of chromatography. A, 1405, 156-167 (2015-05-16)
Comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) offers excellent chromatographic separation performance and superior sensitivity. As such, it is eminently suitable for the analysis of complex biological samples. The applicability of a GC×GC instrument equipped with a fast-scanning qMS detector
M Raro et al.
Journal of mass spectrometry : JMS, 49(6), 509-521 (2014-06-11)
The detection of anabolic androgenic steroids (AAS) is one of the most important topics in doping control analysis. Gas chromatography coupled to (tandem) mass spectrometry (GC-MS(/MS)) with electron ionization and liquid chromatography coupled to tandem mass spectrometry have been traditionally
Venkataramanan Subramanian et al.
Journal of proteome research, 13(12), 5431-5451 (2014-10-22)
Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic
Seçil Ömeroğlu et al.
Talanta, 131, 650-655 (2014-10-05)
Nonylphenol ethoxylates (NPEOs) have drawn significant attention within the last decade for both scientific and legislative reasons. In Turkey, the Regulation Regarding the Use of Domestic and Urban Sludges on Land states a limit value for the sum of nonylphenol
Raúl González-Domínguez et al.
Journal of pharmaceutical and biomedical analysis, 107, 75-81 (2015-01-13)
Gas chromatography coupled to mass spectrometry is the most frequent tool for metabolomic profiling of low molecular weight metabolites. Its suitability in health survey is beyond doubt, given that primary metabolites involved in central pathways of metabolism are usually altered
Teresa Mairinger et al.
Analytical chemistry, 87(23), 11792-11802 (2015-10-30)
For the first time an analytical work flow based on accurate mass gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOFMS) with chemical ionization for analysis providing a comprehensive picture of (13)C distribution along the primary metabolism is elaborated. The method provides a
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