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Showing 1-16 of 16 results for "mab1940" within Papers
Katja Vehanen et al.
Acta ophthalmologica, 86(1), 91-96 (2007-08-23)
The use of biopolymers in peribulbar injection for controlled drug delivery provides alternative options to eyedrops and intravitreal or surgical methods. Polymerizable biopolymers are especially likely to have a role because of their particular properties. In liquid form, they can
Natalie M Landry et al.
Scientific reports, 9(1), 12889-12889 (2019-09-11)
Primary cardiac fibroblasts are notoriously difficult to maintain for extended periods of time in cell culture, due to the plasticity of their phenotype and sensitivity to mechanical input. In order to study cardiac fibroblast activation in vitro, we have developed cell
Grissel Faura Tellez et al.
American journal of physiology. Lung cellular and molecular physiology, 309(7), L725-L735 (2015-07-26)
Genetic studies have identified Protocadherin-1 (PCDH1) and Mothers against decapentaplegic homolog-3 (SMAD3) as susceptibility genes for asthma. PCDH1 is expressed in bronchial epithelial cells and has been found to interact with SMAD3 in yeast two-hybrid (Y2H) overexpression assays. Here, we
Rahul Bhome et al.
Aging, 9(12), 2666-2694 (2017-12-29)
Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to metastatic spread and therefore, a mechanistic dissection of the signals which influence tumor progression is needed. Cancer stroma plays a critical role in tumor proliferation, invasion
Shivika S Gupta et al.
Oncotarget, 7(48), 78516-78531 (2016-10-06)
The incidence of heart failure with concomitant cardiac fibrosis is very high in developed countries. Fibroblast activation in heart is causal to cardiac fibrosis as they convert to hypersynthetic cardiac myofibroblasts. There is no known treatment for cardiac fibrosis. Myofibroblasts
Lynne A Murray et al.
Fibrogenesis & tissue repair, 3, 11-11 (2010-07-07)
To evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model. Hamsters received a single dose of radiation (40 Gy) to the left everted cheek pouch to
Kameswaran Surendran et al.
Journal of the American Society of Nephrology : JASN, 16(8), 2373-2384 (2005-06-10)
beta-Catenin functions as a transducer of Wnt signals to the nucleus, where it interacts with the T cell factor (TCF) family of DNA binding proteins to regulate gene expression. On the basis of the genes regulated by beta-catenin and TCF
Zsolt Urbán et al.
American journal of human genetics, 71(1), 30-44 (2002-05-23)
To elucidate the pathomechanism leading to obstructive vascular disease in patients with elastin deficiency, we compared both elastogenesis and proliferation rate of cultured aortic smooth-muscle cells (SMCs) and skin fibroblasts from five healthy control subjects, four patients with isolated supravalvular
Marcus Ang et al.
Scientific reports, 8(1), 11483-11483 (2018-08-02)
This pilot study uses a micro-optical coherence tomography (micro-OCT) system with ~1 μm axial resolution specifically to image the cornea and corneal scars in vivo. We used an established murine corneal scar model by irregular phototherapeutic keratectomy in ten C57BL/6 mice
Impaired elastogenesis in Hurler disease: dermatan sulfate accumulation linked to deficiency in elastin-binding protein and elastic fiber assembly.
Hinek, A; Wilson, SE
The American Journal of Pathology null
Ryan C Middleton et al.
Journal of extracellular vesicles, 7(1), 1456888-1456888 (2018-04-27)
Newts can regenerate amputated limbs and cardiac tissue, unlike mammals which lack broad regenerative capacity. Several signaling pathways involved in cell proliferation, differentiation and survival during newt tissue regeneration have been elucidated, however the factors that coordinate signaling between cells
Olaf Voets et al.
PloS one, 12(8), e0182974-e0182974 (2017-08-12)
Phenotypic assays using human primary cells are highly valuable tools for target discovery and validation in drug discovery. Expression knockdown (KD) of such targets in these assays allows the investigation of their role in models of disease processes. Therefore, efficient
Yi-Lun Lee et al.
Scientific reports, 8(1), 5358-5358 (2018-03-31)
Metabolic syndrome (MetS) and ovarian hormone deficiency could affect bladder storage dysfunction. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound in green tea, has been shown to protect against ovarian hormone deficiency induced overactive bladder (OAB). The present study investigated oxidative stress induced
Natalie M Landry et al.
Basic research in cardiology, 116(1), 25-25 (2021-04-14)
We have previously shown that overexpression of SKI, an endogenous TGF-β1 repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hippo tumor-suppressor pathway and inhibiting the
Natalie M Landry et al.
Basic research in cardiology, 113(1), 1-1 (2017-11-05)
Tissue development and homeostasis are dependent upon the concerted synthesis, maintenance, and degradation of extracellular matrix (ECM) molecules. Cardiac fibrosis is now recognized as a primary contributor to incidence of heart failure, particularly heart failure with preserved ejection fraction, wherein
Jassim M Al-Hassan et al.
Frontiers in pharmacology, 11, 899-899 (2020-07-07)
Preparations from Arabian Gulf catfish (Arius bilineatus, Val) epidermal gel secretion (PCEGS) effectively heal chronic wounds in diabetic patients. However, specific lipid components of PCEGS that are responsible for various aspects of wound healing are unknown. Here, we report for
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