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Showing 1-18 of 18 results for "mab2011" within Papers
Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.
Hitendra S Chand et al.
The Journal of allergy and clinical immunology, 140(5), 1456-1459 (2017-08-09)
Hitendra S Chand et al.
Scientific reports, 8(1), 436-436 (2018-01-13)
Exposure to lipopolysaccharides (LPS) causes extensive neutrophilic inflammation in the airways followed by mucous cell hyperplasia (MCH) that is sustained by the anti-apoptotic protein, Bcl-2. To identify inflammatory factor(s) that are responsible for Bcl-2 expression, we established an organ culture
Ramesh Pothuraju et al.
Aging, 14(5), 2025-2046 (2022-03-08)
Mucins are components of the mucus layer overlying the intestinal epithelial cells, which maintains physiological homeostasis. Altered mucin expression is associated with disease progression. Expression of MUC4 decreases in colorectal cancer (CRC); however, its functional role and implications in the
Andreea Iliesiu et al.
Oncology letters, 26(4), 442-442 (2023-09-18)
In rare cases, metastatic adenocarcinomas of different origin may exhibit the features of hepatoid carcinoma (HC), a rare malignant epithelial tumor, most commonly occurring in the ovaries and stomach, as well as in the pancreas and biliary ducts. A case
Dinesh Devadoss et al.
Scientific reports, 13(1), 10980-10980 (2023-07-07)
Portable air purifiers help improve indoor air quality by neutralizing allergens, including animal dander proteins. However, there are limited in-vivo models to assess the efficacy of these devices. Here, we developed a novel animal model of experimental asthma using aerosolized
Caroline Ridley et al.
American journal of physiology. Lung cellular and molecular physiology, 310(10), L993-L1002 (2016-03-20)
MUC5B is a major polymeric mucin in the airway mucus gel and is an essential component of innate defense of the respiratory epithelium. Knowledge of the synthesis and intracellular processing of MUC5B is incomplete. We investigated the molecular details of
Julia R Davies et al.
Methods in molecular biology (Clifton, N.J.), 842, 27-47 (2012-01-20)
Secreted and transmembrane mucins are important components of innate defence at the body's mucosal surfaces. The secreted mucins are large, polymeric glycoproteins, which are largely responsible for the gel-like properties of mucus secretions. The cell-tethered mucins, however, are monomeric but
Karen Hoffmann et al.
Communications biology, 5(1), 875-875 (2022-08-26)
Mechanisms of epithelial renewal in the alveolar compartment remain incompletely understood. To this end, we aimed to characterize alveolar progenitors. Single-cell RNA-sequencing (scRNA-seq) analysis of the HTII-280+/EpCAM+ population from adult human lung revealed subclusters enriched for adult stem cell signature
Sara Chiblak et al.
Scientific reports, 6, 29455-29455 (2016-07-07)
Mutational activation of K-Ras is an initiating event of pancreatic ductal adenocarcinomas (PDAC) that may develop either from pancreatic intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplasms (IPMN). Cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) is causally related to pancreatic carcinogenesis. Here
Imayavaramban Lakshmanan et al.
Molecular oncology, 15(7), 1866-1881 (2021-04-02)
Lung cancer (LC) is the leading cause of cancer-related mortality. However, the molecular mechanisms associated with the development of metastasis are poorly understood. Understanding the biology of LC metastasis is critical to unveil the molecular mechanisms for designing targeted therapies.
Rui-Hong Du et al.
Virchows Archiv : an international journal of pathology, 467(6), 657-665 (2015-10-04)
Secretory immunoglobulin A (SIgA) reaches the airway lumen by local transcytosis across airway epithelial cells or with tracheobronchial submucosal gland secretions. In chronic obstructive pulmonary disease (COPD), deficiency of SIgA on the airway surface has been reported. However, reduction of
Ramesh Pothuraju et al.
Molecular cancer, 19(1), 37-37 (2020-02-27)
Differential expression of mucins has been associated with several cancers including colorectal cancer (CRC). In normal physiological conditions, secretory mucin MUC5AC is not expressed in the colonic mucosa, whereas its aberrant expression is observed during development of colon cancer and
Mucin glycosylation is altered by pro-inflammatory signaling in pancreatic-cancer cells.
Wu, YM; Nowack, DD; Omenn, GS; Haab, BB
Journal of Proteome Research null
Sandra L Leibel et al.
Current protocols in stem cell biology, 54(1), e118-e118 (2020-07-09)
The normal development of the pulmonary system is critical to transitioning from placental-dependent fetal life to alveolar-dependent newborn life. Human lung development and disease have been difficult to study due to the lack of an in vitro model system containing
Ludivine Canivet et al.
Journal of applied toxicology : JAT, 41(2), 203-215 (2020-08-09)
Air pollution is a public health issue and the toxicity of ambient particulate matter (PM) is well-recognized. Although it does not mostly contribute to the total mass of PM, increasing evidence indicates that the ultrafine fraction has generally a greater
Jianwu Bai et al.
PloS one, 10(2), e0118286-e0118286 (2015-02-24)
Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1) to evaluate an in vitro air liquid interface cultured human
Michael A Turner et al.
In vivo (Athens, Greece), 36(1), 57-62 (2022-01-02)
Overexpression of mucin-5AC (MUC5AC) makes it a targetable biomarker in pancreatic cancer. The present study evaluated tumor targeting with a MUC5AC antibody conjugated to a near-infrared dye in a patient-derived orthotopic xenograft (PDOX) mouse model. MUC5AC monoclonal antibody was conjugated
Dinesh Devadoss et al.
iScience, 25(8), 104685-104685 (2022-07-06)
Noncoding RNAs are important regulators of mucoinflammatory response, but little is known about the contribution of airway long noncoding RNAs (lncRNAs) in COVID-19. RNA-seq analysis showed a more than 4-fold increased expression of IL-6, ICAM-1, CXCL-8, and SCGB1A1 inflammatory factors; MUC5AC
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