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E A Eckman et al.
The Journal of biological chemistry, 276(27), 24540-24548 (2001-05-05)
Deposition of beta-amyloid (Abeta) peptides in the brain is an early and invariant feature of all forms of Alzheimer's disease. As with any secreted protein, the extracellular concentration of Abeta is determined not only by its production but also by...
Nathanael J Yates et al.
Experimental brain research, 235(7), 2133-2149 (2017-04-19)
Negative outcomes of mild traumatic brain injury (mTBI) can be exacerbated by repeated insult. Animal models of repeated closed-head mTBI provide the opportunity to define acute pathological mechanisms as the number of mTBI increases. Furthermore, little is known about the...
Sadim Jawhar et al.
The Journal of biological chemistry, 286(6), 4454-4460 (2010-12-15)
Pyroglutamate-modified Aβ (AβpE3-42) peptides are gaining considerable attention as potential key players in the pathology of Alzheimer disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Overexpressing AβpE3-42 induced a severe neuron loss...
The effects of amyloid precursor protein on postsynaptic composition and activity.
Hoe, et al.
The Journal of Biological Chemistry, 284, 8495-8506 (2021)
Jose Morales-Corraliza et al.
PloS one, 4(9), e7134-e7134 (2009-09-23)
The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo turnover of APP, secreted APP (sAPP), Abeta and tau in the wild-type and Tg2576 mouse...
Neuropathy target esterase is required for adult vertebrate axon maintenance.
Read DJ, Li Y, Chao MV, Cavanagh JB, Glynn P
The Journal of Neuroscience null
Ebrahim Abdul Shukkur et al.
Human molecular genetics, 15(18), 2752-2762 (2006-08-08)
Trisomy 21 or Down syndrome (DS) is the most common genetic birth defect associated with mental retardation. The over-expression of genes on chromosome 21, including SOD1 (Cu/Zn superoxide dismutase) and APP (amyloid-beta precursor protein) is believed to underlie the increased...
Simone Puccio et al.
PloS one, 6(1), e15163-e15163 (2011-01-22)
Numerous studies show that high circulating level of glucocorticosteroids is a biochemical characteristic of Alzheimer's disease (AD). These stress hormones can increase the amount of AD-like pathology in animal models of the disease. Since they also up-regulate the 5-Lipoxygenase (5-LO)...
Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase.
Christian Czech, Mark P Burns, Lilit Vardanian, Angelique Augustin, Helmut Jacobsen et al.
Journal of Neurochemistry null
Stephen M Ostrowski et al.
The Journal of biological chemistry, 282(37), 26832-26844 (2007-07-25)
Epidemiological evidence suggests that long term treatment with hydroxymethylglutaryl-CoA reductase inhibitors, or statins, decreases the risk for developing Alzheimer disease (AD). However, statin-mediated AD protection cannot be fully explained by reduction of cholesterol levels. In addition to their cholesterol lowering...
Jian Meng et al.
Frontiers in cell and developmental biology, 8, 596030-596030 (2020-11-17)
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with cognitive deficits and synaptic impairments. Amyloid-β (Aβ) plaque deposition, dystrophic neurite accumulation and neurofibrillary tangles are pathological hallmarks of AD. TMEM59 has been implicated to play a role in AD...
Tomoyuki Yamanaka et al.
Nature communications, 5, 3354-3354 (2014-02-26)
Nuclear transcription factor-Y (NF-Y), a key regulator of cell-cycle progression, often loses its activity during differentiation into nonproliferative cells. In contrast, NF-Y is still active in mature, differentiated neurons, although its neuronal significance remains obscure. Here we show that conditional...
Shan-Yu Su et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 932823-932823 (2012-04-05)
Poststroke dementia commonly occurs following stroke, with its pathogenesis related to β-amyloid production and apoptosis. The present study evaluate the effects of paeonol, one of the phenolic phytochemicals isolated from the Chinese herb Paeonia suffruticosa Andrews (MC), on protection from...
Suk Ling Ma et al.
The Journal of biological chemistry, 287(10), 6969-6973 (2011-12-21)
Alzheimer disease (AD) is characterized by the presence of senile plaques of amyloid-β (Aβ) peptides derived from amyloid precursor protein (APP) and neurofibrillary tangles made of hyperphosphorylated Tau. Increasing APP gene dosage or expression has been shown to cause familial...
Victoria Lewis et al.
PloS one, 7(2), e31754-e31754 (2012-03-01)
There is increasing evidence of molecular and cellular links between Alzheimer's disease (AD) and prion diseases. The cellular prion protein, PrP(C), modulates the post-translational processing of the AD amyloid precursor protein (APP), through its inhibition of the β-secretase BACE1, and...
Tony Frugier et al.
Journal of neurotrauma, 27(3), 497-507 (2009-12-25)
Little is known about the molecular events following severe traumatic brain injury (TBI) in humans and to date there are no efficient therapies for the treatment of patients. In this study, the first of its kind in human tissue, a...
Katrin Kuehnle et al.
Neurochemical research, 34(6), 1167-1182 (2008-12-31)
Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain. DHCR24-knock-out mice lack cholesterol and accumulate desmosterol with age. Here we demonstrate that brain cholesterol deficiency in...
Karen Hill et al.
The Journal of biological chemistry, 278(38), 36032-36040 (2003-07-05)
Coat proteins cycle between soluble and membrane-bound locations at the time of vesicle biogenesis and act to regulate the assembly of the vesicle coat that determines the specificity in cargo selection and the destination of the vesicle. A transmembrane cargo...
Feng Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18135-18140 (2005-12-07)
The amyloid beta-protein precursor (AbetaPP) is best known as the parent molecule to the amyloid beta-peptide that accumulates in the brains of patients with Alzheimer's disease. Secreted isoforms of AbetaPP that contain the Kunitz proteinase inhibitor domain are analogous to...
Yeunkum Lee et al.
Neuropharmacology, 117, 387-400 (2017-03-05)
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces amyloid β (Aβ), the major component of hallmark AD plaques. Synaptic activity stimulates APP cleavage, whereas APP promotes excitatory synaptic transmission, suggesting...
B Ray et al.
Neuroscience, 184, 139-150 (2011-04-12)
Both environmental stress and anxiety may represent important risk factors for Alzheimer's disease (AD) pathogenesis. Previous studies demonstrate that restraint stress is associated with increased amyloid beta (Aβ) and decreased brain-derived neurotrophic factor (BDNF) levels in the brain. Aβ deposition...
Isabel Herrmann et al.
Infection and immunity, 74(8), 4841-4848 (2006-07-25)
The course of autoimmune inflammatory diseases of the central nervous system (CNS) can be influenced by infections. Here we assessed the disease-modulating effects of the most frequent respiratory pathogen Streptococcus pneumonia on the course of experimental autoimmune encephalomyelitis (EAE). Mice...
Beatriz Morancho et al.
Breast cancer research : BCR, 17, 106-106 (2015-08-12)
Cellular senescence is a terminal cell proliferation arrest that can be triggered by oncogenes. One of the traits of oncogene-induced senescence (OIS) is the so-called senescence-associated secretory phenotype or senescence secretome. Depending on the context, the non-cell autonomous effects of...
Tomoyuki Yamanaka et al.
Scientific reports, 6, 34575-34575 (2016-10-01)
The mammalian central nervous system (CNS) contains various types of neurons with different neuronal functions. In contrast to established roles of cell type-specific transcription factors on neuronal specification and maintenance, whether ubiquitous transcription factors have conserved or differential neuronal function...
Chera L Maarouf et al.
PloS one, 6(11), e27291-e27291 (2011-11-17)
The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while enduring high amyloid plaque loads for decades. If amyloid accumulation is...
Angiotensin II-inhibition: effect on Alzheimer's pathology in the aged triple transgenic mouse.
Ferrington, L; Palmer, LE; Love, S; Horsburgh, KJ; Kelly, PA; Kehoe, PG
American Journal of Translational Research null
Zoya O Serebrovska et al.
International journal of molecular sciences, 20(21) (2019-11-02)
Alzheimer's disease (AD) affects not only the central nervous system, but also peripheral blood cells including neutrophils and platelets, which actively participate in pathogenesis of AD through a vicious cycle between platelets aggregation and production of excessive amyloid beta (Aβ)....
Mitochondrial dysfunction and accumulation of the ?-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice.
Devi, L; Ohno, M
Neurobiology of Disease null
Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex.
Galvan, V; Banwait, S; Spilman, P; Gorostiza, OF; Peel, A; Ataie, M; Crippen, D; Huang et al.
Neurobiology of Disease null
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