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mabs451

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Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling.

Zhaoquan Wang et al.

The Journal of biological chemistry, 294(40), 14648-14660 (2019-08-09)

The activation of key signaling pathways downstream of antigen receptor engagement is critically required for normal lymphocyte activation during the adaptive immune response. CARD11 is a multidomain signaling scaffold protein required for antigen receptor signaling to NF-κB, c-Jun N-terminal kinase

Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.

Hirohisa Miyashita et al.

Frontiers in immunology, 12, 635475-635475 (2021-04-06)

Nuclear dot protein 52 kDa (NDP52, also known as CALCOCO2) functions as a selective autophagy receptor. The linear ubiquitin chain assembly complex (LUBAC) specifically generates the N-terminal Met1-linked linear ubiquitin chain, and regulates innate immune responses, such as nuclear factor-κB

The EMBO journal

Sasaki, Y; Sano, S; Nakahara, M; Murata, S; Kometani, K; Aiba, Y; Sakamoto, S; Watanabe et al.

The Embo Journal null

LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.

Yuanyuan Chu et al.

Autophagy, 17(7), 1684-1699 (2020-06-17)

Macroautophagy/autophagy is a membrane-mediated intracellular degradation pathway, through which bulky cytoplasmic content is digested in lysosomes. How the autophagy initiation and maturation steps are regulated is not clear. In this study, we found an E3 ubiquitin ligase complex, linear ubiquitin

Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.

Yong-Kang Yang et al.

The Journal of biological chemistry, 291(50), 25921-25936 (2016-10-26)

The activation of NF-κB downstream of T cell receptor (TCR) engagement is a key signaling step required for normal lymphocyte function during the adaptive immune response. During TCR signaling, the adaptor protein Bcl10 is inducibly recruited to the CARD11 scaffold

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC.

Jens Meschede et al.

Science signaling, 13(617) (2020-02-06)

The Parkin-coregulated gene (PACRG), which encodes a protein of unknown function, shares a bidirectional promoter with Parkin (PRKN), which encodes an E3 ubiquitin ligase. Because PRKN is important in mitochondrial quality control and protection against stress, we tested whether PACRG

Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants.

Jacquelyn R Bedsaul et al.

iScience, 25(2), 103810-103810 (2022-02-25)

The CARD11 scaffold controls antigen receptor signaling to NF-κB, JNK, and mTOR. Three classes of germline mutations in CARD11 cause Primary Immunodeficiency, including homozygous loss-of-function (LOF) mutations in CARD11 deficiency, heterozygous gain-of-function (GOF) mutations in BENTA disease, and heterozygous dominant-negative

Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation.

Todd Douglas et al.

The Journal of biological chemistry, 295(16), 5216-5228 (2020-03-04)

The linear ubiquitin assembly complex (LUBAC) is an essential component of the innate and adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflammatory signaling

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USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO.

Jixiao Niu et al.

The EMBO journal, 32(24), 3206-3219 (2013-11-26)

DNA damage-induced activation of the transcription factor NF-κB plays an important role in the cellular response to genotoxic stress. However, uncontrolled NF-κB activation upon DNA damage may lead to deleterious consequences. Although the mechanisms mediating genotoxic NF-κB activation have been

Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function.

Fuxiang Zhu et al.

The Journal of biological chemistry, 293(52), 20099-20111 (2018-11-06)

The CD4+CD25+FOXP3+ regulatory T (Treg) cells are critical for maintaining immune tolerance in healthy individuals and are reported to restrict anti-inflammatory responses and thereby promote tumor progression, suggesting them as a target in the development of antitumor immunotherapy. Forkhead box

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Seshiru Nakazawa et al.

Nature communications, 7, 12547-12547 (2016-08-25)

Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still remains unclear.

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity.

Esther Hoste et al.

Nature communications, 12(1), 5913-5913 (2021-10-10)

OTULIN is a deubiquitinase that specifically cleaves linear ubiquitin chains. Here we demonstrate that the ablation of Otulin selectively in keratinocytes causes inflammatory skin lesions that develop into verrucous carcinomas. Genetic deletion of Tnfr1, knockin expression of kinase-inactive Ripk1 or

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

Ruona Shi et al.

Cell & bioscience, 11(1), 146-146 (2021-07-29)

Linear ubiquitination is a novel type of ubiquitination that plays important physiological roles in signalling pathways such as tumour necrosis factor (TNF) signalling. However, little is known about the regulatory mechanisms of linear ubiquitination, except the well-described enzymatic regulators E3

Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.

Daisuke Oikawa et al.

Communications biology, 3(1), 163-163 (2020-04-05)

The NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and innate immune responses. The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, activates the canonical NF-κB pathway through Met1-linked linear ubiquitination. We identified

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.

Tsuyoshi Takiuchi et al.

Genes to cells : devoted to molecular & cellular mechanisms, 19(3), 254-272 (2014-01-28)

Linear ubiquitin chains generated by the linear ubiquitin chain assembly complex (LUBAC) play an important role in NF-κB activation. However, the regulation of linear ubiquitin chain generation by LUBAC is not well characterized. Here, we identified two deubiquitinating enzymes (DUBs)

Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.

Yibo Zuo et al.

Nature communications, 11(1), 1146-1146 (2020-03-04)

Linear ubiquitination is a critical regulator of inflammatory signaling pathways. However, linearly ubiquitinated substrates and the biological significance of linear ubiquitination is incompletely understood. Here, we show that STAT1 has linear ubiquitination at Lys511 and Lys652 residues in intact cells

IFN-? or IFN-? ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.

Tamiya, H; Terao, M; Takiuchi, T; Nakahara, M; Sasaki, Y; Katayama, I; Yoshikawa, H; Iwai, K

Journal of immunology (Baltimore, Md. : 1950) (1950)

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