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Romain Vidal et al.
Journal of lipid research, 46(2), 258-268 (2004-12-04)
Decrease of plasma lipid levels by polyphenols was linked to impairment of hepatic lipoprotein secretion. However, the intestine is the first epithelium that faces dietary compounds, and it contributes to lipid homeostasis by secreting triglyceride-rich lipoproteins during the postprandial state.
Adele Casaschi et al.
The Journal of nutrition, 134(6), 1340-1346 (2004-06-03)
The present study examined the role of xanthohumol (XN), a plant chalcone, on apolipoprotein B (apoB) and triglyceride (TG) synthesis and secretion, using HepG2 cells as the model system. The data indicated that XN decreased apoB secretion in a dose-dependent
F Y Jin et al.
Arteriosclerosis, thrombosis, and vascular biology, 19(4), 1051-1059 (1999-04-09)
The mechanism by which the potent drug niacin decreases apoB-containing atherogenic lipoproteins and prevents coronary disease is unclear. Utilizing human hepatoblastoma (HepG2) cells as an in vitro model, we have examined the effect of niacin on intracellular degradation of apoB
Lu Li et al.
Journal of lipid research, 47(1), 67-77 (2005-10-18)
Epigallocatechin gallate (EGCG) increases the formation of cytosolic lipid droplets by a mechanism that is independent of the rate of triglyceride biosynthesis and involves an enhanced fusion between lipid droplets, a process that is crucial for their growth in size.
The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways.
E A Fisher et al.
The Journal of biological chemistry, 276(30), 27855-27863 (2001-04-04)
We previously showed that Omega-3 fatty acids reduce secretion of apolipoprotein B (apoB) from cultured hepatocytes by stimulating post-translational degradation. In this report, we now characterize this process, particularly in regard to the two known processes that degrade newly synthesized
Geoffrey K Maiyoh et al.
The Journal of nutrition, 137(10), 2185-2189 (2007-09-22)
The cardioprotective effect of consuming cruciferous vegetables may be attributed to a number of unique indole-based compounds. We investigated the potential role and mechanism of action of an indole-based compound, indole-3-carbinol (I-3-C), on apolipoprotein B-100 (apoB) production using HepG2 cells.
Vincent Frochot et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(11), G1253-G1263 (2012-03-31)
With an excessive postprandial accumulation of intestine-derived, triglyceride-rich lipoproteins being a risk factor of cardiovascular diseases, it is essential to characterize the mechanisms controlling the intestinal absorption of dietary lipids. Our aim was to investigate the role of the transcription
Sandra Jimena Hernández Vallejo et al.
American journal of physiology. Gastrointestinal and liver physiology, 296(4), G782-G792 (2009-02-07)
Western diet is characterized by a hypercaloric and hyperlipidic intake, enriched in saturated fats, that is associated with the increased occurrence of metabolic diseases. To cope with this overload of dietary lipids, the intestine, which delivers dietary lipids to the
Thi Thu Trang Tran et al.
The Journal of biological chemistry, 291(31), 16328-16338 (2016-06-04)
The worldwide prevalence of metabolic diseases is increasing, and there are global recommendations to limit consumption of certain nutrients, especially saturated lipids. Insulin resistance, a common trait occurring in obesity and type 2 diabetes, is associated with intestinal lipoprotein overproduction.
Thomas Pauquai et al.
The Biochemical journal, 395(2), 393-403 (2006-01-06)
Enterocytes are responsible for the absorption of dietary lipids, which involves TRL [TG (triacylglycerol)-rich lipoprotein] assembly and secretion. In the present study, we analysed the effect on TRL secretion of Caco-2 enterocyte adaptation to a differential glucose supply. We showed
J Massart et al.
British journal of pharmacology, 165(5), 1361-1374 (2011-07-12)
Pentoxifylline is in clinical trials for non-alcoholic fatty liver disease and diabetic nephropathy. Metabolic and hepatic effects of pentoxifylline were assessed in a murine model of obesity and type 2 diabetes. Pentoxifylline (100 mg·kg(-1) ·day(-1)) was administered for 4 days
Hiroyuki Taguchi et al.
The Journal of nutritional biochemistry, 13(11), 678-683 (2003-01-29)
We have recently shown that the long-term ingestion of dietary diacylglycerol (DAG) mainly containing 1,3-isoform reduces body fat accumulation in humans as compared to triacylglycerol (TAG) with the same fatty acid composition. The fat reduction in this human experiment was
Benjamin J Stewart et al.
Biochimica et biophysica acta, 1791(8), 772-780 (2009-04-28)
Hepatic oxidative stress and lipid peroxidation are common features of several prevalent disease states, including alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), a common component of the metabolic syndrome. These conditions are characterized in part by excessive
Arup Banerjee et al.
Journal of virology, 84(12), 5936-5946 (2010-04-02)
Chronic hepatitis C virus (HCV) infection is often associated with insulin resistance and hepatic steatosis. Insulin regulates gene expression of key enzymes in glucose and lipid metabolism by modulating the activity of specific Forkhead box transcriptional regulators (FoxO1 and FoxA2)
Yufeng Li et al.
Lipids, 43(4), 301-312 (2008-03-13)
This study aimed to clarify the molecular mechanisms of age-specific hepatic lipid accumulation accompanying hyperinsulinemia in a peroxisome proliferator-activated receptor alpha (PPARalpha) (+/-):low-density lipoprotein receptor (LDLR) (+/-) mouse line. The hepatic fat content, protein amounts, and mRNA levels of genes
Yaakov Nahmias et al.
Hepatology (Baltimore, Md.), 47(5), 1437-1445 (2008-04-09)
Hepatitis C virus (HCV) infects over 3% of the world population and is the leading cause of chronic liver disease worldwide. HCV has long been known to associate with circulating lipoproteins, and its interactions with the cholesterol and lipid pathways
Elzbieta M Kurowska et al.
Lipids, 39(2), 143-151 (2004-05-12)
The purpose of the present study was to examine the role of tangeretin, a polymethoxylated flavone from citrus fruits, on the regulation of apolipoprotein B (apoB) and lipid metabolism in the human hepatoma cell-line HepG2. The marked reduction in apoB
Microsomal triglyceride transfer protein specificity of lipid binding and transport.
Jamil H, et al.
The Journal of Biological Chemistry, 270(12), 6549-6554 (1995)
The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 cells.
Rustaeus S, et al.
The Journal of Biological Chemistry, 273(9), 5196-5203 (1998)
Atorvastatin increases intestinal cholesterol absorption in dogs.
François Briand et al.
The Journal of nutrition, 136(7 Suppl), 2034S-2036S (2006-06-15)
Yusuke Higashi et al.
The Journal of biological chemistry, 278(24), 21450-21458 (2003-04-03)
Very low density lipoprotein (VLDL), a large particle containing apolipoprotein B (apoB) and large amounts of neutral lipids, is formed in the luminal space within the endoplasmic reticulum (ER) of hepatic cells. The assembly mechanism of VLDL particles is a
Angela M Domitrovich et al.
The Journal of biological chemistry, 280(48), 39802-39808 (2005-10-06)
Host genes involved in lipid metabolism are differentially regulated during the early stages of hepatitis C virus (HCV) infection. The majority of lipids synthesized in the liver are exported to other tissues in the form of lipoproteins. The formation of
J Estellé et al.
Animal genetics, 40(6), 813-820 (2009-06-06)
Despite the economic interest of the fatty acid profile in pigs, no gene has been convincingly associated with this trait so far. Here, the porcine microsomal triglyceride transfer protein (MTTP) gene, which plays a crucial role in the assembly of
John M Stafford et al.
Diabetes, 57(6), 1482-1490 (2008-03-12)
Elevated triglyceride (TG) is the major plasma lipid abnormality in obese and diabetic patients and contributes to cardiovascular morbidity in these disorders. We sought to identify novel mechanisms leading to hypertriglyceridemia. Resistance to negative feedback signals from adipose tissue in
Takashi Kosone et al.
American journal of physiology. Gastrointestinal and liver physiology, 293(1), G204-G210 (2007-03-31)
Hepatocyte growth factor (HGF) has various effects especially on epithelial cells. However, the precise role of HGF on lipogenesis is still not fully understood. A high-fat diet was administered to HGF transgenic mice and wild-type control mice in vivo. Furthermore
Ina Bergheim et al.
Gastroenterology, 130(7), 2099-2112 (2006-06-10)
The biguanide drug metformin has recently been found to improve steatosis and liver damage in animal models and in humans with nonalcoholic steatohepatitis. The aim of the present study was to determine whether metformin also prevents steatosis and liver damage
Gabriel Perlemuter et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16(2), 185-194 (2002-01-31)
Liver steatosis, which involves accumulation of intracytoplasmic lipid droplets, is characteristic of hepatitis C virus (HCV) infection. By use of an in vivo transgenic murine model, we demonstrate that hepatic overexpression of HCV core protein interferes with the hepatic assembly
Yuan-Lung Cheng et al.
Clinical science (London, England : 1979), 125(9), 439-448 (2013-05-11)
HCV (hepatitis C virus) infection affects an estimated 180 million people in the world's population. Adverse effects occur frequently with current standard treatment of interferon and ribavirin, while resistance of new direct anti-viral agents, NS3 protease inhibitors, is a major
T Funatsu et al.
Atherosclerosis, 157(1), 107-115 (2001-06-28)
Atorvastatin is a new HMG-CoA reductase inhibitor that strongly lowers plasma cholesterol and triglyceride (TG) levels in humans and animals. Since previous data indicated that atorvastatin has prolonged inhibition of hepatic cholesterol synthesis, we tested whether this longer duration of
Alka Agarwal-Mawal et al.
Canadian journal of physiology and pharmacology, 85(3-4), 430-438 (2007-07-07)
We investigated whether expression of cholesterol ester transfer protein (CETP) in mice alters the regulation of cholesterol metabolism. Transgenic mice expressing human CETP (CETP-TG) and nontransgenic littermates (non-TG) were fed either a monounsaturated fatty acid (MUFA) or a saturated fatty
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