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Showing 1-30 of 38 results for "MAK307" within Papers
Ilke Sen et al.
Nature communications, 11(1), 138-138 (2020-01-11)
In C. elegans, the conservedĀ transcription factor DAF-16/FOXO is a powerful aging regulator, relaying dire conditions into expression of stress resistance and longevity promoting genes. For some of these functions, including low insulin/IGF signaling (IIS), DAF-16 depends on the protein SMK-1/SMEK
Prasanna K R Allu et al.
Diabetes, 71(3), 538-553 (2021-12-05)
Pancreastatin (PST), a chromogranin A-derived potent physiological dysglycemic peptide, regulates glucose/insulin homeostasis. We have identified a nonsynonymous functional PST variant (p.Gly297Ser; rs9658664) that occurs in a large section of human populations. Association analysis of this single nucleotide polymorphism with cardiovascular/metabolic
Seung-Hwa Kwak et al.
Bioorganic chemistry, 102, 104055-104055 (2020-07-15)
The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is essential in lipid A biosynthesis and has emerged as a promising target for the development of novel antibiotics against multidrug-resistant Gram-negative pathogens. Recently, we reported the crystal structure of Klebsiella pneumoniae LpxH in complex
Tamara Rothenburger et al.
Journal of experimental & clinical cancer research : CR, 40(1), 317-317 (2021-10-14)
SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMHD1 inhibitors are promising candidates for the sensitisation of leukaemia cells to
Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH.
Lev S, et al.
mSphere, 2(1), e00381-e00316 (2017)
Dieter WaschbĆ¼sch et al.
EMBO reports, 22(11), e52675-e52675 (2021-09-29)
LRRK2 serine/threonine kinase is associated with inherited Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases within their switch 2 motif to control their interactions with effectors. Recent work has shown that the metal-dependent protein phosphatase PPM1H counteracts LRRK2 by
Methods in Plant Cell Biology, 50 (1995)
Jishma Panichikkal et al.
Biofouling, 36(8), 990-999 (2020-11-06)
In the study,Pseudomonas sp. K6 and Pseudomonas monteilii were found to form an enhanced biofilm when cultured in the presence of organic acids and sugars. Here, the highest biofilm could be observed for Pseudomonas sp. K6 (3.08ā€‰Ā±ā€‰0.13) and P. monteilii
Shuai Huang et al.
Nature, 594(7863), 424-429 (2021-05-28)
Liquid-liquid phase separation (LLPS) has emerged as a central paradigm for understanding how membraneless organelles compartmentalize diverse cellular activities in eukaryotes1-3. Here we identify a superfamily of plant guanylate-binding protein (GBP)-like GTPases (GBPLs) that assemble LLPS-driven condensates within the nucleus
Javier Canales et al.
BMC plant biology, 20(1), 385-385 (2020-08-25)
Sulfur is a major component of biological molecules and thus an essential element for plants. Deficiency of sulfate, the main source of sulfur in soils, negatively influences plant growth and crop yield. The effect of sulfate deficiency on plants has
Sophie Lev et al.
mSphere, 2(1) (2017-02-02)
Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition (PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain and is the commonest cause of fungal meningitis worldwide. To investigate the contribution of PHO signaling to
Xiang-Ping Yao et al.
Cell and tissue research, 370(2), 267-273 (2017-08-03)
Primary familial brain calcification (PFBC) is a neuropsychiatric disorder characterized by bilateral cerebral calcification with diverse neurologic or psychiatric symptoms. Recently, XPR1 variation has accounted for PFBC as another new causative gene. However, little is known about the distribution and
Ivan Bassanini et al.
Biomolecules, 11(1) (2021-01-21)
The natural triterpene celastrol (CE) is here used as lead compound for the design and synthesis of a panel of eleven CE carboxamides that were tested in vitro for their growth inhibitory activity against Leishmania infantum and L.
Sara Ricci et al.
Frontiers in physiology, 12, 645529-645529 (2021-06-22)
Saliva facilitates feed ingestion, nutrient circulation, and represents an important pH buffer for ruminants, especially for cattle fed high-concentrate diets that promote rumen acidification. This experiment evaluated the short-term effects of nine phytogenic compounds on salivation, saliva physico-chemical composition as
Julie Wilson et al.
iScience, 23(6), 101219-101219 (2020-06-17)
In macromolecular crystallization, success is often dependent on the pH of the experiment. However, little is known about the pH of reagents used, and it is generally assumed that the pH of the experiment will closely match that of any
Debasish Kumar Ghosh et al.
FEBS letters, 592(16), 2680-2692 (2018-08-03)
Intracellular protein aggregation is characterized by accumulation of misfolded proteins. Chaperones, degradation machineries, and quality-control mechanisms counteract protein aggregation. In this study, we report that the ATPase valosin-containing protein (VCP/p97) acts as a functional disaggregase that disassembles Huntingtin-exon1 aggregates in
Bregje W M de Wildt et al.
Frontiers in immunology, 13, 915277-915277 (2022-07-08)
To study human physiological and pathological bone remodeling while addressing the principle of replacement, reduction and refinement of animal experiments (3Rs), human in vitro bone remodeling models are being developed. Despite increasing safety-, scientific-, and ethical concerns, fetal bovine serum
Nisansala Abeyrathna et al.
Dalton transactions (Cambridge, England : 2003), 49(45), 16082-16094 (2020-05-30)
Cu(i) P-type ATPases are transmembrane primary active ion pumps that catalyze the extrusion of copper ions across cellular membranes. Their activity is critical in controlling copper levels in all kingdoms of life. Biochemical and structural characterization established the structural framework
Jintong Zhou et al.
Nucleic acids research, 48(20), 11566-11576 (2020-10-15)
Aminoacyl-tRNA synthetases are attractive targets for the development of antibacterial, antifungal, antiparasitic agents and for the treatment of other human diseases. Lysyl-tRNA synthetase (LysRS) from this family has been validated as a promising target for the development of antimalarial drugs.
Edward G.
Synthetic Dyes in Biology, Medicine And Chemistry (2012)
Mohamed A Abouelkhair et al.
Veterinary microbiology, 246, 108720-108720 (2020-07-02)
Staphylococcus pseudintermedius is a major opportunistic bacterial pathogen and the leading cause of pyoderma in dogs. In canines it is also often associated with infections of the urinary system and wounds and occasionally infects people. Widespread antimicrobial resistance has made
Julya Sorokina et al.
Journal of bacteriology, 203(21), e0035921-e0035921 (2021-08-24)
The type 4 secretion system (T4SS) represents a bacterial nanomachine capable of trans-cell wall transportation of proteins and DNA and has attracted intense interest due to its roles in the pathogenesis of infectious diseases. In the current investigation, we uncovered
Swetha Ramadesikan et al.
Human molecular genetics, 30(3-4), 198-212 (2021-02-01)
Lowe Syndrome (LS) is a lethal genetic disorder caused by mutations in the OCRL1 gene which encodes the lipid 5' phosphatase Ocrl1. Patients exhibit a characteristic triad of symptoms including eye, brain and kidney abnormalities with renal failure as the
Vidyasiri Vemulapalli et al.
eLife, 10 (2021-03-24)
SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast cancer cells
Fabian C Herbert et al.
Nature communications, 12(1), 2202-2202 (2021-04-15)
Artificial native-like lipid bilayer systems constructed from phospholipids assembling into unilamellar liposomes allow the reconstitution of detergent-solubilized transmembrane proteins into supramolecular lipid-protein assemblies called proteoliposomes, which mimic cellular membranes. Stabilization of these complexes remains challenging because of their chemical composition
On targeted proteins involved in the neuroprotective effects of lithium citrate.
Torshin I Y, et al.
Neurology, neuropsychiatry, psychosomatics, 9(1), 2017-2017 null
Jurre A Steens et al.
Nature communications, 12(1), 5033-5033 (2021-08-21)
Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA and the subsequent induction of a multifaceted immune response. This involves sequence-specific cleavage of the target RNA and production of cyclic oligoadenylate (cOA) molecules. Here we report that
Xinlu Yuan et al.
Journal of biomaterials applications, 35(7), 849-856 (2020-08-04)
Metformin, the first-line drug to treat type 2 diabetes, inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress gluconeogenesis. The major adverse effects caused by metformin were lactic acidosis and gastrointestinal discomfort. Therefore, there is need to develop a strategy
Molecular cloning and functional characterization of three terpene synthases from unripe fruit of black pepper (Piper nigrum).
Jin Z, et al.
Archives of Biochemistry and Biophysics, 638, 35-40 (2018)
Venus Joumaa et al.
Frontiers in physiology, 11, 567538-567538 (2021-02-05)
Muscle force is enhanced during shortening when shortening is preceded by an active stretch. This phenomenon is known as the stretch-shortening cycle (SSC) effect. For some stretch-shortening conditions this increase in force during shortening is maintained following SSCs when compared
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