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A C Mamede et al.
Medical oncology (Northwood, London, England), 32(12), 257-257 (2015-10-29)
Hepatocellular carcinoma (HCC) has a worldwide high incidence and mortality. For this reason, it is essential to invest in new therapies for this type of cancer. Our team already proved that human amniotic membrane (hAM) is able to inhibit the
Jianbing Zhang et al.
PLoS genetics, 14(9), e1007665-e1007665 (2018-09-25)
Heme-iron recycling from senescent red blood cells (erythrophagocytosis) accounts for the majority of total body iron in humans. Studies in cultured cells have ascribed a role for HRG1/SLC48A1 in heme-iron transport but the in vivo function of this heme transporter
Yue Huang et al.
Cancer cell, 35(4), 677-691 (2019-04-17)
FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two promising FTO inhibitors, namely FB23 and FB23-2, which directly bind to FTO and selectively inhibit FTO's m6A demethylase activity. Mimicking FTO
Markus Bender et al.
Nature communications, 5, 4746-4746 (2014-09-05)
Wiskott-Aldrich syndrome (WAS) is caused by mutations in the WAS gene and is characterized by immunodeficiency, eczema and microthrombocytopenia. The molecular link between WAS mutations and microthrombocytopenia is unknown. Profilin1 (Pfn1) is a key actin-regulating protein that, besides actin, interacts
Claudio Hidalgo-Cantabrana et al.
Applied and environmental microbiology, 81(23), 7960-7968 (2015-09-13)
Exopolysaccharides (EPS) are extracellular carbohydrate polymers synthesized by a large variety of bacteria. Their physiological functions have been extensively studied, but many of their roles have not yet been elucidated. We have sequenced the genomes of two isogenic strains of
Gaucher iPSC-derived macrophages produce elevated levels of inflammatory mediators and serve as a new platform for therapeutic development.
Panicker LM, Miller D, Awad O, et al.
Stem Cells, 32(9), 2338-2349 (2014)
Ashkan Ojaghi et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(26), 14779-14789 (2020-06-21)
Hematological analysis, via a complete blood count (CBC) and microscopy, is critical for screening, diagnosing, and monitoring blood conditions and diseases but requires complex equipment, multiple chemical reagents, laborious system calibration and procedures, and highly trained personnel for operation. Here
Sunmi Park et al.
PLoS genetics, 13(9), e1006991-e1006991 (2017-09-15)
Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders. We previously created a mutant mouse expressing a mutated TRα1 (denoted as PV; Thra1PV/+ mouse) that faithfully reproduces the classical hypothyroidism seen in patients. Using
Historical hematology: May--Hegglin anomaly
Saito, Hidehiko and Kunishima, Shinji
American Journal of Hematology, 83(4) (2008)
Shirin Hasan et al.
Journal of burn care & research : official publication of the American Burn Association, 39(2), 286-294 (2017-06-02)
Mechanisms of erythropoietin (Epo)-resistant anemia in burn patients are poorly understood. We have recently found that administering a nonselective beta 1,2-adrenergic blocker propranolol (PR) was effective in reversing myelo-erythroid commitment through MafB regulation and increase megakaryocyte erythrocyte progenitors in burn
Stephanie Saul et al.
Journal of leukocyte biology, 106(5), 1101-1115 (2019-06-20)
Neutrophils play a central role in immunity and inflammation via their intrinsic ability to migrate into inflamed tissue, to phagocytose pathogens, and to kill bacterial and fungi by releasing large quantities of superoxide anions and lytic enzymes. The molecular pathways
Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy.
Yan HW, Hu WX, Zhang JY, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 35(6), 5381-5388 (2014)
Tomasz Dobrzycki et al.
Communications biology, 3(1), 71-71 (2020-02-15)
Gata2 is a key transcription factor required to generate Haematopoietic Stem and Progenitor Cells (HSPCs) from haemogenic endothelium (HE); misexpression of Gata2 leads to haematopoietic disorders. Here we deleted a conserved enhancer (i4 enhancer) driving pan-endothelial expression of the zebrafish
Nuria Castro-Bravo et al.
Frontiers in microbiology, 8, 1405-1405 (2017-08-10)
An extracellular layer of exopolysaccharides (EPS) covers the surface of some
Adlen Foudi et al.
The Journal of experimental medicine, 211(5), 909-927 (2014-04-09)
The zinc finger transcriptional repressor Gfi-1b is essential for erythroid and megakaryocytic development in the embryo. Its roles in the maintenance of bone marrow erythropoiesis and thrombopoiesis have not been defined. We investigated Gfi-1b's adult functions using a loxP-flanked Gfi-1b
Epidemiological characteristics of Malassezia folliculitis and use of the May-Grunwald-Giemsa stain to diagnose the infection
Durdu, et al.
Diagnostic Microbiology and Infectious Disease, 76(4) (2013)
Roberto Gozalbo-Rovira et al.
International journal of molecular sciences, 22(3) (2021-01-28)
The gut microbiota has emerged as a key factor in the pathogenesis of intestinal viruses, including enteroviruses, noroviruses and rotaviruses (RVs), where stimulatory and inhibitory effects on infectivity have been reported. With the aim of determining whether members of the
Babu P Patlolla et al.
International journal of environmental research and public health, 2(1), 101-106 (2006-05-19)
The major concern for the halogenated compounds is their widespread distribution, in addition to occupational exposures. Several chlorinated alkanes and alkenes were found to induce toxic effects. In this study, we investigated the genotoxic potential of 1,1-dichloroethane in the bone
Shirin Hasan et al.
Surgery, 162(4), 901-916 (2017-07-19)
Anemia of critical illness is resistant to exogenous erythropoietin. Packed red blood cells transfusions is the only treatment option, and despite related cost and morbidity, there is a need for alternate strategies. Erythrocyte development can be divided into erythropoietin-dependent and
Rosanna Salvia et al.
Insects, 12(1) (2021-01-21)
Toxoneuron nigriceps (Viereck) (Hymenoptera, Braconidae) is an endophagous parasitoid of the larval stages of the tobacco budworm, Heliothis virescens (Fabricius) (Lepidoptera, Noctuidae). During oviposition, T. nigriceps injects into the host body, along with the egg, the venom, the calyx fluid
Gökhan Cildir et al.
Immunity, 51(5), 949-965 (2019-10-28)
Mast cells (MCs) are versatile immune cells capable of rapidly responding to a diverse range of extracellular cues. Here, we mapped the genomic and transcriptomic changes in human MCs upon diverse stimuli. Our analyses revealed broad H3K4me3 domains and enhancers
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