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Hikaru Ito et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46(2), 442-454 (2020-09-18)
The lateral habenula (LHb) attracts a growing interest as a regulator of monoaminergic activity which were frequently reported to be defective in depression. Here we found that chronic social defeat stress (CSDS) increased production of pro-inflammatory cytokines in LHb associated
Daniel G Blackmore et al.
iScience, 24(11), 103275-103275 (2021-11-12)
Hippocampal function is critical for spatial and contextual learning, and its decline with age contributes to cognitive impairment. Exercise can improve hippocampal function, however, the amount of exercise and mechanisms mediating improvement remain largely unknown. Here, we show exercise reverses
Sébastien Le Garf et al.
International journal of molecular sciences, 20(20) (2019-10-23)
Regular aerobic exercise, independently of weight loss, improves metabolic and anti-inflammatory states, and can be regarded as beneficial in counteracting obesity-induced low-grade inflammation. However, it is still unknown how exercise alters immunometabolism in a context of dietary changes. Agonists of
Xionghui Ding et al.
Nature communications, 12(1), 6699-6699 (2021-11-20)
Candida albicans is the most common cause of fungal sepsis. Inhibition of inflammasome activity confers resistance to polymicrobial and LPS-induced sepsis; however, inflammasome signaling appears to protect against C. albicans infection, so inflammasome inhibitors are not clinically useful for candidiasis.
Amanda J Martinot et al.
PLoS pathogens, 16(12), e1009096-e1009096 (2020-12-15)
Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis. We previously reported that Mtb lacking
Yingxin Sun et al.
Frontiers in cellular and infection microbiology, 11, 618265-618265 (2021-04-06)
Aging induced chronic systemic inflammatory response is an important risk factor for atherosclerosis (AS) development; however, the detailed mechanism is yet to be elucidated. To explore the underlying mechanism of how aging aggravates AS advancement. A young (five-week-old, YM) and
Alex Bernard Addinsall et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(5), R981-R996 (2020-03-19)
Selenoprotein S (Seps1) can be protective against oxidative, endoplasmic reticulum (ER), and inflammatory stress. Seps1 global knockout mice are less active, possess compromised fast muscle ex vivo strength, and, depending on context, heightened inflammation. Oxidative, ER, and inflammatory stress modulates
Kenji Fujiwara et al.
Journal for immunotherapy of cancer, 8(2) (2020-07-18)
Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal adenocarcinoma (PDAC). Our prior studies demonstrated that
Irene Martínez de Toda et al.
International journal of molecular sciences, 18(7) (2017-07-25)
The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived
Robert A Kazmierczak et al.
Oncotarget, 11(44), 3943-3958 (2020-11-21)
Conventional cancer chemotherapies are not fully efficacious and do not target tumors, leading to significant treatment-related morbidities. A number of genetically attenuated cancer-targeting bacteria are being developed to safely target tumors in vivo. Here we report the toxicological, tumor-targeting, and
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