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Lorel E Burns et al.
Journal of dental education, 83(9), 1057-1064 (2019-09-04)
Pipeline programs aim to increase the representation of underrepresented minorities in the dental profession. At New York University College of Dentistry (NYUCD), two dental students initiated the development of a pipeline program for high school students called Saturday Academy. The...
Alessia Alunno et al.
Journal of cellular and molecular medicine, 19(7), 1689-1696 (2015-03-11)
It has been recently reported that telocytes, a stromal (interstitial) cell subset involved in the control of local tissue homeostasis, are hampered in the target organs of inflammatory/autoimmune disorders. Since no data concerning telocytes in minor salivary glands (MSGs) are...
C Linscheid et al.
Placenta, 36(8), 832-838 (2015-06-23)
Maternal T-cells reactive towards paternally inherited fetal minor histocompatibility antigens are expanded during pregnancy. Placental trophoblast cells express at least four fetal antigens, including human minor histocompatibility antigen 1 (HA-1). We investigated oxygen as a potential regulator of HA-1 and...
D C Roopenian et al.
Immunogenetics, 38(2), 131-140 (1993-01-01)
The purpose of this study was to elucidate the genetic origin of minor histocompatibility (H) antigens. Toward this end common inbred mouse strains, distinct subspecies, and species of the subgenus Mus were examined for expression of various minor H antigens....
D C Roopenian et al.
Journal of immunology (Baltimore, Md. : 1950), 151(9), 4595-4605 (1993-11-01)
This work addresses the functional basis of classical minor histocompatibility (H) loci. We focus on the H-3 locus, which is actually a complex genetic unit to which the phenotypic trait of tissue rejection, genes whose products stimulate specific subsets of...
Hongjun Zhang et al.
Stem cells (Dayton, Ohio), 32(8), 2267-2277 (2014-04-10)
Adult stem cells (SCs) are important to maintain homeostasis of tissues including several mini-organs like hair follicles and sweat glands. However, the existence of stem cells in minor salivary glands (SGs) is largely unexplored. In vivo histone2B green fluorescent protein...
Xavier Alvarez et al.
Viruses, 12(7) (2020-07-08)
HIV/SIV-associated oral mucosal disease/dysfunction (HAOMD) (gingivitis/periodontitis/salivary adenitis) represents a major comorbidity affecting HIV patients on anti-retroviral therapy. Using a systems biology approach, we investigated molecular changes (mRNA/microRNA) underlying HAOMD and its modulation by phytocannabinoids (delta-9-tetrahydrocannabinol (∆9-THC)) in uninfected (n =...
E Simpson et al.
Current opinion in immunology, 9(5), 655-661 (1997-11-22)
The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts...
A R Zuberi et al.
Journal of immunology (Baltimore, Md. : 1950), 161(2), 821-828 (1998-07-22)
The H3 complex, on mouse Chromosome 2, is an important model locus for understanding mechanisms underlying non-self Ag recognition during tissue transplantation rejection between MHC-matched mouse strains. H3a is a minor histocompatibility Ag gene, located within H3, that encodes a...
Richard G Wight et al.
Social science & medicine (1982), 147, 200-208 (2015-11-21)
In this paper we introduce the construct of "internalized gay ageism," or the sense that one feels denigrated or depreciated because of aging in the context of a gay male identity, which we identify as an unexplored aspect of sexual...
L M Mendoza et al.
Immunity, 7(4), 461-472 (1997-11-14)
The products of minor histocompatibility (H) loci are serious barriers to tissue transplantation even among major histocompatibility complex (MHC) identical individuals, frequently causing chronic graft rejection and graft versus host disease. Over 50 minor H loci map to mouse autosomal...
Brittany M Charlton et al.
Cancer causes & control : CCC, 31(2), 173-179 (2020-01-03)
Several studies indicate that sexual minority (e.g., bisexual, lesbian) women may be at an increased risk for breast cancer. However, we know little about how risk factors, such as benign breast disease (BBD)-which can confer nearly a fourfold breast cancer...
J M den Haan et al.
Science (New York, N.Y.), 279(5353), 1054-1057 (1998-03-07)
The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide...
Charles Agyemang et al.
International journal of cardiology, 183, 180-189 (2015-02-14)
Hypertension is a major problem among European ethnic minority groups. We assessed the current situation of hypertension prevalence and its management among a multi-ethnic population in Amsterdam, The Netherlands. Data from the HELIUS study were used including 12,974 participants (1871...
P A Eden et al.
Journal of immunology (Baltimore, Md. : 1950), 162(8), 4502-4510 (1999-04-14)
Of the many minor histocompatibility (H) Ags that have been detected in mice, the ability to induce graft vs host disease (GVHD) after bone marrow transplantation is restricted to a limited number of immunodominant Ags. One such murine Ag, B6dom1...
M H Brilliant et al.
Genetics, 138(1), 203-211 (1994-09-01)
Allelic variation of the mouse pink-eyed dilution (p) gene in common laboratory strains and wild mice was examined by Southern blot and by polymerase chain reaction. In these assays the original p mutation allele found in strains SJL/J, 129/J, B10.129(21m)...
Yoshiki Akatsuka et al.
The Journal of experimental medicine, 197(11), 1489-1500 (2003-05-29)
We report the identification of two novel minor histocompatibility antigens (mHAgs), encoded by two separate single nucleotide polymorphisms on a single gene, BCL2A1, and restricted by human histocompatibility leukocyte antigen (HLA)-A*2402 (the most common HLA-A allele in Japanese) and B*4403...
D C Roopenian
Immunology today, 13(1), 7-10 (1992-01-01)
In this article, Derry Roopenian relates the traditional view of minor histocompatibility (H) loci to recent advances in understanding of the tissue rejection process and the molecular nature of minor histocompatibility antigens. He proposes that minor H loci can be...
Bo-feng Zhu et al.
Human immunology, 71(11), 1116-1123 (2010-07-24)
The aim of this study was to analyze killer immunoglobulin-like receptor (KIR) gene polymorphisms in the Tibetan ethnic minority of China. To that purpose, we have studied KIR gene frequencies and genotype diversities of 16 KIR genes and three pseudogenes...
M-J Park et al.
Tissue antigens, 76(6), 482-486 (2010-08-20)
Single nucleotide polymorphisms of minor histocompatibility antigens (mHags) have been genotyped by allele-specific polymerase chain reaction with sequence-specific primers (PCR-SSP). Because discriminating the genotype of HB-1 Y by PCR-SSP under various PCR conditions was difficult, we optimized the use of...
A R Zuberi et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 4(9), 516-522 (1993-09-01)
Minor histocompatibility (H) loci are significant tissue transplantation barriers but are poorly understood at the genetic and molecular level. We describe the construction of a high-resolution genetic map that positions a class II MHC-restricted minor H antigen locus and orders...
Jaap W Hol et al.
Annals of surgery, 258(6), 1072-1078 (2013-03-09)
To determine the effect of surgical invasiveness on plasma levels of arginine, citrulline, ornithine, and nitric oxide (NO) in humans. Surgical trauma may have a profound effect on the metabolism of NO. However, human studies reported both increased and decreased...
S Malarkannan et al.
Immunity, 13(3), 333-344 (2000-10-06)
Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic...
S Malarkannan et al.
Journal of immunology (Baltimore, Md. : 1950), 161(7), 3501-3509 (1998-10-06)
Minor histocompatibility (H) Ags elicit T cell responses and thereby cause chronic graft rejection and graft-vs-host disease among MHC identical individuals. Although numerous independent H loci exist in mice of a given MHC haplotype, certain H Ags dominate the immune...
Elissa Meites et al.
The Journal of infectious diseases, 222(12), 2052-2060 (2020-06-07)
In the United States, human papillomavirus (HPV) vaccination has been recommended for young adult men who have sex with men (MSM) since 2011. The Vaccine Impact in Men study surveyed MSM and transgender women aged 18-26 years in 3 US...
Shovanne Brown et al.
International journal of environmental research and public health, 18(4) (2021-02-10)
English national guidelines regarding dementia assessment and management recommend consideration of cultural and linguistic diversity when assessing people with cognitive complaints. To date there has been no assessment of adherence to these guidelines. We aimed to assess whether current services...
Bart-Jan de Kreuk et al.
PloS one, 8(9), e73962-e73962 (2013-10-03)
The human minor Histocompatibility Antigen HMHA-1 is a major target of immune responses after allogeneic stem cell transplantation applied for the treatment of leukemia and solid tumors. The restriction of its expression to hematopoietic cells and many solid tumors raised...
Jonas J W Kuiper et al.
Human molecular genetics, 27(24), 4333-4343 (2018-09-15)
Birdshot Uveitis (Birdshot) is a rare eye condition that affects HLA-A29-positive individuals and could be considered a prototypic member of the recently proposed 'MHC-I (major histocompatibility complex class I)-opathy' family. Genetic studies have pinpointed the endoplasmic reticulum aminopeptidase (ERAP1) and...
Valérie Janelle et al.
Journal of translational medicine, 13, 123-123 (2015-05-01)
Adoptive transfer of minor histocompatibility antigen (MiHA)-specific T cells is a promising therapy for patients with hematological cancers. However, the efficacy of the transferred cells is hampered by the acquisition of terminal effector differentiation and exhaustion features during expansion in...
Peng Xu et al.
Journal of dermatological science, 88(2), 216-224 (2017-09-25)
Remodeling of cytoskeleton plays an important role in development of multiple cancers, including melanoma. As a group of F-actin regulators, the Ras homology (Rho) GTPase-activating proteins (ARHGAPs) were reported by accumulating studies as a set of significant mediators in cell...
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