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Likun Li et al.
Molecular cancer research : MCR, 7(11), 1781-1791 (2009-11-12)
Caveolin-1 (cav-1) and the cancer-promoting growth factors vascular endothelial growth factor (VEGF), transforming growth factor beta1 (TGF-beta1), and fibroblast growth factor 2 (FGF2) are often found to be upregulated in advanced prostate cancer and other malignancies. However, the relationship between
Irena Ivanovska et al.
Molecular and cellular biology, 28(7), 2167-2174 (2008-01-24)
microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of
Eran Elyakim et al.
Cancer research, 70(20), 8077-8087 (2010-10-07)
Hepatocellular carcinoma (HCC) is generally a fatal disease due to a paucity of effective treatment options. The identification of oncogenic microRNAs that exert pleiotropic effects in HCC cells may offer new therapeutic targets. In this study, we have identified the
Joanna Boros et al.
Nucleic acids research, 37(22), 7368-7380 (2009-10-01)
ETS-domain transcription factors play important roles in controlling gene expression in a variety of different contexts; however, these proteins bind to very similar sites and it is unclear how in vivo specificity is achieved. In silico analysis is unlikely to
Sutapa Sinha et al.
The Journal of biological chemistry, 284(47), 32610-32618 (2009-10-06)
TIS11B belongs to a group of RNA-binding proteins (including TIS11/tristetraprolin and TIS11D) that share characteristic tandem CCCH-type zinc-finger domains and can be rapidly induced by multiple stimuli. TIS11B has been shown to regulate vascular endothelial growth factor (VEGF) mRNA stability
Emma Y Song et al.
Experimental hematology, 38(10), 908-921 (2010-06-15)
The objective of this study was to investigate the effect of small molecule inhibitors of glycogen synthase kinase-3β (GSK-3β) on leukemia cell growth and survival. Analysis of cytotoxicity and cell proliferation was conducted using the MTS assay, cell-cycle analysis, and
Inhibition of miR-193a expression by Max and RXRα activates K-Ras and PLAU to mediate distinct aspects of cellular transformation
Iliopoulos, D., et al.
Cancer Research, 18, 1619-1629 (2011)
Nathan D Trinklein et al.
Genome research, 14(1), 62-66 (2004-01-07)
The alignment of full-length human cDNA sequences to the finished sequence of the human genome provides a unique opportunity to study the distribution of genes throughout the genome. By analyzing the distances between 23,752 genes, we identified a class of
Brenton R Paolella et al.
Stem cells (Dayton, Ohio), 29(7), 1090-1101 (2011-05-25)
Neural progenitor cells (NPCs) have the capacity to proliferate and give rise to all major central nervous system cell types and represent a possible cell of origin in gliomagenesis. Deletion of the tumor suppressor gene Tp53 (p53) results in increased
Yiping Huang et al.
Aging, 2(12), 959-968 (2010-12-31)
Oxidative stress was shown to promote the translocation of Ataxia-telangiectasia mutated (ATM) to cytoplasm and trigger the LKB1-AMPK-tuberin pathway leading to a down-regulation of mTOR and subsequently inducing the programmed cell death II (autophagy). Cisplatin was previously found to induce
Amy J Murphy et al.
Journal of immunology (Baltimore, Md. : 1950), 184(9), 5029-5037 (2010-03-31)
Previous findings suggest that 17beta-estradiol (estradiol) has a suppressive effect on TNF-alpha, but the mechanism by which estradiol regulates TNF-alpha expression in primary human macrophages is unknown. In this article, we demonstrate that pretreatment of human macrophages with estradiol attenuates
Bing Wang et al.
PloS one, 5(4), e10409-e10409 (2010-05-11)
Beclin 1 plays an essential role in autophagy; however, the regulation of Beclin 1 expression remains largely unexplored. An earlier ChIP-on-chip study suggested Beclin 1 could be an E2F target. Previously, we also reported that 14-3-3tau regulates E2F1 stability, and
An NTD-associated polymorphism in the 3' UTR of MTHFD1L can affect disease risk by altering miRNA binding.
Minguzzi S
Human Mutation, 35(1), 96-104 (2014)
Yong Tang et al.
International journal of cancer, 128(4), 847-856 (2010-10-28)
GPR43 is a G-protein-coupled receptor for short-chain fatty acids (SCFAs). Expression of GPR43 is detected in hematopoietic tissues and the large intestine. SCFAs are derived from bacterial fermentation and metabolism of undigested dietary fibers and have been recognized for their
Mohamed El Gazzar et al.
The Journal of biological chemistry, 285(27), 20940-20951 (2010-05-04)
We reported that gene-selective formation of facultative heterochromatin silences transcription of acute inflammatory genes during endotoxin (LPS) tolerance, according to function. We discovered that reversal of the epigenetically silenced transcription restored mRNA levels but not protein synthesis. Here, we find
A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors
Wong, et al.
Oncogene (2011)
Nathan D Trinklein et al.
Molecular biology of the cell, 15(3), 1254-1261 (2003-12-12)
Previous work has implicated heat shock transcription factor 1 (HSF1) as the primary transcription factor responsible for the transcriptional response to heat stress in mammalian cells. We characterized the heat shock response of mammalian cells by measuring changes in transcript
Gurdeep Marwarha et al.
Journal of neurochemistry, 119(5), 1119-1136 (2011-09-29)
Loss of dopaminergic neurons and α-synuclein accumulation are the two major pathological hallmarks of Parkinson's disease. Currently, the mechanisms governing depletion of dopamine content and α-synuclein accumulation are not well understood. We showed that the oxysterol 27-hydroxycholesterol (27-OHC) reduces the
Nathan D Trinklein et al.
Genome research, 13(2), 308-312 (2003-02-05)
Genomic and full-length cDNA sequences provide opportunities for understanding human gene structure and transcriptional regulatory elements. The simplest regulatory elements to identify are promoters, as their positions are dictated by the location of transcription start sites. We aligned full-length cDNA
Sumie Hiramatsu-Asano et al.
Frontiers in immunology, 11, 616141-616141 (2021-02-13)
The micro RNAs (miRNAs) and their target mRNAs are differentially expressed in various immune-mediated cells. Here, we investigated the role of Mir223 and sphingosine-1-phosphate receptor 1 (S1pr1) in the pathogenesis of systemic lupus erythematosus. We analyzed miRNA and mRNA profiling
Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells
Moffat, C., et al.
Infection and Immunity (2011)
MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes
Akhtar, N., et al.
Annals of the Rheumatic Diseases (2012)
MicroRNA-200b Regulates Cell Proliferation, Invasion, and Migration by Directly Targeting ZEB2 in Gastric Carcinoma
Baba, H., et al.
Annals of Surgical Oncology (2012)
microRNAs regulate human embryonic stem cell division
Qi., et al.
Cell Cycle, 8, 3729-3741 (2010)
MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma
Rothschild, S.I., et al.
Oncogene (2012)
The PLA2R1-JAK2 pathway upregulates ERRa and its mitochondrial program to exert tumor-suppressive action.
Griveau A
Oncogene, 35(38), 5033-5042 (2016)
Lincoln A Edwards et al.
Journal of the National Cancer Institute, 103(15), 1162-1178 (2011-07-21)
Tumor cell invasion is the principal cause of treatment failure and death among patients with malignant gliomas. Connective tissue growth factor (CTGF) has been previously implicated in cancer metastasis and invasion in various tumors. We explored the mechanism of CTGF-mediated
Nung Ky et al.
Apoptosis : an international journal on programmed cell death, 14(9), 1095-1107 (2009-06-23)
Kruppel-like factor 4 (KLF4) belongs to a family of evolutionarily conserved zinc finger-containing transcription factors. It has been shown to mediate self renewal and pluripotency, regulate adipogenesis and play a critical role in monocyte differentiation. KLF4 is also highly expressed
Laura Formentini et al.
Molecular cell, 45(6), 731-742 (2012-02-22)
Recent findings indicate that prevalent human carcinomas overexpress the mitochondrial ATPase Inhibitory Factor 1 (IF1). Overexpression of IF1 inhibits the synthase activity of the mitochondrial H(+)-ATP synthase and plays a crucial role in metabolic adaptation of cancer cells to enhanced
Tae Hoon Kim et al.
Genome research, 15(6), 830-839 (2005-05-19)
Transcriptional regulatory elements play essential roles in gene expression during animal development and cellular response to environmental signals, but our knowledge of these regions in the human genome is limited despite the availability of the complete genome sequence. Promoters mark
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