Showing 1-30 of 181 results for "N-007"
Kshitij A Patkar et al.
The Journal of pharmacology and experimental therapeutics, 346(3), 545-554 (2013-07-16)
In the mouse 55°C warm-water tail-withdrawal assay, a single administration of nor-binaltorphimine (nor-BNI; 10 mg/kg i.p.) antagonized κ-opioid receptor (KOR) agonist-induced antinociception up to 14 days, whereas naloxone (10 mg/kg i.p.)-mediated antagonism lasted less than 1 day. In saturation binding...
Carol A Paronis
Behavioural pharmacology, 24(5-6), 486-495 (2013-08-02)
The relative reinforcing strength of drugs can be characterized by the distribution of operant behavior during the availability of other reinforcing stimuli. 'Choice' procedures are not widely used in rats, with the exception of ethanol self-administration in which there often...
Priyanka Ghosh et al.
Journal of pharmaceutical sciences, 102(5), 1458-1467 (2013-02-19)
Microneedle (MN) enhanced transdermal drug delivery enables the transport of a host of molecules that cannot be delivered across the skin by passive diffusion alone. However, the skin being a self-regenerating organ heals itself and thus prevents delivery of molecules...
[Nalmefene (Selincro) orally].
Journal de pharmacie de Belgique, (4)(4), 51-52 (2015-01-08)
Avoiding narcotics in Crohn's disease.
Whitney E Jackson et al.
Journal of clinical gastroenterology, 47(4), 293-295 (2013-02-22)
Nicholas M Graziane et al.
Neuron, 77(5), 942-954 (2013-03-12)
Stress facilitates reinstatement of addictive drug seeking in animals and promotes relapse in humans. Acute stress has marked and long-lasting effects on plasticity at both inhibitory and excitatory synapses on dopamine neurons in the ventral tegmental area (VTA), a key region...
[Opiate induced constipation--mechanisms, relevance and treatment].
S Müller-Lissner
Deutsche medizinische Wochenschrift (1946), 138(43), 2207-2211 (2013-10-18)
Jennifer T Lamberts et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4369-4377 (2013-03-08)
Regulator of G-protein signaling (RGS) proteins classically function as negative modulators of G-protein-coupled receptor signaling. In vitro, RGS proteins have been shown to inhibit signaling by agonists at the μ-opioid receptor, including morphine. The goal of the present study was...
Marcelo L Silva et al.
Life sciences, 93(20), 742-754 (2013-09-26)
The anterior pretectal nucleus (APtN) and electroacupuncture (EA) activate descending mechanisms to modulate nociceptive inputs in the spinal dorsal horn. This study examines qualitatively whether mechanisms in the APtN participate in the EA-induced analgesia in rats. The tail-flick test was...
Ian S Zagon et al.
Experimental biology and medicine (Maywood, N.J.), 238(5), 579-587 (2013-07-17)
The opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis is a biological pathway that is present in human ovarian cancer cells and tissues. OGF, chemically termed [Met(5)]-enkephalin, is an endogenous opioid peptide that interfaces with OGFr to...
Ralitza Gueorguieva et al.
Addictive behaviors, 38(5), 2119-2127 (2013-02-26)
The primary analyses of the COMBINE Study revealed significant naltrexone and Combined Behavioral Intervention (CBI) main effects on drinking outcomes but failed to find additional benefits of the combination of treatments. Investigating differences in patterns of adherence over time may...
John T Williams
Molecular pharmacology, 86(1), 52-61 (2014-04-22)
Desensitization of µ-opioid receptors (MORs) develops over 5-15 minutes after the application of some, but not all, opioid agonists and lasts for tens of minutes after agonist removal. The decrease in function is receptor selective (homologous) and could result from...
Beatrice Setnik et al.
Journal of opioid management, 9(2), 139-150 (2013-05-28)
To evaluate whether intact or crushed doses of an extended-release formulation of morphine sulfate surrounding an inner core of sequestered naltrexone (MSN) induces signs and symptoms of withdrawal in opioid-dependent patients. Randomized, double-blind, two-way crossover study. Single center. Fourteen patients...
G Testino et al.
Minerva medica, 105(6), 447-466 (2014-11-14)
Alcohol dependence (AD) is a major public health problem. Currently, three drugs for the treatment of AD have been approved by both the European Medicines Agency (EMA) and the Food and Drug Administration (FDA): acamprosate, disulfiram, and oral naltrexone. The...
Gustavo Fenalti et al.
Nature, 506(7487), 191-196 (2014-01-15)
Opioids represent widely prescribed and abused medications, although their signal transduction mechanisms are not well understood. Here we present the 1.8 Å high-resolution crystal structure of the human δ-opioid receptor (δ-OR), revealing the presence and fundamental role of a sodium ion...
Therapy for posttraumatic stress and alcohol dependence--reply.
Edna B Foa et al.
JAMA, 310(22), 2458-2459 (2013-12-12)
Yunyun Yuan et al.
Journal of medicinal chemistry, 56(22), 9156-9169 (2013-10-23)
On the basis of a mu opioid receptor (MOR) homology model and the isosterism concept, three generations of 14-heteroaromatically substituted naltrexone derivatives were designed, synthesized, and evaluated as potential MOR-selective ligands. The first-generation ligands appeared to be MOR-selective, whereas the...
Josefina Higgs et al.
Neuropharmacology, 72, 9-19 (2013-04-30)
The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work...
Stacey C Sigmon et al.
JAMA psychiatry, 70(12), 1347-1354 (2013-10-25)
Although abuse of prescription opioids (POs) is a significant public health problem, few experimental studies have investigated the treatment needs of this growing population. To evaluate, following brief stabilization with a combination of buprenorphine hydrochloride and naloxone hydrochloride dihydrate, the...
Wim van den Brink and colleagues reply to Des Spence and Alain Braillon.
Wim van den Brink et al.
BMJ (Clinical research ed.), 348, g2605-g2605 (2014-04-09)
Carlos García-Esperón et al.
Revista de neurologia, 56(6), 327-331 (2013-03-14)
INTRODUCTION. Anabolic-androgenic steroids are synthetic substances derived from testosterone that are employed for their trophic effect on muscle tissue, among other uses. Their consumption can give trigger a series of adverse side effects on the body, including the suppression of...
Kelly Barbosa Gama et al.
Journal of natural products, 76(4), 559-563 (2013-02-27)
Hecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive properties and to determine its...
Robert Taylor et al.
Expert opinion on investigational drugs, 22(4), 517-525 (2013-03-15)
Opioid receptor antagonists are well known for their ability to attenuate or reverse the effects of opioid agonists. This property has made them useful in mitigating opioid side effects, overdose and abuse. Paradoxically, opioid antagonists have been reported to produce...
Giving laxatives safely and effectively.
Glenda Daniels et al.
Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses, 22(5), 290-296 (2013-12-24)
[Constipation management in palliative care].
Claudia Lötscher et al.
Krankenpflege. Soins infirmiers, 106(6), 32-33 (2013-06-28)
Przemysław Bieńkowski
Psychiatria polska, 47(1), 117-126 (2013-07-31)
Clinical studies performed over the last decades have indicated that combined therapy, involving pharmaco- and psychotherapy, is an optimal approach to alcohol dependence. Both pharmaco- and psychotherapy should be personalised with a careful balance between patient's needs and his/her clinical...
German evaluation says new drug for alcohol dependence is no better than old one.
Ned Stafford
BMJ (Clinical research ed.), 349, g7544-g7544 (2014-12-10)
Johanna Savilampi et al.
Acta anaesthesiologica Scandinavica, 57(8), 1002-1009 (2013-05-30)
A recent study demonstrated that reflux is associated with impaired pressure augmentation in the esophagogastric junction (EGJ), caused by diaphragmal contractions during inspiration. It is unknown whether this augmentation is influenced by opioids. Swallowing difficulties can be a poorly recognised...
Carmen P McLean et al.
Journal of anxiety disorders, 28(8), 894-901 (2014-12-03)
Posttraumatic stress disorder (PTSD) and alcohol dependence (AD) are frequently comorbid and the order in which they develop may affect the clinical presentation and response to treatment. This study compared 73 treatment-seeking participants who developed PTSD prior to developing AD...
Alexander C Ford et al.
The American journal of gastroenterology, 108(10), 1566-1574 (2013-06-12)
There has been no definitive synthesis of the evidence for any benefit of available pharmacological therapies in opioid-induced constipation (OIC). We conducted a systematic review and meta-analysis to address this deficit. We searched MEDLINE, EMBASE, EMBASE Classic, and the Cochrane...

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