Vamshi K Nimmagadda et al.
Journal of immunology (Baltimore, Md. : 1950), 190(9), 4595-4607 (2013-04-03)
Treatment of experimental autoimmune encephalomyelitis (EAE) with resveratrol, an activator of sirtuin 1 (SIRT1), reduces disease severity. This suggested that activators of SIRT1, a highly conserved NAD-dependent protein deacetylase, might have immune-modulating or neuroprotective therapeutic effects in EAE. Previously, we