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Vittoria Locato et al.
Journal of experimental botany, 66(10), 2991-3000 (2015-04-22)
Ophiobolin A, a tetracyclic sesterpenoid produced by phytopathogenic fungi, is responsible for catastrophic losses in crop yield but its mechanism of action is not understood. The effects of ophiobolin A were therefore investigated on the growth and redox metabolism of
Robin P Lazarus et al.
The American journal of tropical medicine and hygiene, 93(5), 931-938 (2015-08-26)
Little is known about the type and longevity of the humoral response to cryptosporidial infections in developing countries. We evaluated serum antibody response to Cryptosporidium gp15 in 150 sets of maternal, preweaning and postinfection/end-of-follow-up sera from children followed up to
Chuanshan Zhang et al.
Parasitology research, 113(10), 3745-3757 (2014-07-21)
Smad family proteins are essential cellular mediators of the transforming growth factor-β superfamily. In the present study, we identified two members of the Smad proteins, Smad8 and Smad4 homologues (termed as EgSmadE and EgSmadD, respectively), from Echinococcus granulosus, the causative
D M Muema et al.
Clinical and experimental immunology, 181(2), 297-305 (2015-04-08)
Memory B cells are long-lived and could contribute to persistence of humoral immunity by maintaining the plasma-cell pool or making recall responses upon re-exposure to an antigen. We determined the ability of a pneumococcal conjugate vaccine to induce anti-pneumococcal memory
Sethu Sankaranarayanan et al.
PloS one, 10(5), e0125614-e0125614 (2015-05-02)
In Alzheimer's disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of AD subjects suggests a sequence of initiation
Anna L Greenshields et al.
Cancer letters, 357(1), 129-140 (2014-12-03)
Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC
Rui Niimi et al.
BMC cancer, 13, 309-309 (2013-06-27)
Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a focus of attention in the field of cancer biology. Cadherin and
Michael Zeisberg et al.
The American journal of pathology, 184(10), 2687-2698 (2014-08-12)
Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of chronic kidney disease. To gain insight into the underlying mechanisms through which TSP1 accelerates chronic kidney disease, we compared disease progression in Col4a3 knockout (KO) mice, which develop
Oliver Koeberling et al.
Vaccine, 32(23), 2688-2695 (2014-04-08)
Neisseria meningitidis causes epidemics of meningitis in sub-Saharan Africa. These have mainly been caused by capsular group A strains, but W and X strains are increasingly contributing to the burden of disease. Therefore, an affordable vaccine that provides broad protection
Soonbong Baek et al.
ACS nano, 8(10), 10125-10138 (2014-09-24)
Life on Earth is constantly exposed to natural electromagnetic fields (EMFs), and it is generally accepted that EMFs may exert a variety of effects on biological systems. Particularly, extremely low-frequency electromagnetic fields (EL-EMFs) affect biological processes such as cell development
Kohei Hashimoto et al.
Laboratory investigation; a journal of technical methods and pathology, 95(3), 283-295 (2015-01-13)
Neuroendocrine (NE) cells in prostate cancer have been shown to be associated with the progression of prostate cancer. However, little is known about the molecular basis of this association. We have previously demonstrated that NE cells promote metastasis of a
Nathaniel A Dyment et al.
Developmental biology, 405(1), 96-107 (2015-07-05)
The sequence of events that leads to the formation of a functionally graded enthesis is not clearly defined. The current study demonstrates that clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis. Prior to mineralization, Col1+ cells
Anne Frentzen et al.
PLoS pathogens, 7(4), e1002029-e1002029 (2011-05-10)
Hepatitis C virus (HCV) is hepatotropic and only infects humans and chimpanzees. Consequently, an immunocompetent small animal model is lacking. The restricted tropism of HCV likely reflects specific host factor requirements. We investigated if dominant restriction factors expressed in non-liver
Yira Bermudez et al.
Cancer prevention research (Philadelphia, Pa.), 8(8), 720-728 (2015-06-03)
The incidence of skin cancer is higher than all other cancers and continues to increase, with an average annual cost over $8 billion in the United States. As a result, identifying molecular pathway alterations that occur with UV exposure to
L A Aqrawi et al.
Clinical and experimental immunology, 177(1), 244-252 (2014-03-29)
Ro52 is an E3 ubiquitin ligase with a prominent regulatory role in inflammation. The protein is a common target of circulating autoantibodies in rheumatic autoimmune diseases, particularly Sjögren's syndrome (SS). In this study we aimed to investigate the expression of
Wai-Hang Leung et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2930-2941 (2015-02-18)
Many malignant cells release the NKG2D ligand ULBP2 from their cell surface to evade immunosurveillance by NK cells and CD8 T cells. Although the shedding mechanism remains unclear, various inhibitors of matrix metalloproteinases have been shown to efficiently block the
Kihyuk Shin et al.
Nature communications, 6, 6196-6196 (2015-02-05)
Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the resolution of LVs is controlled in different inflammatory conditions. Here we
Luca Vergano et al.
Journal of nephrology, 28(1), 51-58 (2014-04-24)
The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to
Alysha A Rauhauser et al.
American journal of physiology. Renal physiology, 309(9), F770-F778 (2015-08-21)
Hedgehog (Hh) is an evolutionary conserved signaling pathway that has important functions in kidney morphogenesis and adult organ maintenance. Recent work has shown that Hh signaling is reactivated in the kidney after injury and is an important mediator of progressive
Yoshinori Seko et al.
Scientific reports, 5, 13737-13737 (2015-09-09)
Oxidative stress plays a critical role in ischemia/reperfusion-injury, atherosclerosis, and aging. It causes cell damage that leads to apoptosis via uncertain mechanisms. Because conditioned medium from cardiac myocytes subjected to hypoxia/reoxygenation induces extensive apoptosis of cardiac myocytes under normoxia, we
Omri Snir et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5703-5712 (2015-05-15)
Autoreactive IgA plasma cells (PCs) specific for the enzyme transglutaminase 2 (TG2) are abundant in the small intestine of patients with active celiac disease (CD), and their number drops in patients treated by dietary gluten elimination. Little is known about
Xiaohong Du et al.
PloS one, 9(7), e103016-e103016 (2014-07-23)
Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand
Michael M Zeineh et al.
Neurobiology of aging, 36(9), 2483-2500 (2015-07-21)
Although amyloid plaques and neurofibrillary pathology play important roles in Alzheimer disease (AD), our understanding of AD is incomplete, and the contribution of microglia and iron to neurodegeneration is unknown. High-field magnetic resonance imaging (MRI) is exquisitely sensitive to microscopic
Nataliya Butenko et al.
Journal of inorganic biochemistry, 147, 165-176 (2015-05-12)
The nuclease activity of VO(acac)2 (1, acac = acetylacetone) and its derivatives VO(hd)2 (2, hd = 3,5-heptanedione), VO(Cl-acac)2 (3, Cl-acac = 3-chloro-2,4-pentanedione), VO(Et-acac)2 (4, Et-acac = 3-ethyl-2,4-pentanedione) and VO(Me-acac)2 (5, Me-acac = 3-methyl-2,4-pentanedione), is studied by agarose gel electrophoresis, UV-visible
Lingyi Li et al.
Gene, 574(1), 69-75 (2015-08-19)
Snake venom neurotoxins and lymphocyte antigen-6 (Ly6) family members identified in many metazoans possess conserved LU domain containing eight or ten conserved cysteine residues which form 4 to 5 conserved disulfide bonds. They are found to execute a wide variety
Jun Kawasaki et al.
The Journal of clinical investigation, 124(6), 2774-2784 (2014-05-20)
Vascular malformations are linked to mutations in RAS p21 protein activator 1 (RASA1, also known as p120RasGAP); however, due to the global expression of this gene, it is unclear how these mutations specifically affect the vasculature. Here, we tested the
A M Shields et al.
Clinical and experimental immunology, 179(2), 210-219 (2014-09-18)
Summary Recombinant human binding immunoglobulin protein (BiP) has previously demonstrated anti-inflammatory properties in multiple models of inflammatory arthritis. We investigated whether these immunoregulatory properties could be exploited using gene therapy techniques. A single intraperitoneal injection of lentiviral vector containing the
Christa E Osuna et al.
Toxicological sciences : an official journal of the Society of Toxicology, 142(1), 158-166 (2014-08-16)
Methylmercury, polychlorinated biphenyls (PCBs), and perfluorinated compounds (PFCs) are ubiquitous and persistent environmental chemicals with known or suspected toxic effects on the nervous system and the immune system. Animal studies have shown that tissue damage can elicit production of autoantibodies.
Jamie K Lemon et al.
Infection and immunity, 83(8), 3204-3212 (2015-06-03)
Streptococcus pneumoniae (the pneumococcus), a leading cause of bacterial disease, is most commonly carried in the human nasopharynx. Colonization induces inflammation that promotes the organism's growth and transmission. This inflammatory response is dependent on intracellular sensing of bacterial components that
Giuseppe Asciutto et al.
Atherosclerosis, 239(2), 289-294 (2015-02-16)
Autoimmune responses against oxidized-LDL (oxLDL) have been suggested to modulate inflammation in atherosclerosis. Previous studies showed an association between autoantibodies against the apolipoprotein B (apoB) p210 antigen and a lower risk of cardiovascular (CV) events. In the present study we
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