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N2780

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Guangye Wang et al.
Molecular medicine reports, 12(1), 877-884 (2015-03-31)
The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by the overproduction of cytokine tumor necrosis factor (TNF)‑α. It has been demonstrated that
Minna Rahnasto et al.
Journal of medicinal chemistry, 48(2), 440-449 (2005-01-22)
The purpose of this study was to develop screening and in silico modeling methods to obtain accurate information on the active center of CYP2A6, a nicotine oxidizing enzyme. The inhibitory potencies of 26 naphthalene and 16 non-naphthalene derivatives were determined
M Shah et al.
European cells & materials, 29, 155-175 (2015-03-05)
Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; alkaline phosphatase (TNAP) mRNA and activity, Runt-related transcription factor-2
Rudell Screven et al.
Veterinary immunology and immunopathology, 161(1-2), 21-31 (2014-07-17)
Veterinary adult stem cell therapy is an emerging area of basic and clinical research. Like their human counterparts, veterinary mesenchymal stem cells (MSCs) offer many potential therapeutic benefits. The characterization of canine-derived MSCs, however, is poorly defined compared to human
Paul Childress et al.
Molecular endocrinology (Baltimore, Md.), 29(9), 1269-1285 (2015-08-06)
PTH is an osteoanabolic for treating osteoporosis but its potency wanes. Disabling the transcription factor nuclear matrix protein 4 (Nmp4) in healthy, ovary-intact mice enhances bone response to PTH and bone morphogenetic protein 2 and protects from unloading-induced osteopenia. These
Nenad Manevski et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(11), 2192-2203 (2012-08-23)
The presence of bovine serum albumin (BSA) largely modulates the enzyme kinetics parameters of the human UDP-glucuronosyltransferase (UGT) 1A9, increasing both the apparent aglycone substrate affinity of the enzyme and its limiting reaction velocity (Drug Metab Dispos 39:2117-2129, 2011). For
Keisuke Kohama et al.
Surgery, 158(2), 399-407 (2015-05-20)
Hemorrhagic shock followed by fluid resuscitation (HS/R) triggers an inflammatory response and causes pulmonary inflammation that can lead to acute lung injury (ALI). Hydrogen, a therapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects. This study examined the effects of
Hongrui Liu et al.
Journal of molecular histology, 46(3), 313-323 (2015-05-15)
The purpose of this study was to investigate the effect of zoledronate (ZA) on osteoclast functions and viability in the tibiae of 8-week-old male mice. After weekly intravenous administration of ZA (125 μg/kg body weight) for 8 weeks, the mice
Claire Tacon et al.
Bioorganic & medicinal chemistry, 20(2), 893-902 (2011-12-27)
Herein we report on the semisynthesis and biological evaluation of β-amino alcohol derivatives of the natural product totarol and other simple aromatic systems. All β-amino alcohol derivatives of totarol exhibited higher antiplasmodial activity than totarol [IC(50): 11.69 μM (K1, chloroquine
Keith L Constantine et al.
Journal of medicinal chemistry, 51(19), 6225-6229 (2008-09-06)
Fragment-like inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK2) include 5-hydroxyisoquinoline (IC50 approximately 85 microM). Modeling studies identified four possible binding modes for this compound. Two-dimensional (1)H-(1)H NOESY data obtained with selectively protonated samples of MK2 in complex with
Priscila Silva Franco et al.
Parasitology research, 113(7), 2655-2664 (2014-05-02)
There is a significant genetic diversity of Toxoplasma gondii in Brazil. Two parasite isolates were recently obtained from chickens in Uberlândia, Minas Gerais state, Brazil, namely, TgChBrUD1 and TgChBrUD2. In this study, we investigated Calomys callosus susceptibility to these atypical
Letícia S Castro-Filice et al.
Journal of translational medicine, 12, 132-132 (2014-06-03)
Although Toxoplasma gondii infection is normally asymptomatic, severe cases of toxoplasmosis may occur in immunosuppressed patients or congenitally infected newborns. When a fetal infection is established, the recommended treatment is a combination of pyrimethamine, sulfadiazine and folinic acid (PSA). The
Zhong-Wei Gao et al.
Dalton transactions (Cambridge, England : 2003), 42(7), 2608-2615 (2012-12-12)
Similar to the larger members of the cucurbituril family, such as cucurbit[8]uril (Q[8]), the smallest member, cucurbit[5]uril (Q[5]), can also induce room-temperature phosphorescence (RTP) of α-naphthol (1) and β-naphthol (2). The relationship between the RTP intensity of 1 and 2
Iu Ie Kolupaiev et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 83(5), 82-88 (2012-01-27)
The comparative study of influence of exogenous salicylic (SaA) and succinic (SuA) acids on the production of reactive oxygen species by isolated wheat coleoptiles has been provided. Under the action of both acids the increase of generation of superoxide anion-radical
Anne Walter et al.
Analytical and bioanalytical chemistry, 405(11), 3907-3911 (2013-02-23)
In this report we describe an electrochemical DNA hybridization sensor approach, in which signal amplification is achieved using heated electrodes together with an enzyme as DNA-label. On the surface of the heatable low temperature co-fired ceramic (LTCC) gold electrode, an
Surajit Rakshit et al.
Photochemistry and photobiology, 88(4), 851-859 (2012-03-16)
Excited state proton transfer (ESPT) in biologically relevant organic molecules in aqueous environments following photoexcitation is very crucial as the reorganization of polar solvents (solvation) in the locally excited (LE) state of the organic molecule plays an important role in
Rozanna Avagyan et al.
Analytical and bioanalytical chemistry, 407(16), 4523-4534 (2015-05-04)
A simple and fast method for analysis of hydroxylated polycyclic aromatic hydrocarbons using pressurized liquid extraction and high performance liquid chromatography utilizing photoionization tandem mass spectrometry was developed. Simultaneous separation and determination of nine hydroxylated polycyclic aromatic hydrocarbons and two
Ju-Young Kim et al.
The American journal of Chinese medicine, 43(3), 495-512 (2015-05-15)
The roots of Ostericum koreanum (OK) Maximowicz have traditionally been used to produce an herbal medicine reported to possess anti-inflammatory, anti-oxidant, antimicrobial, and antitumor activities; however, its effect on bone metabolism has not yet been reported. The present study examined
Iu E Kolupaev et al.
Prikladnaia biokhimiia i mikrobiologiia, 48(5), 550-556 (2012-10-30)
The influence of salicylic (SaA) and succinic (SuA) acids on the generation of active oxygen forms (AOFs) and the heat resistance of wheat (Triticum aestivum L.) coleoptiles has been studied. The treatment of coleoptiles with 10 microM SaA or SuA
Cathrin Sellmann et al.
The Journal of nutritional biochemistry, 26(11), 1183-1192 (2015-07-15)
General overnutrition but also a diet rich in certain macronutrients, age, insulin resistance and an impaired intestinal barrier function may be critical factors in the development of nonalcoholic fatty liver disease (NAFLD). Here the effect of chronic intake of diets
Stephanie Rossnagl et al.
PloS one, 9(4), e94922-e94922 (2014-04-18)
Cancer is associated with increased fracture risk, due either to metastasis or associated osteoporosis. After a fracture, blood clots form. Because proteins of the coagulation cascade and activated platelets promote cancer development, a fracture in patients with cancer often raises
Hongbo Zhang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(8), 1286-1293 (2012-01-24)
In vitro glucuronidation assays of diclofenac and indomethacin at pH 7.4 are biased by the instability of the glucuronides due to acyl migration. The extent of this acyl migration may be reduced significantly by performing the glucuronidation reaction at pH
Sang Hwi Lee et al.
The Journal of organic chemistry, 76(24), 10011-10019 (2011-10-26)
The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described.
Kunal Roy et al.
European journal of medicinal chemistry, 44(5), 1941-1951 (2008-12-27)
A series of naphthalene and non-naphthalene derivatives (n=42) having cytochrome P450 2A6 and 2A5 inhibitory activities, reported by Rahnasto et al., were subjected to QSAR and QAAR studies. The analyses were performed using electronic, spatial, shape and thermodynamic descriptors to
Srinivasan Suresh et al.
The Analyst, 137(17), 4086-4092 (2012-07-13)
An amperometric immunosensor for the specific detection of Ricinus communis is reported. Screen printed electrodes (SPEs) were modified with gold nanoparticles (GNPs) loaded multiwalled carbon nanotubes (MWCNTs)-chitosan (Ch) film. The ratio of MWCNT and GNP was optimised to get best
Zaiming Chen et al.
Environmental science & technology, 46(22), 12476-12483 (2012-11-06)
The bisolute sorption and thermodynamic behavior of organic pollutants on low temperature biochars (LTB) at 300 °C and high temperature biochars (HTB) at 700 °C were determined to elucidate sorptive properties of biochar changed with pyrolytic temperatures. The structural characteristics
Shitong Yang et al.
The Science of the total environment, 420, 214-221 (2012-02-15)
The increasing exploitation of multi-walled carbon nanotubes (MWCNTs) into many industrial processes has raised considerable concerns as they are likely to be released into the environment. The interactions of the pollutants in water with discharged MWNCTs will further influence the
Antonio Torrelo et al.
The American Journal of dermatopathology, 37(7), 517-522 (2015-06-20)
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a newly characterized autoinflammatory disorder, caused by mutations in PSMB8. It is characterized by early-onset fevers, accompanied by a widespread, violaceous, and often annular cutaneous eruption. Although the
Manasa G Garimella et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5136-5148 (2015-11-06)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone loss. The inflammation-induced bone loss is mediated by increased osteoclast formation and function. Current antirheumatic therapies primarily target suppression of inflammatory
Di Yang et al.
Journal of cellular biochemistry, 116(11), 2628-2636 (2015-04-29)
Alteration of methylation status of lysine 27 on histone H3 (H3K27) associates with dramatic changes in gene expression in response to various differentiation signals. Demethylation of H3K27 is controlled by specific histone demethylases including ubiquitously transcribed tetratricopeptide repeat X chromosome
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