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N5893

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Longhai Dai et al.
Plant & cell physiology, 56(6), 1172-1182 (2015-03-12)
Mogrosides, the major bioactive components isolated from the fruits of Siraitia grosvenorii, are a family of cucurbitane-type tetracyclic triterpenoid saponins that are used worldwide as high-potency sweeteners and possess a variety of notable pharmacological activities. Mogrosides are synthesized from 2,3-oxidosqualene...
Ming-Jun Tsai et al.
PloS one, 10(7), e0131026-e0131026 (2015-07-15)
Excessive production of radical oxygen species in skin is a contributor to a variety of skin pathologies. Naringenin is a potent antioxidant. The purpose of the present study was to develop elastic liposomes for naringenin topical application. Naringenin-loaded elastic liposomes...
Brandon T Gufford et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1675-1683 (2014-07-11)
Drug-metabolizing enzymes within enterocytes constitute a key barrier to xenobiotic entry into the systemic circulation. Furanocoumarins in grapefruit juice are cornerstone examples of diet-derived xenobiotics that perpetrate interactions with drugs via mechanism-based inhibition of intestinal CYP3A4. Relative to intestinal CYP3A4-mediated...
Manuel Y Schär et al.
The American journal of clinical nutrition, 101(5), 931-938 (2015-03-20)
Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors. We examined the...
Shingo Miyata et al.
The Journal of biological chemistry, 290(33), 20565-20579 (2015-07-05)
Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that stimulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP inactivator that reduces...
Alka Pawar et al.
Scientific reports, 10(1), 949-949 (2020-01-24)
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB), a highly infectious disease accounting for nearly 1.5 million deaths every year and has been a major global concern. Moreover, resistance to anti-TB drugs is an arduous obstacle to effective prevention, TB...
Tsz Yan Wong et al.
PloS one, 10(8), e0135637-e0135637 (2015-08-25)
High blood cholesterol has been associated with cardiovascular diseases. The enzyme HMG CoA reductase (HMGCR) is responsible for cholesterol synthesis, and inhibitors of this enzyme (statins) have been used clinically to control blood cholesterol. Sterol regulatory element binding protein (SREBP)...
Chung-Hsi Chou et al.
Food chemistry, 168, 63-69 (2014-08-31)
Black vinegar (BV) contains abundant essential and hydrophobic amino acids, and polyphenolic contents, especially catechin and chlorogenic acid via chemical analyses. K and Mg are the major minerals in BV, and Ca, Fe, Mn, and Se are also measured. After...
ZiHuan Yang et al.
Journal of ethnopharmacology, 155(2), 1177-1183 (2014-07-06)
Disturbed gastrointestinal (GI) motility can be associated with smooth muscle abnormalities and dysfunction. Exploring innovative approaches that can modulate the disturbed colonic motility are of great importance for clinical therapeutics. Naringenin, a flavonoid presented in many traditional Chinese herbal medicines...
Panpan Guo et al.
Journal of separation science, 38(7), 1156-1163 (2015-01-27)
A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and four phenolic acids in the total flavonoids extract...
Marely G Figueroa-Pérez et al.
Journal of agricultural and food chemistry, 62(49), 12027-12033 (2014-12-03)
Peppermint (Mentha piperita) infusions represent an important source of antioxidants, which can be enhanced by inducing abiotic stress in plants. The aim of this study was to evaluate the effect of drought stress on peppermint cultivation as well as the...
Nada Oršolić et al.
European journal of nutrition, 53(5), 1217-1227 (2013-11-26)
Reactive oxygen species play a role in a number of degenerative conditions including osteoporosis. Flavonoids as phyto-oestrogens exert physiological effects against oxidative stress diseases. We developed a retinoic acid-induced bone loss model of rats to assess whether flavonoids and alendronate...
Clint M Alfaro et al.
Analytical chemistry, 86(21), 10639-10645 (2014-10-01)
With this study, we investigated why some small molecules demonstrate narrow dynamic ranges in electrospray ionization-mass spectrometry (ESI-MS) and sought to establish conditions under which the dynamic range could be extended. Working curves were compared for eight flavonoids and two...
Amy C Burke et al.
Atherosclerosis, 286, 60-70 (2019-05-19)
Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr-/- mice fed a high-fat diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of...
Sandra Frabasile et al.
Scientific reports, 7, 41864-41864 (2017-02-06)
Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a vaccine was recently approved in certain countries, an anti-dengue virus drug is still...
Ayuta Funaki et al.
Plant & cell physiology, 56(8), 1512-1520 (2015-05-29)
Isoflavone conjugates [7-O-β-D-glucosides and 7-O-(6″-malonyl-β-D-glucosides) of daidzein and genistein] accumulate in soybean roots and serve as the stored precursors of isoflavones (aglycons), which play very important roles in the rhizobia-mediated nodulation of this plant. Thus far, the isoflavone 7-O-glucosyltransferase (GmIF7GT...
Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice
Kanno S, et al.
Biological & Pharmaceutical Bulletin, 28(3), 527-530 (2005)
Hyun Lim et al.
Biochemical pharmacology, 96(4), 337-348 (2015-06-21)
During senescence, cells express molecules called senescence-associated secretory phenotype (SASP), including growth factors, proinflammatory cytokines, chemokines, and proteases. The SASP induces a chronic low-grade inflammation adjacent to cells and tissues, leading to degenerative diseases. The anti-inflammatory activity of flavonoids was...
Peng-Fei Yue et al.
International journal of pharmaceutics, 475(1-2), 35-48 (2014-08-27)
The freezing stress and cryoprotectants were known to be the crucial factors for solidification formability of nanosuspensions during freeze-drying. However, there has been controversy as to whether an aggressive or conservative freezing stress (freezing temperature or freezing rate) prevents from...
Joo Ae Kim et al.
Carcinogenesis, 36(6), 696-706 (2015-04-05)
Heat shock factor 1 (HSF1) is a transcription factor for heat shock proteins (HSPs) expression that enhances the survival of cancer cells exposed to various stresses. HSF1 knockout suppresses carcinogen-induced cancer induction in mice. Therefore, HSF1 is a promising therapeutic...
Rui-Fang Li et al.
Experimental and therapeutic medicine, 9(3), 697-706 (2015-02-11)
Treatments for leukemia remain unsatisfactory. Conventional chemotherapy agents that aim to kill tumor cells may also damage normal cells and thus result in severe side-effects. Naringenin, a natural polyphenolic compound with antioxidant effects, has been revealed to have significant antitumor...
Miriam Martínez-Huélamo et al.
Molecules (Basel, Switzerland), 20(11), 20409-20425 (2015-11-19)
An UHPLC-MS/MS method for the quantification of tomato phenolic metabolites in human fluids was optimized and validated, and then applied in a pilot dietary intervention study with healthy volunteers. A 5-fold gain in speed (3.5 min of total run); 7-fold...
Lizhen Qiao et al.
Journal of chromatography. A, 1396, 62-71 (2015-04-22)
Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chromatography. The obtained columns of tricationic ionic liquids were evaluated respectively in the...
Amy C Burke et al.
Molecular nutrition & food research, 63(6), e1800833-e1800833 (2018-12-24)
Naringenin is a citrus-derived flavonoid that has potent lipid-lowering and insulin-sensitizing effects in obese mouse models of metabolic dysfunction. However, in these models, a significant effect of naringenin supplementation is the prevention of weight gain, which in itself can confer...
Philipp Zeyhle et al.
PloS one, 9(6), e99122-e99122 (2014-06-04)
Recently, novel prenylated derivatives of 1,6-dihydroxyphenazine have been isolated from the marine sponge-associated Streptomyces sp. SpC080624SC-11. Genome sequencing of this strain now revealed a gene cluster containing all genes necessary for the synthesis of the phenazine and the isoprenoid moieties....
Daniel S Peiffer et al.
NPJ breast cancer, 6, 37-37 (2020-08-31)
Recurrence of estrogen receptor (ER)-positive breast tumors despite curative-intent adjuvant therapy is thought to be due to enrichment of tumor initiating cells (TIC) during endocrine therapy (ET). Recently, it was identified that by antagonizing the ER, ET promotes rapid degradation...
Julian K Aschoff et al.
Molecular nutrition & food research, 60(12), 2602-2610 (2016-08-05)
Orange juice contains flavanones including hesperidin and narirutin, albeit at lower concentrations as compared to orange fruit. Therefore, we compared bioavailability and colonic catabolism of flavanones from orange juice to a 2.4-fold higher dose from fresh oranges. Following a randomized...
Dima Albals et al.
Electrophoresis, 35(19), 2807-2818 (2014-07-02)
A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy uses a 45 mM ammonium formate (pH 2.9)/ACN (35/65...
Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells
Park HJ, et al.
Food And Chemical Toxicology, 99(6), 1-8 (2017)
Sophie Dufay et al.
The Journal of pharmacy and pharmacology, 66(10), 1478-1490 (2014-05-16)
Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to...
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