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Simone Ferrero et al.
Archives of gynecology and obstetrics, 287(3), 447-453 (2012-10-12)
To evaluate the changes in the volume of rectovaginal endometriotic nodules infiltrating the rectum during 12-month treatment with hormonal therapies. This prospective, non-randomized, self-controlled clinical trial included patients with rectovaginal endometriotic nodules infiltrating at least the muscularis propria of the
Paula Bernstein et al.
Reviews in cardiovascular medicine, 11(4), 228-236 (2011-03-11)
All combination hormone replacement regimens contain estrogen and a progestational agent. The Women's Health Initiative trial demonstrated that taking the combination of conjugated estrogen and medroxyprogesterone resulted in a higher risk of myocardial infarction and stroke in the study population.
Jeanette F Brosnan et al.
Thrombosis research, 131(1), 72-77 (2012-09-25)
Both oestrogen and progestin and the route of administration have been implicated in cardiovascular and thromboembolic risk in post menopausal hormone users. Transdermal preparations have been reported as safer indicating that liver derived metabolites of oestrogen may be important. The
Rachel Steward et al.
Contraception, 86(6), 710-715 (2012-06-12)
Few studies have examined the action of combined oral contraceptives (COCs) on cervical mucus. We hypothesized that midcycle cervical mucus of women taking COCs is of poor quality when compared to their own midcycle mucus prior to initiating COCs. We
Alessandra Bitto et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 17(11), 844-850 (2010-06-24)
Endometrial hyperplasia without cytological atypia is commonly treated with progestins, but other treatment regimes may be available with equivalent efficacy and low side effects. A randomized double-blind, placebo and progesterone-controlled clinical trial to evaluate the effects of genistein aglycone in
Eija Pöllänen et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 20(5), 372-379 (2010-08-21)
To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone
P Vercellini et al.
Human reproduction (Oxford, England), 27(12), 3450-3459 (2012-08-29)
Does surgical or medical treatment for endometriosis-associated severe deep dyspareunia achieve better results in terms of patients' satisfaction (main study outcome), variation of coital pain and frequency of intercourse? Surgery and progestin therapy were equally effective in the treatment of
Heather Appelbaum
Obstetrics and gynecology, 116 Suppl 2, 488-490 (2010-07-29)
Progesterones are frequently used to treat endometriosis. Exaggerated response of the endometrium to high levels of progesterone can result in a decidualization reaction. Decidualization may cause an exacerbation of symptoms of dysmenorrhea associated with endometriosis. A 16-year-old girl with uterine
Oral contraceptives and endometriosis.
Horace Roman
Human reproduction (Oxford, England), 26(6), 1600-1601 (2011-03-29)
Anieta M Sieuwerts et al.
Molecular oncology, 5(6), 504-516 (2011-10-01)
Risk assessment of future breast cancer risk through exposure to sex steroids currently relies on clinical scorings such as mammographic density. Knowledge about the gene expression patterns in existing breast cancer tumors may be used to identify risk factors in
D J Kaser et al.
Journal of pediatric and adolescent gynecology, 25(2), 105-108 (2011-12-14)
To evaluate the efficacy and tolerability of norethindrone acetate (NA) as single-agent hormonal therapy for suppression of endometriosis symptoms in adolescents and young adults. Retrospective study. Two academic medical centers. A keyword search using the query 'NA' was applied to
Marjo Tuppurainen et al.
Maturitas, 66(4), 423-430 (2010-06-16)
To determine the effects of HRT with or without clodronate on bone mineral density (BMD) change and bone turnover markers. Prospective, partly randomized trial. Kuopio University Hospital, Finland. 167 osteoporotic women (61+/-2.7 years; T-score<or=-2.5 SD). Estradiol 2 mg+NETA 1 mg
Simone Ferrero et al.
Reproductive biology and endocrinology : RB&E, 9, 88-88 (2011-06-23)
When aromatase inhibitors are used to treat premenopausal women with endometriosis, additional drugs should be used to effectively down-regulate gonadal estrogen biosynthesis. This randomized prospective open-label study compared the efficacy in treating pain symptoms and the tolerability of letrozole combined
Juan C Engel et al.
Antimicrobial agents and chemotherapy, 54(8), 3326-3334 (2010-06-16)
Chagas' disease, caused by infection with the parasite Trypanosoma cruzi, is the major cause of heart failure in Latin America. Classic clinical manifestations result from the infection of heart muscle cells leading to progressive cardiomyopathy. To ameliorate disease, chemotherapy must
Rocío L Pérez et al.
Analytica chimica acta, 835, 19-28 (2014-06-24)
Following the green analytical chemistry principles, an efficient strategy involving second-order data provided by liquid chromatography (LC) with diode array detection (DAD) was applied for the simultaneous determination of estriol, 17β-estradiol, 17α-ethinylestradiol and estrone in natural water samples. After a
V Koskela-Niska et al.
Climacteric : the journal of the International Menopause Society, 16(1), 48-53 (2012-05-30)
While previous data link the use of postmenopausal hormone therapy to an increased risk for ovarian cancer, little is known about the impact of various progestins, modes or routes of administration of hormone therapy for this risk. In this nationwide
Kristof Chwalisz et al.
Reproductive sciences (Thousand Oaks, Calif.), 19(6), 563-571 (2012-03-30)
Gonadotropin-releasing hormone agonists (GnRHa) are an effective treatment of endometriosis-associated pelvic pain. The use of hormonal add-back therapy can alleviate the hypoestrogenic symptoms associated with GnRHa therapy, while preserving therapeutic efficacy. Norethindrone acetate (NETA) is a unique progestin that has
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
David F Archer et al.
Obstetrics and gynecology, 122(3), 601-607 (2013-08-08)
To assess the efficacy, safety, and tolerability of an extended-duration, combined hormonal oral contraceptive pill (OCP) that reduces the estrogen exposure by almost half compared with other OCPs. This open-label, uncontrolled, multicenter study used an ultra low-dose OCP (1.0 mg
Maria Karaflou et al.
Fertility and sterility, 94(6), 2399-2401 (2010-05-25)
One hundred healthy postmenopausal women were randomly assigned to receive 17β-E2 1 mg/drospirenone 2 mg or 17β-E2 1 mg/norethisterone acetate 0.5 mg for 6 months, and circulating soluble Fas, soluble Fas ligand, and cytochrome c were measured at baseline and
Donita Africander et al.
Contraception, 84(4), 423-435 (2011-09-17)
Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives are widely used in female reproductive therapy, but little is known about their mechanisms of action via steroid receptors in the female genital tract. MPA used as a contraceptive has been
Herbert A Goldfarb et al.
JSLS : Journal of the Society of Laparoendoscopic Surgeons, 14(2), 192-195 (2010-10-12)
Women seeking emergency care for severe uterine hemorrhage with profound anemia often undergo transfusion dilatation curettage and ultimately hysterectomy. The purpose of this article is to describe a modern conservative approach to treating persistent uterine hemorrhage unresponsive to medical therapy
Endometriosis presenting with hemorrhagic ascites.
Simone Ferrero et al.
Archives of gynecology and obstetrics, 283(6), 1429-1430 (2010-12-15)
Norethisterone and norethisterone acetate.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 21, 441-460 (1979-12-01)
R E J Roach et al.
Journal of thrombosis and haemostasis : JTH, 11(1), 124-131 (2012-11-10)
Oral contraception (OC) and postmenopausal hormone therapy (HT) can be used to alleviate menopausal symptoms. However, the risk of venous thrombosis (VT) associated with OC use in women over 50 years old has never been assessed and the two preparations
Christian W Wallwiener et al.
Archives of gynecology and obstetrics, 292(4), 883-890 (2015-04-24)
To investigate in a large cohort of young university women whether different progestins and different ethinyl estradiol (EE) dosages in oral hormonal contraceptives (OHCs) adversely affect sexual function. Female medical students from German, Austrian, and Swiss universities (14/1/1) completed an
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
Louise Lind Schierbeck et al.
BMJ (Clinical research ed.), 345, e6409-e6409 (2012-10-11)
To investigate the long term effect of hormone replacement therapy on cardiovascular outcomes in recently postmenopausal women. Open label, randomised controlled trial. Denmark, 1990-93. 1006 healthy women aged 45-58 who were recently postmenopausal or had perimenopausal symptoms in combination with
E Lundström et al.
Maturitas, 70(4), 361-364 (2011-10-01)
To determine the effects of continuous combined hormone therapy, tibolone, black cohosh, and placebo on digitized mammographic breast density in postmenopausal women. A prospective, double-blind, placebo-controlled study of 154 postmenopausal women randomized to estradiol 2 mg/norethisterone acetate 1 mg (E2/NETA)
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