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Ludmila A Voloboueva et al.
Investigative ophthalmology & visual science, 46(11), 4302-4310 (2005-10-27)
To determine whether (R)-alpha-lipoic acid (LA) protects cultured human fetal retinal pigment epithelial (hfRPE) cells against oxidative injury and identify the pathways that may mediate protection. Cultured hfRPE cells were pretreated with various concentrations of LA for 14 to 16
Michael Craigie et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 13(2), 126-142 (2017-11-22)
JC virus (JCV) is a human polyomavirus and the etiologic agent of the demyelinating disease progressive multifocal leukoencephalopathy (PML). PML is observed in patients with underlying immunocompromising conditions, suggesting that neuro-immune interactions between peripheral immune cells and neuro-glia play an
Jungwook Paek et al.
ACS nano, 13(7), 7627-7643 (2019-06-14)
The vasculature is an essential component of the circulatory system that plays a vital role in the development, homeostasis, and disease of various organs in the human body. The ability to emulate the architecture and transport function of blood vessels
Audra M A Shadforth et al.
Journal of tissue engineering and regenerative medicine, 11(6), 1915-1924 (2015-10-10)
Silk fibroin provides a promising biomaterial for ocular tissue reconstruction, including the damaged outer blood-retinal barrier of patients afflicted with age-related macular degeneration (AMD). The aim of the present study was to evaluate the function of retinal pigment epithelial (RPE)
Christopher J Alexander et al.
Cerebellum (London, England), 18(3), 406-421 (2019-02-08)
While mixed primary cerebellar cultures prepared from embryonic tissue have proven valuable for dissecting structure-function relationships in cerebellar Purkinje neurons (PNs), this technique is technically challenging and often yields few cells. Recently, mouse embryonic stem cells (mESCs) have been successfully
Nicholas W Kieran et al.
Journal of neuroinflammation, 19(1), 10-10 (2022-01-08)
Astrocytes are the most numerous glial cell type with important roles in maintaining homeostasis and responding to diseases in the brain. Astrocyte function is subject to modulation by microRNAs (miRs), which are short nucleotide strands that regulate protein expression in
Miguel Flores-Bellver et al.
Journal of extracellular vesicles, 10(13), e12165-e12165 (2021-11-10)
Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression. The mechanisms
Ashley L Kalinski et al.
eLife, 9 (2020-12-03)
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes infiltrate the nerve first and rapidly give way to Ly6Cnegative inflammation-resolving macrophages. In axotomized DRGs, few hematogenous leukocytes
Chia-Yi Chen et al.
Matrix biology : journal of the International Society for Matrix Biology, 70, 84-101 (2018-03-25)
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population. Variants in the HTRA1-ARMS2 locus have been linked to increased AMD risk. In the present study we investigated the impact of elevated HtrA1 levels on
Nicholas W Kieran et al.
Journal of neuroinflammation, 19(1), 10-10 (2022-01-08)
Astrocytes are the most numerous glial cell type with important roles in maintaining homeostasis and responding to diseases in the brain. Astrocyte function is subject to modulation by microRNAs (miRs), which are short nucleotide strands that regulate protein expression in
Lucia Lichvarova et al.
Scientific reports, 9(1), 10603-10603 (2019-07-25)
Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a "reactive" phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in
Nicole Schäfer et al.
Frontiers in immunology, 12, 769242-769242 (2021-11-26)
Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD). However, the non-canonical local, cellular functions of FHR-3 remained poorly understood. Here, we report that
Tomasz M Stępkowski et al.
Cellular and molecular neurobiology, 37(6), 1055-1066 (2016-11-11)
Perturbations in the transport of mitochondria and their quality control in neuronal cells underlie many types of neurological pathologies, whereas systems enabling convenient analysis of mitochondria behavior in cellular models of neurodegenerative diseases are limited. In this study, we present
Nathan J Michaels et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(44), 8587-8600 (2020-10-17)
Age is a critical risk factor for many neurologic conditions, including progressive multiple sclerosis. Yet the mechanisms underlying the relationship are unknown. Using lysolecithin-induced demyelinating injury to the mouse spinal cord, we characterized the acute lesion and investigated the mechanisms
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Lucia Lichvarova et al.
Scientific reports, 10(1), 12518-12518 (2020-07-23)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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