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Aubérie Parent et al.
Nature communications, 6, 5686-5686 (2015-01-20)
Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the
Nicole J Van Bergen et al.
PloS one, 10(10), e0140919-e0140919 (2015-10-27)
Primary Open Angle Glaucoma (POAG) is a common neurodegenerative disease characterized by the selective and gradual loss of retinal ganglion cells (RGCs). Aging and increased intraocular pressure (IOP) are glaucoma risk factors; nevertheless patients deteriorate at all levels of IOP
Michael D Roberts et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R1024-R1035 (2013-04-05)
The purpose of the present study was to partially phenotype male and female rats from generations 8-10 (G8-G10) that had been selectively bred to possess low (LVR) vs. high voluntary running (HVR) behavior. Over the first 6 days with wheels
Vlad C Sandulache et al.
Molecular cancer therapeutics, 14(12), 2901-2908 (2015-09-18)
Ionizing radiation is the primary nonsurgical treatment modality for solid tumors. Its effectiveness is impacted by temporal constraints such as fractionation, hypoxia, and development of radioresistant clones. Biomarkers of acute radiation response are essential to developing more effective clinical algorithms.
Huanhuan Pang et al.
Nature metabolism, 3(8), 1109-1124 (2021-08-14)
Zika virus (ZIKV) infection during pregnancy can cause microcephaly in newborns, yet the underlying mechanisms remain largely unexplored. Here, we reveal extensive and large-scale metabolic reprogramming events in ZIKV-infected mouse brains by performing a multi-omics study comprising transcriptomics, proteomics, phosphoproteomics
Ie E Koliesnikova et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(3), 58-64 (2013-08-21)
The results of pharmacological correction of experimental mitochondrial dysfunction in brain stem neurons after single injection of specific respiratory complex I inhibitor rotenone by complex agents mildronate and rhytmocor have been presented. It was shown that 14-days rhytmocor injection promoted
Qian Du et al.
Journal of immunology (Baltimore, Md. : 1950), 201(2), 533-547 (2018-06-03)
Porcine circovirus (PCV) type 2 (PCV2), an immunosuppression pathogen, is often found to increase the risk of other pathogenic infections. Yet the relative immune mechanisms determining the susceptibility of PCV2-infected animals remain unclear. In this study, we confirmed that PCV2
Jeerus Sucharitakul et al.
The Journal of biological chemistry, 288(49), 35210-35221 (2013-10-17)
3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is an NADH-specific flavoprotein monooxygenase that catalyzes the para-hydroxylation of 3-hydroxybenzoate (3HB) to form 2,5-dihydroxybenzoate (2,5-DHB). Based on results from stopped-flow spectrophotometry, the reduced enzyme-3HB complex reacts with oxygen to form a C4a-peroxy
Yaarit Adamovich et al.
Molecular and cellular biology, 33(13), 2603-2613 (2013-05-08)
PGC-1α is a key transcription coactivator regulating energy metabolism in a tissue-specific manner. PGC-1α expression is tightly regulated, it is a highly labile protein, and it interacts with various proteins--the known attributes of intrinsically disordered proteins (IDPs). In this study
Celia Fernández-Blanco et al.
Toxicology letters, 235(2), 61-66 (2015-04-02)
Oxidative stress occurs as a consequence of an imbalance between the prooxidant/antioxidant systems, causing an increase of intracellular generation of reactive oxygen species. Alternariol (AOH), a mycotoxin produced by Alternaria sp. can alter the action of glutathione (GSH) and the
Justine Bellier et al.
Cell reports, 30(5), 1400-1416 (2020-02-06)
The use of cetuximab anti-epidermal growth factor receptor (anti-EGFR) antibodies has opened the era of targeted and personalized therapy in colorectal cancer (CRC). Poor response rates have been unequivocally shown in mutant KRAS and are even observed in a majority
Eleonora Cavallari et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(5), 1200-1204 (2016-11-22)
Hyperpolarization of the 13 C magnetic resonance signal of l-[1-13 C]lactate has been obtained using the chemically based, cost-effective method called parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Two ester derivatives of lactate were tested and the factors that
Weiliang He et al.
Anti-cancer drugs, 26(3), 293-300 (2014-12-24)
Tamoxifen, a selective estrogen receptor modulator, is widely used in the chemotherapy of estrogen receptor-positive breast cancer. Recent studies have indicated that tamoxifen might have a potential chemotherapeutic effect on glioma. In the present study, we determined the chemotherapeutic action
Gergely Kiss et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1682-1697 (2014-01-07)
Substrate-level phosphorylation mediated by succinyl-CoA ligase in the mitochondrial matrix produces high-energy phosphates in the absence of oxidative phosphorylation. Furthermore, when the electron transport chain is dysfunctional, provision of succinyl-CoA by the α-ketoglutarate dehydrogenase complex (KGDHC) is crucial for maintaining
Itamar Yadid et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(24), E2182-E2190 (2013-05-17)
Microbes in contaminated environments often evolve new metabolic pathways for detoxification or degradation of pollutants. In some cases, intermediates in newly evolved pathways are more toxic than the initial compound. The initial step in the degradation of pentachlorophenol by Sphingobium
John M Atack et al.
The Journal of infectious diseases, 212(4), 645-653 (2015-02-26)
Hia is a major adhesin of nontypeable Haemophilus influenzae (NTHi) and has long been investigated as a vaccine candidate. Here we show that Hia phase variation is controlled by changes in the length of a polythymidine tract located in the
Xiao-Hong Zhu et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(9), 2876-2881 (2015-03-03)
NAD is an essential metabolite that exists in NAD(+) or NADH form in all living cells. Despite its critical roles in regulating mitochondrial energy production through the NAD(+)/NADH redox state and modulating cellular signaling processes through the activity of the
Fei Liao et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 23(4), 439-444 (2007-04-11)
Kinetic assay of serum ethanol was investigated by predicting maximal product absorbance at 340 nm (A(mk)) through fitting to the yeast alcohol dehydrogenase reaction curve with the integrated rate equation, taking into account product inhibition in the presence of semicarbazide.
Ivana Milackova et al.
Journal of enzyme inhibition and medicinal chemistry, 30(1), 107-113 (2014-03-29)
The ability of flavonoids to affect multiple key pathways of glucose toxicity, as well as to attenuate inflammation has been well documented. In this study, the inhibition of rat lens aldose reductase by 3,7-di-hydroxy-2-[4-(2-chloro-1,4-naphthoquinone-3-yloxy)-3-hydroxy-phenyl]-5-hydroxy-chromen-4-one (compound 1), was studied in greater
Ajay Krishnamurthy et al.
Microbes and infection, 16(8), 640-647 (2014-07-08)
Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) often share a common niche within the nasopharynx, both associated with infections such as bronchitis and otitis media. This study investigated how the association between NTHi and S. pneumoniae and the host affects
Min Park et al.
Biochimica et biophysica acta, 1848(3), 842-847 (2014-12-22)
"Autodisplay technology" is an expression technique used to display the various recombinant proteins on the outer membrane (OM) of Escherichia coli. The resulting autodisplayed Z-domain has been used to improve the sensitivity of immunoassays. In this work, a facile isolation
Pablo B Martínez de Morentin et al.
Endocrinology, 156(3), 947-960 (2014-12-24)
During gestation, hyperphagia is necessary to cope with the metabolic demands of embryonic development. There were three main aims of this study: Firstly, to investigate the effect of pregnancy on hypothalamic fatty acid metabolism, a key pathway for the regulation
Veronika L Zinsser et al.
Biochimica et biophysica acta, 1844(4), 744-749 (2014-02-26)
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) catalyses one of the two steps in glycolysis which generate the reduced coenzyme NADH. This reaction precedes the two ATP generating steps. Thus, inhibition of GAPDH will lead to substantially reduced energy generation. Consequently, there has
Christian Dölle et al.
The FEBS journal, 280(15), 3530-3541 (2013-04-27)
Mitochondrial metabolism is intimately connected to the universal coenzyme NAD. In addition to its role in redox reactions of energy transduction, NAD serves as substrate in regulatory reactions that lead to its degradation. Importantly, all types of the known NAD-consuming
Gerta Hoxhaj et al.
Science (New York, N.Y.), 363(6431), 1088-1092 (2019-03-09)
Nicotinamide adenine dinucleotide phosphate (NADP+) is essential for producing NADPH, the primary cofactor for reductive metabolism. We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-Akt pathway induces acute synthesis of NADP+ and NADPH. Akt phosphorylates NAD kinase (NADK)
Christoph Koentges et al.
Basic research in cardiology, 110(4), 36-36 (2015-05-13)
Sirtuin 3 (SIRT3) is a mitochondrial NAD(+)-dependent deacetylase that regulates energy metabolic enzymes by reversible protein lysine acetylation in various extracardiac tissues. The role of SIRT3 in myocardial energetics and in the development of mitochondrial dysfunction in cardiac pathologies, such
Eran Blacher et al.
Annals of neurology, 78(1), 88-103 (2015-04-22)
Alzheimer's disease (AD)-associated dementia is due to tissue damage caused by amyloid β (Aβ) deposition within the brain and by accompanying neuroinflammation. The nicotinamide adenine dinucleotide (NAD) glycohydrolase CD38, which is expressed by neurons, astrocytes, and microglial cells, regulates inflammatory
Y Gong et al.
European review for medical and pharmacological sciences, 18(19), 2808-2820 (2014-10-24)
Obesity has long been suspected to be a risk factor for cancer. The relationship between body fat deposition and the pathogenesis of cancer has been the subject of many studies, however, no clear consensus has emerged linking these two biological
Jocelyn M Madeira et al.
Journal of neuroimmunology, 276(1-2), 71-79 (2014-09-02)
Neuroinflammation contributes to the pathogenesis of neurological disorders. Anti-inflammatory treatments could potentially be used to slow down the progression of these diseases. We studied the anti-neuroinflammatory activity of gold compounds which have been used to treat rheumatoid arthritis. Non-toxic concentrations
Soo-Jin Lee et al.
Archives of biochemistry and biophysics, 535(2), 187-196 (2013-04-09)
This study was initiated to determine whether the protective effect of nicotinamide (NAM) on high glucose/palmitate (HG/PA)-induced INS-1 beta cell death was due to its role as an anti-oxidant, nicotinamide dinucleotide (NAD+) precursor, or inhibitor of NAD+-consuming enzymes such as
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