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S D Joshi et al.
European journal of medicinal chemistry, 43(9), 1989-1996 (2008-01-22)
In the present study, a novel series of 4-pyrrol-1-yl benzoic acid hydrazide analogs, some derived 5-substituted-2-thiol-1,3,4-oxadiazoles, 5-substituted-4-amino-1,2,4-triazolin-3-thione and 2,5-dimethyl pyrroles have been synthesized in good yields and characterized by IR, NMR, mass spectral and elemental analyses. Compounds were evaluated for...
Jigar A Makawana et al.
Bioorganic & medicinal chemistry letters, 21(20), 6166-6169 (2011-09-06)
A new series of fused pyran derivatives 5a-x bearing 2-morpholinoquinoline nucleus has been synthesized under microwave irradiation by a reaction of 2-morpholinoquinoline-3-carbaldehyde 2a-c, malononitrile 3 and compounds 4a-h in presence of NaOH as basic catalyst. All the compounds were screened...
Kunikazu Yamane et al.
Antimicrobial agents and chemotherapy, 52(4), 1564-1566 (2008-02-21)
Seven hundred fifty-one Escherichia coli clinical isolates collected from 140 Japanese hospitals between 2002 and 2006 were screened for the qepA and qnr genes. Two E. coli isolates (0.3%) harbored qepA, but no qnr was identified. The results suggested a...
L Miano et al.
European urology, 17 Suppl 1, 13-18 (1990-01-01)
A review of worldwide clinical trials with norfloxacin in the treatment of uncomplicated urinary tract infections (UTIs), as well as our personal experience with 215 assessable patients, is presented. Almost all patients received 400 mg b.i.d. for 3-15 days. Bacteriological...
Junqiang Wu et al.
Antimicrobial agents and chemotherapy, 51(9), 3131-3135 (2007-07-04)
Bovine subclinical mastitis is an inflammation of the mammary gland caused by bacterial intramammary infection, accounting for large economic losses. Treatment of subclinical mastitis is not suggested for lactating cows due to the risk of milk contamination. The objectives of...
High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali.
Véronique Duval et al.
Antimicrobial agents and chemotherapy, 53(11), 4957-4958 (2009-09-02)
Julien Brillault et al.
Antimicrobial agents and chemotherapy, 54(1), 543-545 (2009-10-14)
The transport characteristics of six fluoroquinolones (FQs) with various lipophilicities were compared in a Calu-3 cell model. For each FQ, an active polarized transport was observed in the direction of the apical side. However, the apparent permeability of FQs resulted...
Kenji Kurokawa et al.
Antimicrobial agents and chemotherapy, 53(9), 4025-4027 (2009-06-24)
The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness of antibiotics was examined. The 50% effective doses (ED50) of D-cycloserine against the Staphylococcus aureus ddlA mutant-mediated killing of larvae were remarkably lower than those against the...
Jang-Gi Choi et al.
PloS one, 9(7), e102697-e102697 (2014-07-23)
Galla rhois is a commonly used traditional medicine for the treatment of pathogenic bacteria in Korea as well as in other parts of Asia. Methyl gallate (MG), a major component of Galla Rhois, exhibits strong antibacterial activity, but its mechanism...
Vincent Cattoir et al.
Antimicrobial agents and chemotherapy, 52(8), 2929-2932 (2008-06-04)
A novel QnrB-like plasmid-mediated resistance determinant, QnrB19, was identified from an Escherichia coli clinical isolate from Colombia. Its gene was associated with an ISEcp1-like insertion element that did not act as a promoter for its expression. Using an in vitro...
Chieh Jason Chou et al.
Nestle Nutrition workshop series. Paediatric programme, 62, 127-137 (2008-07-16)
Recent data suggest that gut microbiota plays a significant role in fat accumulation. However, it is not clear whether gut microbiota is involved in the pathophysiology of type-2 diabetes. To address this issue, we modulated gut microbiota with two combinations...
Sandra Aedo et al.
Antimicrobial agents and chemotherapy, 56(11), 5458-5464 (2012-08-08)
DNA topoisomerases are important targets in anticancer and antibacterial therapy because drugs can initiate cell death by stabilizing the transient covalent topoisomerase-DNA complex. In this study, we employed a method that uses CsCl density gradient centrifugation to separate unbound from...
Marianne Gunell et al.
Antimicrobial agents and chemotherapy, 53(9), 3832-3836 (2009-07-15)
Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC...
Feng Long et al.
Antimicrobial agents and chemotherapy, 52(9), 3052-3060 (2008-07-02)
Active efflux of antimicrobial agents is one of the most important adapted strategies that bacteria use to defend against antimicrobial factors that are present in their environment. The NorM protein of Neisseria gonorrhoeae and the YdhE protein of Escherichia coli...
Yu Bin Ho et al.
The Science of the total environment, 488-489, 261-267 (2014-05-20)
Repeated applications of animal manure as fertilizer are normal agricultural practices that may release veterinary antibiotics and hormones into the environment from treated animals. Broiler manure samples and their respective manure-amended agricultural soil samples were collected in selected locations in...
Alireza Foroumadi et al.
Bioorganic & medicinal chemistry letters, 16(13), 3499-3503 (2006-04-29)
N-(Phenethyl)piperazinyl quinolone derivatives that bear a methoxyimino-substituent have been synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. In addition, to define structure-activity relationships, ciprofloxacin derivatives containing 2-oxo-2-phenylethyl or 2-hydroxyimino-2-phenylethyl moieties at N-4 position of piperazine ring were...
Fluorescence reaction and complexation equilibria between norfloxacin and aluminium (III) ion in chloride medium
Djurdjevic.TP, et al.
Analytica Chimica Acta, 300, 253-259 (1995)
Junwei Zhang et al.
Journal of environmental sciences (China), 24(4), 743-749 (2012-08-17)
Photodegradation of Norfloxacin in aqueous solution containing algae under a medium pressure mercury lamp (15 W, lambda(max) = 365 nm) was investigated. Results indicated that the photodegradation of Norfloxacin could be induced by the algae in the heterogeneous algae-water systems....
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated...
Jason A Wiles et al.
Journal of medicinal chemistry, 49(1), 39-42 (2006-01-06)
We report the syntheses of first-generation derivatives of isothiazolopyridones and their in vitro evaluation as antibacterial agents. These compounds, containing a novel heterocyclic nucleus composed of an isothiazolone fused to a quinolizin-4-one (at C-2 and C-3 of the quinolizin-4-one), were...
Nai-Wen Fan et al.
American journal of ophthalmology, 154(6), 927-933 (2012-09-11)
To report the effect of repeated corneal swabbing in patients with microsporidial keratoconjunctivitis. Retrospective noncomparative case series. Sixteen eyes of 14 healthy patients with microsporidial keratoconjunctivitis were diagnosed based on the detection of microsporidia in corneal scrapings using Gram stain...
Li-Li Xu et al.
European journal of medicinal chemistry, 48, 174-178 (2011-12-24)
In the present study, a series of 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties were synthesized and their antimicrobial activities were tested against various Gram-positive and Gram-negative bacteria. 1,3-diaryl-4-formylpyrazoles were synthesized as key intermediates following a Vilsmeier-Haack strategy. Several compounds...
Yoshikazu Asahina et al.
Journal of medicinal chemistry, 48(9), 3443-3446 (2005-04-29)
Novel 1-trifluoromethyl-4-quinolone derivatives (8a,b) were synthesized, and the antibacterial activity of each was evaluated. An oxidative desulfurization-fluorination reaction was employed to introduce a trifluoromethyl group at the N-1 position as a key step. Among the derivatives, 8a was found to...
Jürgen A Bohnert et al.
Antimicrobial agents and chemotherapy, 54(9), 3770-3775 (2010-07-08)
AcrAB-TolC is the major constitutively expressed efflux pump system that provides resistance to a variety of antimicrobial agents and dyes in Escherichia coli. However, no systematically optimized real-time dye efflux assay has been published for the measurement of its activity...
Milagrosa Montes et al.
Antimicrobial agents and chemotherapy, 54(1), 93-97 (2009-10-07)
The aim of this study was to determine the prevalence and characteristics of non-fluoroquinolone (FQ)-susceptible Streptococcus pyogenes isolates and to study their mechanisms of resistance. We performed a prospective prevalence study with 468 isolates collected from 2005 to 2007 and...
Shlomo Brill et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(42), 16894-16899 (2012-10-05)
EmrE, a multidrug antiporter from Escherichia coli, has presented biochemists with unusual surprises. Here we describe the transformation of EmrE, a drug/H(+) antiporter to a polyamine importer by a single mutation. Antibiotic resistance in microorganisms may arise by mutations at...
Jyotika B Varshney et al.
Foodborne pathogens and disease, 11(10), 822-829 (2014-10-01)
A study was conducted to determine the prevalence of Clostridium difficile and characterize C. difficile isolates from human stool and retail grocery meat samples. Human stool samples (n=317) were obtained from a clinical laboratory and meat samples (n=303) were collected...
S Page et al.
Antimicrobial agents and chemotherapy, 52(11), 4155-4158 (2008-08-30)
Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes....
Victor Kuete et al.
Antimicrobial agents and chemotherapy, 54(5), 1749-1752 (2010-02-18)
The activities of two naturally occurring compounds, isobavachalcone and diospyrone, against documented strains and multidrug-resistant (MDR) Gram-negative bacterial isolates were evaluated. The results indicated that the two compounds exhibited intrinsic antibacterial activity against several Gram-negative bacteria, and their activities were...
Tian Shi et al.
Mikrochimica acta, 186(6), 362-362 (2019-05-20)
A fluorescent nanoprobe consisting of CdTe quantum dots (QDs) and coated with molecularly imprinted layers was prepared and successfully applied to the determination of norfloxacin (NOR) in seawater and wastewater samples. The 3-mercaptopropionic acid capped QDs were prepared and then...
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