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Alessandro Scacchetti et al.
Life science alliance, 1(1), e201800024-e201800024 (2018-11-21)
The chromatin remodeling complexes chromatin accessibility complex and ATP-utilizing chromatin assembly and remodeling factor (ACF) combine the ATPase ISWI with the signature subunit ACF1. These enzymes catalyze well-studied nucleosome sliding reactions in vitro, but how their actions affect physiological gene...
Sonia Boughattas et al.
Parasites & vectors, 4, 167-167 (2011-08-30)
Clinical manifestation due to infection by Toxoplasma gondii is closely linked to the infecting strain of the parasite. Several genetic markers are available to determinate its genotype but few of them are able to discriminate between the three predominant lineages...
Madoka Kuramitsu et al.
Blood, 119(10), 2376-2384 (2012-01-21)
Fifty percent of Diamond-Blackfan anemia (DBA) patients possess mutations in genes coding for ribosomal proteins (RPs). To identify new mutations, we investigated large deletions in the RP genes RPL5, RPL11, RPL35A, RPS7, RPS10, RPS17, RPS19, RPS24, and RPS26. We developed...
B Sandford et al.
International journal of immunogenetics, 36(4), 199-205 (2009-05-30)
C-C chemokine receptor 5 (CCR5) is involved in the regulation of the inflammatory response. Abdominal aortic aneurysms (AAA) may arise as the result of a chronic inflammatory process which is influenced by genetic predisposition. The CCR5 gene is associated with...
Dagmar Skálová et al.
Journal of biomedicine & biotechnology, 2010, 475432-475432 (2011-01-15)
Prezygotic interspecific crossability barrier in the genus Cucumis is related to the ploidy level of the species (cucumber (C. sativus), x = 7; muskmelon (C. melo) and wild Cucumis species, x = 12). Polyploidization of maternal plants helps hybridization among...
Teresa Kamińska-Gibas et al.
Fish & shellfish immunology, 102, 511-518 (2020-05-18)
In this study, the expression of pro-inflammatory and iron metabolism genes were analysed under Trypanoplasma borreli (T. borreli) challenge in common carp. Three transferrin (Tf) genotypic groups: two homozygous - DD, GG, and heterozygous DG were intraperitoneally infected with a...
Sara Tomei et al.
Journal of translational medicine, 10, 7-7 (2012-01-12)
A large amount of information has been collected on the molecular tumorigenesis of thyroid cancer. A low expression of c-KIT gene has been reported during the transformation of normal thyroid epithelium to papillary carcinoma suggesting a possible role of the...
Jing Wang et al.
PloS one, 10(5), e0126432-e0126432 (2015-05-21)
The mechanism by which pancreas secretes high HCO3- has not been fully resolved. This alkaline secretion, formed in pancreatic ducts, can be achieved by transporting HCO3- from serosa to mucosa or by moving H+ in the opposite direction. The aim...
Sandy Devries et al.
The Journal of molecular diagnostics : JMD, 7(1), 65-71 (2005-02-01)
Identification of prognostic and predictive genomic markers requires long-term clinical follow-up of patients. Extraction of high-quality DNA from archived formalin-fixed, paraffin-embedded material is essential for such studies. Of particular importance is a robust reproducible method of whole genome amplification for...
Célia Deville et al.
Cell reports, 27(12), 3433-3446 (2019-06-20)
AAA+ proteins form asymmetric hexameric rings that hydrolyze ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops. Understanding how ATPase and threading activities are regulated and intertwined is key to understanding the AAA+ protein mechanism....
Heinz Kutzner et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 25(6), 838-845 (2012-03-06)
Cutaneous melanomas are characterized by a range of histological appearances, and several morphological variants have been described. In this study, we report a variant of superficial spreading melanoma that is characterized by large, irregular junctional melanocytic nests. The junctional nests...
Katherine S Ryan
PloS one, 6(8), e23694-e23694 (2011-08-31)
The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed among bis-indole alkaloids. I report here the isolation, sequencing, and annotation of the cladoniamide biosynthetic gene cluster and...
Hashem Al-Sheikh
Saudi journal of biological sciences, 17(4), 347-352 (2010-10-01)
During a survey of pathogenic and non-pathogenic Pythium spp. in different localities in Egypt, several isolates of Pythia were obtained and maintained on corn meal agar. Among these isolates, Pythium aphanidermatum and Pythium diclinum were obtained from rhizosphere of wheat...
Anna C Shore et al.
Antimicrobial agents and chemotherapy, 52(12), 4407-4419 (2008-10-15)
Methicillin-susceptible Staphylococcus aureus (MSSA) can arise from methicillin-resistant S. aureus (MRSA) following partial or complete excision of staphylococcal cassette chromosome mec (SCCmec). This study investigated whether multiresistant MSSA isolates from Irish hospitals, where MRSA has been endemic for decades, harbor...
A Sundqvist et al.
Oncogene, 32(31), 3606-3615 (2012-08-29)
Deregulation of the transforming growth factor β (TGFβ) signal transduction cascade is functionally linked to cancer. In early phases, TGFβ acts as a tumor suppressor by inhibiting tumor cell proliferation, whereas in late phases, it can act as a tumor...
Francesco Chemello et al.
Bio-protocol, 9(19), e3378-e3378 (2019-10-05)
Skeletal muscle is composed of different cells and myofiber types, with distinct metabolic and structural features. Generally, transcriptomic analysis of skeletal muscle is performed using whole muscle, resulting in average information as all cells composing the organ contribute to the...
Jianyu Liu et al.
Nanoscale, 12(6), 4159-4166 (2020-02-06)
Thrombin aptamers (TBAs) have attracted much attention due to their various applications. The structures and properties of long ssDNA chains with multiple TBA repeat sequences are interesting and distinct from those of their monomers. Due to the complexity of the...
Katie E Fowler et al.
BMC research notes, 5, 503-503 (2012-09-15)
The ability to transport and store DNA at room temperature in low volumes has the advantage of optimising cost, time and storage space. Blood spots on adapted filter papers are popular for this, with FTA (Flinders Technology Associates) Whatman™TM technology...
L Beke et al.
Oncogene, 26(31), 4590-4595 (2007-01-24)
PSP94, for prostatic secretory protein of 94 amino acids, is secreted by the prostate gland and functions as a suppressor of tumor growth and metastasis. The expression of PSP94 is lost in advanced, hormone-refractory prostate cancer and this correlates with...
Jochen B Geigl et al.
Nucleic acids research, 37(15), e105-e105 (2009-06-23)
Clinical DNA is often available in limited quantities requiring whole-genome amplification for subsequent genome-wide assessment of copy-number variation (CNV) by array-CGH. In pre-implantation diagnosis and analysis of micrometastases, even merely single cells are available for analysis. However, procedures allowing high-resolution...
Dhawal Jain et al.
Nucleic acids research, 43(14), 6959-6968 (2015-06-29)
Chromatin immunoprecipitation (ChIP) is widely used to identify chromosomal binding sites. Chromatin proteins are cross-linked to their target sequences in living cells. The purified chromatin is sheared and the relevant protein is enriched by immunoprecipitation with specific antibodies. The co-purifying...
D F Young et al.
The Journal of general virology, 90(Pt 11), 2731-2738 (2009-07-25)
Although the Enders strain of mumps virus (MuV) encodes a functional V protein that acts as an interferon (IFN) antagonist, in multi-cycle growth assays MuV Enders grew poorly in naïve ('IFN-competent' Hep2) cells but grew to high titres in 'IFN-compromised'...
Anna C Obenauf et al.
Journal of cellular and molecular medicine, 14(8), 2078-2084 (2010-07-06)
The analysis of structural variants associated with specific phenotypic features is promising for the elucidation of the function of involved genes. There is, however, at present no approach allowing the rapid mapping of chromosomal translocation breakpoints to the basepair level...
Savita Shanker et al.
Journal of biomolecular techniques : JBT, 26(1), 4-18 (2015-02-05)
This article includes supplemental data. Please visit to obtain this information.Multiple recent publications on RNA sequencing (RNA-seq) have demonstrated the power of next-generation sequencing technologies in whole-transcriptome analysis. Vendor-specific protocols used for RNA library construction often require at least...
Genetic analysis of uveal melanoma by array comparative genomic hybridization before and after radiotherapy
Werner Wackernagel
Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 27.6, 286-291 (2013)
Histological and genetic evidence for a variant of superficial spreading melanoma composed predominantly of large nests.
Kutzner H
Modern Pathology, 25(6), 838-845 (2012)
David Brunn et al.
Cancers, 13(2) (2021-01-13)
Transcription factors can serve as links between tumor microenvironment signaling and oncogenesis. Interferon regulatory factor 9 (IRF9) is recruited and expressed upon interferon stimulation and is dependent on cofactors that exert in tumor-suppressing or oncogenic functions via the JAK-STAT pathway....
Elisa M Salas et al.
Genes & cancer, 2(5), 593-596 (2011-09-09)
A search for genes potentially regulated by STAT5 identified leukemia inhibitory factor (LIF) as a good candidate. Using various experimental approaches, we have validated LIF as a direct transcriptional target of STAT5 in myeloid cell lines: STAT5 binds to LIF...
Charlotte G Cole et al.
Genome biology, 9(5), R78-R78 (2008-05-15)
Although the human genome sequence was declared complete in 2004, the sequence was interrupted by 341 gaps of which 308 lay in an estimated approximately 28 Mb of euchromatin. While these gaps constitute only approximately 1% of the sequence, knowledge...
Jing Wang et al.
American journal of physiology. Cell physiology, 304(7), C673-C684 (2013-02-01)
Purinergic agonists have been considered for the treatment of respiratory epithelia in cystic fibrosis (CF) patients. The pancreas, one of the most seriously affected organs in CF, expresses various purinergic receptors. Studies on the rodent pancreas show that purinergic signaling...
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