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Showing 1-30 of 885 results for "neurons"
SMAN1
survival of motor and autonomic neurons 1
Species:
Human SMAN1 (574013)
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
Synonyms:
SDPII
Species:
Human PACSIN2 (11252), Mouse Pacsin2 (23970), Rat Pacsin2 (124461), Zebrafish pacsin2 (404601), cow PACSIN2 (540107), Horse PACSIN2 (100056169), domestic cat PACSIN2 (101085989), chicken PACSIN2 (395975), dog PACSIN2 (100683200), sheep PACSIN2 (101115867), domestic guinea pig Pacsin2 (100721526), naked mole-rat Pacsin2 (101715072)
Summary:
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010
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NAV1
neuron navigator 1
Synonyms:
POMFIL3, STEERIN1, UNC53H1
Species:
Human NAV1 (89796), Mouse Nav1 (215690), Rat Nav1 (304818), Zebrafish nav1 (100536287), chicken NAV1 (430162), cow NAV1 (531974), domestic cat NAV1 (101096869), dog NAV1 (490238), domestic guinea pig Nav1 (100732683), naked mole-rat Nav1 (101719454), sheep NAV1 (101112917)
Summary:
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009
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NPTXR
neuronal pentraxin receptor
Synonyms:
NPR
Species:
Human NPTXR (23467), Mouse Nptxr (73340), Rat Nptxr (81005), chicken NPTXR (427902), cow NPTXR (100848095), domestic cat NPTXR (101082420), dog NPTXR (100685212), domestic guinea pig Nptxr (100731015), naked mole-rat Nptxr (101701104)
Summary:
This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008
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NAV2
neuron navigator 2
Synonyms:
HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2
Species:
Human NAV2 (89797), Mouse Nav2 (78286), Rat Nav2 (171563), sheep NAV2 (101115490), naked mole-rat Nav2 (101723248), Domestic Rabbit NAV2 (100352991), domestic guinea pig Nav2 (100726158), Zebrafish nav2 (100333160), dog NAV2 (485411), chicken NAV2 (422977), domestic cat NAV2 (101082943), cow NAV2 (100139508), Horse NAV2 (100071978)
Summary:
This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011
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NEUROD2
neuronal differentiation 2
Synonyms:
NDRF, bHLHa1
Species:
Human NEUROD2 (4761), Mouse Neurod2 (18013), Rat Neurod2 (54276), domestic guinea pig Neurod2 (100723910), naked mole-rat Neurod2 (101709326), Zebrafish neurod2 (114435), dog NEUROD2 (491026), cow NEUROD2 (528817), domestic cat NEUROD2 (101101096)
Summary:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008
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TMOD2
tropomodulin 2 (neuronal)
Synonyms:
N-TMOD, NTMOD
Species:
Human TMOD2 (29767), Mouse Tmod2 (50876), Rat Tmod2 (58814), cow TMOD2 (532085), sheep TMOD2 (101104240), domestic guinea pig Tmod2 (100722174), naked mole-rat Tmod2 (101702934), Domestic Rabbit TMOD2 (100339581), Zebrafish tmod2 (447869), dog TMOD2 (478309), chicken TMOD2 (415422), Horse TMOD2 (100055095), domestic cat TMOD2 (101094022)
Summary:
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008
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CPNE6
copine VI (neuronal)
Species:
Human CPNE6 (9362), Mouse Cpne6 (12891), Rat Cpne6 (691478), sheep CPNE6 (101118614), Domestic Rabbit CPNE6 (100342224), domestic guinea pig Cpne6 (100717208), naked mole-rat Cpne6 (101706959), dog CPNE6 (608275), domestic cat CPNE6 (101098638), cow CPNE6 (508059)
Summary:
This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2008
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NCS1
neuronal calcium sensor 1
Synonyms:
FLUP, FREQ
Species:
Human NCS1 (23413), Mouse Ncs1 (14299), Rat Ncs1 (65153), chicken NCS1 (396336), domestic cat NCS1 (101097027), cow NCS1 (526544), dog NCS1 (491294), sheep NCS1 (101102136), naked mole-rat Ncs1 (101697732), domestic guinea pig Ncs1 (100732388)
Summary:
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008
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PACSIN3
protein kinase C and casein kinase substrate in neurons 3
Synonyms:
SDPIII
Species:
Human PACSIN3 (29763), Mouse Pacsin3 (80708), Rat Pacsin3 (311187), naked mole-rat Pacsin3 (101716275), Domestic Rabbit PACSIN3 (100352135), sheep PACSIN3 (101116087), Zebrafish pacsin3 (393964), chicken PACSIN3 (423186), dog PACSIN3 (475984), Horse PACSIN3 (100057860), cow PACSIN3 (535109), domestic cat PACSIN3 (101091971)
Summary:
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010
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CLN5
ceroid-lipofuscinosis, neuronal 5
Synonyms:
NCL
Species:
Human CLN5 (1203), Mouse Cln5 (211286), Rat Cln5 (306128), sheep CLN5 (100034668), naked mole-rat Cln5 (101715781), domestic guinea pig Cln5 (100726787), Zebrafish cln5 (569407), domestic cat CLN5 (101085427), cow CLN5 (529186), dog CLN5 (485498), chicken CLN5 (101752092)
Summary:
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.[provided by RefSeq, Oct 2008
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NPTX1
neuronal pentraxin I
Synonyms:
NP1
Species:
Human NPTX1 (4884), Mouse Nptx1 (18164), Rat Nptx1 (266777), chicken NPTX1 (422078), domestic cat NPTX1 (101095700), cow NPTX1 (513538), dog NPTX1 (483356), domestic guinea pig Nptx1 (100729432), naked mole-rat Nptx1 (101723897), sheep NPTX1 (101119737)
Summary:
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008
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NAV3
neuron navigator 3
Synonyms:
POMFIL1, STEERIN3, unc53H3
Species:
Human NAV3 (89795), Mouse Nav3 (260315), Rat Nav3 (314814), Zebrafish nav3 (567779), chicken NAV3 (417869), dog NAV3 (482577), domestic cat NAV3 (101088856), cow NAV3 (528870), Horse NAV3 (100050448), domestic guinea pig Nav3 (100713036), Domestic Rabbit NAV3 (100349570), naked mole-rat Nav3 (101703345), sheep NAV3 (101102301)
Summary:
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008
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NPTX2
neuronal pentraxin II
Synonyms:
NARP, NP-II, NP2
Species:
Human NPTX2 (4885), Mouse Nptx2 (53324), Rat Nptx2 (288475), chicken NPTX2 (416438), dog NPTX2 (489866), domestic cat NPTX2 (101094720), cow NPTX2 (100336779), sheep NPTX2 (101104118), naked mole-rat Nptx2 (101720728), domestic guinea pig Nptx2 (100135579)
Summary:
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009
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PACSIN1
protein kinase C and casein kinase substrate in neurons 1
Synonyms:
SDPI
Species:
Human PACSIN1 (29993), Mouse Pacsin1 (23969), Rat Pacsin1 (29704), naked mole-rat Pacsin1 (101699093), domestic guinea pig Pacsin1 (100726771), Goat PACSIN1 (100860994), sheep PACSIN1 (101119942), chicken PACSIN1 (419903), domestic cat PACSIN1 (101095898), cow PACSIN1 (520488), Horse PACSIN1 (100062613), dog PACSIN1 (608087)
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CLN9
ceroid-lipofuscinosis, neuronal 9
Species:
Human CLN9 (497231)
ANK2
ankyrin 2, neuronal
Synonyms:
ANK-2, LQT4, brank-2
Species:
Human ANK2 (287), Mouse Ank2 (109676), Rat Ank2 (362036), fruit fly Ank2 (38863), Horse ANK2 (100064198), domestic cat ANK2 (101100129), chicken ANK2 (422689), dog ANK2 (487908), sheep ANK2 (101115623), domestic guinea pig Ank2 (100717265), naked mole-rat Ank2 (101697466)
Summary:
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011
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NEUROD6
neuronal differentiation 6
Synonyms:
Atoh2, MATH2, Math-2, NEX1M, Nex1, bHLHa2
Species:
Human NEUROD6 (63974), Mouse Neurod6 (11922), Rat Neurod6 (500137), sheep NEUROD6 (101122515), domestic guinea pig Neurod6 (100717179), naked mole-rat Neurod6 (101715972), chicken NEUROD6 (420754), domestic cat NEUROD6 (101089001), cow NEUROD6 (540464), Horse NEUROD6 (100055160), dog NEUROD6 (482387)
Summary:
This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012
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NEUROD4
neuronal differentiation 4
Synonyms:
ATH-3, ATH3, Atoh3, MATH-3, bHLHa4
Species:
Human NEUROD4 (58158), Mouse Neurod4 (11923), Rat Neurod4 (288821), Zebrafish neurod4 (266958), chicken NEUROD4 (395959), cow NEUROD4 (519656), domestic cat NEUROD4 (101095025), naked mole-rat Neurod4 (101708343), domestic guinea pig Neurod4 (100724964), sheep NEUROD4 (101120316)
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NEUROD1
neuronal differentiation 1
Synonyms:
BETA2, BHF-1, MODY6, NEUROD, bHLHa3
Species:
Human NEUROD1 (4760), Mouse Neurod1 (18012), Rat Neurod1 (29458), chicken NEUROD1 (395754), dog NEUROD1 (488431), domestic cat NEUROD1 (101081998), cow NEUROD1 (539487), naked mole-rat Neurod1 (101710071), domestic guinea pig Neurod1 (100717228), sheep NEUROD1 (554337)
Summary:
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008
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ENO2
enolase 2 (gamma, neuronal)
Synonyms:
NSE
Species:
Human ENO2 (2026), Mouse Eno2 (13807), Rat Eno2 (24334), Zebrafish eno2 (402874), cow ENO2 (526006), Horse ENO2 (100052776), dog ENO2 (477709), domestic cat ENO2 (101086660), chicken ENO2 (395689), domestic guinea pig Eno2 (100723977), naked mole-rat Eno2 (101721709), sheep ENO2 (101109164), Domestic Rabbit ENO2 (100348989)
Summary:
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008
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NRCAM
neuronal cell adhesion molecule
Species:
Human NRCAM (4897), Mouse Nrcam (319504), Rat Nrcam (497815), Zebrafish nrcam (556537), dog NRCAM (475881), chicken NRCAM (396202), cow NRCAM (534500), Horse NRCAM (100050997), domestic cat NRCAM (101093257), naked mole-rat Nrcam (101696564), domestic guinea pig Nrcam (100720343), sheep NRCAM (101106001)
Summary:
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008
Products:
NPAS2
neuronal PAS domain protein 2
Synonyms:
MOP4, PASD4, bHLHe9
Species:
Human NPAS2 (4862), Mouse Npas2 (18143), Rat Npas2 (316351), Zebrafish npas2 (352934), chicken NPAS2 (395433), cow NPAS2 (614049), domestic cat NPAS2 (101082484), dog NPAS2 (474552), sheep NPAS2 (101104647), naked mole-rat Npas2 (101703217), domestic guinea pig Npas2 (100721253)
Summary:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008
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LRRN3
leucine rich repeat neuronal 3
Synonyms:
FIGLER5, NLRR-3, NLRR3
Species:
Human LRRN3 (54674), Mouse Lrrn3 (16981), Rat Lrrn3 (81514), Zebrafish lrrn3 (559559), dog LRRN3 (482406), cow LRRN3 (539665), Horse LRRN3 (100055630), domestic cat LRRN3 (101082555), chicken LRRN3 (770169), sheep LRRN3 (101113322), domestic guinea pig Lrrn3 (100728613), naked mole-rat Lrrn3 (101722493)
Products:
NOS1
nitric oxide synthase 1 (neuronal)
Synonyms:
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Species:
Human NOS1 (4842), Mouse Nos1 (18125), Rat Nos1 (24598), Zebrafish nos1 (60658), domestic cat NOS1 (101100342), cow NOS1 (536132), Horse NOS1 (100051079), dog NOS1 (477498), chicken NOS1 (427721), naked mole-rat Nos1 (101711993), Domestic Rabbit NOS1 (100009243), domestic guinea pig Nos1 (100729682)
Summary:
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011
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SMN1
survival of motor neuron 1, telomeric
Synonyms:
BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3, SMA4, SMA@, SMN, SMNT, T-BCD541, TDRD16A
Species:
Human SMN1 (6606), Mouse Smn1 (20595), Rat Smn1 (64301), Zebrafish smn1 (30432), cow SMN1 (281492), sheep SMN1 (101110178), domestic guinea pig Smn1 (100713418), naked mole-rat Smn1 (101706874)
Summary:
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008
Products:
CALY
calcyon neuron-specific vesicular protein
Synonyms:
DRD1IP, NSG3
Species:
Human CALY (50632), Mouse Caly (68566), Rat Caly (192349), Zebrafish caly (100307104), cow CALY (531593), dog CALY (491697), sheep CALY (101118913), naked mole-rat Caly (101699272), domestic guinea pig Caly (100726251)
Summary:
The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008
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LRRN2
leucine rich repeat neuronal 2
Synonyms:
FIGLER7, GAC1, LRANK1, LRRN5
Species:
Human LRRN2 (10446), Mouse Lrrn2 (16980), Rat Lrrn2 (289020), domestic guinea pig Lrrn2 (101789278), sheep LRRN2 (101109030), chicken LRRN2 (428261), cow LRRN2 (767860), Horse LRRN2 (100054439), dog LRRN2 (488564), domestic cat LRRN2 (101083057)
Summary:
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008
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LRRN4
leucine rich repeat neuronal 4
Synonyms:
C20orf75, NLRR-4, NLRR4, dJ1056H1.1
Species:
Human LRRN4 (164312), Mouse Lrrn4 (320974), Rat Lrrn4 (311443), naked mole-rat Lrrn4 (101720945), domestic guinea pig Lrrn4 (100733256), sheep LRRN4 (101109900), chicken LRRN4 (427686), dog LRRN4 (485776), cow LRRN4 (527351), domestic cat LRRN4 (101088828)
Products:
CLN3
ceroid-lipofuscinosis, neuronal 3
Synonyms:
BTS, JNCL
Species:
Human CLN3 (1201), Mouse Cln3 (12752), Rat Cln3 (293485), Zebrafish cln3 (492340), dog CLN3 (479794), domestic cat CLN3 (101089821), cow CLN3 (504799), fruit fly cln3 (39981), domestic guinea pig Cln3 (100727617), naked mole-rat Cln3 (101722930), sheep CLN3 (101112942), Domestic Rabbit CLN3 (100009244)
Summary:
This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008
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