Showing 1-30 of 316 results for "norfloxacin*"
Brim Stevy Ondon et al.
Bioresource technology, 304, 122984-122984 (2020-02-26)
Norfloxacin (NFLX) is a synthetic antibiotic widely used in the treatment of infectious diseases. In this work, the performance of microbial fuel cells (MFCs) toward NFLX degradation, electricity production and the antibiotics resistances genes (ARGs) generation was investigated. NFLX degradation...
Isabel Gómez-Hurtado et al.
Journal of hepatology, 61(4), 799-808 (2014-06-03)
Bacterial endotoxin is present in patients with advanced cirrhosis and can induce an immunogenic response without an overt infection. Norfloxacin is a gram-negative bactericidal drug able to maintain low endotoxin levels and stimulate IL-10 production. We aimed at investigating the...
Evan Trofimchuk et al.
Journal of food science, 85(3), 736-743 (2020-02-06)
By utilizing the coffee-ring effect and microfluidic paper-based analytical devices (µPADs), this study improved the sensitivity of the determination of norfloxacin in four different food matrices. Micro-PADs in this study were fabricated by designing and embedding wax channels onto cellulose-based...
Balwinder Kaur et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 214, 261-268 (2019-02-21)
Highly crystalline polyethylene glycol (PEG) coated Tb3+ doped ZnS nanoparticles have been synthesized and successfully used for norfloxacin sensing. The crystallographic and morphological analyses of PEG coated Tb3+ doped ZnS nanoparticles were performed by X-ray diffraction and Transmission electron microscopy...
Xi-Zhi Niu et al.
Water research, 106, 214-222 (2016-10-11)
Many fluoroquinolone (FLQ) antibiotics undergo rapid photodegradation in sunlit waters and form multifaceted photo-products. The high photodegradation rate is primarily ascribed to their photosensitizing properties. Though widely studied, the photo-reaction pathways are not completely revealed; photo-products mediated by different reactive...
Ximei Liang et al.
Ecotoxicology (London, England), 24(7-8), 1566-1573 (2015-04-22)
The presence of antibiotics including norfloxacin in the aquatic environment may cause adverse effects in non-target organisms. But the toxic mechanisms of fluoroquinolone to fish species are still not completely elucidated. Thus, it is essential to investigate the response of...
Mingjie Huang et al.
Water research, 119, 47-56 (2017-04-25)
This study demonstrated the efficient degradation of a typical bio-refractory antibiotic norfloxacin (NOR) in a photochemical iron oxides/oxalate system adopting magnetic catalyst (Fe
Yong Guo et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 136, 104966-104966 (2019-06-25)
Toward the search of new antibacterial agents to control methicillin-resistant Staphylococcus aureus (MRSA), a class of new norfloxacin-1,3,4-oxadiazole hybrids were designed and synthesized. Antibacterial activities against drug-sensitive bacteria S. aureus and clinical drug resistant isolates of MRSA were evaluated. Compound...
Meltem Yolal Mentese et al.
European journal of medicinal chemistry, 67, 230-242 (2013-07-23)
Norfloxacin was converted to 7-(4-amino-2-fluorophenyl)piperazin derivative (2) via the formation of nitro compound. The synthesis of the norfloxacin derivatives containing 1,3-thiazole or 1,3-thiazolidin moiety was performed from the reaction of 4-chlorophenacylbromide or ethyl bromoacetate with compounds 4-7 obtained starting from...
Eyas Dayyoub et al.
International journal of pharmaceutics, 531(1), 205-214 (2017-08-24)
Bacterial biofilm and crystalline deposits are the common causes of failure of long-term indwelling urinary catheter. Bacteria colonise the catheter surface causing serious infections in the urinary tract and encrustations that can block the catheter and induce trauma in patients....
Irma Garcia-Martinez et al.
Journal of gastroenterology and hepatology, 30(1), 147-154 (2014-07-22)
Proton pump inhibitors (PPIs) are commonly used antisecretory drugs and have been linked to an increased risk of bacterial infections in cirrhosis. We investigated whether the treatment with PPIs in cirrhosis affects the oxidative burst activity of granulocytes and monocytes...
Elias Baghdan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 139, 59-67 (2019-03-06)
Nanostructured coatings of dental implants have shown great potential in overcoming many challenges responsible for implant failure. In this study, nano spray drying technology was utilized to produce novel biocompatible nanocoatings with antibacterial activity. The experiments were applied on titanium...
Dae-Wi Kim et al.
Applied and environmental microbiology, 79(1), 314-321 (2012-10-30)
Microbacterium sp. 4N2-2, isolated from a wastewater treatment plant, converts the antibacterial fluoroquinolone norfloxacin to N-acetylnorfloxacin and three other metabolites. Because N-acetylation results in loss of antibacterial activity, identification of the enzyme responsible is important for understanding fluoroquinolone resistance. The...
Ying-Jun Zhou et al.
FEMS microbiology letters, 355(2), 124-130 (2014-05-13)
The antimicrobial activity of one 3-hydroxypyridin-4-one (HPO) hexadentate (1) and three HPO hexadentate-based dendrimeric chelators (2-4) was evaluated. They were found to exhibit marked inhibitory effect on the growth of two Gram-positive bacteria and two Gram-negative bacteria. The combination treatment...
I Smolders et al.
Antimicrobial agents and chemotherapy, 46(2), 471-477 (2002-01-18)
Fluoroquinolones are antibiotics with central excitatory side effects. These adverse effects presumably result from inhibition of gamma-aminobutyric acid (GABA) binding to GABA(A) receptors. This GABA antagonistic effect is greatly potentiated by the active metabolite of fenbufen, biphenylacetic acid (BPAA). Nevertheless...
Chieh Jason Chou et al.
Nestle Nutrition workshop series. Paediatric programme, 62, 127-137 (2008-07-16)
Recent data suggest that gut microbiota plays a significant role in fat accumulation. However, it is not clear whether gut microbiota is involved in the pathophysiology of type-2 diabetes. To address this issue, we modulated gut microbiota with two combinations...
L Miano et al.
European urology, 17 Suppl 1, 13-18 (1990-01-01)
A review of worldwide clinical trials with norfloxacin in the treatment of uncomplicated urinary tract infections (UTIs), as well as our personal experience with 215 assessable patients, is presented. Almost all patients received 400 mg b.i.d. for 3-15 days. Bacteriological...
Birgit Stattin Norinder et al.
Antimicrobial agents and chemotherapy, 50(4), 1528-1530 (2006-03-30)
Similar changes in the periurethral and vaginal microflora were observed in 19 women with recurrent urinary tract infection following treatment with norfloxacin (NOR) or pivmecillinam (PIV). Escherichia coli strains were suppressed by both treatments. Staphylococcus spp. and enterococci colony counts...
Yan-Ni Yi et al.
Analytica chimica acta, 707(1-2), 128-134 (2011-10-27)
A novel method for the simultaneous determination of norfloxacin (NFLX) and lomefloxacin (LFLX) in milk samples was developed by using first derivative synchronous fluorimetry. The synchronous fluorescence (Δλ=160 nm) spectra and first derivative synchronous fluorescence spectra of NFLX, LFLX and...
Junwei Zhang et al.
Journal of environmental sciences (China), 24(4), 743-749 (2012-08-17)
Photodegradation of Norfloxacin in aqueous solution containing algae under a medium pressure mercury lamp (15 W, lambda(max) = 365 nm) was investigated. Results indicated that the photodegradation of Norfloxacin could be induced by the algae in the heterogeneous algae-water systems....
Lauren Becnel Boyd et al.
Antimicrobial agents and chemotherapy, 53(1), 229-234 (2008-10-08)
Fluoroquinolones are some of the most prescribed antibiotics in the United States. Previously, we and others showed that the fluoroquinolones exhibit a class effect with regard to the CLSI-established breakpoints for resistance, such that decreased susceptibility (i.e., an increased MIC)...
E J Goldstein
The American journal of medicine, 82(6B), 3-17 (1987-06-26)
Norfloxacin is an orally absorbed fluoroquinolone antibacterial with a fluorine at position 6 and a piperazine ring at position 7. These changes have resulted in a marked enhancement (compared with that of the older quinolones) of in vitro antibacterial activity....
C T Lee et al.
Scandinavian journal of infectious diseases. Supplementum, 56, 49-54 (1988-01-01)
In 12 recent clinical studies, norfloxacin given in various dosage regimens was shown to be highly effective in treating 1,588 gonococcal infections in 1,486 patients. A single oral dose of norfloxacin 800 mg cured 99.2% of 783 patients with penicillinase...
Manoj Devaraj et al.
Colloids and surfaces. B, Biointerfaces, 102, 554-561 (2012-10-30)
A novel and facile (single-step) method was developed for the synthesis of CuO nanoleaves in the presence of a cationic polyelectrolyte, poly(diallyldimethylammonium chloride) (PDDA) at pH 10.5. The mechanism and self-assembly for the formation of CuO nanoleaves are discussed. The...
Alba Souto et al.
Bioorganic & medicinal chemistry, 21(1), 295-302 (2012-11-28)
From synthetic functionalized analogues of vanchrobactin, a siderophore produced by the fish pathogenic bacteria Vibrio anguillarum serotype O2, several vanchrobactin analogues-norfloxacin conjugates were obtained and their antimicrobial activities against the wild-type and mutant strains of Vibrio anguillarum serotype O2 have...
Naresh Sunduru et al.
European journal of medicinal chemistry, 46(4), 1232-1244 (2011-02-25)
A series of novel 8-fluoro Norfloxacin derivatives and the hybrids of its piperazinyl derivatives incorporated with 1,3,5-triazine and pyrimidine were synthesized. All the above compounds were evaluated for their antibacterial activity against Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus and methicillin &...
Artur Beberok et al.
Molecular and cellular biochemistry, 401(1-2), 107-114 (2014-12-01)
Fluoroquinolone antibiotics provide broad-spectrum coverage for a number of infectious diseases, including respiratory as well as urinary tract infections. One of the important adverse effects of these drugs is phototoxicity which introduces a serious limitation to their use. To gain...
Khalid A Tazi et al.
Gastroenterology, 129(1), 303-314 (2005-07-14)
Arterial vasodilation plays a role in the pathogenesis of the complications of cirrhosis. This vasodilation is caused by the overproduction of arterial nitric oxide (NO). Bacterial translocation may be involved in NO synthase (NOS) up-regulation by activating both endothelial NOS...
Tadashi Itoh et al.
Toxicology, 222(3), 240-246 (2006-04-04)
This study aimed to examine the in vivo initiation activity of the quinolone antimicrobials--nalidixic acid (NA), pipemidic acid (PPA), ciprofloxacin (CPFX), and norfloxacin (NFLX)--by using an in vivo short-term liver initiation assay. Rats were subjected to a two-thirds partial hepatectomy...
J S Wolfson et al.
Annals of internal medicine, 108(2), 238-251 (1988-02-01)
Norfloxacin is an oral fluoroquinolone antimicrobial agent recently released for the treatment of uncomplicated and complicated urinary tract infections. The drug antagonizes DNA gyrase, an enzyme essential for bacterial DNA replication. Norfloxacin is more potent and broader in spectrum than...

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