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Gaowa Jin et al.
Journal of chromatography. A, 1638, 461825-461825 (2021-01-16)
A silica based hydrophilic stationary phase bonding with 2,3-pyrazinedicarboxylic anhydride and amino groups was synthesized via amino-acid anhydride ring opening reaction. The bonded groups could not only provide hydrophilic interaction, but also electrostatic, π-π and hydrogen bonding interactions, etc. The
Silvia N Mirica et al.
Canadian journal of physiology and pharmacology, 91(2), 108-115 (2013-03-06)
Orotic acid and its salts chronically administered have been shown to significantly improve cardiac function in pathological settings associated with ischemia-reperfusion (I/R) injury. The aim of our study was to investigate the effect of magnesium orotate (Mg-Or) administration at the
Valeska Gerhardt et al.
Acta crystallographica. Section C, Crystal structure communications, 68(Pt 2), o92-o98 (2012-02-07)
Hydantoin-5-acetic acid [2-(2,5-dioxoimidazolidin-4-yl)acetic acid] and orotic acid (2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid) each contain one rigid acceptor-donor-acceptor hydrogen-bonding site and a flexible side chain, which can adopt different conformations. Since both compounds may be used as coformers for supramolecular complexes, they have been
W J Visek et al.
Journal of the American College of Nutrition, 5(2), 153-166 (1986-01-01)
This communication presents evidence from the literature and recent experiments that describe circumstances wherein arginine may be a conditional dietary essential. Previous work has established that the synthesis of orotic acid (OA), the first pyrimidine formed in the de novo
Dong Liu et al.
Bioprocess and biosystems engineering, 35(5), 729-737 (2011-11-15)
A whole-cell biocatalytic process for uridine 5'-monophosphate (UMP) production from orotic acid by Saccharomyces cerevisiae was developed. To rationally redistribute the metabolic flux between glycolysis and pentose phosphate pathway, statistical methods were employed first to find out the critical factors
Donald F Smee et al.
Antiviral chemistry & chemotherapy, 22(6), 263-272 (2012-04-21)
The discovery of novel influenza virus inhibitors remains an important priority in light of the emergence of drug-resistant viruses. Toward this end, a library of over 6,000 compounds was tested for antiviral activity. Strains of influenza virus were evaluated by
Bei Zhang et al.
Lipids in health and disease, 11, 48-48 (2012-05-10)
Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease in industrialized countries. The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from Acaudina molpadioides in fatty liver rats. Male Wistar
Chao Liang et al.
Nature communications, 10(1), 4579-4579 (2019-10-09)
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressive bone erosion. Leflunomide is originally developed to suppress inflammation via its metabolite A77 1726 to attenuate bone erosion. However, distinctive responsiveness to Leflunomide is observed among RA individuals. Here
Yong Chen et al.
Applied microbiology and biotechnology, 86(1), 75-81 (2009-10-15)
A whole cell biocatalytic process for uridine 5'-monophosphate (UMP) production from orotic acid by Saccharomyces cerevisiae was developed. The concentration of UMP was increased by 23% when 1 g l(-1) sodium citrate was fed into the broth. Effects of citrate
Enhanced uridine 5'-monophosphate production by whole cell of Saccharomyces cerevisiae through rational redistribution of metabolic flux.
Liu D, Chen Y, Li A, Xie J, Xiong J, et al.
Bioprocess and Biosystems Engineering (2011)
Lili Wang et al.
Molecular genetics and metabolism, 105(2), 203-211 (2011-12-03)
Ornithine transcarbamylase deficiency (OTCD), the most common and severe urea cycle disorder, is an excellent model for developing liver-directed gene therapy. No curative therapy exists except for liver transplantation which is limited by available donors and carries significant risk of
Inhibiton of lipoprotein synthesis by orotic acid.
Nutrition reviews, 24(1), 27-29 (1966-01-01)
[Use of orotic acid and orotates].
H Van der Meersch
Journal de pharmacie de Belgique, 61(4), 97-104 (2007-02-01)
Kyungjin Lee et al.
Oncotarget, 8(70), 115315-115325 (2018-02-01)
Gemcitabine, an anti-cancer chemotherapy drug, has additionally shown the antiviral activity against a broad range of viruses and we also have previously reported its synergistic antiviral activity with ribavirin against enteroviruses. As a cytidine analog, gemcitabine has been reported to
Ernie Zuraida Ali et al.
European journal of pediatrics, 175(3), 339-346 (2015-10-07)
Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a rare autosomal recessive disorder of ureagenesis presenting as life-threatening hyperammonemia. In this study, we present the main clinical features and biochemical and molecular data of six Malaysian patients with CPS1 deficiency. All
Albin Fontaine et al.
Malaria journal, 9, 276-276 (2010-10-12)
Plasmodium falciparum infections could lead to severe malaria, principally in non-immune individuals as children and travellers from countries exempted of malaria. Severe malaria is often associated with the sequestration of P. falciparum-infected erythrocytes in deep micro-vascular beds via interactions between
Joe Rainger et al.
Human molecular genetics, 21(18), 3969-3983 (2012-06-14)
Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo pyrimidine biosynthesis, have been identified as the cause of Miller (Genée-Weidemann or postaxial acrofacial dysostosis) syndrome (MIM 263750). We report compound heterozygous DHODH mutations
O B Stepura et al.
Vestnik Rossiiskoi akademii meditsinskikh nauk, (2)(2), 39-41 (2002-04-02)
The paper reviews clinical and experimental studies into the mechanisms of action of orotic acid (OA). OA has been shown to take an active participation in metabolic processes in the body. As a pyrimidine precursor, it plays a key role
Laura Sierra-Zapata et al.
Scientific reports, 10(1), 5563-5563 (2020-03-30)
The world is in the midst of an antimicrobial resistance crisis, driving a need to discover novel antibiotic substances. Using chemical cues as inducers to unveil a microorganism's full metabolic potential is considered a successful strategy. To this end, we
Costantino Salerno et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 781(1-2), 57-71 (2002-11-27)
Urinary orotic acid determination is a useful tool for screening hereditary orotic aciduria and for differentiating the hyperammonemia disorders which cannot be readily diagnosed by amino acid chromatography, thus reducing the need for enzyme determination in tissue biopsies. This review
Laura Cristina Jardim Pôrto et al.
Life sciences, 90(13-14), 476-483 (2012-01-31)
As cardiac performance is closely related to its energy supply, our study investigated the effect of the orotic acid cardioprotective agent on the pathways of energy supply, in both conditions of normal flow and ischemia. Male Wistar rats were fed
Juliana Cheleski et al.
European journal of medicinal chemistry, 45(12), 5899-5909 (2010-10-23)
The enzyme dihydroorotate dehydrogenase (DHODH) has been suggested as a promising target for the design of trypanocidal agents. We report here the discovery of novel inhibitors of Trypanosoma cruzi DHODH identified by a combination of virtual screening and ITC methods.
S Ortiz et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 948-962 (2012-08-28)
The Raman and IR spectra of the biomolecule 5-aminoorotic acid in the solid state were simulated by a dimer and tetramer forms, with the special interest in the interactions that involve the NH and NH(2) groups. The unit cell expected
Xing Wang et al.
Applied microbiology and biotechnology, 76(2), 321-328 (2007-05-24)
Attempts were made with success to develop a two-step biocatalytic process for uridine 5'-monophosphate (UMP) production from orotic acid by Corynebacterium ammoniagenes ATCC 6872: the strain was first cultivated in a high salt mineral medium, and then cells were harvested
Patricia Alvarez-Sieiro et al.
Food chemistry, 168, 439-444 (2014-08-31)
For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrogen, was developed for screening for microorganisms with gliadinase
Charles Grubmeyer et al.
Biochemistry, 51(22), 4397-4405 (2012-04-26)
Dimeric Salmonella typhimurium orotate phosphoribosyltransferase (OMP synthase, EC, a key enzyme in de novo pyrimidine nucleotide synthesis, has been cocrystallized in a complete substrate E·MgPRPP·orotate complex and the structure determined to 2.2 Å resolution. This structure resembles that of
Patrice K Held et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 149-154 (2014-06-03)
Orotic aciduria in the presence of hyperammonemia is a key indicator for a defect in the urea cycle, specifically ornithine transcarbamylase (OTC) deficiency. Current newborn screening (NBS) protocols can detect several defects of the urea cycle, but screening for OTC
Ling Li et al.
Molecular cell, 80(3), 525-540 (2020-10-18)
Well-balanced and timed metabolism is essential for making a high-quality egg. However, the metabolic framework that supports oocyte development remains poorly understood. Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo maturation by isolating large number of
Monika Feigenbutz et al.
PloS one, 8(11), e80752-e80752 (2013-11-14)
Rrp6 is a conserved catalytic subunit of the eukaryotic nuclear exosome ribonuclease complex that functions in the productive 3' end maturation of stable RNAs, the degradation of transiently expressed noncoding transcripts and in discard pathways that eradicate the cell of
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