Showing 1-30 of 160 results for "O5504"
Israel Matos et al.
Molecular immunology, 54(3-4), 482-492 (2013-03-05)
The pentacyclic triterpene α,β-amyrin has been previously reported as an effective compound in the treatment of several inflammatory conditions. Recent evidence indicates that α,β-amyrin displayed its effects through interaction with the cannabinoid pathway. We assessed the anti-inflammatory effects of the...
Snezana Agatonovic-Kustrin et al.
Journal of chromatography. A, 1620, 460970-460970 (2020-02-25)
This study focuses on the health benefits of several fresh herbs that are commonly used in the Mediterranean diet. Antioxidant activity, phytosterol content and α-amylase inhibitory activity of fresh basil, lavender, oregano, rosemary, sage, and thyme are analyzed and compared....
Simone C B Gnoatto et al.
European journal of medicinal chemistry, 43(9), 1865-1877 (2008-01-15)
The inhibitory potency of ursolic acid extracted from Ilex paraguariensis, a plant used in South American population for a tea preparation known as maté, and its derivatives to inhibit aromatase activity was assessed and compared to a phytoestrogen apigenin and...
Claudio Baiocchi et al.
European journal of mass spectrometry (Chichester, England), 19(1), 1-15 (2013-07-12)
The many effects of the African medicinal herb Desmodium adscendens were studied in the 1980s and 1990s. In spite of this, a comprehensive analytical protocol for the quality control of its constituents (soyasaponins, alkaloids and flavonoids) has not yet been...
Adeleke Clement Adebajo et al.
Journal of diabetes, 5(3), 336-343 (2012-12-12)
The insulinotropic activity of the combined root and stem of Gongronema latifolium (Asclepiadaceae) was evaluated to justify its African ethnomedicinal use in the management of diabetes. A methanolic extract and its chromatographic fractions (A1 -A6 ) were tested for glucose-reducing...
Flora Pensec et al.
Journal of agricultural and food chemistry, 62(32), 7998-8007 (2014-07-25)
Triterpenoids present in grape cuticular waxes are of interest due to their potential role in protection against biotic stresses, their impact on the mechanical toughness of the fruit surface, and the potential industrial application of these biologically active compounds from...
Renata Nowak et al.
Acta poloniae pharmaceutica, 70(3), 413-418 (2013-06-14)
Spices play an important role in the chemoprevention and they can be a rich source of biologically active compounds such as triterpenes in the human diet. A method based on high performance thin-layer chromatography combined with densitometry for determination of...
Tiantian Guo et al.
Archiv der Pharmazie, 348(9), 615-628 (2015-07-25)
Sixteen naturally occurring oleanolic acid saponins and their derivatives were synthesized in an efficient and practical strategy, and their inhibitory activities against α-glucosidase and α-amylase were evaluated in vitro. Among all the compounds, 28-O-monoglucoside 8 exhibited remarkably potent inhibitory activity...
Anupam Bishayee et al.
International journal of cancer, 133(5), 1054-1063 (2013-02-14)
Breast cancer represents one of the most frequently diagnosed cancers and predominant causes of death in women worldwide. The value of preventive therapy to limit the devastating impact of breast cancer is well established. Various plant triterpenoids and their synthetic...
Yuan-Fu Lu et al.
Molecules (Basel, Switzerland), 18(3), 3060-3071 (2013-03-09)
Oleanolic acid (OA) is a triterpenoid and a fantastic molecule with many beneficial effects. However, high-doses and long-term use can produce adverse effects. This study aimed to characterize the hepatotoxic potential of OA. Mice were given OA at doses of...
Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.
Dionysios V Chartoumpekis et al.
The New England journal of medicine, 370(18), 1767-1767 (2014-05-03)
Liangfeng Fu et al.
Organic letters, 15(7), 1622-1625 (2013-03-28)
Bardoxolone methyl (2-cyano-3,12-dioxooleane-1,9(11)-dien-28-oic acid methyl ester; CDDO-Me) (1), a synthetic oleanane triterpenoid with highly potent anti-inflammatory activity (levels below 1 nM), has completed a successful phase I clinical trial for the treatment of cancer and a successful phase II trial...
Dick de Zeeuw et al.
The New England journal of medicine, 369(26), 2492-2503 (2013-11-12)
Although inhibitors of the renin-angiotensin-aldosterone system can slow the progression of diabetic kidney disease, the residual risk is high. Whether nuclear 1 factor (erythroid-derived 2)-related factor 2 activators further reduce this risk is unknown. We randomly assigned 2185 patients with...
Anamika Khajuria et al.
Bioorganic & medicinal chemistry letters, 17(6), 1608-1612 (2007-02-03)
Two Triterpenoids (sapogenins 1 and 2) isolated from Luffa cylindrica were subjected to immunomodulatory activity in male Balb/c mice. Mice were treated with three doses of sapogenins 1 and 2 (10, 30 and 100 mg/kg) and levamisole (2.5 mg/kg) used...
Amélia M Silva et al.
Pharmaceutics, 11(8) (2019-07-28)
Oleanolic (OA) and ursolic (UA) acids are recognized triterpenoids with anti-cancer properties, showing cell-specific activity that can be enhanced when loaded into polymeric nanoparticles. The cytotoxic activity of OA and UA was assessed by Alamar Blue assay in three different...
Gustavo Moura-Letts et al.
Journal of natural products, 69(6), 978-979 (2006-06-24)
Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the...
Narendra Kumar Singh et al.
Pakistan journal of pharmaceutical sciences, 27(1), 187-191 (2014-01-01)
The roots of Ichnocarpus frutescens along with roots of Cissampelos pareira, Bauhinia vahlii and Ardisia solanacea are processed together and given orally to cure stomach cancer by the tribes of Chotanagpur and Santhal parganas of Bihar, India. In vitro anticancer...
Li-ting Tian et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 27(12), 884-886 (2003-06-05)
To summarize the pharmacological function of oleanolic acid. Based on the documents and related achievements, the pharmacological function and its mechanism including its clinical use were summed up. Oleanolic Acid is a natural chemical which has wide-ranging function and abundant...
Yanyan Bu et al.
Bioorganic & medicinal chemistry letters, 21(2), 874-878 (2010-12-21)
Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a...
Aminu Muhammad et al.
Natural product communications, 8(10), 1435-1437 (2013-12-21)
The stem bark extracts of Bauhinia rufescens Lam. (Fabaceae) yielded 6-methoxy-7-methyl-8-hydroxydibenz[b,f]oxepin, alpha-amyrin acetate, beta-sitosterol 3-O-beta-D-xylopyranoside, 4-(2'-Hydroxyphenethyl)-5-methoxy-2-methylphenol, menisdaurin and sequoyitol. Their structures were determined using spectroscopic methods and comparisons with the literature data. For the antimicrobial assay Gram-positive and Gram-negative bacterial...
Pooi Yin Chung et al.
PloS one, 8(2), e56687-e56687 (2013-02-26)
Staphylococcus aureus is an important human pathogen in both hospital and the community that has demonstrated resistance to all currently available antibiotics over the last two decades. Multidrug-resistant isolates of methicillin-resistant S. aureus (MRSA) exhibiting decreased susceptibilities to glycopeptides has...
Sejeong Kim et al.
PloS one, 10(3), e0118800-e0118800 (2015-03-11)
This study investigated the antimicrobial action of oleanolic acid against Listeria monocytogenes, Enterococcus faecium, and Enterococcus faecalis. To determine the cytotoxicity of oleanolic acid, HEp-2 cells were incubated with oleanolic acid at 37°C. MICs (minimal inhibition concentrations) for L. monocytogenes...
Li Li et al.
International journal of oncology, 47(6), 2247-2254 (2015-10-16)
Due to drug resistance and unacceptable cytotoxicity of most currently-used cancer chemotherapies, naturally occurring products have gained attention in the field of anticancer treatment. Oleanolic acid (OA) is a natural pentacyclic triterpenoic acid and a principal active compound in many...
Duraisamy Ramasamy et al.
Natural product communications, 8(4), 433-434 (2013-06-07)
A new oleanane triterpenoid, methyl 27-caffeoyloxyoleanolate (2), together with eight known compounds viz. oleanolic acid, kaempferol, quercetin, beta-sitosterol-3-O-beta-D-glucopyranoside, kaempferol-3-O-alpha-D-rhamnopyranoside, gossypin, quercetin-3-O-beta-D-glucopyranoside and mangiferin were isolated from the ethanol extract of roots of Hibiscus vitifolius Linn. The structure of the new...
Phuong Thien Thuong et al.
Journal of natural products, 71(10), 1775-1778 (2008-09-19)
Phytochemical study on a methanol-soluble extract of the leaves of persimmon (Diospyros kaki) resulted in the isolation of two new ursane-type triterpenoids, 3alpha,19alpha-dihydroxyurs-12,20(30)-dien-24,28-dioic acid (1) and 3alpha,19alpha-dihydroxyurs-12-en-24,28-dioic acid (2), together with 12 known ursane- and oleanane-type triterpenoids (3-14). Triterpenoids with...
Maria Chiara Monti et al.
Biochimica et biophysica acta, 1844(4), 713-721 (2014-02-18)
The proteasome, a complex multimeric structure strictly implicated in cell protein degradation, has gained the status of privileged drug target since its functional involvement in relevant pathways ruling the cell life, such as cell cycle, transcription and protein quality control...
Dorrah Deeb et al.
Molecules (Basel, Switzerland), 18(3), 3250-3265 (2013-03-15)
Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) is a synthetic derivative of oleanolic acid, a triterpene, with apoptosis-inducing activity in a wide range of cancer cells. Induction of apoptosis by CDDO-Me is associated with the generation of reactive oxygen species (ROS) and inhibition of telomerase...
Kuo Xu et al.
Die Pharmazie, 69(7), 483-495 (2014-07-31)
The natural product oleanolic acid has been widely used for treating hepatopathy in China, whereas its clinical application was confined by poor solubility in water. Inspired by remarkable bioactivities and physical properties of triterpenoid saponins, synthesis and biological evaluation of...
Nandani Darshika Kodithuwakku et al.
Journal of ethnopharmacology, 163, 278-289 (2015-01-24)
Shuang-Qi gout capsule, a traditional Chinese medicine prescription, has been used in the treatment of, gout arthritis, arthralgia and inflammation. Since renal urate overload associated with severe disability including gout, elimination of excess renal uric acid is highly essential. Therefore...
Longhai Dai et al.
Plant & cell physiology, 56(6), 1172-1182 (2015-03-12)
Mogrosides, the major bioactive components isolated from the fruits of Siraitia grosvenorii, are a family of cucurbitane-type tetracyclic triterpenoid saponins that are used worldwide as high-potency sweeteners and possess a variety of notable pharmacological activities. Mogrosides are synthesized from 2,3-oxidosqualene...

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