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Nicole Urban et al.
Cells, 9(1) (2020-01-18)
(1) Background: Members of the TRPC3/TRPC6/TRPC7 subfamily of canonical transient receptor potential (TRP) channels share an amino acid similarity of more than 80% and can form heteromeric channel complexes. They are directly gated by diacylglycerols in a protein kinase C-independent
Sabrina Bréchard et al.
Journal of leukocyte biology, 85(4), 638-647 (2009-01-02)
The requirement of calcium ion (Ca(2)(+)) entry for neutrophil NADPH oxidase (NOX2) regulation is clearly established. However, its role in the signaling pathway leading to NOX2 activation is still elusive. 1-oleoyl-2-acetyl-sn-glycerol (OAG) causes an increase in NOX2 activity and has
Yasunori Kanaho et al.
Advances in biological regulation, 53(1), 128-134 (2012-10-16)
In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLD(-/-) neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 is involved in these fMLP-induced neutrophil functions. The results
Evan W Weber et al.
The Journal of experimental medicine, 212(11), 1883-1899 (2015-09-24)
Leukocyte transendothelial migration (TEM) is a tightly regulated, multistep process that is critical to the inflammatory response. A transient increase in endothelial cytosolic free calcium ion concentration (↑[Ca(2+)]i) is required for TEM. However, the mechanism by which endothelial ↑[Ca(2+)]i regulates
Y C Kim et al.
Pflugers Archiv : European journal of physiology, 436(1), 1-8 (1998-06-20)
The possibility of the protein kinase C (PKC) pathway being a mechanism underlying the desensitization of carbachol- (CCh-)activated nonselective cationic current (ICCh) was investigated in a study of guinea-pig gastric myocytes. Using the conventional whole-cell patch-clamp technique with symmetrical CsCl-rich
Ursula Storch et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), E37-E46 (2016-12-21)
The activation mechanism of the classical transient receptor potential channels TRPC4 and -5 via the Gq/11 protein-phospholipase C (PLC) signaling pathway has remained elusive so far. In contrast to all other TRPC channels, the PLC product diacylglycerol (DAG) is not
Yang Wang et al.
eLife, 10 (2021-06-09)
NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to study the atomistic details of NompC gating.
Dao Yan Liu et al.
American journal of hypertension, 20(10), 1111-1118 (2007-10-02)
We recently showed that increased expression of the transient receptor potential canonical Type 3 (TRPC3) channel is associated with genetic hypertension. It is unknown whether store-operated TRPC3 channels, which are activated after depletion of intracellular stores, or second messenger-operated TRPC3
Kathryn P Burdon et al.
American journal of ophthalmology, 159(1), 31-36 (2014-09-23)
To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction. Case-control from within a population-based longitudinal study. study population: Individuals aged over 49 years
Yukio Okada et al.
PloS one, 6(4), e19158-e19158 (2011-05-12)
Elevation of extracellular Ca(2+) concentration induces intracellular Ca(2+) signaling in parathyroid cells. The response is due to stimulation of the phospholipase C/Ca(2+) pathways, but the direct mechanism responsible for the rise of intracellular Ca(2+) concentration has remained elusive. Here, we
Xiaoting Yang et al.
Experimental and therapeutic medicine, 14(1), 73-78 (2017-07-05)
Pulp capping is a restorative technique employed in an attempt to maintain pulpal vitality and generate reparative dentin. Ca
L A Barber et al.
Journal of neurochemistry, 67(1), 72-80 (1996-07-01)
To determine whether protein kinase C (PKC) mediates release of peptides from sensory neurons, we examined the effects of altering PKC activity on resting and evoked release of substance P (SP) and calcitonin gene-related peptide (CGRP). Exposing rat sensory neurons
Qian Wang et al.
Journal of diabetes research, 2020, 3634974-3634974 (2020-10-06)
Tangshen Formula (TSF) is a Chinese Medicine formula that has been reported to alleviate proteinuria and protect renal function in humans and animals with diabetic kidney disease (DKD). However, little is known about its mechanism in improving proteinuria. The dysregulation
Loïc Lemonnier et al.
Cell calcium, 43(5), 506-514 (2007-10-19)
TRPC3, 6 and 7 channels constitute a subgroup of non-selective, calcium-permeable cation channels within the TRP superfamily that are activated by products of phospholipase C-mediated breakdown of phosphatidylinositol-4,5-bisphosphate (PIP(2)). A number of ion channels, including other members of the TRP
L Tůmová et al.
Animal : an international journal of animal bioscience, 7(2), 279-286 (2012-10-04)
Nitric oxide (NO) and protein kinase C (PKC) are involved in the activation of mammalian oocytes, although their role in the exit from the metaphase II stage and cortical granule (CG) exocytosis is still not fully understood. The aim of
Y Saito et al.
Molecular and cellular endocrinology, 146(1-2), 197-205 (1999-02-18)
The effect of phorbol ester on human growth hormone-binding protein (hGH-BP) release was investigated. The hGH-BP release from human IM-9 cells measured by immunoblotting was dose-dependently enhanced by a phorbol ester, phorbol 12, 13-dibutyrate (PDBu), and reached plateau at 100
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes.
Fusi, et al.
Biochemical Pharmacology, 182, 114263-114263 (2021)
Kaivon Assani et al.
Journal of immunology (Baltimore, Md. : 1950), 198(5), 1985-1994 (2017-01-18)
Macrophage intracellular pathogen killing is defective in cystic fibrosis (CF), despite abundant production of reactive oxygen species (ROS) in lung tissue.
Dong Ho Woo et al.
Molecular pain, 4, 42-42 (2008-10-02)
The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamide, and phosphorylation by protein kinase C (PKC). However, the
Sarah Farukhi Ahmed et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 256(9), 1703-1710 (2018-06-02)
To compare the efficacy of ab-interno trabeculotomy with Trabectome® in mild glaucoma versus moderate/severe glaucoma along the spectrum of glaucoma disease severity. Subjects with at least 12 months follow-up were separated into two groups based on glaucoma severity. Severity was determined
Seishiro Sawamura et al.
Molecular pharmacology, 89(3), 348-363 (2016-01-07)
Transient receptor potential canonical (TRPC) proteins form Ca(2+)-permeable cation channels activated upon stimulation of metabotropic receptors coupled to phospholipase C. Among the TRPC subfamily, TRPC3 and TRPC6 channels activated directly by diacylglycerol (DAG) play important roles in brain-derived neurotrophic factor
Shinji Takai et al.
Life sciences, 81(7), 585-591 (2007-08-04)
We have recently reported that attenuated phosphorylation of heat shock protein (HSP) 27 correlates with tumor progression in patients with hepatocellular carcinoma (HCC). In the present study, we investigated what kind of kinase regulates phosphorylation of HSP27 in human HCC-derived
Wen-Li Hsu et al.
Molecules (Basel, Switzerland), 20(11), 20297-20311 (2015-11-17)
Ultraviolet-B (UVB) is one of the most cytotoxic and mutagenic stresses that contribute to skin damage and aging through increasing intracellular Ca(2+) and reactive oxygen species (ROS). Derinat (sodium deoxyribonucleate) has been utilized as an immunomodulator for the treatment of
Takanobu Sato et al.
Molecular and cellular biology, 33(1), 136-145 (2012-10-31)
Phospholipase D (PLD), which produces the lipid messenger phosphatidic acid (PA), has been implicated in superoxide generation and degranulation in neutrophils. The basis for this conclusion is the observation that primary alcohols, which interfere with PLD-catalyzed PA production, inhibit these
A Chabi et al.
International journal of clinical practice, 70(7), 577-586 (2016-06-14)
The aim of this study was to evaluate the efficacy and safety of preservative-free (PF) tafluprost compared with PF timolol in Indian subjects with open-angle glaucoma (OAG) or ocular hypertension. This was a randomised, multicentre, double-masked, phase III trial. Subjects
Kexin Meng et al.
PloS one, 9(6), e98777-e98777 (2014-06-07)
Calcium-sensing receptor (CaSR) has been demonstrated to be present in several tissues and cells unrelated to systemic calcium homeostasis, where it regulates a series of diverse cellular functions. A previous study indicated that CaSR is expressed in mouse glomerular mesangial
Jie Li et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(14), 3843-3855 (2020-04-29)
Although platinum compounds are the first-line treatment for ovarian cancer, the majority of patients relapse and develop resistance to treatment. However, the mechanism underlying resistance is unclear. The goal of our study is to decipher the mechanism by which a
Tom Litjens et al.
The Biochemical journal, 405(2), 269-276 (2007-04-17)
Repetitive hormone-induced changes in concentration of free cytoplasmic Ca2+ in hepatocytes require Ca2+ entry through receptor-activated Ca2+ channels and SOCs (store-operated Ca2+ channels). SOCs are activated by a decrease in Ca2+ concentration in the intracellular Ca2+ stores, but the molecular
Natasha N Tirko et al.
Neuron, 100(3), 593-608 (2018-10-09)
Oxytocin is an important neuromodulator in the mammalian brain that increases information salience and circuit plasticity, but its signaling mechanisms and circuit effect are not fully understood. Here we report robust oxytocinergic modulation of intrinsic properties and circuit operations in
Matthew T Harper et al.
The Journal of biological chemistry, 285(26), 19865-19873 (2010-04-15)
Platelet activation must be tightly controlled to provide an effective, but not excessive, response to vascular injury. Cytosolic calcium is a critical regulator of platelet function, including granule secretion, integrin activation, and phosphatidylserine (PS) exposure. Here we report that the
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