Cristóbal de Los Ríos et al.
Journal of medicinal chemistry, 53(14), 5129-5143 (2010-06-26)
1,8-Naphthyridine derivatives related to 17 (ITH4012), a neuroprotective compound reported by our research group, have been synthesized. In general, they have shown better inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) than most tacrine derivatives previously synthesized in our laboratory. The