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Md Mostafizur Rahman et al.
Scientific reports, 5, 10063-10063 (2015-05-20)
PP2A is a master controller of multiple inflammatory signaling pathways. It is a target in asthma; however the molecular mechanisms by which PP2A controls inflammation warrant further investigation. In A549 lung epithelial cells in vitro we show that inhibition of
Yann S Gallot et al.
Cancer research, 74(24), 7344-7356 (2014-10-23)
Cachexia is a muscle-wasting syndrome that contributes significantly to morbidity and mortality of many patients with advanced cancers. However, little is understood about how the severe loss of skeletal muscle characterizing this condition occurs. In the current study, we tested
Hannieh Sotoud et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(3), 283-293 (2014-11-25)
Phosphatase inhibitor-1 (I-1) inhibits the catalytic subunit of protein phosphatase type 1 (PP1c) in its protein kinase A (PKA)-phosphorylated form (I-1(P)). It thereby amplifies PKA signaling, which, in the heart, mediates both beneficial (acute) and adverse (chronic) effects of catecholamines.
Lauy Al-Anati et al.
Chemico-biological interactions, 219, 159-167 (2014-06-24)
TCDD, polychlorinated biphenyls (PCB) and polycyclic aromatic hydrocarbons (PAH) coexist in the environment. However, there are few studies on combined effects of these compounds. We have studied the effect of TCDD, PCB153 and estradiol on p53 signaling induced by PAHs.
Cohesin removal along the chromosome arms during the first meiotic division depends on a NEK1-PP1gamma-WAPL axis in the mouse
Brieno-Enriquez MA, et al.
Testing, 17(4), 977-986 (2016)
Fernando Huete-Toral et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 119-128 (2014-10-26)
Melatonin and its analog 5-MCA-NAT (5-methylcarboxyamino-N-acetyl tryptamine) are active compounds reducing intraocular pressure (IOP). This action is mediated through MT2 and the putative MT3 melatonin receptor, producing a transient reduction of IOP that lasts for a few hours and has
P O Bogatcheva et al.
Bulletin of experimental biology and medicine, 154(3), 316-319 (2013-03-14)
Calmodulin inhibitor W-7 did not cause changes in the quantal content of postsynaptic end-plate potentials (EPP) in newly formed synapses, but prevented facilitation of acetylcholine secretion induced by L-type Ca(2+)channels blocker nitrendipine. CaMKII inhibitor KN-62 produced similar effect and suppressed
M A Battistone et al.
Molecular human reproduction, 19(9), 570-580 (2013-05-01)
In all mammalian species studied so far, sperm capacitation correlates with an increase in protein tyrosine (Tyr) phosphorylation mediated by a bicarbonate-dependent cAMP/protein kinase A (PKA) pathway. Recent studies in mice revealed, however, that a Src family kinase (SFK)-induced inactivation
Maria Francisca Arteaga et al.
Cancer cell, 23(3), 376-389 (2013-03-23)
While all-trans retinoic acid (ATRA) treatment in acute promyelocytic leukemia (APL) has been the paradigm of targeted therapy for oncogenic transcription factors, the underlying mechanisms remain largely unknown, and a significant number of patients still relapse and become ATRA resistant.
Celia López-Menéndez et al.
Human molecular genetics, 22(3), 466-482 (2012-11-03)
Failures in neurotrophic support and signalling play key roles in Alzheimer's disease (AD) pathogenesis. We previously demonstrated that downregulation of the neurotrophin effector Kinase D interacting substrate (Kidins220) by excitotoxicity and cerebral ischaemia contributed to neuronal death. This downregulation, triggered
Cristóbal de Los Ríos et al.
Journal of medicinal chemistry, 53(14), 5129-5143 (2010-06-26)
1,8-Naphthyridine derivatives related to 17 (ITH4012), a neuroprotective compound reported by our research group, have been synthesized. In general, they have shown better inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) than most tacrine derivatives previously synthesized in our laboratory. The
Limin Chen et al.
PloS one, 9(7), e103033-e103033 (2014-07-23)
The M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) represents an unmet challenge because of poor clinical outcomes in a sizable portion of patients. In this study,we report that FTY720 (Fingolimod), a sphingosine analogue and an FDA approved drug for
Maria Prado-Alvarez et al.
Marine environmental research, 81, 90-93 (2012-09-25)
Individuals of Mytilus galloprovincialis, contaminated with Diarrheic Shellfish Poisoning (DSP) toxins, were studied with the aim to correlate the okadaic acid (OA) body burden and the percentage of damaged haemocytes by quantifying annexin V positive cells by flow cytometry. Results
A B Dounay et al.
Current medicinal chemistry, 9(22), 1939-1980 (2002-10-09)
As the first recognized member of the "okadaic acid class" of phosphatase inhibitors, the marine natural product okadaic acid is perhaps the most well-known member of a diverse array of secondary metabolites that have emerged as valuable probes for studying
David R Jones et al.
The FEBS journal, 281(16), 3591-3608 (2014-06-19)
Glucose provides an essential nutrient source that supports glycolysis and the hexosamine biosynthesis pathway (HBP) to maintain tumour cell growth and survival. Here we investigated if short-term glucose deprivation specifically modulates the phosphatidylinositol 3-kinase/protein kinase B (PI3K/PKB) cell survival pathway.
Enyu Rao et al.
Oncotarget, 6(10), 7944-7958 (2015-03-12)
A number of studies have linked AMPK, a major metabolic sensor coordinating of multiple cellular functions, to tumor development and progression. However, the exact role of AMPK in tumor development is still controversial. Here we report that activation of AMPK
Identification of okadaic acid production in the marine dinoflagellate Prorocentrum rhathymum from Florida Bay
An T, et al.
Toxicon, 55(2-3), 653-657 (2010)
Henry Smienk et al.
Journal of AOAC International, 96(1), 77-85 (2013-03-22)
An interlaboratory collaborative study to validate a colorimetric phosphatase inhibition assay for quantitative determination of the okadaic acid (OA) toxins group in molluscs, OkaTest, was conducted. Eight test materials, including mussels, scallops, clams, and cockles, were analyzed as blind duplicates.
J J Fernández et al.
Current medicinal chemistry, 9(2), 229-262 (2002-02-28)
One of the most interesting groups of substances of marine origin, from structural and pharmacological points of view are polyether toxins, which generally present a great diversity in size and potent biological activities. The subject of this review is limited
Sherzad K Rashid et al.
PloS one, 9(5), e97458-e97458 (2014-05-17)
Portal hypertension characterized by generalized vasodilatation with endothelial dysfunction affecting nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) has been suggested to involve bacterial translocation and/or the angiotensin system. The possibility that ingestion of probiotics prevents endothelial dysfunction in rats following
Mounia SidAhmed-Mezi et al.
PloS one, 9(6), e100612-e100612 (2014-06-27)
GABAA receptor (GABAAR) function is maintained by an endogenous phosphorylation mechanism for which the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is the kinase. This phosphorylation is specific to the long intracellular loop I2 of the α1 subunit at two identified serine
Damir Alzhanov et al.
Physiological genomics, 47(11), 559-568 (2015-09-04)
Growth hormone (GH) plays a central role in regulating somatic growth and in controlling multiple physiological processes in humans and other vertebrates. A key agent in many GH actions is the secreted peptide, IGF-I. As established previously, GH stimulates IGF-I
Dave J Koss et al.
Cellular and molecular life sciences : CMLS, 72(23), 4613-4632 (2015-06-14)
Patients suffering from tauopathies including frontotemporal dementia (FTD) and Alzheimer's disease (AD) present with intra-neuronal aggregation of microtubule-associated protein Tau. During the disease process, Tau undergoes excessive phosphorylation, dissociates from microtubules and aggregates into insoluble neurofibrillary tangles (NFTs), accumulating in
Takeshi Nakajima et al.
American journal of respiratory cell and molecular biology, 51(2), 294-299 (2014-03-20)
Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells (e.g., neutrophils and macrophages) are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamycin
Izaskun Buendia et al.
ACS chemical neuroscience, 6(2), 288-296 (2014-11-14)
We have investigated the protective effects of ITH91/IQM157, a hybrid of melatonin and N,N-dibenzyl(N-methyl)amine, in an in vitro model of Alzheimer's disease (AD)-like pathology that combines amyloid beta (Aβ) and tau hyperphosphorylation induced by okadaic acid (OA), in the human
Justyna T Polit et al.
Journal of plant physiology, 170(4), 397-405 (2012-12-19)
The sucrose-induced resumption of cell cycle in the Vicia faba root meristem cells, blocked in two principal control points PCP1/2 by carbohydrate starvation, occurs after 12 h of metabolic regeneration comprising increased activity of sucrose synthase (SuSy) and hexokinase (HK)
A S Pivovarov et al.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 63(2), 256-268 (2013-07-23)
Effects of some inhibitors of serine/threonine and tyrosine protein phosphatases on the depression and spontaneous recovery of the acetylcholine-induced inward current (ACh-current) in command Helix neurons of defensive behavior at the cellular correlate of habituation were investigated. The following drugs
Se Won Park et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(8), G863-G870 (2014-09-06)
Rab proteins (Ras homologous for brain) play an important role in vesicle trafficking. Rab4 and Rab11 are involved in vesicular trafficking to the plasma membrane from early endosomes and recycling endosomes, respectively. Tauroursodeoxycholate (TUDC) and cAMP increase bile formation, in
D-z Yuan et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(11), 761-767 (2014-07-10)
Under normal conditions, progesterone inhi-bits the estrogen-induced proliferation of endometrial epithelium. Our previous studies have shown that cyclin G1 was progesterone-dependent in mouse endometrial epithelium at peri-implantation, and exogenous cyclin G1 suppressed the proliferation of endometrial cancer cells. The objectives
R Tapia et al.
Neurochemical research, 24(11), 1423-1430 (1999-11-11)
Protein phosphorylation and dephosphorylation reactions, catalyzed by kinases and phosphatases, are involved in the regulation of a wide variety of physiological processes. In the nervous system, such reactions seem to modulate the function of several proteins crucial in synaptic transmission
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