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Pawel M Bartlewski et al.
Theriogenology, 84(9), 1594-1602 (2015-09-10)
The underlying theme of this study involved the evaluation of the dilatory effects of prostaglandin E2 on the ovine cervix and thus the assessment of its potential applicability to transcervical artificial insemination (TCAI) in ewes. A novel method of prostaglandin...
Libia Pérez-Torres et al.
The Journal of reproduction and development, 61(3), 199-203 (2015-03-06)
The aim of this study was to establish if pre-synchronization would enhance the number of animals cycling prior to conventional breeding at 45 days irrespective of the length of calf separation. Multiparous Bos indicus cows were allotted in four groups...
Carolina Panis et al.
Cancer letters, 357(1), 186-195 (2014-12-02)
Overexpression of human epithelial growth factor receptor 2 (HER2) is a poor prognostic factor in breast cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity. Receptor...
Tahereh Hosseinabadi et al.
Iranian journal of pharmaceutical research : IJPR, 14(3), 919-924 (2015-09-04)
Microbial steroid biotransformations have found a wide-reaching application for the production of more precious and functionalized compounds due to their high regio-and stereo selectivity. In this study, the possibility of using filamentous fungi Aspergillus brasiliensiscells in the biotransformation of progesterone...
Hsun-Ming Chang et al.
The Journal of clinical endocrinology and metabolism, 99(10), E1922-E1932 (2014-07-26)
Exerting a broad range of biological effects in various tissues, activins are homo- or heterodimers of activin/inhibin β-subunits (βA, βB, βC, and βE in humans). Although activins A (βAβA), B (βBβB), AB (βAβB), and AC (βAβC) have been demonstrated in...
Xunmin Ji et al.
Toxicology, 334, 22-32 (2015-05-20)
Heavy metals are common environmental toxicants with adverse effects on steroid biosynthesis. The importance of mitochondria has been recognized in cytotoxic mechanism of heavy metals on Leydig cells these years. But it is still poorly known. Our previous study reported...
Miro Kasum et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29(8), 744-748 (2013-06-12)
The aim of this review is to analyze the relationship between the preovulatory progesterone (P) rise and the in vitro fertilization (IVF) pregnancy outcome. It also investigates the sources and effects of P level increase, including the underlying mechanisms and...
Progesterone for traumatic brain injury--resisting the sirens' song.
Lee H Schwamm
The New England journal of medicine, 371(26), 2522-2523 (2014-12-11)
C V Barnwell et al.
Domestic animal endocrinology, 52, 75-81 (2015-04-29)
The hormone progesterone is essential for proper embryonic development. The objective of this study was to examine the relationship between recipient serum concentrations of progesterone, at the time of embryo transfer and at conceptus recovery, on conceptus development from in...
Xi Zha et al.
Cell reports, 31(3), 107517-107517 (2020-04-23)
Despite being innate, displays of aggression are influenced by cortical activities. Here, using Vglut1 as a marker for inputs from cortical structures, we identify a small population of excitatory neurons located in the posterior amygdala (PA) that project to the...
Haolin Chen et al.
Experimental gerontology, 72, 8-15 (2015-09-04)
The capacity of Brown Norway rat Leydig cells to produce testosterone (T) decreases with aging. In a previous study, we reported that a new generation of Leydig cells can be restored in both young and old rat testes after a...
Vijay Kumar et al.
Scientific reports, 7(1), 1885-1885 (2017-05-17)
Integrin beta8 (ITGB8) is involved in the endometrial receptivity. The blastocyst first interacts with the luminal endometrial epithelial cells during its implantation; therefore, we have investigated the signaling of ITGB8 via FAK and VAV-RAC1 in the endometrial epithelial cells. Integrin...
Eva Vergaño-Vera et al.
Developmental neurobiology, 75(8), 823-841 (2014-12-03)
The transcription factor Nurr1 is expressed in the mouse olfactory bulb (OB), although it remains unknown whether it influences the generation of dopaminergic neurons (DA) (DA neurons) in cells isolated from this brain region. We found that expressing Nurr1 in...
Maša Sinreih et al.
PloS one, 10(2), e0117984-e0117984 (2015-02-14)
Progesterone has a number of important functions throughout the human body. While the roles of progesterone are well known, the possible actions and implications of progesterone metabolites in different tissues remain to be determined. There is a growing body of...
Rachel Sarabia-Estrada et al.
Journal of neurosurgery, 123(1), 270-282 (2015-02-14)
Transection of peripheral nerves produces loss of sensory and/or motor function. After complete nerve cutting, the distal and proximal segment ends retract, but if both ends are bridged with unaltered chitosan, progesterone-impregnated chitosan, or silicone tubes, an axonal repair process...
V A Nunes et al.
The Journal of endocrinology, 221(2), 273-284 (2014-03-07)
Progesterone has been associated with the development of gestational diabetes (GD) due to the enhancement of insulin resistance. As β-cell apoptosis participates in type 1 and type 2 diabetes pathophysiology, we proposed the hypothesis that progesterone might contribute to the...
Xiao-Ming Wang et al.
Stem cell research & therapy, 6, 158-158 (2015-09-01)
Zellweger spectrum disorder (PBD-ZSD) is a disease continuum caused by mutations in a subset of PEX genes required for normal peroxisome assembly and function. They highlight the importance of peroxisomes in the development and functions of the central nervous system...
Yuko Ikemoto et al.
Nutrients, 10(7) (2018-07-18)
Vitamin D (VD) deficiency is associated with reproductive failure. However, the relationship between VD and maternal immunity remains unclear. We investigated the clinical efficacy of VD in maternal T-helper (Th) cytokines in 276 infertile women and examined for Th1 and...
Alexandra J White et al.
Environmental health : a global access science source, 13, 108-108 (2014-12-17)
Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. Indoor air pollution from use of indoor stoves and/or fireplaces is an important source of ambient PAH exposure. However, the association between indoor stove/fireplace use and...
D R Khan et al.
Molecular human reproduction, 21(9), 688-701 (2015-06-27)
Understanding the mechanisms regulating oocyte developmental competence is essential to enhance the clinical efficiency of assisted reproduction. FSH orchestrates the acquisition of oocyte competence, both in vivo and in vitro. Multiple pathways are implicated in FSH signalling; however, their precise...
Weiming Zheng et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(3), 285-299 (2015-01-08)
Hormonal regulation of pituitary gonadotropin gene expression has been attributed to gonadotropin-releasing hormone (GnRH)-mediated stimulation of immediate early gene expression and gonadal steroid interactions with their respective nuclear receptors. A number of orphan nuclear receptors including steroidogenic factor 1, liver...
S M Robertson et al.
Animal reproduction science, 162, 62-72 (2015-10-12)
High intake of lucerne pastures or feeding of other high quality diets during early pregnancy may increase embryo mortality, negating any benefit of improved nutrition on ovulation rate in ewes. This study was conducted to determine whether grazing ewes on...
Brigid K Jensen et al.
Journal of neuropathology and experimental neurology, 74(11), 1093-1118 (2015-10-16)
Despite effective viral suppression through combined antiretroviral therapy (cART), approximately half of HIV-positive individuals have HIV-associated neurocognitive disorders (HAND). Studies of antiretroviral-treated patients have revealed persistent white matter abnormalities including diffuse myelin pallor, diminished white matter tracts, and decreased myelin...
Mei Fu et al.
PloS one, 9(12), e113669-e113669 (2014-12-06)
This study aimed to establish yak mammary epithelial cells (YMECs) for an in vitro model of yak mammary gland biology. The primary culture of YMECs was obtained from mammary gland tissues of lactating yak and then characterized using immunocytochemistry, RT-PCR...
Jaesung Peter Choi et al.
Endocrine-related cancer, 22(5), 687-701 (2015-08-20)
Haploinsufficient inactivating phosphatase and tensin homolog (Pten) mutations cause Cowden syndrome, an autosomal dominant risk genotype for hormone dependent reproductive cancers. As androgen actions mediated via the androgen receptor (AR) supports uterine growth and may modify uterine cancer risk, we...
Katarzyna Gajos et al.
Theriogenology, 84(3), 457-466 (2015-05-13)
Mares that fail to become pregnant after repeated breeding, without showing typical signs of clinical endometritis, should be suspected of subclinical endometritis (SE). Contact with infectious agents results in altered synthesis and secretion of inflammatory mediators, including cytokines and arachidonic...
Safiya A Wahd et al.
Reproductive biology and endocrinology : RB&E, 12, 120-120 (2014-12-03)
The role of ovarian reserve markers as predictors of the controlled ovarian stimulation (COS) response in intracytoplasmic sperm injection (ICSI) cycles in women with endometriosis has been much debated. The aim of the present study is to assess the predictability...
Rong-Hu Ke et al.
Journal of neuro-oncology, 118(2), 369-376 (2014-04-18)
Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2) has been indicated to have a critical role in various tumors. In the study, we aimed to evaluate the LASS2 expression level in prognostic significance and compare it with commonly...
Yingchun Liu et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 74(1), 26-37 (2015-02-25)
The retarded development of fetal thymus in intrauterine growth restriction (IUGR) from maternal undernutrition during late pregnancy destroys the tridimensional structure and modifies the development of fetal T lymphocytes. The mechanisms, however, remain unclear. The objective of this study was...
Yan Yang et al.
Stem cells and development, 24(4), 459-470 (2014-10-24)
The primary function of Leydig cells is to secrete testosterone, which is critical in the regulation of male reproduction and development. Low levels of testosterone will lead to male hypogonadism. Stem cell-derived Leydig cell transplantation may be a promising alternative...
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