Showing 1-30 of 90 results for "P0515"
Mohamed-Raafet Ammar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(50), 19470-19479 (2013-12-18)
More than 80 human X-linked genes have been associated with mental retardation and deficits in learning and memory. However, most of the identified mutations induce limited morphological alterations in brain organization and the molecular bases underlying neuronal clinical features remain...
Thomas R Burkard et al.
BMC systems biology, 5, 17-17 (2011-01-29)
On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties...
Pingfu Feng et al.
Journal of psychiatric research, 47(5), 579-585 (2013-02-21)
Depression is associated with structural and neurochemical changes in limbic structures, including the hippocampus, that control emotion and mood. Structural abnormalities such as decrease in hippocampal cell proliferation, neurogenesis and hippocampal volume, and loss of neurons and glial cells have...
Feng Zhang et al.
Molecular and cellular biology, 34(1), 84-95 (2013-10-30)
The Ras-extracellular signal-regulated kinase (ERK) cascade is an important signaling module in cells. One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK). Using a newly developed PA biosensor, PASS (phosphatidic...
K D Philipson et al.
The Journal of biological chemistry, 259(1), 16-19 (1984-01-10)
Treatment of canine cardiac sarcolemmal vesicles with phospholipase D resulted in a large stimulation (up to 400%) of Na+-Ca2+ exchange activity. The phospholipase D treatment decreased the apparent Km (Ca2+) for the initial rate of Nai+-dependent Ca2+ uptake from 18.2...
Frank Chen et al.
Journal of lipid research, 54(2), 379-385 (2012-12-06)
Functional defects in ATPase class I type 8B membrane 1 (ATP8B1 or familial intrahepatic cholestasis 1, FIC1) lead to cholestasis by mechanism(s) that are not fully understood. One proposed pathophysiology involves aberrant signaling to the bile acid sensor, the farnesoid...
Plant phospholipase D. I. Studies on cottonseed and cabbage phospholipase D.
H L TOOKEY et al.
The Journal of biological chemistry, 218(1), 213-224 (1956-01-01)
Sheng Chen et al.
Bioscience, biotechnology, and biochemistry, 77(9), 1939-1941 (2013-09-11)
Phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) in a biphasic system was limited by the hydrolysis reaction. A biphasic system can produce a large amount of water. To solve this problem, a microaqueous water-immiscible organic solvent was used for the...
S M Hammond et al.
The Journal of biological chemistry, 272(6), 3860-3868 (1997-02-07)
We previously reported the cloning of a cDNA encoding human phosphatidylcholine-specific phospholipase D1 (PLD1), an ADP-ribosylation factor (ARF)-activated phosphatidylcholine-specific phospholipase D (Hammond, S. M., Tsung, S., Autschuller, Y., Rudge, S. A., Rose, K., Engebrecht, J., Morris, A. J., and Frohman...
P M Steed et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 12(13), 1309-1317 (1998-10-08)
Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Recent advances in this field include the...
Won Chan Hwang et al.
Experimental & molecular medicine, 46, e124-e124 (2014-12-06)
Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase D (PLD) isozymes are dysregulated in various cancers. Recently, we...
S M Hammond et al.
The Journal of biological chemistry, 270(50), 29640-29643 (1995-12-15)
Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. We report here the identification of the first human PLD cDNA, which defines...
Jonathan J Ipsaro et al.
Nature, 491(7423), 279-283 (2012-10-16)
PIWI-family proteins and their associated small RNAs (piRNAs) act in an evolutionarily conserved innate immune mechanism to provide essential protection for germ-cell genomes against the activity of mobile genetic elements. piRNA populations comprise a molecular definition of transposons, which permits...
Zhi-Yan Du et al.
The Plant journal : for cell and molecular biology, 74(2), 294-309 (2013-03-02)
A family of six genes encoding acyl-CoA-binding proteins (ACBPs), ACBP1-ACBP6, has been characterized in Arabidopsis thaliana. In this study, we demonstrate that ACBP1 promotes abscisic acid (ABA) signaling during germination and seedling development. ACBP1 was induced by ABA, and transgenic...
Dong Woo Kang et al.
Molecular and cellular biology, 33(14), 2760-2772 (2013-05-22)
Interleukin-1β (IL-1β) is a potent proinflammatory and immunoregulatory cytokine playing an important role in the progression of rheumatoid arthritis (RA). However, the signaling network of IL-1β in synoviocytes from RA patients is still poorly understood. Here, we show for the...
Biancamaria Farina et al.
Biochimica et biophysica acta, 1834(8), 1572-1580 (2013-04-24)
PED/PEA15 is a small protein involved in many protein-protein interactions that modulates the function of a number of key cellular effectors involved in major cell functions, including apoptosis, proliferation and glucose metabolism. In particular, PED/PEA15 interacts with the phospholipase D...
J X Cao et al.
Virus research, 48(1), 11-18 (1997-04-01)
We have identified a human gene encoding a protein with 48% amino acid identity to the vaccinia virus (VV) K4L gene product. Both contain motifs characteristic of the phospholipase D (PLD) protein superfamily. These proteins are also related to vaccinia...
Takanobu Sato et al.
Molecular and cellular biology, 33(1), 136-145 (2012-10-31)
Phospholipase D (PLD), which produces the lipid messenger phosphatidic acid (PA), has been implicated in superoxide generation and degranulation in neutrophils. The basis for this conclusion is the observation that primary alcohols, which interfere with PLD-catalyzed PA production, inhibit these...
Zhang-Qun Duan et al.
Journal of biotechnology, 163(1), 45-49 (2012-11-13)
2-Methyltetrahydrofuran has recently been described as a promising and green solvent. Herein, it was successfully used as the reaction medium for enzyme-mediated transphosphatidylation of phosphatidylcholine with L-serine with the aim of phosphatidylserine synthesis for the first time. Our results indicated...
Senthil N Arun et al.
Journal of lipid research, 54(3), 581-591 (2013-01-05)
Plasma membrane disruptions occur in mechanically active tissues such as the epidermis and can lead to cell death if the damage remains unrepaired. Repair occurs through fusion of vesicle patches to the damaged membrane region. The enzyme phospholipase D (PLD)...
Hai-Long Wang et al.
The Chinese journal of physiology, 56(1), 11-17 (2013-01-26)
In this study, C6 glioma cells were used to test the effects of 2-azafluorenone and its related compounds on membrane phosphatidylinositol (PI) and phosphatidylcholine (PC) turnover. An increase of [³H]-labeled inositol phosphate (IP1) formation by histamine (100 μM) or A23187...
Francis J Speranza et al.
Journal of leukocyte biology, 94(5), 953-962 (2013-07-31)
Monocytes and neutrophils infiltrate into tissues during inflammation and stay for extended periods of time until the initial insult is resolved or sometimes remain even longer in the case of chronic inflammation. The mechanism as to why phagocytes become immobilized...
Qiong Liu et al.
Biochimica et biophysica acta, 1828(9), 2111-2120 (2013-05-11)
The ability to adjust cell volume is required for the adaptation to osmotic stress. Plant protoplasts can swell within seconds in response to hypoosmotic shock suggesting that membrane material is released from internal stores. Since the stability of plant membranes...
Aaron R Navratil et al.
Infection and immunity, 82(8), 3299-3311 (2014-05-29)
Francisella tularensis induces the synthesis of prostaglandin E(2) (PGE(2)) by infected macrophages to alter host immune responses, thus providing a survival advantage to the bacterium. We previously demonstrated that PGE(2) synthesis by F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2))...
Alpha K Gebeh et al.
The Journal of clinical endocrinology and metabolism, 98(3), 1226-1234 (2013-02-02)
Studies from knockout mice suggest that perturbations in oviductal endocannabinoid levels, endocannabinoid receptors, or endocannabinoid degrading enzyme [fatty acid amide hydrolase (FAAH)] expression result in infertility secondary to physical trapping of embryos. Similar observations have been made in ectopic pregnant...
Songyi Han et al.
Experimental & molecular medicine, 46, e126-e126 (2014-12-20)
Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is believed to play an important role in tumorigenesis. In this...
[Arfaptine-1 controls secretory granule biogenesis].
Joëlle Morvan et al.
Medecine sciences : M/S, 29(3), 247-249 (2013-04-03)
Lawrence O Olala et al.
Molecular and cellular endocrinology, 366(1), 31-37 (2012-11-28)
The mineralocorticoid aldosterone plays an important role in regulating blood pressure, with excess causing hypertension and exacerbating cardiovascular disease. Previous studies have indicated a role for both phospholipase D (PLD) and protein kinase D (PKD) in angiotensin II (AngII)-regulated aldosterone...
Chikashi Terao et al.
Arthritis and rheumatism, 65(2), 472-480 (2012-11-06)
Systemic sclerosis (SSc) is an autoimmune disease for which multiple susceptibility genes have been reported. Genome-wide association studies have shown that large numbers of susceptibility genes are shared among autoimmune diseases. Recently, our group identified 9 novel susceptibility genes associated...
Qin Chen et al.
Science signaling, 5(249), ra79-ra79 (2012-11-08)
Angiogenesis inhibitors, which target tumor cells, confer only short-term benefits on tumor growth. We report that ablation of the lipid signaling enzyme phospholipase D1 (PLD1) in the tumor environment compromised the neovascularization and growth of tumors. PLD1 deficiency suppressed the...

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