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P1585

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M Di Giovangiulio et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(11), 1542-1552 (2015-08-01)
The orexigenic peptide ghrelin has anti-inflammatory properties in colitis, however, the mechanism of action and the immune cells targeted remain still to be elucidated. Here, we assessed the possible effect of ghrelin on T helper (Th) cells in a T...
Ana Carolina da Silva Almeida et al.
Nature genetics, 47(12), 1465-1470 (2015-11-10)
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformation of skin-homing central memory CD4(+) T cells. Here we performed whole-exome sequencing of tumor-normal sample pairs from 25 patients with Sézary...
Opas Traitanon et al.
PloS one, 10(6), e0129658-e0129658 (2015-06-19)
The direct effect of immunosuppressive drugs calcineurin inhibitor (Tacrolimus, TAC) and mTOR inhibitor (Sirolimus, SRL) on B cell activation, differentiation and proliferation is not well documented. Purified human B cells from healthy volunteers were stimulated through the B Cell Receptor...
Sarah E M Herman et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), 4642-4651 (2015-06-20)
Ibrutinib leads to a transient lymphocytosis in patients with chronic lymphocytic leukemia (CLL) that develops within hours of starting drug and is due to the efflux of cells from lymphoid tissues into the blood. We therefore sought to investigate the...
Afshin Namdar et al.
Iranian journal of immunology : IJI, 12(3), 176-187 (2015-09-29)
Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing...
Shannon Sanacora et al.
Biochemical and biophysical research communications, 460(2), 375-379 (2015-03-21)
Bortezomib (BZ) is the first clinically approved proteasome inhibitor that has shown remarkable anticancer activity in patients with hematological malignancies. However, many patients relapse and develop resistance; yet, the molecular mechanisms of BZ resistance are not fully understood. We have...
Minchao Duan et al.
Mediators of inflammation, 2015, 802939-802939 (2015-05-15)
The presence of Th17 cells and IL-27 is observed in a variety of inflammatory associated cancers. However, there are some data on the role of Th17 cells and IL-27 in the regulation of immune reactions in non-small-cell lung cancer (NSCLC)....
Yi Cao et al.
Environmental toxicology and pharmacology, 40(1), 164-171 (2015-07-01)
Exposure to diesel exhaust particles (DEP) has been associated with adverse cardiopulmonary health effects, which may be related to dysregulation of lipid metabolism and formation of macrophage foam cells. In this study, THP-1 derived macrophages were exposed to an automobile...
Ran You et al.
eLife, 4, e09623-e09623 (2015-10-06)
Chronic inhalation of cigarette smoke is the major cause of sterile inflammation and pulmonary emphysema. The effect of carbon black (CB), a universal constituent of smoke derived from the incomplete combustion of organic material, in smokers and non-smokers is less...
Sagie Wagage et al.
PloS one, 10(5), e0128335-e0128335 (2015-05-27)
Intestinal infection with the intracellular parasite Toxoplasma gondii results in the translocation of commensal bacteria to peripheral organs and the development of a T cell response specific to the microbiota. In naïve mice, the recently described RORγt+ group 3 innate...
Lumin Wei et al.
Pathogens and disease, 72(1), 45-54 (2014-04-23)
Regulatory T (Treg) cells play a critical role in Helicobacter pylori immune evasion and persistent infection. In addition to Treg cells, it is still unknown whether a newly defined B-cell subset, interleukin (IL)-10-producing B cells, is involved. Using a mouse...
Angélica Quintero-Flórez et al.
Journal of agricultural and food chemistry, 63(30), 6731-6738 (2015-07-18)
Although the beneficial role of Extra Virgin Olive Oil (EVOO) in the Mediterranean diet is well-known, its effects on health cannot be attributed solely to oleic acid. In addition to minor components, the presence of other fatty acids (FA), which...
Marshall P Thomas et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5390-5397 (2014-04-29)
Killer lymphocyte granzyme (Gzm) serine proteases induce apoptosis of pathogen-infected cells and tumor cells. Many known Gzm substrates are nucleic acid binding proteins, and the Gzms accumulate in the target cell nucleus by an unknown mechanism. In this study, we...
Esther Florsheim et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4621-4630 (2015-04-17)
Proteases are recognized environmental allergens, but little is known about the mechanisms responsible for sensing enzyme activity and initiating the development of allergic inflammation. Because usage of the serine protease subtilisin in the detergent industry resulted in an outbreak of...
Osiris Marroquin Belaunzaran et al.
PloS one, 10(6), e0130811-e0130811 (2015-07-01)
HLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B272) and induce pro-inflammatory responses that may lead to SpA pathogenesis. The presence of B272 can be detected...
Shuzheng Chen et al.
International journal of clinical and experimental pathology, 8(8), 9052-9061 (2015-10-16)
There is now considerable evidence supporting the view that macrophage infiltration is playing a critical role in the proliferation and progression of breast cancer but the underlying molecular mechanisms remain largely unknown. To this end, using long non-coding RNA (lncRNA)...
E Ono et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(6), 1654-1665 (2015-04-03)
Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to...
Yuji Nozaki et al.
American journal of physiology. Renal physiology, 308(8), F899-F909 (2015-02-05)
Nephrotoxicity is a frequent complication of cisplatin-induced chemotherapy, in which T cells are known to promote acute kidney injury (AKI). Apoptosis and necrosis of tubules and inflammatory events also contribute to the nephrotoxicity. A delineation of the mechanisms that underlie...
Yutaka Kimura et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(5), 759-768 (2014-03-08)
We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), to evaluate the effects on key predictivein vitro components of the human immune system. The system is composed of 3 stable reporter cell lines transfected with 3 luciferase genes...
Charlotte M Mousset et al.
Cancer immunology, immunotherapy : CII, 69(11), 2259-2273 (2020-06-07)
AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4+ T cells is insufficiently explored. Previously, we and others showed that AKT-inhibition during ex vivo CD8+ T cell expansion facilitates the generation of polyfunctional T...
Dàlia Raïch-Regué et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4767-4776 (2015-04-05)
The mammalian/mechanistic target of rapamycin (mTOR) is a key integrative kinase that functions in two independent complexes, mTOR complex (mTORC) 1 and mTORC2. In contrast to the well-defined role of mTORC1 in dendritic cells (DC), little is known about the...
Lauren E Hillers-Ziemer et al.
Cancers, 12(2) (2020-02-27)
Obesity is correlated with worsened prognosis and treatment resistance in breast cancer. Macrophage-targeted therapies are currently in clinical trials, however, little is known about how obesity may impact treatment efficacy. Within breast adipose tissue, obesity leads to chronic, macrophage-driven inflammation...
Jie Li et al.
Digestive diseases and sciences, 59(7), 1475-1483 (2014-01-21)
Both interleukin (IL)-17-secreting CD4(+) T (Th17) and CD4(+)CD25(+)Foxp3(+) T regulatory (Treg) cells have been shown to be associated with disease progression or liver damage in chronic hepatitis B (CHB) patients. However, the relationship between Treg cells and IL-17-secreting T cells...
Hao Feng et al.
International journal of clinical and experimental medicine, 8(6), 8674-8685 (2015-08-27)
Hepatitis B is a worldwide infectious disease caused by hepatitis B virus (HBV), it leaded to millions of deaths every year, HBV mainly through immune response to damage liver cells. The purpose of this study was to judge the value...
Luisa Mori et al.
Journal of virology (2020-11-27)
HIV transcription requires assembly of cellular transcription factors at the HIV-1promoter. The TFIIH general transcription factor facilitates transcription initiation by opening the DNA strands around the transcription start site and phosphorylating the C-terminal domain for RNA polymerase II (RNAPII) for...
Kirsten A Kulcsar et al.
Journal of virology, 89(16), 8280-8291 (2015-06-05)
Susceptibility to alphavirus encephalomyelitis is dependent on a variety of factors, including the genetic background of the host. Neuroadapted Sindbis virus (NSV) causes uniformly fatal disease in adult C57BL/6 (B6) mice, but adult BALB/c (Bc) mice recover from infection. In...
Wioleta Jesionek et al.
Journal of AOAC International, 98(4), 1013-1020 (2015-08-14)
Fast high-throughput TLC-direct bioautography (DB) is an effect-directed analysis method that enables searching for biologically active (e.g., antimicrobial) substances in complex mixtures like plant extracts. The principle of the method is that separation and detection of biological properties of given...
Hirotake Tsukamoto et al.
Cancer immunology research, 1(1), 64-76 (2014-04-30)
Collaborative action between tumor cells and host-derived suppressor cells leads to peripheral tolerance of T cells to tumor antigens. Here, we showed that in tumor-bearing mice, generation of tumor antigen-specific effector T-helper cells (TH1) was significantly attenuated, and impaired TH1...
Judith Leitner et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 477-487 (2015-06-05)
A substantial proportion of CD8(+) T cells in adults lack the expression of the CD28 molecule, and the aging of the immune system is associated with a steady expansion of this T cell subset. CD28(-)CD8(+) T cells are characterized by...
Yumeng Shen et al.
Cell death & disease, 10(12), 905-905 (2019-12-04)
Progressive degeneration of retinal ganglion cells (RGCs) will cause a blinding disease. Most of the study is focusing on the RGCs itself. In this study, we demonstrate a decline of the presynaptic rod bipolar cells (RBCs) response precedes RGCs loss...
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