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Jesse Hwang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), E5706-E5715 (2014-12-17)
An shRNA-mediated screen of the 48 human nuclear receptor genes identified multiple candidates likely to influence the production of human cytomegalovirus in cultured human fibroblasts, including the estrogen-related receptor α (ERRα), an orphan nuclear receptor. The 50-kDa receptor and a
Chike F Oguejiofor et al.
Biology of reproduction, 93(4), 100-100 (2015-09-12)
The dysregulation of endometrial immune response to bacterial lipopolysaccharide (LPS) has been implicated in uterine disease and infertility in the postpartum dairy cow, although the mechanisms are not clear. Here, we investigated whole-transcriptomic gene expression in primary cultures of mixed
Y M Lv et al.
Bone & joint research, 4(4), 56-64 (2015-04-04)
The major problem with repair of an articular cartilage injury is the extensive difference in the structure and function of regenerated, compared with normal cartilage. Our work investigates the feasibility of repairing articular osteochondral defects in the canine knee joint
André Said et al.
Immunology, 144(2), 218-230 (2014-07-26)
The specific function of human skin-resident dendritic cell (DC) subsets in the regulation of immunity or tolerance is still a matter of debate. Langerhans cells (LC) induce anti-viral immune responses but, conversely to dermal DC, maintain tolerance to bacteria. However
Xi Zhan et al.
Pharmaceutical research, 32(7), 2280-2291 (2015-01-17)
A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular functions. In this study, we examined the intracellular distribution of both fluorecent
Johan B Fagman et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1540-1550 (2015-01-01)
Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)-dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein
Anna E Rapp et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1235-1241 (2015-04-17)
Abatement of fracture-related pain is important in patient welfare. However, the frequently used non-steroidal anti-inflammatory drugs are considered to impair fracture healing through blockade of cyclooxygenase-2. An alternative for fracture-related pain treatment may be blockade of nerve growth factor (NGF)/neurotrophic
Jacqueline Stockley et al.
Scientific reports, 5, 13426-13426 (2015-08-28)
Castration-resistant (CR) prostate cancer (PCa) partly arises due to persistence of androgen receptor (AR) transcriptional activity in the absence of cognate ligand. An emerging mechanism underlying the CRPCa phenotype and predicting response to therapy is the expression of the constitutively-active
Irina Ushach et al.
Clinical immunology (Orlando, Fla.), 156(2), 119-127 (2014-12-09)
Cytokines are involved in many functions of the immune system including initiating, amplifying and resolving immune responses. Through bioinformatics analyses of a comprehensive database of gene expression (BIGE: Body Index of Gene Expression) we observed that a small secreted protein
H Almåsbak et al.
Gene therapy, 22(5), 391-403 (2015-02-06)
Cancer therapy with T cells expressing chimeric antigen receptors (CARs) has produced remarkable clinical responses in recent trials, but also severe side effects. Whereas most protocols use permanently reprogrammed T cells, we have developed a platform for transient CAR expression
Natalie Reimers et al.
PLoS neglected tropical diseases, 9(3), e0003593-e0003593 (2015-03-17)
Schistosomiasis is a serious health problem especially in developing countries and affects more than 243 million people. Only few anthelmintic drugs are available up to now. A major obstacle for drug treatment is the different developmental stages and the varying
Sonal Dalvi et al.
Applied and environmental microbiology, 80(21), 6664-6676 (2014-08-26)
Arhodomonas sp. strain Seminole was isolated from a crude oil-impacted brine soil and shown to degrade benzene, toluene, phenol, 4-hydroxybenzoic acid (4-HBA), protocatechuic acid (PCA), and phenylacetic acid (PAA) as the sole sources of carbon at high salinity. Seminole is
L F Heinrich et al.
The British journal of nutrition, 113(11), 1704-1711 (2015-04-17)
Obesity and type 2 diabetes lead to dramatically increased risks of atherosclerosis and CHD. Multiple mechanisms converge to promote atherosclerosis by increasing endothelial oxidative stress and up-regulating expression of pro-inflammatory molecules. Microvesicles (MV) are small ( < 1 μm) circulating
Šárka Kubinová et al.
Journal of tissue engineering and regenerative medicine, 9(11), 1298-1309 (2013-02-13)
The architecture and mechanical properties of a scaffold for spinal cord injury treatment must provide tissue integration as well as effective axonal regeneration. Previous work has demonstrated the cell-adhesive and growth-promoting properties of the SIKVAV (Ser-Ile-Lys-Val-Ala-Val)-modified highly superporous poly(2-hydroxethyl methacrylate)
Nina C Weber et al.
Basic research in cardiology, 110(2), 17-17 (2015-02-27)
Short repeated cycles of peripheral ischemia/reperfusion (I/R) can protect distant organs from subsequent prolonged I/R injury; a phenomenon known as remote ischemic preconditioning (RIPC). A RIPC-mediated release of humoral factors might play a key role in this protection and vascular
Marcus Klein et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(2), 273-283 (2014-12-07)
Inflammatory processes are associated with compromised metabolism and elimination of drugs in the liver, largely mediated by proinflammatory cytokines, such as interleukin-6. The Hepa-RG cell line is an established surrogate for primary human hepatocytes (PHH) in drug metabolism and toxicity
Elaheh Esmaelbeygi et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 31(5), 489-497 (2015-05-12)
In this study the effect of PLGA polymeric nanoparticles as a 5-fluorouracil (5-FU) carrier with and without iron oxide core and hyperthermia were investigated on the level of DNA damage in a spheroid culture model of HT-29 colon cancer cell
Kim Beilstein et al.
ACS synthetic biology, 4(5), 526-534 (2014-09-30)
Robust synthetic devices are requisite for the construction of synthetic genetic circuits and important scientific and technological tools to control cellular processes. We developed tetracycline-dependent ribozymes, which can switch on gene expression up to 8.7-fold upon addition of tetracycline. A
Stefanie Steiner et al.
Archivum immunologiae et therapiae experimentalis, 63(1), 53-63 (2014-08-27)
Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel diseases (IBD), which are defined as relapsing inflammations of the gastrointestinal tract. Cyclosporine A (CsA) is a potential rescue treatment to avoid colectomy in severe
Abdulrahman Khazim Al-Asmari et al.
PloS one, 10(8), e0135814-e0135814 (2015-08-20)
In this study we investigated the anti-cancer effect of Moringa oleifera leaves, bark and seed extracts. When tested against MDA-MB-231 and HCT-8 cancer cell lines, the extracts of leaves and bark showed remarkable anti-cancer properties while surprisingly, seed extracts exhibited
Svetlana N Rubtsova et al.
PloS one, 10(7), e0133578-e0133578 (2015-07-25)
Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells. Live-cell imaging of neoplastic cells stably expressing EGFP and of normal epithelial cells stably expressing
Harald Schwarz et al.
PloS one, 9(12), e113840-e113840 (2014-12-06)
Many commercially available recombinant proteins are produced in Escherichia coli, and most suppliers guarantee contamination levels of less than 1 endotoxin unit (EU). When we analysed commercially available proteins for their endotoxin content, we found contamination levels in the same
Wojciech Witkowski et al.
PloS one, 10(7), e0133651-e0133651 (2015-07-25)
The function of dendritic cells (DCs) in the immune system is based on their ability to sense and present foreign antigens. Powerful tools to research DC function and to apply in cell-based immunotherapy are either silencing or overexpression of genes
Susanne Burdak-Rothkamm et al.
Cancer letters, 356(2 Pt B), 454-461 (2014-10-12)
Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct
Jessica Schmitt et al.
Molecular medicine (Cambridge, Mass.), 21, 185-196 (2015-03-27)
Parent-of-origin imprints have been implicated in the regulation of neural differentiation and brain development. Previously we have shown that, despite the lack of a paternal genome, human parthenogenetic (PG) embryonic stem cells (hESCs) can form proliferating neural stem cells (NSCs)
Zhiheng Chen et al.
Oncotarget, 6(35), 38139-38150 (2015-10-27)
miR-124 and miR-506 are reportedly down-regulated and associated with tumor progression in many cancers, but little is known about their intrinsic regulatory mechanisms in colorectal cancer (CRC). In this study, we found that the miR-124 and miR-506 levels were significantly
Meng-Liu Yu et al.
BioMed research international, 2015, 582359-582359 (2015-09-30)
Cell sheet technology is a new strategy in tissue engineering which could be possible to implant into the body without a scaffold. In order to get an integrated cell sheet, a light-induced method via UV365 is used for cell sheet
K P Dalton et al.
Veterinary microbiology, 178(3-4), 208-216 (2015-05-27)
Despite the success of vaccination against myxoma virus, myxomatosis remains a problem on rabbit farms throughout Spain and Europe. In this study we set out to evaluate possible causes of myxoma virus (MYXV) vaccine failures addressing key issues with regard
Céline Labouesse et al.
Biophysical journal, 108(10), 2437-2447 (2015-05-21)
The mechanical interaction between adherent cells and their substrate relies on the formation of adhesion sites and on the stabilization of contractile acto-myosin bundles, or stress fibers. The shape of the cell and the orientation of these fibers can be
Rachel S Dakin et al.
Human gene therapy, 26(5), 312-319 (2015-03-12)
Neointima formation and vascular remodeling through vascular smooth muscle cell migration and proliferation can limit the long-term success of coronary interventions, for example, in coronary artery bypass grafting (CABG). Ex vivo gene therapy has the potential to reduce unnecessary cell
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