Showing 1-11 of 11 results for "P2482"
Alejandro García-Regalado et al.
Molecular biology of the cell, 19(10), 4188-4200 (2008-08-15)
G-protein coupled receptors activate heterotrimeric G proteins at the plasma membrane in which most of their effectors are intrinsically located or transiently associated as the external signal is being transduced. This paradigm has been extended to the intracellular compartments by...
Kedar S Vaidya et al.
The Journal of biological chemistry, 283(42), 28354-28360 (2008-07-31)
That metastatic tumor cells grow in selective non-native environments suggests an ability to differentially respond to local microenvironments. BRMS1, like other metastasis suppressors, halts ectopic growth (metastasis) without blocking orthotopic tumor formation. BRMS1-expressing tumor cells reach secondary sites but do...
Jinling Wu et al.
Development (Cambridge, England), 133(18), 3651-3660 (2006-08-18)
GIPC is a PDZ-domain-containing protein identified in vertebrate and invertebrate organisms through its interaction with a variety of binding partners including many membrane proteins. Despite the multiple reports identifying GIPC, its endogenous function and the physiological significance of these interactions...
P J Coffer et al.
European journal of biochemistry, 201(2), 475-481 (1991-10-15)
Highly degenerate oligonucleotide primers designed from regions conserved between protein-serine kinases have been used specifically to amplify human epithelial (HeLa) cDNA by the polymerase chain reaction (PCR). Of several novel cDNA fragments encoding putative kinases thus isolated, one was further...
Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells
Garcia RA, et al.
Molecular Cancer, 12(1), 44-44 (2013)
Rodolfo Daniel Cervantes-Villagrana et al.
The Journal of biological chemistry, 294(2), 531-546 (2018-11-18)
G protein-coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammalian cell migration. Rac and Rho GTPases exert opposing effects on cell morphology and are stimulated downstream of Gβγ and Gα12/13 or Gαq, respectively. These Gα subunits might in...
Annaïg Hamon et al.
Cell reports, 27(6), 1712-1725 (2019-05-09)
Contrasting with fish or amphibian, retinal regeneration from Müller glia is largely limited in mammals. In our quest toward the identification of molecular cues that may boost their stemness potential, we investigated the involvement of the Hippo pathway effector YAP...
AKT1 (v-akt murine thymoma viral oncogene homolog 1)
Etro D, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
Lydia Chávez-Vargas et al.
The Journal of biological chemistry, 291(12), 6182-6199 (2016-01-23)
Morphology of migrating cells is regulated by Rho GTPases and fine-tuned by protein interactions and phosphorylation. PKA affects cell migration potentially through spatiotemporal interactions with regulators of Rho GTPases. Here we show that the endogenous regulatory (R) subunit of type...

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