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Blassan Plackal Adimuriyil George et al.
Scientific reports, 8(1), 14368-14368 (2018-09-27)
Metallic nanoparticles (NPs) especially silver (Ag) NPs have shown immense potential in medical applications due to their distinctive physio-chemical and biological properties. This article reports the conjugation of Ag NPs with Rubus fairholmianus extract. The modification of Ag NPs was
Till Stephan et al.
The EMBO journal, 39(14), e104105-e104105 (2020-06-23)
Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. With the MICOS complex, OPA1 and the F1 Fo -ATP synthase, key players of cristae
Motoko Niida-Kawaguchi et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 40(2), 152-166 (2019-12-29)
Previous studies on sporadic amyotrophic lateral sclerosis (SALS) demonstrated iron accumulation in the spinal cord and increased glutamate concentration in the cerebrospinal fluid. To clarify the relationship between the two phenomena, we first performed quantitative and morphological analyses of substances
Qingqiu Yang et al.
In vitro cellular & developmental biology. Animal, 55(8), 641-655 (2019-07-13)
The equine hoof dermal-epidermal interface requires progenitor cells with distinct characteristics. This study was designed to provide accurate ultrastructural depictions of progenitor cells isolated from inflamed tissue and normal tissue before and after cryopreservation and following selection of cells expressing
Lingli Long et al.
Journal of diabetes research, 2019, 4875421-4875421 (2020-01-25)
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. This study demonstrates the antiangiogenic effects of scutellarin (SCU) on high glucose- and hypoxia-stimulated human retinal endothelial cells (HRECs) and on a diabetic rat model by oral administration. The antiangiogenic
Yonghua Han et al.
Transgenic research, 24(6), 1055-1063 (2015-09-26)
Although particle bombardment is the predominant method of foreign DNA direct transfer, whether transgene is integrated randomly into the genome has not been determined. In this study, we identified the distribution of transgene loci in 45 transgenic wheat (Triticum aestivum
Ting-Ting Hou et al.
Journal of Alzheimer's disease : JAD, 74(2), 521-534 (2020-02-18)
Hyperphosphorylated tau is one of the key characteristics of Alzheimer's disease (AD), and tau pathology correlates with cognitive impairment in AD better than amyloid-β (Aβ) pathology. Thus, a complete understanding of the relevant factors involved in tau phosphorylation is important
Mariano Catanesi et al.
Cell biology international, 44(8), 1734-1744 (2020-04-29)
Alzheimer's disease represents the most prevalent neurodegeneration worldwide, clinically characterized by cognitive and memory impairment. New therapeutic approaches are extremely important to counteract this disorder. This research is focused on the potential use of choline alfoscerate in preventing neuronal death
Xi Chen et al.
Cytokine, 136, 155292-155292 (2020-09-21)
Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a crucial role in osteoporosis. Irisin, an exercise-induced muscle-dependent myokine, has been reported to stimulate the development of brown adipose tissue and regulate energy expenditure. The present study aimed to
Tahereh Komeili-Movahhed et al.
Iranian journal of basic medical sciences, 18(5), 472-477 (2015-07-01)
Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in
Jean Christopher Chamcheu et al.
Skin pharmacology and physiology, 28(4), 177-188 (2015-01-27)
Psoriasis is a chronic inflammatory disorder of skin and joints for which conventional treatments that are effective in clearing the moderate-to-severe disease are limited due to long-term safety issues. This necessitates exploring the usefulness of botanical agents for treating psoriasis.
Anna-Maria Husa et al.
Stem cells and development, 27(19), 1376-1384 (2018-07-17)
Hematopoietic stem and progenitor cells (HSPCs) derived from human induced pluripotent stem cells (hiPSCs) hold great promise for disease modeling, drug screens, and eventually cell therapy approaches. During in vitro differentiation of hiPSCs into hematoendothelial progenitors, the emergence of CD34-positive
Yuhan Chang et al.
International journal of molecular sciences, 22(3) (2021-01-29)
Bacterial infection in orthopedic surgery is challenging because cell wall components released after bactericidal treatment can alter osteoblast and osteoclast activity and impair fracture stability. However, the precise effects and mechanisms whereby cell wall components impair bone healing are unclear.
Guochang Huang et al.
PloS one, 14(1), e0209995-e0209995 (2019-01-18)
Squamous cell carcinoma-related oncogene (SCCRO, also known as DCUN1D1) is a component of the E3 for neddylation. As such, DCUN1D1 regulates the neddylation of cullin family members. Targeted inactivation of DCUN1D1 in mice results in male-specific infertility. Infertility in DCUN1D1-/-
L Kuzelova et al.
Reproduction in domestic animals = Zuchthygiene, 50(4), 580-586 (2015-04-29)
The goal of this study was to evaluate the occurrence of macrophages in rooster semen and to investigate their impact on the spermatozoa quality. Ross 308 breeder males (n = 30) with no evidence of genital tract infections were used to determine
Yoshiyuki Morishita et al.
International journal of nanomedicine, 10, 3475-3488 (2015-05-23)
Renal fibrosis is the final common pathway leading to end-stage renal disease. Although microRNA (miR) was recently shown to be involved in the development of renal fibrosis, few studies have focused on the effects on renal fibrosis of exogenous miR
Zhili Ma et al.
Theranostics, 9(10), 2967-2983 (2019-06-28)
The devastating prognosis of hepatocellular carcinoma (HCC) is partially attributed to chemotherapy resistance. Accumulating evidence suggests that the epithelial-mesenchymal transition (EMT) is a key driving force of carcinoma metastasis and chemoresistance in solid tumors. Leucine-rich repeat-containing G protein-coupled receptor 5
Francy L Crosby et al.
Applied and environmental microbiology, 81(6), 2206-2214 (2015-01-18)
Anaplasma marginale is the causative agent of anaplasmosis in cattle. Transposon mutagenesis of this pathogen using the Himar1 system resulted in the isolation of an omp10 operon insertional mutant referred to as the omp10::himar1 mutant. The work presented here evaluated
Chang Hee Woo et al.
Journal of biomaterials science. Polymer edition, 26(13), 841-854 (2015-06-23)
We designed bilayer composites composed of an upper layer of titanium dioxide (TiO2)-incorporated chitosan membrane and a sub-layer of human adipose-derived extracellular matrix (ECM) sheet as a wound dressing for full-thickness wound healing. The dense and fibrous top layer, which
Abdolrahman Omidinia-Anarkoli et al.
Acta biomaterialia, 113, 350-359 (2020-07-15)
Surface topographies at micro- and nanoscales can influence different cellular behavior, such as their growth rate and directionality. While different techniques have been established to fabricate 2-dimensional flat substrates with nano- and microscale topographies, most of them are prone to
Richard Cheng-An Chang et al.
Investigative ophthalmology & visual science, 56(4), 2367-2380 (2015-03-20)
The purpose of this study was to investigate the impact of obesity-induced prediabetes/early diabetes on the retina to provide new evidence on the pathogenesis of type 2 diabetes-associated diabetic retinopathy (DR). A high-fat diet (HFD)-induced obesity mouse model (male C57BL/6J)
Halina T Norbertczak et al.
Tissue engineering. Part C, Methods, 26(11), 565-576 (2020-10-15)
Intervertebral disc (IVD) degeneration is a major cause of back pain. Current surgical interventions have limitations. An alternative approach is to replace degenerated IVDs with a natural biological scaffold. The removal of cellular components from human IVDs should render them
Sayali Dharmadhikari et al.
Acta biomaterialia, 102, 181-191 (2019-11-11)
The ideal construct for tracheal replacement remains elusive in the management of long segment airway defects. Tissue engineered tracheal grafts (TETG) have been limited by the development of graft stenosis or collapse, infection, or lack of an epithelial lining. We
Can Jiang et al.
Inflammation, 42(1), 20-34 (2018-08-15)
Poor homing of cells after transplantation is an unresolved common issue in cardiac cell therapies. To enhance stem cell homing, the ligand CXC motif chemokine 12 (CXCL12) and its specific receptor CXC receptor type 4 (CXCR4) have been employed as
Cuilian Yu et al.
Journal of virology, 94(18) (2020-07-10)
Promyelocytic leukemia nuclear bodies (PML-NBs) possess an important intrinsic antiviral activity against alphaherpesvirus infection. PML is the structural backbone of NBs, comprising different isoforms. However, the contribution of each isoform to alphaherpesvirus restriction is not well understood. Here, we report
Stephen Lee et al.
The American journal of surgical pathology, 38(1), 54-59 (2013-09-26)
The tunica vaginalis is an embryologically derived mesothelium-lined outpouching of the peritoneal cavity, which may develop neoplastic mesothelial proliferations similar to, although much less commonly than, pleural or peritoneal surfaces. We herein report our experience with 12 cases of florid
Lifu Xiao et al.
Analytica chimica acta, 843, 73-82 (2014-08-26)
Epidermal growth factor receptor (EGFR) is widely used as a biomarker for pathological grading and therapeutic targeting of human cancers. This study investigates expression, spatial distribution as well as the endocytosis of EGFR in single breast cancer cells using surface-enhanced
Yinpei Luo et al.
Frontiers in aging neuroscience, 12, 134-134 (2020-07-01)
Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disease. Intervention in the early stage of AD is a new path for AD treatment that is being explored. The behavioral and pathological effects of anodal transcranial direct current stimulation (AtDCS) at
Haoyuan Yu et al.
Brain research bulletin, 165, 161-168 (2020-10-14)
The effects of autophagy on neuronal damage can be positive or detrimental negative. Through establishing a model of fetal rat cortical neuron hydraulic shock injury, dipotassium bisperoxo (picolinoto) oxovanadate (V) [bpv(pic)] was used to inhibit PTEN at different time points
Hailey A Parry et al.
Frontiers in physiology, 10, 436-436 (2019-05-02)
The current study investigated how bovine milk extracellular vesicles (EVs) affected rotarod performance and biomarkers of skeletal muscle physiology in young, growing rats. Twenty-eight-day Fisher 344 rats were provided an AIN-93G-based diet for 4 weeks that either remained unadulterated [EVs
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