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P2870

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Yiqin Shi et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 5129-5139 (2014-10-05)
Diffuse pulmonary hemorrhage (DPH) is an uncommon but critical complication of systemic lupus erythematosus. Peritoneal administration of 2,6,10,14-tetramethylpentadecane (pristane) can recapitulate a lupus-like syndrome in mice, which can develop into DPH within a few weeks, especially in C57BL/6 mice. Mac-1...
D Kienhöfer et al.
PloS one, 9(12), e115474-e115474 (2014-12-24)
Apart from their role in the immune defence against pathogens evidence of a role of antimicrobial peptides (AMPs) in autoimmune diseases has accumulated in the past years. The aim of this project was to examine the functional impact of the...
R Holmdahl et al.
Immunological reviews, 184, 184-202 (2002-06-28)
Rat models are useful for studies of the pathogenesis of rheumatoid arthritis (RA) since rats are extraordinarily sensitive to induction of arthritis with adjuvants. Injection of not only the classical complete Freund's adjuvant but also mineral oil without mycobacteria and...
Chih-Hung Chen et al.
Chemosphere, 233, 843-851 (2019-07-26)
The bioremediation efficiency of petroleum hydrocarbons in natural soil-water systems is regulated by active microbial populations and other system parameters. Relevant factors include the transfer rate of petroleum contaminants from a medium into microorganisms, the partitioning behavior of contaminants from...
Allison Sang et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1609-1621 (2014-07-13)
AM14 rheumatoid factor (RF) B cells in the MRL/lpr mice are activated by dual BCR and TLR7/9 ligation and differentiate into plasmablasts via an extrafollicular (EF) route. It was not known whether this mechanism of activation of RF B cells...
Qiufang Ouyang et al.
Journal of immunology research, 2014, 613136-613136 (2014-08-20)
We investigated the protective role of chloroquine against pristane-induced macrophage activation, oxidative stress, and Th1/Th2 skewness in C57BL/6J mice. Those mice were treated with pristane alone or combined with chloroquine. Hematological and biochemical parameters, macrophage phagocytic function, the oxidant/antioxidant index...
Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat.
Tuncel J
PLoS ONE, 11, e0155936-e0155936 (2016)
Allison Sang et al.
PloS one, 9(8), e102151-e102151 (2014-08-06)
The breakdown in tolerance of autoreactive B cells in the lupus-prone NZM2410-derived B6.Sle1.Sle2.Sle3 (TC) mice results in the secretion of autoantibodies. TC dendritic cells (DCs) enhance B cell proliferation and antibody secretion in a cytokine-dependent manner. However, the specific cytokine...
Marli L Moraes et al.
Journal of nanoscience and nanotechnology, 19(7), 3772-3776 (2019-02-16)
The diagnostics of the autoimmune hemolytic anemia (AIHA), a rare disease caused by autoantibody-induced hemolysis, is still prone to false positives for it is based on visual observation in the so-called Direct Coombs test. In this study, we developed a...
Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse.
Sanchez-Gonzalez B
Mediators of Inflammation, 2015, 313140-313140 (2015)
Rahul D Pawar et al.
Clinical immunology (Orlando, Fla.), 154(1), 49-65 (2014-06-28)
The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here...
Christine M Coquery et al.
PloS one, 9(7), e102284-e102284 (2014-07-11)
Despite increased frequencies of neutrophils found in autoimmune diseases such as systemic lupus erythematosus (SLE), how they contribute to disease pathogenesis and the mechanisms that affect the accumulation of neutrophils are poorly understood. The aim of this study was to...
D A C Botte et al.
Clinical and experimental immunology, 177(2), 381-390 (2014-03-29)
Alpha-melanocyte stimulating hormone (α-MSH) is a neuropeptide exhibiting anti-inflammatory activity in experimental models of autoimmune diseases. However, no studies thus far have examined the effects of α-MSH on systemic lupus erythematosus (SLE). This study aimed to determine the effects of...
Lei Cao et al.
Science advances, 7(5) (2021-02-12)
Na+/K+-ATPase (NKA) plays important roles in maintaining cellular homeostasis. Conversely, reduced NKA activity has been reported in aging and neurodegenerative diseases. However, little is known about the function of NKA in the pathogenesis of Parkinson's disease (PD). Here, we report...
Zhuo-Long Wang et al.
PloS one, 9(12), e114792-e114792 (2014-12-17)
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of autoantibodies. To date, no therapy has been found to satisfactorily treat SLE. SIRT1 deficiency results in the development of an autoimmune syndrome in mice, including a...
Sae Won Kim et al.
Oncotarget, 5(5), 1226-1240 (2014-04-10)
Identification of novel biomarkers for tumor-initiating cells (TICs) is of critical importance for developing diagnostic and therapeutic strategies against cancers. Here we identified the role of KIAA1114, a full-length translational product of the trophinin gene, as a distinctive marker for...
Mehdi Yousefi et al.
Human vaccines & immunotherapeutics, 10(2), 344-351 (2013-10-16)
Tetanus is caused by the tetanus neurotoxin (TeNT), a 150 kDa single polypeptide molecule which is cleaved into an active two-chain molecule composed of a 50 kDa N-terminal light (L) and a 100 kDa C-terminal heavy (H) chains. Recently, extensive...
K Gadó et al.
Haematologica, 86(3), 227-236 (2001-03-20)
There is no ideal animal model for human multiple myeloma (MM). All the models resemble the human disease in some respect, but none of them fulfils all the criteria of a perfect animal model. The pristane oil (2,6,10,12-tetramethylpentadecane)-induced mouse plasmacytoma...
Sabrina Haag et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2539-2550 (2015-02-13)
Rheumatoid arthritis (RA) is associated with amino acid variants in multiple MHC molecules. The association to MHC class II (MHC-II) has been studied in several animal models of RA. In most cases these models depend on T cells restricted to...
Andrew T Bender et al.
Translational research : the journal of laboratory and clinical medicine, 163(6), 515-532 (2014-01-28)
Lupus is an autoimmune disease with a poorly understood etiology that manifests with a diverse pathology. This heterogeneity has been a challenge to clinical drug development efforts. A related difficulty is the uncertain translational power of animal models used for...
Masayuki Ikeda et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12029-12038 (2014-09-05)
The hypothalamic suprachiasmatic nucleus (SCN) plays a pivotal role in the mammalian circadian clock system. Bmal1 is a clock gene that drives transcriptional-translational feedback loops (TTFLs) for itself and other genes, and is expressed in nearly all SCN neurons. Despite...
Gil Amarilyo et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 540-543 (2014-06-13)
The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of...
Acid-mediated reactions under microfluidic conditions: a new strategy for practical synthesis of biofunctional natural products.
Tanaka K and Fukase K
Beilstein Journal of Organic Chemistry, 5, 40-40 (2009)
Arnab Das et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 37(8), 394-406 (2014-09-10)
Carcinoembryonic antigen (CEA) is one of the promising tumor antigens mainly associated with carcinoma of the colon, lung, breast, etc. and received wide attention for cancer immunotherapy. Neem leaf glycoprotein (NLGP), an effective immunomodulator, is able to generate humoral and...
Zhenlu Chong et al.
Cellular & molecular immunology, 15(12), 1057-1070 (2018-10-03)
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, and the pathogenesis of SLE has not been fully elucidated. The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and...
Mohsen Rokni et al.
International immunopharmacology, 59, 295-300 (2018-04-21)
Murine hybridoma cells can produce monoclonal antibody (MAb) and the production of these antibodies in culture and peritoneum can be affected by different factors, including stimulants, inhibitors and supplements. Among these factors, the impact of micronutrients on the production of...
J Michelle Kahlenberg et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(1), 152-162 (2014-01-23)
Systemic lupus erythematosus (SLE) is a systemic autoimmune syndrome associated with organ damage and an elevated risk of cardiovascular disease resulting from activation of both innate and adaptive immune pathways. Recently, increased activation of the inflammasome machinery in SLE has...
WeiYu Lin et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 215-224 (2014-10-11)
To determine whether a combination of B cell depletion and BAFF blockade is more effective than monotherapy in treating models of spontaneous or accelerated systemic lupus erythematosus (SLE) in (NZB × NZW)F1 mice. Clinical parameters such as disease progression-free survival...
M Satoh et al.
Clinical and experimental immunology, 121(2), 399-405 (2000-08-10)
Unlike other agents associated with drug-induced lupus, the isoprenoid alkane pristane induces autoantibodies pathognomonic of lupus, including anti-Sm, anti-dsDNA, and anti-ribosomal P in BALB/c and SJL/J mice. The susceptibility of other strains of mice to pristane-induced lupus is unknown and...
Sudesh Pawaria et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3288-3295 (2014-08-26)
Systemic lupus erythematosus (SLE) is a type I IFN (IFN-I)-driven autoimmune disorder with exaggerated B and Th cell responses. Th17 cells, a recently identified Th cell subset, have been strongly implicated in the pathogenesis of SLE. Because IFN-I suppresses the...
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