Showing 1-30 of 32 results for "P3053"
Hai-Xia Lu et al.
Brain research bulletin, 84(2), 169-173 (2010-12-15)
Cerebellar ataxia is a high profile cerebella disorder currently without viable treatment. In order to establish an in vitro model of cerebellar ataxia for evaluating the potential of neural stem cells (NSC) to repair damage caused by cerebella disorders, organotypic...
Angel Moldes-Anaya et al.
Drug and chemical toxicology, 32(1), 26-37 (2009-06-12)
Penitrem A is a potent neurotoxin produced by several species in the genus Penicillium, which primarily affects the central nervous system. The toxin has several effects on neurotransmitter release, both at the central and peripheral level, as well as on...
Peter R Lewis et al.
The Medical journal of Australia, 182(11), 582-584 (2005-06-09)
We report on an elderly couple who presented with a syndrome that included severe generalised tremor and incoordination after eating soup from a damaged can. Black mould contaminating the can was subcultured and the fungus Penicillium crustosum was identified. This...
Mary K McGahon et al.
Investigative ophthalmology & visual science, 46(9), 3281-3287 (2005-08-27)
By their control of membrane potential and intracellular free Ca(2+) ([Ca(2+)](i)), K(+) currents are pivotal in the regulation of arterial smooth muscle tone. The goal of the present study was to identify and characterize the A-type K(+) current in retinal...
Thomas Rundberget et al.
Mycopathologia, 157(3), 349-357 (2004-06-08)
The levels of penitrems A, B, C, D, E, F, roquefortine C and thomitrem A and E recovered from extracts of 36 Norwegian, 2 American and one each of Japanese, German, South African, Danish and Fijian isolates of Penicillum crustosum...
Léna Borbouse et al.
American journal of physiology. Heart and circulatory physiology, 297(5), H1629-H1637 (2009-09-15)
The role of large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in regulation of coronary microvascular function is widely appreciated, but molecular and functional changes underlying the deleterious influence of metabolic syndrome (MetS) have not been determined. Male Ossabaw miniature swine consumed for...
Shinichi Asano et al.
The Journal of pharmacology and experimental therapeutics, 342(2), 453-460 (2012-05-15)
Large conductance, Ca(2+)/voltage-sensitive K(+) channels (BK channels) are well characterized, but their physiological roles, often determined through pharmacological manipulation, are less clear. Iberiotoxin is considered the "gold standard" antagonist, but cost and membrane-impermeability limit its usefulness. Economical and membrane-permeable alternatives...
Ciprian Dospinescu et al.
American journal of physiology. Lung cellular and molecular physiology, 303(5), L476-L486 (2012-07-10)
Hypoxia contracts the pulmonary vein, but the underlying cellular effectors remain unclear. Utilizing contractile studies and whole cell patch-clamp electrophysiology, we report for the first time a hypoxia-sensitive K(+) current in porcine pulmonary vein smooth muscle cells (PVSMC). Hypoxia induced...
Acute penitrem A and roquefortine poisoning in a dog
Walter SL
The Canadian Veterinary Journal. La Revue Veterinaire Canadienne, 43(5), 372-372 (2002)
Barry D Kyle et al.
American journal of physiology. Cell physiology, 305(6), C609-C622 (2013-06-28)
We used the perforated patch-clamp technique at 37°C to investigate the mechanisms underlying the activation of a transient large-conductance K(+) (tBK) current in rabbit urethral smooth muscle cells. The tBK current required an elevation of intracellular Ca(2+), resulting from ryanodine...
Claudia Welz et al.
PLoS pathogens, 7(4), e1001330-e1001330 (2011-04-15)
The calcium-gated potassium channel SLO-1 in Caenorhabditis elegans was recently identified as key component for action of emodepside, a new anthelmintic drug with broad spectrum activity. In this study we identified orthologues of slo-1 in Ancylostoma caninum, Cooperia oncophora, and...
Lihong Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(48), 19023-19028 (2007-11-21)
Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Reduction of autophagy activity has been shown to lead to the accumulation of misfolded proteins in neurons and may be involved in chronic neurodegenerative...
Angel Moldes-Anaya et al.
Toxicon : official journal of the International Society on Toxinology, 60(8), 1428-1435 (2012-10-23)
Several cases of neurological disease in dogs after poisoning by food- and feed-borne Penicillium toxins in Norway during the last years have uncovered a lack of knowledge regarding the toxicity and mechanism of action of neuroactive mycotoxins. In the present...
H G Knaus et al.
Biochemistry, 33(19), 5819-5828 (1994-05-17)
Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminants. The mode of action of these fungal mycotoxins is not understood but may be related to their known effects on neurotransmitter release. To determine whether these effects could be...
Ching-Chia Chang Chien et al.
Journal of biomedical science, 22, 42-42 (2015-06-17)
5-hydroxytryptamine (5-HT)-induced coronary artery responses have both vasoconstriction and vasorelaxation components. The vasoconstrictive effects of 5-HT have been well studied while the mechanism(s) of how 5-HT causes relaxation of coronary arteries has been less investigated. In isolated rat hearts, 5-HT-induced...
Hai-xia Lu et al.
Brain research, 1207, 207-213 (2008-04-01)
Purkinje cell loss is the hallmark of the cerebellar ataxias. Here the fungal neurotoxin Penitrem A was used to create partially Purkinje-cell-deficient cerebella in neonate and young adult rats suitable for use in neural stem cell transplantation studies. I.p. administration...
Léna Borbouse et al.
American journal of physiology. Heart and circulatory physiology, 298(3), H966-H973 (2010-01-02)
This investigation was designed to examine the hypothesis that impaired function of coronary microvascular large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in metabolic syndrome (MetS) significantly attenuates the balance between myocardial oxygen delivery and metabolism at rest and during exercise-induced increases in...
Angel S Moldes-Anaya et al.
Neurochemistry international, 59(7), 1074-1081 (2011-09-20)
The effects of the fungal neurotoxin penitrem A on the GABAergic and glutamatergic systems in rat brain were evaluated. Penitrem A inhibited binding of the GABA(A)-receptor ligand [³H]TBOB to rat forebrain and cerebellar membrane preparations with IC₅₀ (half maximal inhibitory...
Akitoshi Ohno et al.
Biochemical and biophysical research communications, 378(4), 867-871 (2008-12-17)
The expression of large-conductance Ca(2+)-activated K(+) (BK) channel protein in amygdala complex was higher in adult (8-10 weeks old) male rats than in female. Castration at 4-6 weeks old significantly reduced BK channel expression in amygdala to the level similar...
Silva Sonjak et al.
FEMS microbiology ecology, 53(1), 51-60 (2005-12-07)
Penicillium crustosum is common in food and feed both in subtropical and temperate regions. Recently, it has also been found occurring frequently in glacier ice, sea ice and sea water of Arctic regions of Svalbard. The aim of the study...
Karen D McCloskey
The Journal of urology, 173(1), 296-301 (2004-12-14)
Outward currents were characterized from cells resembling interstitial cells of Cajal (ICCs) isolated from the detrusor of the guinea pig bladder. ICC-like cells were studied using the whole cell patch clamp technique and K+ filled pipettes. Outward currents were evoked...
Penitrem A and analogues: Toxicokinetics, toxicodynamics including mechanism of action and clinical significance
Eriksen GS, et al.
World Mycotoxin Journal, 6(3), 263-272 (2013)
Roger D Kouyos et al.
PLoS pathogens, 7(4), e1001334-e1001334 (2011-05-03)
The evolution of drug resistant bacteria is a severe public health problem, both in hospitals and in the community. Currently, some countries aim at concentrating highly specialized services in large hospitals in order to improve patient outcomes. Emergent resistant strains...
B Kyle et al.
American journal of physiology. Cell physiology, 301(5), C1186-C1200 (2011-08-05)
We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and biophysical properties with K(v)2.1 and K(v)2.2 channels cloned from the rabbit urethra and stably expressed in human embryonic kidney...
Elizabeth R Tor et al.
Analytical chemistry, 78(13), 4624-4629 (2006-07-01)
A rapid LC-MS/MS method, using a triple quadrupole/linear ion trap mass spectrometer, was developed for determination of penitrem A and roquefortine C in serum and urine samples. Penitrem A and roquefortine C were extracted from samples with methylene chloride. The...
H F Berntsen et al.
Neurotoxicology, 35, 129-136 (2013-01-15)
The fungal neurotoxin penitrem A has previously been found to cause neurological disorders in animals and humans after ingestion of contaminated food and/or feed. It penetrates the blood-brain-barrier and causes cerebellar pathology in rats, including mild effects on granule neurons....
Mark W Sumarah et al.
Mycopathologia, 159(4), 571-577 (2005-06-29)
Penicillium roqueforti, P. crustosum and P. paneum grow on ensiled grain and recycled feed unless properly treated. The former two species occur also on cut lumber in Canada. These are known to produce a number of secondary metabolites including roquefortine....
Silvio Uhlig et al.
Toxins, 12(5) (2020-05-08)
The tremorgenic mycotoxin penitrem A is produced by Penicillium species as a secondary metabolite on moldy food and feed. Dogs are sometimes exposed to penitrem A by consumption of spoiled food waste or fallen fruit. The lipophilic toxin crosses the...
Prolonged activation of ca2+-activated k+ current contributes to the long-lasting refractory period ofaplysia bag cell neurons
Zhang Y, et al.
The Journal of Neuroscience, 22(23), 10134-10141 (2002)
W R Sones et al.
British journal of pharmacology, 158(2), 521-531 (2009-08-04)
Recent pharmacological studies have proposed there is a high degree of similarity between calcium-activated Cl(-) channels (CaCCs) and large conductance, calcium-gated K(+) channels (K(Ca)1.1). The goal of the present study was to ascertain whether blockers of K(Ca)1.1 inhibited calcium-activated Cl(-)...

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