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Rong-Hu Ke et al.
Journal of neuro-oncology, 118(2), 369-376 (2014-04-18)
Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2) has been indicated to have a critical role in various tumors. In the study, we aimed to evaluate the LASS2 expression level in prognostic significance and compare it with commonly...
Carolina Panis et al.
Cancer letters, 357(1), 186-195 (2014-12-02)
Overexpression of human epithelial growth factor receptor 2 (HER2) is a poor prognostic factor in breast cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity. Receptor...
Xiu Xu et al.
FEBS letters, 588(9), 1580-1589 (2014-03-19)
Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mice are...
Hsun-Ming Chang et al.
The Journal of clinical endocrinology and metabolism, 99(10), E1922-E1932 (2014-07-26)
Exerting a broad range of biological effects in various tissues, activins are homo- or heterodimers of activin/inhibin β-subunits (βA, βB, βC, and βE in humans). Although activins A (βAβA), B (βBβB), AB (βAβB), and AC (βAβC) have been demonstrated in...
Progesterone for traumatic brain injury--resisting the sirens' song.
Lee H Schwamm
The New England journal of medicine, 371(26), 2522-2523 (2014-12-11)
Jennifer R Taube et al.
Human molecular genetics, 23(20), 5464-5478 (2014-06-04)
Alternative splicing of the proteolipid protein 1 gene (PLP1) produces two forms, PLP1 and DM20, due to alternative use of 5' splice sites with the same acceptor site in intron 3. The PLP1 form predominates in central nervous system RNA....
Maria Teresa Dell'Anno et al.
The Journal of clinical investigation, 124(7), 3215-3229 (2014-06-18)
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional...
Xindong Zhang et al.
BMC bioinformatics, 16, 92-92 (2015-04-19)
Identifying diagnosis and prognosis biomarkers from expression profiling data is of great significance for achieving personalized medicine and designing therapeutic strategy in complex diseases. However, the reproducibility of identified biomarkers across tissues and experiments is still a challenge for this...
Hideyuki Ohzawa et al.
Breast cancer (Tokyo, Japan), 21(5), 563-570 (2012-10-31)
The effectiveness of neoadjuvant chemotherapy is evaluated on the basis of pathological responses and survival outcome, because achievement of a pathological complete response (pCR) is a good predictor of long-term survival. However, few studies have assessed the survival of breast...
Xiao-Huan Liang et al.
The Journal of biological chemistry, 289(34), 23534-23545 (2014-07-12)
Embryo implantation is a highly synchronized process between an activated blastocyst and a receptive uterus. Successful implantation relies on the dynamic interplay of estrogen and progesterone, but the key mediators underlying embryo implantation are not fully understood. Here we show...
Esteban Grasso et al.
The Journal of endocrinology, 221(1), 121-131 (2014-02-05)
During early pregnancy, the human uterus undergoes profound tissue remodeling characterized by leukocyte invasion and production of proinflammatory cytokines, followed by tissue repair and tolerance maintenance induction. Vasoactive intestinal peptide (VIP) is produced by trophoblast cells and modulates the maternal...
Jee Hyun Kim et al.
Journal of Korean medical science, 29(9), 1266-1270 (2014-09-24)
This prospective study investigated the relationship between anti-Müllerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was...
Ana Cristina S Herrera et al.
Clinical breast cancer, 14(6), 451-459 (2014-08-01)
Recent studies have suggested a regulatory role for some of the metabolites derived from oxidative stress in breast cancer. In this way, cancer-induced oxidative changes could modify the breast environment and potentially trigger systemic responses that may affect disease prognosis and...
Si Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 78-89 (2014-06-15)
In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenicity, i.e., other...
Jianfeng Zhang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 65, 15-20 (2014-09-10)
We assessed the efficacy of biodegradable microspheres (MSs) containing nomegestrol acetate (NOMAC) for treatment of endometriosis in a rat model and investigated its preliminary mechanism of action. Sprague-Dawley rats with surgically implanted endometrial autografts were divided randomly into four groups...
Prevention of preterm parturition.
Jay D Iams
The New England journal of medicine, 370(19), 1861-1861 (2014-05-09)
Khatera Ibrahimi et al.
Neurology, 84(2), 125-131 (2014-12-17)
A case-control study to investigate the effect of the menstrual cycle on trigeminal nerve-induced vasodilation in healthy women and patients with menstrually related migraine (MRM). Using a laser-Doppler imager, we compared the vasodilator effects of capsaicin application and electrical stimulation...
Eddy J Chen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(6), 1273-1280 (2014-10-17)
The CYP17A1 inhibitor abiraterone markedly reduces androgen precursors and is thereby effective in castration-resistant prostate cancer (CRPC). However, abiraterone increases progesterone, which can activate certain mutant androgen receptors (AR) identified previously in flutamide-resistant tumors. Therefore, we sought to determine if...
Julie A Ray et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 330-336 (2014-08-12)
Challenges for steroid analysis by LC-MS/MS include low ionization efficiency, endogenous isobars with similar fragmentation patterns and chromatographic retention. Differential ion mobility spectrometry (DMS) provides an additional degree of separation prior to MS/MS detection, and shows promise in improving specificity...
Maureen E Groer et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 73(3), 193-198 (2014-09-18)
Little is known about postpartum immune recovery and relationships of common dysphoric moods, stress, immunology, and endocrinology. Healthy women (n = 72) were followed for six postpartum months with immune and hormone measures and dysphoric moods and stress scales. A panel of...
Weiming Zheng et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(3), 285-299 (2015-01-08)
Hormonal regulation of pituitary gonadotropin gene expression has been attributed to gonadotropin-releasing hormone (GnRH)-mediated stimulation of immediate early gene expression and gonadal steroid interactions with their respective nuclear receptors. A number of orphan nuclear receptors including steroidogenic factor 1, liver...
Juanjuan Wu et al.
Experimental cell research, 328(2), 351-360 (2014-08-31)
The actions of the transcription factor Nuclear factor erythroid 2-related factor (Nrf2) in breast cancer have been shown to include both pro-oncogenic and anti-oncogenic activities which is influenced, at least in part, by the hormonal environment. However, direct regulation of...
Imran A Khan et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(4), 566-571 (2013-11-06)
Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Insertion/deletion (I/D) polymorphism of a 287 bp Alu repetitive sequence in intron 16 of the angiotensin-converting enzyme (ACE) gene has been widely investigated in Asian Indian populations...
Francesco Massari et al.
Histology and histopathology, 29(10), 1295-1303 (2014-03-08)
Adenocarcinoma of the paraurethral glands represents a very rare neoplasm of the urinary tract. Due to the rarity of this disease, there is no standard therapeutic approach. We report a case of adenocarcinoma of the paraurethral glands in a 56-year-old...
Naoyuki Maeda et al.
PloS one, 10(2), e0117795-e0117795 (2015-02-24)
Corticosterone is synthesized in the adrenal glands and is circulated throughout the body to perform regulatory functions in various tissues. The testis is known to synthesize and secrete testosterone and other androgens. We developed an accurate method to measure steroid...
Michael Cho et al.
Contraception, 90(1), 94-96 (2014-03-07)
The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). Blood samples were obtained from 62 women. When COCs were grouped...
Miro Kasum et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29(8), 744-748 (2013-06-12)
The aim of this review is to analyze the relationship between the preovulatory progesterone (P) rise and the in vitro fertilization (IVF) pregnancy outcome. It also investigates the sources and effects of P level increase, including the underlying mechanisms and...
Amandine Grimm et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2427-2438 (2014-10-05)
The brain has high energy requirements to maintain neuronal activity. Consequently impaired mitochondrial function will lead to disease. Normal aging is associated with several alterations in neurosteroid production and secretion. Decreases in neurosteroid levels might contribute to brain aging and...
Wen-Bo Deng et al.
Endocrinology, 155(7), 2704-2717 (2014-05-07)
Thyroid dysfunction during human pregnancy is closely related to serious pregnancy outcome. However, the regulation and function of thyroid hormones during early pregnancy are largely unknown. We found that type II deiodinase, an enzyme converting T4 to activated T3, is...
Hua Zhao et al.
BMC cancer, 15, 109-109 (2015-04-18)
The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple...
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