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S Cherkaoui et al.
Journal of pharmaceutical and biomedical analysis, 53(2), 172-178 (2010-03-03)
Due to their high specificity and efficiency, antibodies are ideal ligands for target-specific ultrasound contrast agents. The present study focuses on the chemical stability of antibodies during functionalisation with sulfosuccinimidyl-pyridyldithiopropionamidohexanoate (SPDP), a heterobifunctional linker, which exposes free thiol groups upon
Ranjit C Singh et al.
Indian journal of biochemistry & biophysics, 40(1), 31-39 (2003-02-01)
A ribosome-inactivating protein (RIP), luffin has been isolated from the seeds of Luffa cylindrica of Cucurbitaceae family by ammonium sulfate fractionation followed by cation exchange and gel-filtration chromatography. Extensive physico-chemical, immunological and biological characterizations were carried out on luffin and
Gerui Fan et al.
Acta biomaterialia, 30, 94-105 (2015-11-08)
Adenoviral vectors have attracted substantial interest for systemic tumor gene therapy, but further work is needed to reduce their immunogenicity and alter their biodistribution before they can be used in the clinic. Here we describe a bio-inspired, cleavable PEGylated β-cyclodextrin-polyethyleneimine
Yi He et al.
ACS applied materials & interfaces, 7(24), 13360-13366 (2015-06-03)
In this work, we have demonstrated a novel electrochemical method based on target-induced cleavage of a specific peptide for sensitive analysis of prostate specific antigen (PSA) by using silver enhancement. First, multiwalled carbon nanotubes/poly(amidoamine) dendrimers (MWCNTs-PAMAM) nanohybrids were assembled on
Xiao Huang et al.
Nature nanotechnology, 16(2), 214-223 (2020-12-16)
Biomaterials can improve the safety and presentation of therapeutic agents for effective immunotherapy, and a high level of control over surface functionalization is essential for immune cell modulation. Here, we developed biocompatible immune cell-engaging particles (ICEp) that use synthetic short
Xunqing Jiang et al.
Journal of virology, 90(24), 11007-11019 (2016-11-01)
The V1V2 region of HIV-1 gp120 harbors a major vulnerable site targeted by a group of broadly neutralizing monoclonal antibodies (MAbs) such as PG9 through strand-strand recognition. However, this epitope region is structurally polymorphic as it can also form a
Melvin E Klegerman et al.
Journal of liposome research, 24(3), 216-222 (2014-03-07)
Thermodynamic analysis of ligand-target binding has been a useful tool for dissecting the nature of the binding mechanism and, therefore, potentially can provide valuable information regarding the utility of targeted formulations. Based on a consistent coupling of antibody-antigen binding and
Julian P Sefrin et al.
Frontiers in immunology, 10, 1962-1962 (2019-09-27)
Anti-tumor immunity is limited by a number of factors including the lack of fully activated T-cells, insufficient antigenic stimulation and the immune-suppressive tumor microenvironment. We addressed these hurdles by developing a novel class of immunoconjugates, Antibody-Targeted Pathogen-derived Peptides (ATPPs), which
Jessica Méndez et al.
Bioconjugate chemistry, 23(4), 698-704 (2012-03-02)
Mesoporous silica nanoparticles (MSN) have emerged as an attractive class of drug delivery carriers for therapeutic agents. Herein, we explored the covalent immobilization of proteins into MSN to generate a stimulus-responsive controlled release system. First, MSN were functionalized with thiol
Marko Moser et al.
Analytical chemistry, 90(9), 5887-5895 (2018-04-11)
Many applications of nanometer- and micrometer-sized particles include their surface functionalization with linkers, sensor molecules, and analyte recognition moieties like (bio)ligands. This requires knowledge of the chemical nature and number of surface groups accessible for subsequent coupling reactions. Particularly attractive
Ying Ji et al.
Nanoscale, 11(20), 9987-10003 (2019-05-14)
Reduction-sensitive nanomedicine is a promising strategy to achieve controlled release of payloads in response to intracellular reductive milieu. However, endolysosomal sequestration of internalized carriers and insufficient redox potential in endolysosomes may delay the release of payloads and impact their therapeutic
Sagar V Chhabria et al.
Apoptosis : an international journal on programmed cell death, 20(10), 1388-1409 (2015-08-20)
Allicin, an extremely active constituent of freshly crushed garlic, is produced upon reaction of substrate alliin with the enzyme alliinase (EC 4.4.1.4). Allicin has been shown to be toxic to several mammalian cells in vitro in a dose-dependent manner. In
Junxiao Ye et al.
Theranostics, 7(9), 2495-2508 (2017-07-27)
Because of the unparalleled efficiency and universal utility in treating a variety of disease types, siRNA agents have evolved as the future drug-of-choice. Yet, the inability of the polyanionic siRNA macromolecules to cross the cell membrane remains as the bottleneck
Xueqin Zhao et al.
Nanoscale research letters, 14(1), 273-273 (2019-08-16)
RNA interference (RNAi) has potential advantages over other gene therapy approaches due to its high specificity and the ability to inhibit target gene expression. However, the stability and tissue-specific delivery of siRNA remain as the biggest obstacles for RNAi therapeutics.
Integrin-independent tyrosine phosphorylation of p125fak in human platelets stimulated by collagen.
Achison M
The Journal of Biological Chemistry, 276, 3167-3174 (2001)
Sebastian A Kollenda et al.
Acta biomaterialia, 109, 244-253 (2020-04-07)
Calcium phosphate nanoparticles were covalently surface-functionalized with the ligand DOTA and loaded with the radioisotope 68Ga. The biodistribution of such 68Ga-labelled nanoparticles was followed in vivo in mice by positron emission tomography in combination with computer tomography (PET-CT). The biodistribution
Kyoung Jin Lee et al.
Biomaterials, 255, 120151-120151 (2020-06-07)
Neoadjuvant radiotherapy has become an important therapeutic option for colorectal cancer (CRC) patients, whereas complete tumor response is observed only in 20-30% patients. Therefore, the development of diagnostic probe for radio-resistance is important to decide an optimal treatment timing and
Jia Zhu et al.
Biomaterials, 162, 47-59 (2018-02-13)
Despite the extracellular barriers for siRNA delivery have been overcome by utilizing advanced nanoparticle delivery systems, the key intracellular barriers after internalization including efficient disassembly of siRNA and endosomal escape still remains challenging. To address the issues, we developed a
Tobias Weber et al.
Journal of immunology research, 2015, 561814-561814 (2015-11-26)
Antibody-drug conjugates (ADCs) have evolved as a new class of potent cancer therapeutics. We here report on the development of ADCs with specificity for the B-cell lineage specific (surface) antigen CD22 being expressed in the majority of hematological malignancies. As
Stefano Rossi et al.
Immunology letters, 187, 47-52 (2017-05-18)
Coeliac disease (CD) is characterized by an intestinal lesion sustained by an abnormal mucosal T-cell response to wheat gliadin. An immunological approach that is able to suppress this immune response is a perspective worth pursuing. Several strategies of antigen administration
M Mollaev et al.
International journal of pharmaceutics, 559, 138-146 (2019-01-02)
Despite the presence of a variety of modern anticancer drugs at the market, doxorubicin (Dox) is still widely used in antineoplastic therapy, although its administration causes severe side effects. To enhance specific activity of such molecules, various approaches have been
Freidrich M Cruz et al.
The EMBO journal, 39(2), e102020-e102020 (2019-12-11)
For CD8 T lymphocytes to mount responses to cancer and virally-infected cells, dendritic cells must capture antigens present in tissues and display them as peptides bound to MHC-I molecules. This is most often accomplished through a pathway called antigen cross-presentation
Eyk A Schellenberger et al.
Chembiochem : a European journal of chemical biology, 5(3), 275-279 (2004-03-05)
We have developed techniques for the efficient synthesis and screening of small libraries of surface-functionalized nanoparticles for the recognition of specific types of cells. To illustrate this concept we describe the development of a nanoparticle that preferentially recognizes apoptotic Jurkat
Atsushi Shoji et al.
Journal of pharmaceutical and biomedical analysis, 95, 47-53 (2014-03-19)
Evaluation of cathepsin B activities for degrading collagen IV and heat-denatured collagen IV (gelatin) were performed by surface plasmon resonance (SPR) and circular dichroism (CD) measurements. The optimal pH of cathepsin B activity for degrading each substrate was around 4.0.
Hidenori Matsuo et al.
Journal of nanobiotechnology, 16(1), 59-59 (2018-08-06)
Various nanocarriers have been used to deliver subunit vaccines specifically to dendritic cells (DCs) for the improvement of immunogenicity. However, due to their insufficient DC priming ability, these vaccines could not elicit effective innate immunity. We have recently developed a
Da Li et al.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 35(6), 615-621 (2006-12-21)
To construct a novel gene delivery vector using polyethylenimine (PEI) as backbone modified with the peptide CP9 containing Arginine-Glycine-Aspartic acid (RGD) sequence and to verify its physicochemical characters and the gene delivery function. The chemical linker [N-Succinimidyl-3- (2-pyridyldithio) ] propionate
Targeting chemotherapy using antibody-combined liposome against human pancreatic cancer cell-line.
Akaishi S
The Tohoku Journal of Experimental Medicine, 175, 29-29 (1995)
Protein Engineering for Therapeutics (2012)
Bispecific Antibodies (2011)
Pu Zhang et al.
Nanoscale, 9(6), 2310-2316 (2017-01-31)
The construction of DNA nanomachines holds great significance in the development of DNA nanostructures; however, the real application of nanomachines is still in its early stage. Moreover, one-step regenerated sensing platforms for the detection of biomarkers in the current research
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