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Gerui Fan et al.
Acta biomaterialia, 30, 94-105 (2015-11-08)
Adenoviral vectors have attracted substantial interest for systemic tumor gene therapy, but further work is needed to reduce their immunogenicity and alter their biodistribution before they can be used in the clinic. Here we describe a bio-inspired, cleavable PEGylated β-cyclodextrin-polyethyleneimine
Yi He et al.
ACS applied materials & interfaces, 7(24), 13360-13366 (2015-06-03)
In this work, we have demonstrated a novel electrochemical method based on target-induced cleavage of a specific peptide for sensitive analysis of prostate specific antigen (PSA) by using silver enhancement. First, multiwalled carbon nanotubes/poly(amidoamine) dendrimers (MWCNTs-PAMAM) nanohybrids were assembled on
Sebastian A Kollenda et al.
Acta biomaterialia, 109, 244-253 (2020-04-07)
Calcium phosphate nanoparticles were covalently surface-functionalized with the ligand DOTA and loaded with the radioisotope 68Ga. The biodistribution of such 68Ga-labelled nanoparticles was followed in vivo in mice by positron emission tomography in combination with computer tomography (PET-CT). The biodistribution
M Mollaev et al.
International journal of pharmaceutics, 559, 138-146 (2019-01-02)
Despite the presence of a variety of modern anticancer drugs at the market, doxorubicin (Dox) is still widely used in antineoplastic therapy, although its administration causes severe side effects. To enhance specific activity of such molecules, various approaches have been
Eyk A Schellenberger et al.
Chembiochem : a European journal of chemical biology, 5(3), 275-279 (2004-03-05)
We have developed techniques for the efficient synthesis and screening of small libraries of surface-functionalized nanoparticles for the recognition of specific types of cells. To illustrate this concept we describe the development of a nanoparticle that preferentially recognizes apoptotic Jurkat
Ranjit C Singh et al.
Indian journal of biochemistry & biophysics, 40(1), 31-39 (2003-02-01)
A ribosome-inactivating protein (RIP), luffin has been isolated from the seeds of Luffa cylindrica of Cucurbitaceae family by ammonium sulfate fractionation followed by cation exchange and gel-filtration chromatography. Extensive physico-chemical, immunological and biological characterizations were carried out on luffin and
Sagar V Chhabria et al.
Apoptosis : an international journal on programmed cell death, 20(10), 1388-1409 (2015-08-20)
Allicin, an extremely active constituent of freshly crushed garlic, is produced upon reaction of substrate alliin with the enzyme alliinase (EC 4.4.1.4). Allicin has been shown to be toxic to several mammalian cells in vitro in a dose-dependent manner. In
Jessica Méndez et al.
Bioconjugate chemistry, 23(4), 698-704 (2012-03-02)
Mesoporous silica nanoparticles (MSN) have emerged as an attractive class of drug delivery carriers for therapeutic agents. Herein, we explored the covalent immobilization of proteins into MSN to generate a stimulus-responsive controlled release system. First, MSN were functionalized with thiol
Robert H Mo et al.
Molecular pharmaceutics, 9(2), 299-309 (2011-12-17)
Cell penetrating peptides (CPPs) are short strands of arginine- and/or lysine-rich peptides (<30 amino acids) that use their cationic nature for efficient intracellular accumulation. CPPs have been used for small interfering RNA (siRNA) delivery by direct complexation with the siRNA
Marko Moser et al.
Analytical chemistry, 90(9), 5887-5895 (2018-04-11)
Many applications of nanometer- and micrometer-sized particles include their surface functionalization with linkers, sensor molecules, and analyte recognition moieties like (bio)ligands. This requires knowledge of the chemical nature and number of surface groups accessible for subsequent coupling reactions. Particularly attractive
Jia Zhu et al.
Biomaterials, 162, 47-59 (2018-02-13)
Despite the extracellular barriers for siRNA delivery have been overcome by utilizing advanced nanoparticle delivery systems, the key intracellular barriers after internalization including efficient disassembly of siRNA and endosomal escape still remains challenging. To address the issues, we developed a
Junxiao Ye et al.
Theranostics, 7(9), 2495-2508 (2017-07-27)
Because of the unparalleled efficiency and universal utility in treating a variety of disease types, siRNA agents have evolved as the future drug-of-choice. Yet, the inability of the polyanionic siRNA macromolecules to cross the cell membrane remains as the bottleneck
Julian P Sefrin et al.
Frontiers in immunology, 10, 1962-1962 (2019-09-27)
Anti-tumor immunity is limited by a number of factors including the lack of fully activated T-cells, insufficient antigenic stimulation and the immune-suppressive tumor microenvironment. We addressed these hurdles by developing a novel class of immunoconjugates, Antibody-Targeted Pathogen-derived Peptides (ATPPs), which
S Cherkaoui et al.
Journal of pharmaceutical and biomedical analysis, 53(2), 172-178 (2010-03-03)
Due to their high specificity and efficiency, antibodies are ideal ligands for target-specific ultrasound contrast agents. The present study focuses on the chemical stability of antibodies during functionalisation with sulfosuccinimidyl-pyridyldithiopropionamidohexanoate (SPDP), a heterobifunctional linker, which exposes free thiol groups upon
Xiao Huang et al.
Nature nanotechnology, 16(2), 214-223 (2020-12-16)
Biomaterials can improve the safety and presentation of therapeutic agents for effective immunotherapy, and a high level of control over surface functionalization is essential for immune cell modulation. Here, we developed biocompatible immune cell-engaging particles (ICEp) that use synthetic short
Melvin E Klegerman et al.
Journal of liposome research, 24(3), 216-222 (2014-03-07)
Thermodynamic analysis of ligand-target binding has been a useful tool for dissecting the nature of the binding mechanism and, therefore, potentially can provide valuable information regarding the utility of targeted formulations. Based on a consistent coupling of antibody-antigen binding and
Da Li et al.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 35(6), 615-621 (2006-12-21)
To construct a novel gene delivery vector using polyethylenimine (PEI) as backbone modified with the peptide CP9 containing Arginine-Glycine-Aspartic acid (RGD) sequence and to verify its physicochemical characters and the gene delivery function. The chemical linker [N-Succinimidyl-3- (2-pyridyldithio) ] propionate
Immobilization of gene vectors on bisphosphonate-mediated gene-eluting metal stents using antibody for localized gene delivery.
Yong Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e173-e174 (2011-12-27)
Ludivine Vossier et al.
Transfusion, 59(1), 277-286 (2018-11-16)
Despite current preventive strategies, bacterial contamination of platelets is the highest residual infectious risk in transfusion. Bacteria can grow from an initial concentration of 0.03-0.3 colony-forming units (CFUs)/mL up to 108 to 109 CFUs/mL over the product shelf life. The
Targeting chemotherapy using antibody-combined liposome against human pancreatic cancer cell-line.
Akaishi S
The Tohoku Journal of Experimental Medicine, 175, 29-29 (1995)
Keith A Luhrs et al.
Oncotarget, 8(10), 16275-16292 (2017-02-12)
Necrosis is induced by ischemic conditions within the core of many solid tumors. Using fluorescent fusion proteins, we provide in vivo evidence of histone trafficking among cancer cells in implanted tumors. In particular, the most abundant H1 isoform (H1.2) was
Dagmar Högemann-Savellano et al.
Neoplasia (New York, N.Y.), 5(6), 495-506 (2004-02-18)
Noninvasive imaging of differences between the molecular properties of cancer and normal tissue has the potential to enhance the detection of tumors. Because overexpression of endogenous transferrin receptor (TfR) has been qualitatively described for various cancers and is presumably due
Yusuke Kitamura et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(8), 959-964 (2020-02-18)
Ferrocene (Fc) and β-cyclodextrin (βCyD) were modified at each end of stem-loop structured DNA as an electrochemical signal generator and its quencher, respectively, to give an electrochemical molecular beacon (eMB). A relatively high efficiency of signal quenching was achieved by
Luis J Cruz et al.
Molecular pharmaceutics, 11(12), 4299-4313 (2014-10-08)
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs), involved in the induction of immunity and currently exploited for antitumor immunotherapies. An optimized noninvasive imaging modality capable of determining and quantifying DC-targeted nanoparticle (NP) trajectories could provide valuable information
Xuesong Shi et al.
Nucleic acids research, 45(8), e64-e64 (2017-01-22)
The conformational ensembles of structured RNA's are crucial for biological function, but they remain difficult to elucidate experimentally. We demonstrate with HIV-1 TAR RNA that X-ray scattering interferometry (XSI) can be used to determine RNA conformational ensembles. X-ray scattering interferometry
Lin Mei et al.
The journal of gene medicine, 8(6), 690-698 (2006-04-25)
Conventional strategies of gene therapy using viral vectors result in suboptimal localization and potentially dangerous distal spread of vector. We hypothesized that localized delivery of adenoviral gene vectors could be achieved from a polyurethane (PU) film through a mechanism involving
Xiaoli Li et al.
International journal of nanomedicine, 12, 6963-6972 (2017-10-17)
Hemangioma is a common benign tumor affecting infants. In this study, we prepared sodium morrhuate immunoliposomes through encapsulation of sodium morrhuate with liposomes coupled with an anti-VEGFR2/KDR antibody and examined its effect on the biology of human hemangioma endothelial cells
J Carlsson et al.
The Biochemical journal, 173(3), 723-737 (1978-09-01)
A heterobifunctional reagent, N-succinimidyl 3-(2-pyridyldithio)propionate, was synthesized. Its N-hydroxysuccinimide ester group reacts with amino groups and the 2-pyridyl disulphide structure reacts with aliphatic thiols. A new thiolation procedure for proteins is based on this reagent. The procedure involves two steps.
Ambra Giannetti et al.
Sensors (Basel, Switzerland), 15(5), 9666-9680 (2015-04-29)
Optical fiber sensors, thanks to their compactness, fast response and real-time measurements, have a large impact in the fields of life science research, drug discovery and medical diagnostics. In recent years, advances in nanotechnology have resulted in the development of
Jikui Wu et al.
Sensors (Basel, Switzerland), 19(12) (2019-06-21)
The sensitive detection of Pb2+ is of significant importance for food safety, environmental monitoring, and human health care. To this end, a novel fluorescent biosensor, DNAzyme-functionalized R-phycoerythrin (DNAzyme-R-PE), was presented for Pb2+ analysis. The biosensor was prepared via the immobilization
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