Showing 1-30 of 51 results for "P3510"
Knut Fredrik Seip et al.
Journal of chromatography. A, 1347, 1-7 (2014-05-06)
Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical...
Jillian M Hagel et al.
The Journal of biological chemistry, 287(51), 42972-42983 (2012-11-03)
Benzylisoquinoline alkaloids are a diverse class of plant specialized metabolites that includes the analgesic morphine, the antimicrobials sanguinarine and berberine, and the vasodilator papaverine. The two-electron oxidation of dihydrosanguinarine catalyzed by dihydrobenzophenanthridine oxidase (DBOX) is the final step in sanguinarine...
Andrea Šlampová et al.
Analytica chimica acta, 887, 92-100 (2015-09-01)
Electrolysis is omnipresent in all electrochemical processes including electromembrane extraction (EME). The effects of electrolysis on quantitative aspects of EME were comprehensively evaluated for a set of acidic (substituted phenols) and basic (basic drugs) analytes. EMEs were carried out across...
Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice
Suen RS, et al.
The American Journal of Pathology, 179(3), 1549-1559 (2011)
[Basic evaluation principles of coronary blood flow to establish new diagnostic procedures. Part 1. Fractional reserve of blood flow conception].
A S Tereshchenko et al.
Vestnik rentgenologii i radiologii, (2)(2), 44-51 (2012-06-27)
J M Mathis et al.
Neuroradiology, 39(2), 90-98 (1997-02-01)
Intra-arterial infusion of papaverine hydrochloride for subarachnoid hemorrhage-induced cerebral vasospasm has become an adjunctive endovascular therapy along with cerebral angioplasty. Our knowledge concerning the mechanism of action, method of administration and potential side effects of this therapeutic alternative are reviewed.
Isabel Desgagné-Penix et al.
The Plant journal : for cell and molecular biology, 72(2), 331-344 (2012-06-26)
Papaverine, a major benzylisoquinoline alkaloid in opium poppy (Papaver somniferum), is used as a vasodilator and antispasmodic. Conversion of the initial intermediate (S)-norcoclaurine to papaverine involves 3'-hydroxylation, four O-methylations and dehydrogenation. However, our understanding of papaverine biosynthesis remains controversial more...
Papaverine-induced inhibition of phosphodiesterase activity in various mammalian tissues.
G Pöch et al.
Life sciences. Pt. 1: Physiology and pharmacology, 10(3), 133-144 (1971-02-01)
Bojidarka Ivanov et al.
Natural product communications, 7(5), 581-586 (2012-07-18)
The electronic structures, optical properties and molecular structures of a series of isoquinoline alkaloids resulting in the formation of papaverine, through a proposed biosynthetic pathway via S(+)-reticuline were elucidated. The mechanism of papaverine synthesis was studied by electronic absorption, diffuse...
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were...
V P Demushkin et al.
Bulletin of experimental biology and medicine, 152(4), 444-446 (2012-07-18)
The neurocytotoxic effect of drotaverine hydrochloride was studied in culture of rat cerebellar granulocytes. Incubation of cells with 100 and 250 μM drotaverine reduced neuronal survival to 60 and 4%, respectively.
Javier Fandino et al.
Acta neurochirurgica. Supplement, 115, 113-117 (2012-08-15)
The use of intraoperative digital substraction angiography (iDSA) is a tool in cerebrovascular surgery. According to recent studies, iDSA has been shown to alter surgical treatment in approximately 12% of cases. Moreover, it has been demonstrated that even experienced cerebrovascular...
Qiao Yu Li et al.
Journal of neurological surgery. Part A, Central European neurosurgery, 73(2), 84-88 (2012-04-03)
Sudden internal carotid artery (ICA) occlusive vasospasm is a serious complication of intracranial aneurysm embolization. Conventional spasmolysis with papaverine yields a generally poor outcome. We believe that arterial infusion of lidocaine may offer a better outcome. We retrospectively reviewed the...
Robert Jansen et al.
The West Virginia medical journal, 109(5), 30-31 (2013-12-04)
Testicular torsion is an emergent condition requiring prompt surgical intervention to avoid permanent testicular compromise and death. As its symptoms overlap with other disease processes, diagnosis is sometimes difficult. When considering the presenting symptoms, one must be careful not to...
Yong Tang et al.
Journal of plastic surgery and hand surgery, 46(6), 389-392 (2012-11-20)
Blood flow in expanding tissue can be improved by papaverine through a special delivery system in early report. Because the delivery system was complex and inconvenient, another way of using papaverine was tested to observe the blood flow and the...
George T Kedia et al.
Urology, 80(4), 952-952 (2012-08-21)
To investigate further the potential significance of the cyclic adenosine monophosphate (cAMP) pathway in the control of prostate smooth muscle. The cAMP pathway has been assumed to be an alternative pharmacologic target to treat dysfunctions of the human lower urinary...
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells
Grundemann D, et al.
British Journal of Pharmacology, 137(6), 910-918 (2002)
Effects of antiallergic agents, compound 48/80, and some reference inhibitors on the activity of partially purified human lung tissue adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate phosphodiesterases.
H Bergstrand et al.
Molecular pharmacology, 13(1), 38-43 (1977-01-01)
N N Pshenkina
Eksperimental'naia i klinicheskaia farmakologiia, 75(2), 30-34 (2012-05-04)
The influence of perfluorocarbon blood substitute Perfloran on the plasma concentrations of bendazole, drotaverine, ketorolac and verapamil upon intravenous introduction after Perfloran infusion (5 ml/kg) has been investigated on rabbits. It has been found that the plasma concentrations of verapamil...
Mayumi Mori-Kawabe et al.
Journal of atherosclerosis and thrombosis, 22(8), 845-853 (2015-03-06)
Chronic kidney disease (CKD) is known to frequently cause cardiovascular events. However, it is unclear how renal dysfunction affects the vascular response. We herein studied the effects of renal dysfunction on the aortic behavior in adenine-fed mice, investigating mechanisms underlying...
I N Ruchkina et al.
Terapevticheskii arkhiv, 85(2), 21-26 (2013-05-09)
To estimate the incidence of secondary lactase deficiency (SLD) in patients with postinfectious irritable bowel syndrome (PIBS) and the value of the small bowel microflora in its development and to elaborate treatment options for SLD. One hundred and thirty-eight patients...
Seyed Alaeddin Asgari et al.
BJU international, 110(3), 449-452 (2012-02-22)
• To assess the efficacy of papaverine hydrochloride combined with a diclofenac sodium suppository to relieve renal colic compared with diclofenac suppository monotherapy, as the effect of phosphodiesterase inhibitors on ureteric muscles might reduce the pain of renal colic. •...
Edibe Karasu-Minareci et al.
Iranian journal of allergy, asthma, and immunology, 11(3), 246-252 (2012-09-06)
Asthma is a clinical syndrome characterized by chronic airway inflammation, airway responsiveness, and expiratory airflow limitation. Nocturnal symptoms and decreases in lung function are common aspects of the asthma clinical syndrome. Nocturnal symptoms also appear to be associated with asthma-related...
H L Karpman et al.
Angiology, 26(8), 592-604 (1975-09-01)
Using the atraumatic diagnostic technique of forehead thermography to indirectly evaluate cerebral arterial circulation, nine patients with vascular disease in the extracranial or intracranial carotid arterial system were given 300 mg. papaverine hydrochloride. All patients demonstrated some degree of improvement...
Kyoko Hayashi et al.
Bioorganic & medicinal chemistry letters, 17(6), 1562-1564 (2007-01-24)
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC(50) 0.68 microM) of 1 was equivalent to that (IC(50) 0.91 microM) of ganciclovir (GCV). The mechanism...
Shaukat Nawaz Khan et al.
The Cochrane database of systematic reviews, 10, CD003635-CD003635 (2012-10-19)
During aortic aneurysm surgery, cross-clamping can lead to inadequate blood supply to the spinal cord resulting in neurological deficit. Cerebrospinal fluid drainage (CSFD) may increase the perfusion pressure to the spinal cord and hence reduce the risk of ischaemic spinal...
Prasad P Dahivelkar et al.
Journal of chromatographic science, 50(8), 694-701 (2012-05-11)
A simple high-performance liquid chromatographic method with ultraviolet detection is proposed for the estimation of diclofenac potassium and drotaverine hydrochloride in human plasma. Liquid-liquid extraction was carried out with a mixture of dichloromethane-isopropyl alcohol (80:20, v/v). Chromatographic separation of the...
Hillary Johnston-Cox et al.
PloS one, 9(6), e98775-e98775 (2014-06-04)
High fat diet (HFD)-induced type 2 diabetes continues to be an epidemic with significant risk for various pathologies. Previously, we identified the A2b adenosine receptor (A2bAR), an established regulator of inflammation, as a regulator of HFD-induced insulin resistance. In particular...
Severe hypotension, cardiac arrest, and death after intracisternal instillation of papaverine during anterior communicating artery aneurysm clipping. A case report.
Forhad Hossain Chowdhury et al.
Acta neurochirurgica, 155(2), 281-282 (2012-11-28)
Brian Lima et al.
The Journal of thoracic and cardiovascular surgery, 143(4), 945-952 (2012-02-22)
An array of neuroprotective strategies has evolved to limit spinal cord injury during descending thoracic aneurysm and thoracoabdominal aortic aneurysm repair. This study prospectively assessed the neuroprotective impact of intrathecal papaverine added to other techniques in aortic aneurysm repairs. From...

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.