Showing 1-30 of 115 results for "P4334"
Gema Esquiva et al.
Frontiers in neuroanatomy, 10, 61-61 (2016-07-05)
The blind mole rat, Spalax ehrenbergi, can, despite severely degenerated eyes covered by fur, entrain to the daily light/dark cycle and adapt to seasonal changes due to an intact circadian timing system. The present study demonstrates that the Spalax retina...
Mei-Ling Gao et al.
Frontiers in cell and developmental biology, 8, 128-128 (2020-03-27)
Although an increasing number of disease genes have been identified, the exact cellular mechanisms of retinitis pigmentosa (RP) remain largely unclear. Retinal organoids (ROs) derived from the induced pluripotent stem cells (iPSCs) of patients provide a potential but unvalidated platform...
Protein kinase C, an elusive therapeutic target?
Mochly-Rosen D, et al.
Nature Reviews Drug Discovery, 11(12), 937-937 (2012)
Diego F Buenaventura et al.
Investigative ophthalmology & visual science, 60(8), 2787-2799 (2019-07-02)
The early transcriptional events that occur in newly generated cone photoreceptors are not well described. Knowledge of these events is critical to provide benchmarks for in vitro-derived cone photoreceptors and to understand the process of cone and rod photoreceptor diversification....
Nicolas D Lutz et al.
PloS one, 13(8), e0202089-e0202089 (2018-08-30)
The retinal rod pathway, featuring dedicated rod bipolar cells (RBCs) and AII amacrine cells, has been intensely studied in placental mammals. Here, we analyzed the rod pathway in a nocturnal marsupial, the South American opossum Monodelphis domestica to elucidate whether...
The Rod Pathway of the Microbat Retina Has Bistratified Rod Bipolar Cells and Tristratified AII Amacrine Cells
Muller B, et al.
The Journal of Neuroscience, 33(3), 1014-1023 (2013)
Antonia Stefanov et al.
The Journal of comparative neurology, 528(9), 1502-1522 (2019-12-08)
Rod-cone degenerations, for example, retinitis pigmentosa are leading causes of blindness worldwide. Despite slow disease progression in humans, vision loss is inevitable; therefore, development of vision restoration strategies is crucial. Among others, promising approaches include optogenetics and prosthetic implants, which...
Simultaneous visualization of the translocation of protein kinase C alpha-green fluorescent protein hybrids and intracellular calcium concentrations
ALMHOLT K, et al.
The Biochemical Journal, 337(2), 211-218 (1999)
Abirami Santhanam et al.
Cells, 9(10) (2020-10-11)
More than 1.5 million people suffer from Retinitis Pigmentosa, with many experiencing partial to complete vision loss. Regenerative therapies offer some hope, but their development is challenged by the limited regenerative capacity of mammalian model systems. As a step toward...
Anuradha Dhingra et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11343-11355 (2012-08-17)
Heterotrimeric G-proteins, comprising Gα and Gβγ subunits, couple metabotropic receptors to various downstream effectors and contribute to assembling and trafficking receptor-based signaling complexes. A G-protein β subunit, Gβ(3), plays a critical role in several physiological processes, as a polymorphism in...
David Jimeno et al.
Journal of cell science, 129(4), 729-742 (2016-01-09)
Detailed immunocytochemical analyses comparing wild-type (WT), GRF1-knockout (KO), GRF2-KO and GRF1/2 double-knockout (DKO) mouse retinas uncovered the specific accumulation of misplaced, 'ectopic' cone photoreceptor nuclei in the photoreceptor segment (PS) area of retinas from GRF2-KO and GRF1/2-DKO, but not of...
Marijana Samardzija et al.
Investigative ophthalmology & visual science, 55(8), 5304-5313 (2014-07-19)
Due to the low abundance of cone photoreceptors in the mouse retina and the scarcity of alternative animal models, little is known about mechanisms of cone degeneration. Nrl knockout mice develop exclusively the cone-type of photoreceptors. However, the cone photoreceptor...
Severin Reinhard Heynen et al.
PloS one, 8(1), e53806-e53806 (2013-02-02)
The small GTPase CDC42 has pleiotropic functions during development and in the adult. These functions include intra- as well as intercellular tasks such as organization of the cytoskeleton and, at least in epithelial cells, formation of adherens junctions. To investigate...
Masahito Yamagata et al.
eLife, 10 (2021-01-05)
Retinal structure and function have been studied in many vertebrate orders, but molecular characterization has been largely confined to mammals. We used single-cell RNA sequencing (scRNA-seq) to generate a cell atlas of the chick retina. We identified 136 cell types...
Salvatore L Stella et al.
Brain research, 1215, 20-29 (2008-05-17)
Glutamate is the major excitatory neurotransmitter in the retina, and most glutamatergic neurons express one of the three known vesicular glutamate transporters (VGLUT1, 2, or 3). However, the expression profiles of these transporters vary greatly in the retina. VGLUT1 is...
S W Wang et al.
Genes & development, 15(1), 24-29 (2001-01-13)
math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5...
Peter G Fuerst et al.
Neuron, 64(4), 484-497 (2009-12-01)
DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell type, and gene family member studied. We examined the function of DSCAM and DSCAML1 in the developing mouse retina. In...
Karthik Shekhar et al.
Cell, 166(5), 1308-1323 (2016-08-28)
Patterns of gene expression can be used to characterize and classify neuronal types. It is challenging, however, to generate taxonomies that fulfill the essential criteria of being comprehensive, harmonizing with conventional classification schemes, and lacking superfluous subdivisions of genuine types....
Yumeng Shen et al.
Cell death & disease, 10(12), 905-905 (2019-12-04)
Progressive degeneration of retinal ganglion cells (RGCs) will cause a blinding disease. Most of the study is focusing on the RGCs itself. In this study, we demonstrate a decline of the presynaptic rod bipolar cells (RBCs) response precedes RGCs loss...
Rod bipolar cells and horizontal cells form displaced synaptic contacts with rods in the outer nuclear layer of the nob2 retina.
Bayley, et al.
The Journal of Comparative Neurology, 500, 286-298 (2019)
Viviana Guadagni et al.
Scientific reports, 6, 35919-35919 (2016-10-25)
Retinitis pigmentosa (RP) comprises a group of inherited pathologies characterized by progressive photoreceptor degeneration. In rodent models of RP, expression of defective genes and retinal degeneration usually manifest during the first weeks of postnatal life, making it difficult to distinguish...
Yasser Elshatory et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(46), 12707-12720 (2007-11-16)
Whereas the mammalian retina possesses a repertoire of factors known to establish general retinal cell types, these factors alone cannot explain the vast diversity of neuronal subtypes. In other CNS regions, the differentiation of diverse neuronal pools is governed by...
Jesse Roman et al.
American journal of physiology. Lung cellular and molecular physiology, 287(1), L239-L249 (2004-04-06)
LPS is an outer-membrane glycolipid component of gram-negative bacteria known for its fervent ability to activate monocytic cells and for its potent proinflammatory capabilities. In addition, LPS triggers the release of cytokines and chemokines as well as cell-cell adhesion molecules....
Ivan A Anastassov et al.
The Journal of comparative neurology, 527(1), 52-66 (2017-05-27)
Retinal responses to photons originate in rod photoreceptors and are transmitted to the ganglion cell output of the retina through the primary rod bipolar pathway. At the first synapse of this pathway, input from multiple rods is pooled into individual...
Daisy Umutoni et al.
Genes to cells : devoted to molecular & cellular mechanisms, 25(6), 402-412 (2020-03-28)
Di- and trimethylation of lysine 27 on histone 3 (H3K27me2/3) is a critical gene repression mechanism. We previously showed that down-regulation of the H3K27 demethylase, Jumonji domain-containing protein 3 (JMJD3), resulted in a reduced number of protein kinase C (PKC)α-positive...
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Ilaria Barone et al.
PloS one, 7(11), e50726-e50726 (2012-12-05)
Slow, progressive rod degeneration followed by cone death leading to blindness is the pathological signature of all forms of human retinitis pigmentosa (RP). Therapeutic schemes based on intraocular delivery of neuroprotective agents prolong the lifetime of photoreceptors and have reached...
Christian Puller et al.
The Journal of comparative neurology, 519(4), 759-774 (2011-01-20)
Parallel processing of an image projected onto the retina starts at the first synapse, the cone pedicle, and each cone feeds its light signal into a minimum of eight different bipolar cell types. Hence, the morphological classification of bipolar cells...
Daniela Intartaglia et al.
Frontiers in cell and developmental biology, 8, 132-132 (2020-03-21)
Mucopolysaccharidosis type IIIA (MPS-IIIA, Sanfilippo A) is one of the most severe lysosomal storage disorder (LSD) caused by the inherited deficiency of sulfamidase, a lysosomal sulfatase enzyme involved in the stepwise degradation of heparan sulfates (HS). MPS-IIIA patients show multisystemic...
Ning Shen et al.
Investigative ophthalmology & visual science, 57(6), 2788-2796 (2016-05-24)
Frizzled3 (Fzd3), a member of the core planar cell polarity (PCP) family in mammals, contributes to visual development by guiding axonal projections of some retinal ganglion cells. However, its other functions in the maturation of the visual system, especially the...

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