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P4668

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Anthony Danso-Appiah et al.
The Cochrane database of systematic reviews, 2(2), CD000528-CD000528 (2013-03-02)
Schistosoma mansoni is a parasitic infection common in the tropics and sub-tropics. Chronic and advanced disease includes abdominal pain, diarrhoea, blood in the stool, liver cirrhosis, portal hypertension, and premature death. To evaluate the effects of antischistosomal drugs, used alone
Neurological presentation of schistosomiasis.
Cecilia Szekeres et al.
Lancet (London, England), 381(9879), 1788-1788 (2013-05-21)
Mohamed Ag Ayoya et al.
Food and nutrition bulletin, 33(4), 235-241 (2013-02-22)
Relationships among Schistosoma haematobium, anemia, and iron deficiency have been documented, and all have been found to be associated with a decline in school attendance and lower performance. To assess the effect of single or combined iron and multiple micronutrients
J Adisa et al.
African health sciences, 12(4), 563-565 (2013-03-22)
Testicular schistosomiasis caused by Schistosoma mansoni is very rare and more so when associated with primary infertility. A 40 years old man from the Jos Plateau, North Central Nigeria presented with primary infertility after ten years of marriage. Sperm count
I N Grigor'eva
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (4)(4), 54-59 (2013-02-14)
THE PURPOSE OF THE REVIEW: Present new data on the causative agent, pathogenesis, diagnosis and treatment of opisthorchiasis. When samples of parasites were genotyped by novel nuclear marker Pm-int9, it was shown various properties of Opisthorchis viverrini, O. felineus and
Th Vancauwenberghe et al.
JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR), 96(5), 292-294 (2014-02-01)
We report a unusual case of hydro-ureteronephrosis caused by schistosomiasis in a 66-year-old female. Computed tomography (CT) and biochemistry initially suggested a transitional cell carcinoma of the left proximal ureter. The patient was referred for reno-ureterectomy, but histopathological examination of
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Lucja A Labuda et al.
PLoS neglected tropical diseases, 7(3), e2094-e2094 (2013-03-19)
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell
Treatment of neurocysticercosis.
The Lancet Infectious Diseases
The Lancet. Infectious diseases, 14(8), 657-657 (2014-07-25)
Schistosomiasis: number of people treated in 2011.
Releve epidemiologique hebdomadaire, 88(8), 81-88 (2013-04-02)
Jean T Coulibaly et al.
PLoS neglected tropical diseases, 7(3), e2109-e2109 (2013-04-05)
The Kato-Katz technique is widely used for the diagnosis of Schistosoma mansoni, but shows low sensitivity in light-intensity infections. We assessed the accuracy of a commercially available point-of-care circulating cathodic antigen (POC-CCA) cassette test for the diagnosis of S. mansoni
Rosimeire Nunes de Oliveira et al.
Experimental parasitology, 139, 63-72 (2014-03-08)
Although its efficiency against all Schistosoma species, praziquantel (PZQ) shows low efficacy against schistosomula and juvenile stages. The potential for development of resistance to PZQ has justified the search for new alternative chemotherapies. In this scenario, studies to new formulations
Christel A S Bergström et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 224-231 (2013-10-01)
In this paper we analyse how the biopharmaceutics classification system (BCS) has been used to date. A survey of the literature resulted in a compilation of 242 compounds for which BCS classes were reported. Of these, 183 compounds had been
J M Bygott et al.
Acta tropica, 111(2), 95-101 (2009-04-21)
The role of praziquantel in hydatid disease has not been well defined. This review evaluates the evidence on the use of praziquantel in treatment of cystic hydatid disease from in vitro and in vivo animal studies, human clinical studies and
Yi-biao Zhou et al.
Parasites & vectors, 4, 194-194 (2011-10-11)
Worldwide schistosomiasis continues to be a serious public health problem. Over the past five decades, China has made remarkable progress in reducing Schistosoma japonicum infections in humans to a relatively low level. Endemic regions are currently circumscribed in certain core
Badreldin H Ali
Pakistan journal of pharmaceutical sciences, 19(2), 170-175 (2006-06-06)
Praziquantel is the current drug of choice against many trematodes and cestodes in both man and animals. This article summarizes the main pharmacological, therapeutic and toxicological properties of the drug, especially that have been reported during the last 10 years.
Wei Wang et al.
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(5), 505-509 (2013-02-05)
To compare the sensitivities of different isolates of Schistosoma japonicum in marshland and lake regions of Chinese Mainland to praziquantel, so as to provide experimental evidence for establishing the techniques of detecting and monitoring praziquantel sensitivity. Mice were infected with
Erick M O Muok et al.
The American journal of tropical medicine and hygiene, 89(1), 42-45 (2013-05-15)
Previously, we have shown that persons with human immunodeficiency virus 1 (HIV-1) infection and reduced CD4(+) T-lymphocyte counts excrete significantly fewer Schistosoma mansoni eggs than HIV-1-negative persons with similar intensities of schistosome infections. To determine how antiretroviral therapy (ART) might
B S Naher et al.
Mymensingh medical journal : MMJ, 22(2), 397-399 (2013-05-30)
A 5 year old girl hailing from Keraniganj, presented with the complaints of fever, periumbilical pain and vomiting. In vomitus, Fasciolopsis buski worm in adult form was identified by naked eye examination. In stool, ova of Fasciolopsis buski were also
Lucía Alvela-Suárez et al.
The American journal of tropical medicine and hygiene, 90(5), 819-822 (2014-03-13)
There is still no well-established consensus about the clinical management of hydatidosis. Currently, surgery continues to be the first therapeutic option, although treatment with anti-parasitic drugs is indicated as an adjuvant to surgery to decrease the number of relapses and
Sarah Logan et al.
The American journal of tropical medicine and hygiene, 88(6), 1032-1034 (2013-03-27)
We report 79 cases of acute schistosomiasis. Most of these cases were young, male travelers who acquired their infection in Lake Malawi. Twelve had a normal eosinophil count at presentation and 11 had negative serology, although two had neither eosinophilia
Hatem Tallima et al.
International journal of antimicrobial agents, 29(5), 570-575 (2007-03-08)
Praziquantel (PZQ) is widely used for the treatment of schistosomiasis. It induces worm muscle contractions and tegumental disruption, followed by exposure of parasite surface membrane antigens to the host immunological defence mechanisms. It may be assumed that PZQ, like cholesterol
Malay Patra et al.
Journal of medicinal chemistry, 56(22), 9192-9198 (2013-11-14)
In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula (η(6)-PZQ)Cr(CO)3 (1 and 2), by use of human liver microsomes. The metabolic profiles of the derivatives differ significantly. The optically
Sanaa S Botros et al.
Antimicrobial agents and chemotherapy, 53(12), 5284-5287 (2009-08-26)
9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [(S)-HPMPA] has been reported to have antischistosomal activity. Ether lipid esters of (S)-HPMPA and cidofovir (CDV) have greatly increased activities in antiviral assays and in lethal animal models of poxvirus diseases. To see if ether lipid esters of CDV
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Xiaoping Xie et al.
Human vaccines & immunotherapeutics, 10(6), 1688-1699 (2014-03-20)
Previously, we have reported that either CIM or PZQ, 2 clinical drugs, could be used to develop as adjuvants on HBV DNA vaccine to elicit both humoral and cellular immune responses. Here, we demonstrate that combinations of CIM and PZQ
Christine Baker et al.
Veterinary parasitology, 202(1-2), 54-58 (2014-04-08)
The efficacy of a novel topical combination of fipronil 8.3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v) and praziquantel 8.3% (w/v) (BROADLINE(®)) was tested against adult and immature stages of Ctenocephalides felis fleas in six studies. For that purpose, fleas
Xi-Cheng Hong et al.
PLoS neglected tropical diseases, 7(3), e2122-e2122 (2013-03-22)
More than 80% of schistosomiasis patients in China live in the lake and marshland regions. The purpose of our study is to assess the effect of a comprehensive strategy to control transmission of Schistosoma japonicum in marshland regions. In a
Charles H King et al.
PLoS neglected tropical diseases, 5(9), e1321-e1321 (2011-09-29)
Controversy persists about the optimal approach to drug-based control of schistosomiasis in high-risk communities. In a systematic review of published studies, we examined evidence for incremental benefits from repeated praziquantel dosing, given 2 to 8 weeks after an initial dose
Piero L Olliaro et al.
Tropical medicine & international health : TM & IH, 18(9), 1085-1089 (2013-08-14)
Schistosomiasis is known to occur in preschool-aged children, but achieving accurate dosing of praziquantel in its current form is challenging. While waiting for a paediatric formulation, there is a need to develop a means for using the available products to
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