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Kyle P Feeley et al.
Cancer research, 75(20), 4429-4436 (2015-10-17)
Current paradigms of carcinogenic risk suggest that genetic, hormonal, and environmental factors influence an individual's predilection for developing metastatic breast cancer. Investigations of tumor latency and metastasis in mice have illustrated differences between inbred strains, but the possibility that mitochondrial
Yukie Yoda et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 18(1), 65-76 (2014-02-11)
The profiles of genetic and epigenetic alterations in cancer-related pathways are considered to be useful for selection of patients likely to respond to specific drugs, including molecular-targeted and epigenetic drugs. In this study, we aimed to characterize such profiles in
Ammar A Albalasmeh et al.
Carbohydrate polymers, 97(2), 253-261 (2013-08-06)
A new UV spectrophotometry based method for determining the concentration and carbon content of carbohydrate solution was developed. This method depends on the inherent UV absorption potential of hydrolysis byproducts of carbohydrates formed by reaction with concentrated sulfuric acid (furfural
Jun-Jian Wang et al.
The New phytologist, 206(4), 1261-1273 (2015-04-11)
Fine roots constitute a significant source of plant productivity and litter turnover across terrestrial ecosystems, but less is known about the quantitative and qualitative profile of phenolic compounds within the fine-root architecture, which could regulate the potential contribution of plant
Teresa Sposito et al.
Human molecular genetics, 24(18), 5260-5269 (2015-07-03)
The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult human central nervous system (CNS). Tau splicing is developmentally regulated and dysregulated in disease. Mutations in MAPT that alter tau splicing cause frontotemporal dementia (FTD)
Soo Jung Lee et al.
International journal of biological macromolecules, 72, 1056-1062 (2014-12-03)
Lignin was isolated from the residue of bioethanol production with oak wood via alkaline and catalyzed organosolv treatments at ambient temperature to improve the purity of lignin for the materials application. The isolated lignins were analyzed for their chemical composition
Justin M Dean et al.
Developmental neuroscience, 37(4-5), 289-304 (2015-02-28)
One of the central, unanswered questions in perinatology is why preterm infants continue to have such poor long-term neurodevelopmental, cognitive and learning outcomes, even though severe brain injury is now rare. There is now strong clinical evidence that one factor
Malathi Banda et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 789-790, 53-60 (2015-08-02)
This study investigated whether Kras mutation is an early event in the development of lung tumors induced by inhalation of particulate vanadium pentoxide (VP) aerosols. A National Toxicology Program tumor bioassay of inhaled particulate VP aerosols established that VP-induced alveolar/bronchiolar
Tsiry Rasamiravaka et al.
PloS one, 10(7), e0132791-e0132791 (2015-07-18)
Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in biofilm formation. One of the active compounds has been isolated and
Rebecca J Linger et al.
PloS one, 10(10), e0141544-e0141544 (2015-10-28)
In most animals that have X and Y sex chromosomes, chromosome-wide mechanisms are used to balance X-linked gene expression in males and females. In the fly Drosophila melanogaster, the dosage compensation mechanism also generally extends to X-linked transgenes. Over 70
Pankaj Aggarwal et al.
Journal of chromatography. A, 1364, 96-106 (2014-09-07)
Highly cross-linked monolithic networks (i.e., polyethylene glycol diacrylate, PEGDA) synthesized from monomers containing varying ethylene oxide chain lengths were fabricated inside fused silica capillary columns for use in liquid chromatography (LC) of small molecules. Tergitol was used as a surfactant
Derek Power et al.
Virology, 481, 142-150 (2015-03-18)
IFI44 is an interferon-alfa inducible protein, and is associated with infection of several viruses. However, IFI44 elicits minimal antiviral effects on these viruses, and its exact role is still unknown. Here we show that IFI44 inhibits HIV-1 replication in vitro.
Jelle Hendrix et al.
The Journal of cell biology, 210(4), 629-646 (2015-08-19)
Assembly of the Gag polyprotein into new viral particles in infected cells is a crucial step in the retroviral replication cycle. Currently, little is known about the onset of assembly in the cytosol. In this paper, we analyzed the cytosolic
Takahiro Ogura et al.
BMC research notes, 8, 644-644 (2015-11-06)
Agarose hydrogels are widely used for three-dimensional cell scaffolding in tissue engineering and cell biology. Recently, molecular profiles have been obtained with extraction of a minimal volume of RNA using fluorescent-tagged quantitative polymerase chain reaction (qPCR), which requires high integrity
Milica Vujicic et al.
The British journal of nutrition, 113(5), 770-782 (2015-02-12)
Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic β-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin replacement, the aim of the present study was to evaluate the therapeutic potential
Jae-Won Ha et al.
Applied and environmental microbiology, 81(13), 4517-4524 (2015-04-26)
The aim of this study was to investigate the efficacy of near-infrared radiation (NIR) heating combined with lactic acid (LA) sprays for inactivating Salmonella enterica serovar Enteritidis on almond and pine nut kernels and to elucidate the mechanisms of the
Matt Hrapchak et al.
Journal of labelled compounds & radiopharmaceuticals, 57(12), 687-694 (2014-10-22)
Empagliflozin, (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol was recently approved by the FDA for the treatment of chronic type 2 diabetes mellitus. Herein, we report the synthesis of carbon-13 and carbon-14 labeled empagliflozin. Carbon-13 labeled empagliflozin was prepared in five steps and in 34% overall
Zhenyu Cheng et al.
Journal of pharmaceutical and biomedical analysis, 96, 162-169 (2014-04-24)
A method for two-steps extraction of essential oil, polysaccharides and lignans from Schisandra chinensis Baill had been established. Firstly, S. chinensis was extracted by hydro-distillation, the extracted solution was separated from the water-insoluble residue and precipitated by adding dehydrated alcohol
Yiliang Ding et al.
Nature protocols, 10(7), 1050-1066 (2015-06-19)
Structure-seq is a high-throughput and quantitative method that provides genome-wide information on RNA structure at single-nucleotide resolution. Structure-seq can be performed both in vivo and in vitro to study RNA structure-function relationships, RNA regulation of gene expression and RNA processing.
T Sathyapalan et al.
Scientific reports, 5, 16890-16890 (2015-11-20)
MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and miRNA-223 are differentially expressed
Ying Guo et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 79-86 (2015-08-22)
Near-infrared spectroscopy (NIRS) calibrations were developed for the discrimination of spectra of the jujube (Zizyphus jujuba Mill.) fruit samples from four geographical regions. Prediction models were developed for the quantitative prediction of the contents of jujube fruit, i.e., total sugar
Salma Makhoul Ahwach et al.
Life sciences, 134, 9-15 (2015-05-27)
Reactive oxygen species are associated with cardiovascular disease, diabetes, and atherosclerosis, yet the use of antioxidants in clinical trials has been ineffective at improving outcomes. In endothelial cells, high-dextrose-induced oxidative stress and endoplasmic reticulum stress promote endothelial dysfunction leading to
Abigail K Myers et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(23), 7787-7801 (2014-06-06)
Proper assembly of cortical circuitry relies on the correct migration of cortical interneurons from their place of birth in the ganglionic eminences to their place of terminal differentiation in the cerebral cortex. Although molecular mechanisms mediating cortical interneuron migration have
Rectovaginal fistula: an extremely rare complication after injection sclerotherapy for hemorrhoids.
Sukanta Ray et al.
The American surgeon, 79(4), E143-E144 (2013-04-12)
Mélanie Mignot et al.
Journal of chromatography. A, 1419, 45-57 (2015-10-13)
This study reports the impact of thermal pretreatment between 400 and 1100°C on superficially porous silica particles (e.g. core-shell, fused-core; here abbreviated as SPP silica). The different thermally pretreated SPP silica (400°C, 900°C and 1100°C) were chemically bonded with an
Natsuko Kageyama-Yahara et al.
PloS one, 9(8), e106106-e106106 (2014-08-29)
MUC5AC is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. Immunohistochemistry revealed that expression of MUC5AC decreases accompanied with increased malignant property of gastric mucosa, which further suggests the importance of MUC5AC
Le Truc Nguyen et al.
Enzyme and microbial technology, 78, 34-39 (2015-07-29)
Enzymatic hydrolysis of cellulose is often conducted in batch processes in which hydrolytic products tend to inhibit enzyme activity. In this study, we report a method for continuous hydrolysis of carboxymethyl cellulose (CMC) by using cross-linked cellulase aggregate (XCA) trapped
Marta Lores et al.
Talanta, 140, 134-142 (2015-06-07)
An important trend in the extraction of chemical compounds is the application of new environmentally friendly, food grade solvents. Ethyl lactate (ethyl 2-hydroxypropanoate), produced by fermentation of carbohydrates, is miscible with both hydrophilic and hydrophobic compounds being a potentially good
Anna Maria Wróbel et al.
Toxicology letters, 238(2), 110-116 (2015-08-09)
In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells. Cells were exposed to methyl-, propyl- or butylparaben at
Réka Balogh et al.
Journal of chromatography. A, 1422, 140-146 (2015-10-20)
This study presents a validated, porous graphitic carbon stationary phase-based LC-MS/MS method for the identification and quantification of lacto-N-biose (LNB) and N-acetyllactosamine (LacNAc). These compounds are the major building blocks of human milk oligosaccharides, however the presence of their unbound
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