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M H Marana et al.
Fish & shellfish immunology, 105, 16-23 (2020-07-04)
Enteric redmouth disease (ERM), caused by the Gram negative enterobacterium Yersinia ruckeri, affects farming of salmonids, but vaccination against ERM confers a certain degree of protection dependent on the administration route. Recent studies on oral vaccination of rainbow trout suggest
Ralf Küppers et al.
Methods in molecular biology (Clifton, N.J.), 971, 49-63 (2013-01-09)
Normal and malignant B cells carry rearranged immunoglobulin (Ig) variable region genes, which due to their practically limitless diversity represent ideal clonal markers for these cells. We describe here an approach to isolate single cells from frozen tissue sections by
Karen Dobie et al.
Journal of virology, 87(10), 5895-5903 (2013-03-15)
Most current diagnostic tests for transmissible spongiform encephalopathies (TSE) rely on the presence of proteinase K (PK)-resistant PrP(Sc) (PrP-res) in postmortem tissues as an indication of TSE disease. However, a number of studies have highlighted a discrepancy between TSE infectivity
Eva Dvorakova et al.
BMC neurology, 13, 126-126 (2013-09-26)
The accumulation of the misfolded forms of cellular prion protein, i.e. prions (PrPSc), in the brain is one of the crucial characteristics of fatal neurodegenerative disorders, called transmissible spongiform encephalopathies (TSEs). Cellular prion protein is normally linked to the cell
Rebecca Z Fan et al.
Acta neuropathologica communications, 7(1), 184-184 (2019-11-21)
Targeting alpha-synuclein (α-syn) as a therapeutic strategy for Parkinson's disease (PD) has been intensively pursued largely due to its well-recognized pathogenic role. Since its discovery as the first familial link to PD over two decades ago, this protein has been
Fangzhong Yuan et al.
Journal of molecular neuroscience : MN, 51(1), 219-224 (2013-05-30)
Prion diseases characterize a category of fatal neurodegenerative diseases. Although reports have increasingly shown that oxidative stress plays an important role in the progression of prion diseases, little is known about whether oxidative stress is a cause or a consequence
Three-dimensional porous network structure developed in hydroxyapatite-based nanocomposites containing enzyme pretreated silk fibroin.
Wang Li, et al.
Journal of Nanoparticle Research, 6, 91-98 (2004)
Chao Wang et al.
Journal of medicinal chemistry, 56(6), 2527-2539 (2013-03-06)
The small molecule fusion inhibitors N-(4-carboxy-3-hydroxyphenyl)-2,5-dimethylpyrrole (NB-2) and N-(3-carboxy-4-hydroxyphenyl)-2,5-dimethylpyrrole (A12) target a hydrophobic pocket of HIV-1 gp41 and have moderate anti-HIV-1 activity. In this paper, we report the design, synthesis, and structure-activity relationship of a group of hybrid molecules in
Ester Vázquez-Fernández et al.
PloS one, 7(11), e50111-e50111 (2012-11-28)
Elucidation of the structure of PrP(Sc) continues to be one major challenge in prion research. The mechanism of propagation of these infectious agents will not be understood until their structure is solved. Given that high resolution techniques such as NMR
A S Neimanis et al.
Transboundary and emerging diseases, 65(1), 213-220 (2017-04-14)
Incursion of rabbit haemorrhagic disease virus (RHDV) into Sweden was documented in 1990 and it is now considered endemic in wild rabbit (Oryctolagus cuniculus) populations. Rabbit haemorrhagic disease virus 2 (RHDV2), a new, related lagovirus was first detected in France
Ellen Marie Straarup et al.
Nucleic acids research, 38(20), 7100-7111 (2010-07-10)
The potency and specificity of locked nucleic acid (LNA) antisense oligonucleotides was investigated as a function of length and affinity. The oligonucleotides were designed to target apolipoprotein B (apoB) and were investigated both in vitro and in vivo. The high
Jessica Varela Villarreal et al.
Journal of microbiological methods, 94(3), 161-169 (2013-07-03)
Molecular techniques, such as polymerase chain reaction (PCR) and quantitative PCR (qPCR), are very sensitive, but may detect total DNA present in a sample, including extracellular DNA (eDNA) and DNA coming from live and dead cells. DNase I is an
Nadezda A Fursova et al.
Molecular cell, 74(5), 1020-1036 (2019-04-29)
The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic. Here, we use combinatorial genetic perturbation
Catherine Arden et al.
Diabetes, 60(12), 3110-3120 (2011-10-21)
The induction of hepatic glucose 6-phosphatase (G6pc) by glucose presents a paradox of glucose-induced glucose intolerance. We tested whether glucose regulation of liver gene expression is geared toward intracellular homeostasis. The effect of glucose-induced accumulation of phosphorylated intermediates on expression
Zhang-Wei Liu et al.
Scientific reports, 10(1), 3094-3094 (2020-02-23)
Involvement of long non-coding RNAs (lncRNAs) in the regulation of gene expression in cis has been well studied in eukaryotes but relatively little is known whether and how lncRNAs affect gene expression in tans. In Arabidopsis thaliana, COLDAIR, a previously
Yi-sheng Chen et al.
Archives of microbiology, 196(3), 193-199 (2014-02-05)
Lactobacillus plantarum 510, previously isolated from a koshu vineyard in Japan, was found to produce a bacteriocin-like inhibitory substance which was purified and characterized. Mass spectrometry analysis showed that the mass of this bacteriocin is 4,296.65 Da. A partial sequence, NH2-
Amudha Nagarathinam et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(49), 19284-19294 (2013-12-07)
Pathological, genetic, and biochemical hallmarks of Alzheimer's disease (AD) are linked to amyloid-β (Aβ) peptide aggregation. Especially misfolded Aβ42 peptide is sufficient to promote amyloid plaque formation. However, the cellular compartment facilitating the conversion of monomeric Aβ to aggregated toxic
Jorge Gómez-Miragaya et al.
Molecular cancer research : MCR, 17(10), 2063-2076 (2019-07-20)
Taxanes are standard therapy in clinical practice for metastatic breast cancer; however, primary or acquired chemoresistance are a common cause of mortality. Breast cancer patient-derived xenografts (PDX) are powerful tools for the study of cancer biology and drug treatment response.
Margherita Y Turco et al.
Nature cell biology, 19(5), 568-577 (2017-04-11)
In humans, the endometrium, the uterine mucosal lining, undergoes dynamic changes throughout the menstrual cycle and pregnancy. Despite the importance of the endometrium as the site of implantation and nutritional support for the conceptus, there are no long-term culture systems
Enzymatic sculpting of nanoscale and microscale surface topographies.
Jen-Huang Huang et al.
Angewandte Chemie (International ed. in English), 51(38), 9619-9623 (2012-08-29)
Bovine herpes virus type 4 alters TNF-alpha and IL-8 profiles and impairs the survival of bovine endometrial epithelial cells
Chanrot M, et al.
Reproductive Biology, 17(3), 225-232 (2017)
The specificity of proteinase K against oxidized insulin B chain.
E Kraus et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 357(2), 233-237 (1976-02-01)
Neetu Kumra Taneja et al.
Journal of bacteriology, 195(22), 5102-5111 (2013-09-10)
Bordetella pertussis is the causative agent of pertussis, a highly contagious disease of the human respiratory tract. Despite very high vaccine coverage, pertussis has reemerged as a serious threat in the United States and many developing countries. Thus, it is
Han Sun et al.
Bing du xue bao = Chinese journal of virology, 28(4), 409-413 (2012-09-18)
In order to explore the potential influences of the disulfide bridge on the physical and chemical properties of PrP protein, the expressed recombinant human wild-type PrP protein was purified for using in an established redox process for the reduction and
Chromatin isolation by RNA purification (ChIRP).
Chu, C., et al.
Journal of Visualized Experiments (2012)
Desingu Ayyappa Raja et al.
Development (Cambridge, England), 147(5) (2020-02-27)
In the neural crest lineage, progressive fate restriction and stem cell assignment are crucial for both development and regeneration. Whereas fate commitment events have distinct transcriptional footprints, fate biasing is often transitory and metastable, and is thought to be moulded
Gerhild Zauner et al.
Methods in molecular biology (Clifton, N.J.), 951, 113-127 (2013-01-09)
Liquid chromatography-tandem stage mass spectrometry of glycopeptides is a powerful tool for the site-specific glycosylation analysis of glycoproteins. Using fetuin as a model substance, we describe a protocol for glycopeptide dissection using nonspecific proteolysis by proteinase K. Proteolysis is achieved
Shi-Qin Lv et al.
Neural regeneration research, 16(8), 1598-1605 (2021-01-13)
Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat
Yoshitaka Yamaguchi et al.
PloS one, 7(8), e43540-e43540 (2012-08-29)
Accumulating lines of evidence indicate that the N-terminal domain of prion protein (PrP) is involved in prion susceptibility in mice. In this study, to investigate the role of the octapeptide repeat (OR) region alone in the N-terminal domain for the
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