Amudha Nagarathinam et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(49), 19284-19294 (2013-12-07)
Pathological, genetic, and biochemical hallmarks of Alzheimer's disease (AD) are linked to amyloid-β (Aβ) peptide aggregation. Especially misfolded Aβ42 peptide is sufficient to promote amyloid plaque formation. However, the cellular compartment facilitating the conversion of monomeric Aβ to aggregated toxic