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p4864

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Jingjing Wang et al.
Journal of pharmacological sciences, 126(3), 198-207 (2014-10-25)
SKLB-M8, a derivative of millepachine, showed significant anti-proliferative effects in melanoma cell lines. In this study, we investigated the anti-melanoma and anti-angiogenic activity of SKLB-M8 on three melanoma cell lines (A2058, CHL-1, and B16F10) and human umbilical vein endothelial cells
Sae-Bom Kwon et al.
Journal of microbiology and biotechnology, 25(3), 343-352 (2015-01-08)
H9 is an ethanol extract prepared from nine traditional/medicinal herbs. This study was focused on the anticancer effect of H9 in non-small-cell lung cancer cells. The effects of H9 on cell viability, apoptosis, mitochondrial membrane potential (MMP; Δφm), and apoptosis-related
Lei Yang et al.
Molecular biology reports, 42(5), 927-935 (2014-11-26)
MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. MiR-1908 is a recently identified miRNA that is highly expressed in human adipocytes. However, it is not known what role of miR-1908 is involved in the regulation
C van Pul et al.
Magnetic resonance in medicine, 53(2), 348-355 (2005-01-29)
Diffusion-weighted imaging (DWI) is frequently used to diagnose stroke. However, the origin of the observed reduction in the apparent diffusion coefficient (ADC) in the acute phase following ischemia is not well understood. Although cell swelling is considered to play an
Omar Naneh et al.
Journal of immunological methods, 426, 19-28 (2015-07-22)
Perforin (PFN) is one of the most important protein effectors of the immune system. It is produced by cytotoxic T lymphocytes and natural killer cells and helps with the clearance of virus-infected and tumor cells. PFN is a pore-forming protein
Qingquan Ma et al.
Chemical biology & drug design, 84(3), 348-353 (2014-03-22)
Our previous study reported Val/Arg-rich peptides, and the relationship was linear between hydrophobicity and antimicrobial potency within a certain range. Here, we further develop a new series of analogs to investigate the effect of net charge and Pro residue on
Xiang S Ye et al.
Molecular cancer therapeutics, 14(11), 2463-2472 (2015-08-26)
Intervention of cancer cell mitosis by antitubulin drugs is among the most effective cancer chemotherapies. However, antitubulin drugs have dose-limiting side effects due to important functions of microtubules in resting normal cells and are often rendered ineffective by rapid emergence
Landa Zeenelabdin Ali Salim et al.
PloS one, 9(12), e115340-e115340 (2014-12-23)
Thymoquinone is an active ingredient isolated from Nigella sativa (Black Seed). This study aimed to evaluate the in vitro and in vivo anti-leukemic effects of thymoquinone on WEHI-3 cells. The cytotoxic effect of thymoquinone was assessed using an MTT assay
Ning Zhang et al.
Oncology reports, 33(3), 1493-1498 (2015-01-13)
Despite advances in the detection and treatment of hepatocellular carcinoma (HCC), the prognosis remains poor partly due to recurrence or extra/intrahepatic metastasis. Stem‑like cancer cells are considered the source of malignant phenotypes including metastasis in various types of cancer. HCC
Y Uehara et al.
Osteoarthritis and cartilage, 22(7), 1007-1017 (2014-05-06)
When endoplasmic reticulum (ER) stress, i.e., the excessive accumulation of unfolded proteins in ER, endangers homeostasis, apoptosis is induced by C/EBP homologous protein (Chop). In osteoarthritis (OA) cartilage, Chop expression and apoptosis increase as degeneration progresses. We investigated the role
Enni Markkanen et al.
Nucleic acids research, 43(7), 3667-3679 (2015-03-25)
Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is
Jenny E Hernandez-Davies et al.
Journal of translational medicine, 13, 210-210 (2015-07-04)
(V600) BRAF mutations drive approximately 50% of metastatic melanoma which can be therapeutically targeted by BRAF inhibitors (BRAFi) and, based on resistance mechanisms, the combination of BRAF and MEK inhibitors (BRAFi + MEKi). Although the combination therapy has been shown to provide
Feng-Yu Gao et al.
Molecular medicine reports, 12(5), 7005-7010 (2015-09-02)
Gastric cancer is one of the most frequent malignancies and a leading cause of cancer-related mortality worldwide. MicroRNAs (miRs), a class of small non‑coding RNAs, have been shown to be critical in tumorigenesis. In the present study, the expression levels
Bo Jiang et al.
Cellular immunology, 290(1), 10-20 (2014-05-27)
NK cells hold promise for protecting hosts from cancer and pathogen infection through direct killing and expressing immune-regulatory cytokines. In our study, a genetically modified K562 cell line with surface expression of 4-1BBL and MICA was constructed to expand functional
Neng Wang et al.
Oncotarget, 6(12), 9854-9876 (2015-04-29)
Breast cancer stem cells (CSCs) are considered as the root of mammary tumorigenesis. Previous studies have demonstrated that ISL efficiently limited the activities of breast CSCs. However, the cancer prevention activities of ISL and its precise molecular mechanisms remain largely
Tri Budi Hartomo et al.
International journal of oncology, 46(3), 1089-1098 (2014-12-20)
Despite the introduction of 13-cis-retinoic acid (13-cis-RA) into the current chemotherapy, more than half of high-risk neuroblastoma patients have experienced tumor relapses driven by chemoresistant cancer stem cells (CSCs) that can be isolated by their ability to grow as spheres.
Hiroyuki Takano et al.
Toxicology, 326, 53-61 (2014-12-03)
Microcystin-LR is a cyclic peptide released by several bloom-forming cyanobacteria. Understanding the mechanism of microcystin-LR toxicity is important, because of the both potencies of its acute cytotoxicity and tumor-promoting activity in hepatocytes of animals and humans. Recently, we have reported
Paul Z Elias et al.
Journal of controlled release : official journal of the Controlled Release Society, 208, 76-84 (2015-03-10)
Thermosensitive injectable hydrogels have been used for the delivery of pharmacological and cellular therapies in a variety of soft tissue applications. A promising class of synthetic, injectable hydrogels based upon oligo(ethylene glycol) methacrylate (OEGMA) monomers has been previously reported, but
Laurent Pascal et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(4), 625-631 (2015-02-03)
Slow reconstitution of T cell immunity remains a critical issue after umbilical cord blood (CB) transplantation. Although this may be a consequence of the low cell dose, it may also reflect the propensity of naïve T cells, which predominate in
J L Berlier et al.
Stem cell reviews, 11(6), 841-851 (2015-08-10)
Human bone marrow-derived mesenchymal stem cells (hBMSC) are able to differentiate into cells of connective tissue lineages, including bone and cartilage. They are therefore considered as a promising tool for the treatment of bone degenerative diseases. One of the major
Vinayak Palve et al.
PloS one, 9(11), e111927-e111927 (2014-11-20)
Altered expression of Mcl-1, an anti-apoptotic member of the Bcl-2 family, has been linked to the progression and outcome of a variety of malignancies. We have previously reported the overexpression of Mcl-1 protein in human oral cancers. The present study
Yunbo Sun et al.
International journal of pharmaceutics, 469(1), 31-39 (2014-04-22)
Curcumin (Cur) is a hydrophobic polyphenol with diverse pharmacological effects, especially for cancer treatment. However, its weak water solubility and stability was the major obstacle for the formulation research of Cur. The complexation of Cur and hydroxypropyl-β-cyclodextrin (HP-β-CD) was done
Jui-Ling Hsu et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(10), 979-990 (2014-07-10)
Hormone-refractory metastatic prostate cancer (HRMPC), which is metastatic and resistant to hormone therapy, is an intractable problem in clinical treatment. Anthraquinone-based natural products and synthetic compounds have shown anticancer activity. However, cardiac toxicity is a major adverse reaction in these
Susana P Mejía et al.
Microbiology (Reading, England), 161(Pt 5), 1008-1017 (2015-02-24)
Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi, including Aspergillus spp., Candida albicans and Cryptococcus
Liang-Tzung Lin et al.
BioMed research international, 2015, 415269-415269 (2015-11-12)
Taiwanofungus camphoratus (synonym Antrodia camphorata) is a widely used medicinal fungus in the folk medicine of Taiwan with several pharmacological features such as anti-inflammatory, liver protection, antihypertensive, and antioxidative activities. The ethanolic extract of T. camphoratus (TCEE) which contains abundant
Bin Li et al.
Journal of hematology & oncology, 8, 89-89 (2015-07-23)
Gliomas are the most common types of primary brain tumors in the adult central nervous system. TMEM140 is identified as an amplified gene in the human gastric cancer genome. However, the function of TMEM140 in gliomas has not been thoroughly
Silvina Grasso et al.
Neoplasia (New York, N.Y.), 16(10), 845-860 (2014-11-08)
Selumetinib (AZD6244, ARRY-142886) is a MEK1/2 inhibitor that has gained interest as an anti-tumour agent. We have determined the degree of sensitivity/resistance to Selumetinib in a panel of colorectal cancer cell lines using cell proliferation and soft agar assays. Sensitive
Maike Buchner et al.
Nature communications, 6, 6471-6471 (2015-03-11)
Despite recent advances in the cure rate of acute lymphoblastic leukaemia (ALL), the prognosis for patients with relapsed ALL remains poor. Here we identify FOXM1 as a candidate responsible for an aggressive clinical course. We show that FOXM1 levels peak
Byung-Kwon Choi et al.
Cell cycle (Georgetown, Tex.), 19(4), 479-491 (2020-01-22)
The phosphoinositide-3-kinase like kinases (PIKK) such as ATM and ATR play a key role in initiating the cellular DNA damage response (DDR). One key ATM target is the cyclin-dependent kinase inhibitor p27Kip1 that promotes G1 arrest. ATM activates p27Kip1-induced arrest
Jeremy Charles Welsch et al.
Bio-protocol, 7(22), e2605-e2605 (2017-11-20)
According to the World Health Organization (WHO), at least 50% of emerging viruses endowed with pathogenicity in humans can infect the Central Nervous System (CNS) with induction of encephalitis and other neurologic diseases ( Taylor et al., 2001 ; Olival
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