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Changfeng Chen et al.
Colloids and surfaces. B, Biointerfaces, 105, 173-179 (2013-02-05)
The time dependent molecular interactions of sodium dodecyl sulfate (SDS) with dipalmitoylphosphatidylcholine (DPPC) liposomes were studied using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy. In particular, the ATR spectra provided information on the dynamic amount of SDS incorporated and DPPC
Michelle L Gee et al.
Scientific reports, 3, 1557-1557 (2013-03-28)
Antimicrobial peptides hold promise as broad-spectrum alternatives to conventional antibiotics. The mechanism of action of this class of peptide is a topical area of research focused predominantly on their interaction with artificial membranes. Here we compare the interaction mechanism of
Maryam Ghanbari Safari et al.
Journal of liposome research, 23(3), 174-186 (2013-04-19)
Cationic liposome (CL)-DNA complexes (lipoplexes) have appeared as leading nonviral gene carriers in worldwide gene therapy clinical trials. Arriving at therapeutic dosages requires the full understanding of the mechanism of transfection. However, using CLs to deliver therapeutic nucleic acids and
Yann von Hansen et al.
Physical review letters, 111(11), 118103-118103 (2013-10-01)
The diffusional water dynamics in the hydration layer of a dipalmitoylphosphatidylcholine bilayer is studied using molecular dynamics simulations. By mapping the perpendicular water motion on the ordinary diffusion equation, we disentangle free energetic and friction effects and show that perpendicular
Tienyi T Hsu et al.
Langmuir : the ACS journal of surfaces and colloids, 29(6), 1948-1955 (2013-01-24)
3-Hydroxybutyric acid (also referred to as β-hydroxybutyric acid or BHB), a small molecule metabolite whose concentration is elevated in type I diabetes and diabetic coma, was found to modulate the properties of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayers when added to the subphase
Ana Maria S Simão et al.
Calcified tissue international, 93(3), 222-232 (2013-08-15)
During endochondral bone formation, chondrocytes and osteoblasts synthesize and mineralize the extracellular matrix through a process that initiates within matrix vesicles (MVs) and ends with bone mineral propagation onto the collagenous scaffold. pH gradients have been identified in the growth
Mohsen Pourmousa et al.
The journal of physical chemistry. B, 117(1), 230-241 (2012-12-12)
Translocation of peptides through cellular membranes is a fundamental problem in developing antimicrobial peptides and in drug delivery. There is a class of peptides, known as cell-penetrating peptides, that are able to penetrate membranes without disrupting them. They can carry
Kamil Wojciechowski et al.
Biochimica et biophysica acta, 1838(7), 1931-1940 (2014-04-22)
The interactions between a model phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a biosurfactant Quillaja Bark Saponin (QBS) obtained from the bark of Quillaja saponaria Molina were studied using simple models of biological membranes. QBS is known to interact strongly with the latter
S Raffy et al.
Biophysical journal, 76(4), 2072-2080 (1999-03-30)
Cholesterol has a concentration-dependent effect on membrane organization. It is able to control the membrane permeability by inducing conformational ordering of the lipid chains. A systematic investigation of lipid bilayer permeability is described in the present work. It takes advantage
Zeynep Busra Bolat et al.
Frontiers in bioengineering and biotechnology, 8, 50-50 (2020-03-03)
Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a collaborative action. Curcumin, isolated from turmeric, and piperine, isolated from black long pepper, are two dietary polyphenols studied for
Dinh-Duy Pham et al.
International journal of pharmaceutics, 454(2), 668-677 (2013-04-23)
We have designed a novel formulation of pyrazinamide (PZA), an antitubercular drug within large porous particles intended for deep lung delivery. By simply spray-drying PZA, we have obtained crystalline particles of the δ polymorph of PZA that were unstable and
Michael J Davies et al.
International journal of pharmaceutics, 446(1-2), 34-45 (2013-02-09)
This study aims to crystallise salbutamol sulphate beneath simulated pulmonary surfactant monolayers. Such ensembles serve as heterogeneous nucleating sites to direct crystallisation. This contribution builds upon previous work to confirm the suitability of Langmuir monolayers in supporting the rational generation
Olga Wesołowska et al.
Biochimica et biophysica acta, 1838(1 Pt B), 173-184 (2013-09-26)
Common hop (Humulus lupulus) constitutes a source of numerous prenylated chalcones such as xanthohumol (XH) and flavanones such as 8-prenylnaringenin (8-PN) and isoxanthohumol (IXH). Range of their biological activities includes estrogenic, anti-inflammatory, anti-infective, anti-cancer, and antioxidant activities. The aim of
Anirban Polley et al.
Chemistry and physics of lipids, 166, 1-11 (2012-12-12)
The molecular mechanism of ethanol and its effects on neurological function is far from clear. In this study, we investigate the effects of ethanol on various structural and dynamical properties of mixed bilayers consisting of different ratios of dipalmitoylphosphatidylcholine (DPPC)
Ekaterina L Nemashkalova et al.
Biochemistry, 52(36), 6286-6299 (2013-08-21)
HAMLET is a complex of human α-lactalbumin (hLA) with oleic acid (OA) that kills various tumor cells and strains of Streptococcus pneumoniae. More potent protein-OA complexes were previously reported for bovine α-lactalbumin (bLA) and β-lactoglobulin (bLG), and pike parvalbumin (pPA)
Katherine C Thompson et al.
Langmuir : the ACS journal of surfaces and colloids, 29(14), 4594-4602 (2013-03-14)
The presence of unsaturated lipids in lung surfactant is important for proper respiratory function. In this work, we have used neutron reflection and surface pressure measurements to study the reaction of the ubiquitous pollutant gas-phase ozone, O3, with pure and
Julio H K Rozenfeld et al.
Biochimica et biophysica acta, 1848(1 Pt A), 127-133 (2014-10-16)
In this work, the bilayer structure of novel cationic lipid diC16-amidine was compared to the one of zwitterionic dipalmitoyl phosphatidylcholine ( DPPC), which shares the same hydrophobic domain. Differential scanning calorimetry shows that DPPC and diC16-am idine bilayers have similar
You-Liang Zhu et al.
Journal of computational chemistry, 34(25), 2197-2211 (2013-10-19)
GALAMOST [graphics processing unit (GPU)-accelerated large-scale molecular simulation toolkit] is a molecular simulation package designed to utilize the computational power of GPUs. Besides the common features of molecular dynamics (MD) packages, it is developed specially for the studies of self-assembly
M Rosa Hernández et al.
International journal of nanomedicine, 7, 2339-2347 (2012-06-02)
The contribution of fibrinogen (FBN) to hemostasis acting on platelet aggregation and clot formation is well established. It has been suggested that FBN-coated liposomes could be useful in restoring hemostasis. In the present study, we evaluated the modifications induced by
Davit Hakobyan et al.
The journal of physical chemistry. B, 117(14), 3841-3851 (2013-03-09)
Ternary mixtures of saturated and unsaturated phospholipids and cholesterol constitute a well-known model system to study raft formation in membranes. This phenomenon is, e.g., observed in cell membranes. Here, coarse-grained (CG) and microscopic united-atom (UA) simulations are performed to investigate
Evelien A W Smits et al.
Journal of pharmaceutical and biomedical analysis, 75, 47-54 (2013-01-15)
This paper presents the development of a new method for the simple and reliable quantification of the free drug amount in liposomal preparations of prednisolone phosphate (PP). In this method the free drug is distinguished from the encapsulated drug by
Julio C P Damalio et al.
Biochimica et biophysica acta, 1828(6), 1441-1448 (2013-02-19)
The molecular mechanisms responsible for protein structural changes in the central nervous system leading to Alzheimer's disease are unknown, but there is evidence that a family of proteins known as septins may be involved. Septins are a conserved group of
Eduardo Guzmán et al.
Colloids and surfaces. B, Biointerfaces, 105, 284-293 (2013-02-07)
Langmuir monolayers of Cholesterol (Chol) and a mixture of Chol with 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), at a ratio of 17:83 in weight, spread on pure water and on silica nanoparticle dispersions, have been investigated measuring the compression isotherms as well as the
Agustín Mangiarotti et al.
Biochimica et biophysica acta, 1838(7), 1823-1831 (2014-03-04)
For the biophysical study of membranes, a variety of model systems have been used to measure the different parameters and to extract general principles concerning processes that may occur in cellular membranes. However, there are very few reports in which
Keith J Fritzsching et al.
Biochimica et biophysica acta, 1828(8), 1889-1898 (2013-04-10)
The interaction between cholesterol (Chol) and phospholipids in bilayers was investigated for the ternary model lipid rafts, DOPC/eSM/Chol and DOPC/DPPC/Chol, with differential scanning calorimetry (DSC) and (13)C cross polarization magic angle spinning (CP-MAS) solid-state NMR. The enthalpy and transition temperature
Elisa Dalla Pozza et al.
Biochimica et biophysica acta, 1828(5), 1396-1404 (2013-02-07)
Pancreatic adenocarcinoma is often diagnosed when metastatic events have occurred. The early spread of circulating cancer cells expressing the CD44 receptor may play a crucial role in this process. In this study, we have investigated the cellular delivery ability and
H Kristian Ijäs et al.
Biochimica et biophysica acta, 1828(3), 932-937 (2012-12-12)
Lipid self-organization is believed to be essential for shaping the lateral structure of membranes, but it is becoming increasingly clear that also membrane proteins can be involved in the maintenance of membrane architecture. Cholesterol is thought to be important for
Riya J Muckom et al.
The journal of physical chemistry. B, 117(6), 1810-1818 (2013-01-22)
Molecular dynamics (MD) simulations were used to gain insight on the molecular interactions in a model biological membrane comprised of a bilayer with DPPC (dipalmitoylphosphotidylcholine) and antimicrobial dendritic amphiphile molecules [RCONHC(CH(2)CH(2)COOH)(3), where R is the saturated hydrocarbon tail (R =
Matthew G K Benesch et al.
Biochimica et biophysica acta, 1838(7), 1941-1949 (2014-04-08)
We present a comparative differential scanning calorimetric study of the effects of the animal sterol cholesterol (Chol) and the plant sterols campesterol (Camp) and brassicasterol (Bras) on the thermotropic phase behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers. Camp and Bras differ from
Matthias Schnurr et al.
Physical chemistry chemical physics : PCCP, 15(34), 14178-14181 (2013-06-25)
Using spin hyperpolarized xenon ((129)Xe) we investigate the impact of the local molecular environment on reversible host-guest interactions. We label Xe guest atoms that are temporarily bound to cryptophane-A hosts using the Hyper-CEST technique. By varying the length of the
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