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Belthrand Habiyakare et al.
International journal of experimental pathology, 95(4), 290-295 (2014-06-24)
Novel treatments are necessary to reduce the burden of cardiovascular disease (CVD). Alamandine binds to MrgD and is reported to induce vasodilation via stimulation of endothelial nitric oxide synthase (eNOS), but its role in atherogenic blood vessels is yet to
Su Young Han et al.
The European journal of neuroscience, 42(9), 2690-2698 (2015-09-06)
Vasopressin secretion from the posterior pituitary gland is determined by action potential discharge of hypothalamic magnocellular neurosecretory cells. Vasopressin is a potent vasoconstrictor, but vasopressin levels are paradoxically elevated in some patients with established hypertension. To determine whether vasopressin neurons
Yeh Siang Lau et al.
Nutrients, 7(7), 5239-5253 (2015-07-03)
Botanical herbs are consumed globally not only as an essential diet but also as medicines or as functional/recreational food supplements. The extract of the Apocynum venetum leaves (AVLE), also known as Luobuma, exerts its antihypertensive effect via dilating the blood
Angela Troia et al.
Function (Oxford, England), 2(3), zqab015-zqab015 (2021-07-06)
Elastin (ELN) insufficiency leads to the cardiovascular hallmarks of the contiguous gene deletion disorder, Williams-Beuren syndrome, including hypertension and vascular stiffness. Previous studies showed that Williams-Beuren syndrome deletions, which extended to include the NCF1 gene, were associated with lower blood
Tao He et al.
Journal of molecular and cellular cardiology, 145, 88-98 (2020-06-03)
Class IIa histone deacetylases (HDACs) critically regulate cardiac function through the repression of the activity of myocyte enhancer factor 2 (MEF2)-dependent gene programs. Protein kinase D (PKD) and Ca2+/Calmodulin-dependent kinase II (CaMKII) activate MEF2 by phosphorylating distinct HDAC isoforms and
Joana Galvao et al.
Experimental eye research, 140, 65-74 (2015-08-25)
Death of retinal neural cells, namely retinal ganglion cells (RGCs), is a characteristic of several retinal neurodegenerative diseases. Although the role of adenosine A3 receptor (A3R) in neuroprotection is controversial, A3R activation has been reported to afford protection against several
Preventing spinal hypotension during Caesarean delivery: what is the latest?
A J Butwick et al.
British journal of anaesthesia, 114(2), 183-186 (2014-08-01)
Sheila A Engi et al.
PloS one, 9(8), e105172-e105172 (2014-08-15)
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive
Tanja Ilmarinen et al.
PloS one, 10(11), e0143669-e0143669 (2015-11-26)
In this study, we investigated the suitability of ultrathin and porous polyimide (PI) membrane as a carrier for subretinal transplantation of human embryonic stem cell (hESC) -derived retinal pigment epithelial (RPE) cells in rabbits. The in vivo effects of hESC-RPE
Panagiotis Laspas et al.
Experimental eye research, 127, 1-8 (2014-07-16)
Nitric oxide synthases (NOS) are involved in regulation of ocular vascular tone and blood flow. While endothelial NOS (eNOS) has recently been shown to mediate endothelium-dependent vasodilation in mouse retinal arterioles, the contribution of individual NOS isoforms to vascular responses
Jacky W Y Lee et al.
Medicine, 94(8), e567-e567 (2015-02-26)
To investigate the association between macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in Chinese children. This cross-sectional study recruited consecutive cases of healthy pediatric subjects aged 4 to 18 from Caritas Medical Centre in Hong Kong Special
Jin O-Uchi et al.
Biochemical and biophysical research communications, 433(2), 188-193 (2013-03-05)
Adrenoceptor stimulation is a key determinant of cardiac excitation-contraction coupling mainly through the activation of serine/threonine kinases. However, little is known about the role of protein tyrosine kinases (PTKs) activated by adrenergic signaling on cardiac excitation-contraction coupling. A cytoplasmic tyrosine
Julian Uwe Gabriel Wagner et al.
Journal of molecular and cellular cardiology, 138, 269-282 (2019-12-24)
Cellular specialization and interaction with other cell types in cardiac tissue is essential for the coordinated function of cell populations in the heart. The complex interplay between cardiomyocytes, endothelial cells and fibroblasts is necessary for adaptation but can also lead
Ashraf S Habib et al.
Obstetrics and gynecology, 121(3), 615-623 (2013-05-03)
To estimate whether the addition of metoclopramide or its combination with ondansetron to a prophylactic phenylephrine infusion provides improved intraoperative nausea and vomiting prophylaxis compared with phenylephrine infusion alone. Women scheduled for elective cesarean delivery were randomized to one of
Natalia M Arzeno et al.
American journal of physiology. Heart and circulatory physiology, 304(8), H1114-H1123 (2013-02-12)
Spaceflight-induced orthostatic intolerance has been studied for decades. Although ∼22% of the astronaut corps are women, most mechanistic studies use mostly male subjects, despite known sex differences in autonomic control and postflight orthostatic intolerance. We studied adrenergic, baroreflex, and autonomic
Yu-Hua Sun et al.
Pharmaceutical biology, 51(9), 1158-1164 (2013-06-15)
The buds of Coreopsis tinctoria Nutt (Compositae) are used in the treatment of hypertension in the Uyghur folk medicine in China. To investigate vasorelaxant properties of extracts and some flavonoids from C. tinctoria (CT) and their underlying mechanisms in isolated
Aaron J Polichnowski et al.
American journal of physiology. Renal physiology, 305(7), F1074-F1084 (2013-07-05)
Chronic ANG II infusion in rodents is widely used as an experimental model of hypertension, yet very limited data are available describing the resulting blood pressure-renal blood flow (BP-RBF) relationships in conscious rats. Accordingly, male Sprague-Dawley rats (n = 19)
Dale A Currigan et al.
Anesthesiology, 121(5), 930-936 (2014-09-10)
Vasopressor drugs, commonly used to treat systemic hypotension and maintain organ perfusion, may also induce regional vasoconstriction in specialized vascular beds such as the lung. An increase in pulmonary vascular tone may adversely affect patients with pulmonary hypertension or right
Ashok Jadhav et al.
The Journal of pharmacology and experimental therapeutics, 345(3), 383-392 (2013-03-28)
Catharanthine is a constituent of anticancer vinca alkaloids. Its cardiovascular effects have not been investigated. This study compares the in vivo hemodynamic as well as in vitro effects of catharanthine on isolated blood vessels, vascular smooth muscle cells (VSMCs), and
Anna Bryndis Einarsdottir et al.
Journal of Alzheimer's disease : JAD, 49(1), 79-83 (2015-10-08)
Structural and physiological abnormalities have been reported in the retina in Alzheimer's disease (AD). Retinal oximetry detects changes in retinal oxygen metabolism in many eye diseases, where structural changes are seen. To compare oxygen saturation in retinal blood vessels in
Somruedee Yorsin et al.
Journal of ethnopharmacology, 156, 162-174 (2014-08-30)
In Thai traditional medicine, rhizomes of Kaempferia parviflora (KP) have been used for treating hypertension and for the promotion of longevity with good health and well being. Ageing is one of the most important risk factors for development of cardiovascular
Ke Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), E5716-E5723 (2014-12-17)
Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed
Ruijie Liu et al.
Biochemical and biophysical research communications, 533(1), 17-22 (2020-09-13)
Extracellular signal-regulated kinase 1 and 2 (ERK1/2) have been implicated as important regulators of metabolic homeostasis. Here we generated a new mouse model with genetic deletion of two ERK1/2 phosphatases, dual specificity phosphatase (DUSP) 6 and 8, to further define
Claire Lewis et al.
Rapid communications in mass spectrometry : RCM, 29(12), 1107-1114 (2015-05-20)
A current challenge for analytical chemists is the development of the measurement systems and approaches required to understand dynamic processes such as tablet dissolution. The design and development of oral tablets could be improved by the availability of detailed information
Enzo R Porrello et al.
Neonatology, 97(3), 257-265 (2009-11-06)
Perinatal glucocorticoid treatment is associated with hypertrophic cardiomyopathy, but the cellular mechanism is controversial. An underlying interaction between glucocorticoids and the renin-angiotensin system may be important, but whether glucocorticoids modulate angiotensin II (AngII)-dependent cardiomyocyte growth responses in the neonate has
Molly Yao et al.
Methods and protocols, 4(4) (2021-10-27)
Homeostasis of vascular tone is intricately and delicately maintained systemically and locally, by autonomic nerves and hormones in the blood and by intimal vasoactive substances, respectively. The balance can be acutely or chronically interrupted secondary to many alterations, especially under
Hoon Dong Kim et al.
Investigative ophthalmology & visual science, 56(1), 122-131 (2014-12-17)
To evaluate the changes of retinal function with multifocal electroretinogram (mfERG), and estimate the association between functional and structural changes after selective retina therapy (SRT) with microsecond-pulsed laser in comparison to continuous wave laser photocoagulation (cwPC). Selective retina therapy and
Christopher J LeSar et al.
Journal of the American College of Surgeons, 218(4), 760-766 (2014-03-25)
Carotid endarterectomy (CEA) is often completed with general anesthesia and routine shunting; however, shunting is only required in a small group of at-risk patients to maintain adequate cerebral perfusion. Selective shunting during CEA is performed to normalize cerebral hemodynamics for
Zhan-Ping Xu et al.
Scandinavian journal of urology, 49(3), 260-266 (2015-04-10)
The aim of this study was determine whether intracavernosal injection (ICI) of insulin-like growth factor-1 (IGF-1) protein can improve corpus cavernosal smooth muscle relaxation in aging rats. Ten young (4-month-old) and 30 old (24-month-old) Sprague-Dawley male rats were enrolled in
Robin Verjans et al.
Scientific reports, 9(1), 6055-6055 (2019-04-17)
Heart failure (HF) is the leading cause of death in the Western world. Pathophysiological processes underlying HF development, including cardiac hypertrophy, fibrosis and inflammation, are controlled by specific microRNAs (miRNAs). Whereas most studies investigate miRNA function in one particular cardiac
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