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Enzo R Porrello et al.
Neonatology, 97(3), 257-265 (2009-11-06)
Perinatal glucocorticoid treatment is associated with hypertrophic cardiomyopathy, but the cellular mechanism is controversial. An underlying interaction between glucocorticoids and the renin-angiotensin system may be important, but whether glucocorticoids modulate angiotensin II (AngII)-dependent cardiomyocyte growth responses in the neonate has
Belthrand Habiyakare et al.
International journal of experimental pathology, 95(4), 290-295 (2014-06-24)
Novel treatments are necessary to reduce the burden of cardiovascular disease (CVD). Alamandine binds to MrgD and is reported to induce vasodilation via stimulation of endothelial nitric oxide synthase (eNOS), but its role in atherogenic blood vessels is yet to
Anna Bryndis Einarsdottir et al.
Journal of Alzheimer's disease : JAD, 49(1), 79-83 (2015-10-08)
Structural and physiological abnormalities have been reported in the retina in Alzheimer's disease (AD). Retinal oximetry detects changes in retinal oxygen metabolism in many eye diseases, where structural changes are seen. To compare oxygen saturation in retinal blood vessels in
Jacky W Y Lee et al.
Medicine, 94(8), e567-e567 (2015-02-26)
To investigate the association between macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in Chinese children. This cross-sectional study recruited consecutive cases of healthy pediatric subjects aged 4 to 18 from Caritas Medical Centre in Hong Kong Special
Julian Uwe Gabriel Wagner et al.
Journal of molecular and cellular cardiology, 138, 269-282 (2019-12-24)
Cellular specialization and interaction with other cell types in cardiac tissue is essential for the coordinated function of cell populations in the heart. The complex interplay between cardiomyocytes, endothelial cells and fibroblasts is necessary for adaptation but can also lead
Ashraf S Habib et al.
Obstetrics and gynecology, 121(3), 615-623 (2013-05-03)
To estimate whether the addition of metoclopramide or its combination with ondansetron to a prophylactic phenylephrine infusion provides improved intraoperative nausea and vomiting prophylaxis compared with phenylephrine infusion alone. Women scheduled for elective cesarean delivery were randomized to one of
Su Young Han et al.
The European journal of neuroscience, 42(9), 2690-2698 (2015-09-06)
Vasopressin secretion from the posterior pituitary gland is determined by action potential discharge of hypothalamic magnocellular neurosecretory cells. Vasopressin is a potent vasoconstrictor, but vasopressin levels are paradoxically elevated in some patients with established hypertension. To determine whether vasopressin neurons
Gopireddy R Reddy et al.
iScience, 25(1), 103693-103693 (2022-01-18)
Sinoatrial node (SAN) cells are the pacemakers of the heart. This study describes a method for culturing and infection of adult mouse SAN cells with FRET-based biosensors that can be exploited to examine signaling events. SAN cells cultured in media
Yu-Hua Sun et al.
Pharmaceutical biology, 51(9), 1158-1164 (2013-06-15)
The buds of Coreopsis tinctoria Nutt (Compositae) are used in the treatment of hypertension in the Uyghur folk medicine in China. To investigate vasorelaxant properties of extracts and some flavonoids from C. tinctoria (CT) and their underlying mechanisms in isolated
Natalia M Arzeno et al.
American journal of physiology. Heart and circulatory physiology, 304(8), H1114-H1123 (2013-02-12)
Spaceflight-induced orthostatic intolerance has been studied for decades. Although ∼22% of the astronaut corps are women, most mechanistic studies use mostly male subjects, despite known sex differences in autonomic control and postflight orthostatic intolerance. We studied adrenergic, baroreflex, and autonomic
Fei Luo et al.
Journal of neurochemistry, 132(1), 38-50 (2014-09-10)
α1 -adrenoceptors (α1 -ARs) stimulation has been found to enhance excitatory processes in many brain regions. A recent study in our laboratory showed that α1 -ARs stimulation enhances glutamatergic transmission via both pre- and post-synaptic mechanisms in layer V/VI pyramidal
Ruijie Liu et al.
Biochemical and biophysical research communications, 533(1), 17-22 (2020-09-13)
Extracellular signal-regulated kinase 1 and 2 (ERK1/2) have been implicated as important regulators of metabolic homeostasis. Here we generated a new mouse model with genetic deletion of two ERK1/2 phosphatases, dual specificity phosphatase (DUSP) 6 and 8, to further define
Claire Lewis et al.
Rapid communications in mass spectrometry : RCM, 29(12), 1107-1114 (2015-05-20)
A current challenge for analytical chemists is the development of the measurement systems and approaches required to understand dynamic processes such as tablet dissolution. The design and development of oral tablets could be improved by the availability of detailed information
Rajendra K Gangalum et al.
Investigative ophthalmology & visual science, 55(11), 7227-7240 (2014-08-30)
The clinical management of cataracts in infancy involves surgical removal of the lens to ensure transmission of light to the retina, which is essential for normal neural development of the infant. This surgery, however, entails a lifelong follow-up and impaired
Casey A Mueller et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(8), R855-R863 (2013-09-06)
ANG II alters the short-term blood pressure buffering capacity of the baroreflex in many adult animals. In embryonic chickens, high plasma ANG II levels contribute to baseline mean arterial pressure (MAP, kPa) without changing heart rate (ƒH, beats/min). We hypothesized
Yeh Siang Lau et al.
Nutrients, 7(7), 5239-5253 (2015-07-03)
Botanical herbs are consumed globally not only as an essential diet but also as medicines or as functional/recreational food supplements. The extract of the Apocynum venetum leaves (AVLE), also known as Luobuma, exerts its antihypertensive effect via dilating the blood
Molly Yao et al.
Methods and protocols, 4(4) (2021-10-27)
Homeostasis of vascular tone is intricately and delicately maintained systemically and locally, by autonomic nerves and hormones in the blood and by intimal vasoactive substances, respectively. The balance can be acutely or chronically interrupted secondary to many alterations, especially under
Hoon Dong Kim et al.
Investigative ophthalmology & visual science, 56(1), 122-131 (2014-12-17)
To evaluate the changes of retinal function with multifocal electroretinogram (mfERG), and estimate the association between functional and structural changes after selective retina therapy (SRT) with microsecond-pulsed laser in comparison to continuous wave laser photocoagulation (cwPC). Selective retina therapy and
Jin O-Uchi et al.
Biochemical and biophysical research communications, 433(2), 188-193 (2013-03-05)
Adrenoceptor stimulation is a key determinant of cardiac excitation-contraction coupling mainly through the activation of serine/threonine kinases. However, little is known about the role of protein tyrosine kinases (PTKs) activated by adrenergic signaling on cardiac excitation-contraction coupling. A cytoplasmic tyrosine
A myocardial slice culture model reveals alpha-1A-adrenergic receptor signaling in the human heart
Thomas RC, et al.
JACC. Basic to translational science, 1(3), 155-167 (2016)
Sheila A Engi et al.
PloS one, 9(8), e105172-e105172 (2014-08-15)
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive
Panagiotis Laspas et al.
Experimental eye research, 127, 1-8 (2014-07-16)
Nitric oxide synthases (NOS) are involved in regulation of ocular vascular tone and blood flow. While endothelial NOS (eNOS) has recently been shown to mediate endothelium-dependent vasodilation in mouse retinal arterioles, the contribution of individual NOS isoforms to vascular responses
Ke Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), E5716-E5723 (2014-12-17)
Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed
Somruedee Yorsin et al.
Journal of ethnopharmacology, 156, 162-174 (2014-08-30)
In Thai traditional medicine, rhizomes of Kaempferia parviflora (KP) have been used for treating hypertension and for the promotion of longevity with good health and well being. Ageing is one of the most important risk factors for development of cardiovascular
Jiung-Pang Huang et al.
Journal of cardiovascular pharmacology, 72(5), 231-241 (2018-11-07)
We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2
Simone R Potje et al.
Free radical biology & medicine, 106, 148-157 (2017-02-14)
Nicotinamide adenine dinucleotide phosphate oxidase (NAD(P)H-oxidase) is a multicomponent enzyme system that generates superoxide anion by one-electron reduction of molecular oxygen and represents the major source of reactive oxygen species (ROS) in the vascular cells. Apocynin has been extensively used
Xing Fu et al.
The Journal of clinical investigation, 128(5), 2127-2143 (2018-04-18)
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts.
Katherine A Poole et al.
Anesthesia and analgesia, 117(3), 641-643 (2013-07-23)
Quetiapine is an atypical antipsychotic with known α-adrenergic antagonism. We present a case of refractory hypotension that occurred after induction of general anesthesia in a patient being treated with quetiapine. This patient was not currently taking antihypertensives and had no
Shreyasi Choudhury et al.
Molecular neurodegeneration, 10, 40-40 (2015-08-27)
Axonal injury of the optic nerve (ON) is involved in various ocular diseases, such as glaucoma and traumatic optic neuropathy, which leads to apoptotic death of retinal ganglion cells (RGCs) and loss of vision. Caspases have been implicated in RGC
Zhan-Ping Xu et al.
Scandinavian journal of urology, 49(3), 260-266 (2015-04-10)
The aim of this study was determine whether intracavernosal injection (ICI) of insulin-like growth factor-1 (IGF-1) protein can improve corpus cavernosal smooth muscle relaxation in aging rats. Ten young (4-month-old) and 30 old (24-month-old) Sprague-Dawley male rats were enrolled in
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