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Xiaofan Sui et al.
European journal of medicinal chemistry, 44(11), 4455-4460 (2009-07-10)
We developed an improved Lombardeo's method (J. Med. Chem., 2004) for prediction of VD(ss) in human. With ElogD substituted by logk(IAM), together with f(i (7.4)) (the fraction of compound ionized at pH 7.4) and logf(u) (logarithmic fraction of compound unbound
[Giant cell arteritis].
Patrick Hakman et al.
Praxis, 102(12), 703-708 (2013-06-06)
Jiazhen Xing et al.
European journal of clinical pharmacology, 71(2), 191-198 (2014-12-10)
Interleukin 18 (IL-18) is a potent proinflammatory cytokine thought to down-regulate cytochrome P450 (CYP) enzyme activities. This study aimed to assess the potential influence of two functional single nucleotide polymorphisms (SNPs) in the IL-18 promoter region on the tacrolimus pharmacokinetics
Chronic inflammatory demyelinating polyneuropathy associated with neurosyphilis.
Evangelia Kararizou et al.
The American journal of the medical sciences, 349(1), 90-91 (2014-12-04)
Histologic transformation of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly.
Eunyoung Lee et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e332-e334 (2013-05-30)
Naomi R Goldberg et al.
American journal of ophthalmology, 158(6), 1310-1317 (2014-09-10)
To evaluate the success of single-agent immunosuppression for patients with the posterior uveitides, birdshot chorioretinitis, multifocal choroiditis with panuveitis, and punctate inner choroiditis. Retrospective case series. setting: Tertiary care uveitis practices. population: Patients initiated on immunomodulatory therapy. intervention: Patients were
He Huang et al.
JAMA, 312(23), 2521-2530 (2014-12-17)
Hepatitis B virus (HBV) reactivation is a serious complication for patients with lymphoma treated with rituximab-containing chemotherapies, despite lamivudine prophylaxis treatment. An optimal prophylactic antiviral protocol has not been determined. To compare the efficacy of entecavir and lamivudine in preventing
Xiaoyang Li et al.
Annals of hematology, 94(1), 57-63 (2014-08-03)
The Glasgow Prognostic Score (GPS) incorporates C-reactive protein and albumin as clinically useful markers of tumor behavior and shows significant prognostic value in several types of solid tumors. The accuracy of the GPS in predicting outcomes in diffuse large B
Jingjing Wang et al.
Oncology reports, 32(6), 2557-2563 (2014-10-18)
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma worldwide. Although patient outcomes have significantly improved to a greater than 40% cure rate by the combinatorial cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, which is widely
Sarah Alexander et al.
Pediatric blood & cancer, 61(12), 2236-2242 (2014-08-27)
Optimal therapy for children and adolescents with advanced stage anaplastic large cell lymphoma (ALCL) is unknown. ANHL0131 examined whether a maintenance regimen including vinblastine compared to the standard APO (doxorubicin, prednisone, vincristine, methotrexate, 6-mercaptopurine) regimen would result in superior event-free
Intermittent glucocorticoid dosing improves muscle repair and function in mice with limb-girdle muscular dystrophy
Quattrocelli M, et al.
The American Journal of Pathology, 187(11), 2520-2535 (2017)
C M Spies et al.
Clinical and experimental rheumatology, 29(5 Suppl 68), S42-S45 (2011-11-11)
Glucocorticoids (GCs) are widely used in clinical medicine because of their anti-inflammatory and immunosuppressive effects. However, these agents have a considerable potential for adverse effects, especially if used in high doses. The currently most advanced approach to improve the risk-benefit
Frank Buttgereit et al.
Expert opinion on pharmacotherapy, 14(8), 1097-1106 (2013-04-19)
Despite the widespread use of glucocorticoid (GC) treatment for inflammatory conditions, there remains a need to optimize use by improving efficacy and/or reducing adverse consequences. The most advanced approach, already licensed for clinical use, is delayed-release prednisone. Delayed-release prednisone consists
Takayuki Ise et al.
Heart (British Cardiac Society), 100(15), 1165-1172 (2014-05-16)
Gadolinium-enhanced cardiovascular magnetic resonance is an emerging tool for the diagnosis of cardiac sarcoidosis (CS); however, the correlations between extent of late gadolinium enhancement (LGE) and efficacy of steroid therapy and adverse outcomes in patients with CS remain unclear. We
Polymyalgia rheumatica or lymphoma recurrence? Positron emission tomography/computed tomography is a specific imaging technique that helps differential diagnosis.
Dario Camellino et al.
Rheumatology (Oxford, England), 53(5), 809-809 (2014-03-20)
Karim Aouam et al.
Therapeutic drug monitoring, 37(4), 524-530 (2015-01-30)
Limited sampling strategies (LSS), using few sampling times after dosing, have been used to reliably predict tacrolimus area under the 12-hour concentration-time curve (AUC). Because the pharmacokinetics of tacrolimus is subject to significant changes over the exposure time to this
Ryan A Crane et al.
The Laryngoscope, 125(1), 209-217 (2014-07-22)
To systematically review the available evidence regarding steroid treatment for sudden sensorineural hearing loss (SSHL) and to update prior analyses when possible. OVID Medline. An electronic database search (OVID Medline) was performed with the objective of identifying all randomized controlled
Florentien D O de Steenwinkel et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1705-1711 (2014-03-01)
Active rheumatoid arthritis (RA) during pregnancy and the presence of rheumatoid factor (RF) or anti-citrullinated protein antibodies (ACPAs) are associated with lower birth weight of the child. Moreover, treatment of the mothers with prednisone may shorten the gestational age at
Daniel P Petrylak et al.
The Lancet. Oncology, 16(4), 417-425 (2015-03-07)
Patients with metastatic castration-resistant prostate cancer have few treatment options. We investigated the safety and efficacy of lenalidomide, an immunomodulatory agent with anti-angiogenic properties, in combination with docetaxel and prednisone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer. In this
Michaela Rancea et al.
Journal of the National Cancer Institute, 106(8), doi:10-doi:10 (2014-07-18)
This sixteenth biannual report of the Cochrane Haematological Malignancies Group highlights recently published randomized controlled trials (RCTs) in the field of hemato-oncology, with special focus on non-Hodgkin's lymphoma. The report covers the publication period June 2012 to July 2013. Trials
Stefanie Schuster et al.
Praxis, 102(14), 873-876 (2013-07-05)
We report the case of a 73 year old patient with a COPD. A severe exazerbation was treated with glucocorticoids and Quinolones. A few days later both ankles were tender and painful. Ultrasound examination showed bilateral Achilles tendon ruptures. Diagnostics
Samantha J Allen et al.
Current protocols in chemical biology, 12(1), e78-e78 (2020-03-10)
Small-molecule drug discovery can be hindered by the formation of aggregates that act as non-selective inhibitors of drug targets. Such aggregates appear as false positives in high-throughput screening campaigns and can bedevil structure-activity relationships during compound optimization. Protocols are described
Leping Zhao et al.
Journal of molecular endocrinology, 55(2), 119-131 (2015-07-30)
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) controls the production of active glucocorticoid (GC) and has been proposed as a new target for the treatment of type 2 diabetes. We have previously reported that a natural product, curcumin, exhibited moderate inhibition and
David A Nace et al.
The Journal of infectious diseases, 211(12), 1915-1924 (2014-12-20)
Despite vaccination, residents of long-term-care facilities (LTCFs) remain at high risk of influenza-related morbidity and mortality. More-effective vaccine options for this population are needed. We conducted a single-blinded, randomized, controlled trial comparing high-dose (HD) to standard-dose (SD) inactivated influenza vaccine
[EBV-positive diffuse large B-cell lymphoma in young individual: report of a case].
Wen-sheng Li et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 42(2), 128-129 (2013-05-29)
Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma.
Evan J Lipson et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(19), e69-e71 (2014-02-05)
Yuksel Urun et al.
Tumori, 99(2), e65-e69 (2013-06-12)
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid follicles. FDCS has been increasingly reported in recent years. However, data on FDCS are mostly based on single case reports or case series
Simon Yu Tian et al.
The Journal of rheumatology, 42(8), 1392-1400 (2015-06-17)
To determine the most effective immunosuppressive therapy for the longterm management of proliferative lupus nephritis (PLN) based on the outcome of renal failure. A systematic review of randomized controlled trials (RCT) was conducted. MEDLINE and EMBASE were searched. RCT designed
Recurrent erythema multiforme.
Jarad Levin et al.
JAMA, 312(4), 426-427 (2014-07-20)
Karim Fizazi et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(7), 723-731 (2015-01-28)
Orteronel (TAK-700) is an investigational, nonsteroidal, reversible, selective 17,20-lyase inhibitor. This study examined orteronel in patients with metastatic castration-resistant prostate cancer that progressed after docetaxel therapy. In our study, 1,099 men were randomly assigned in a 2:1 schedule to receive
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