Showing 1-25 of 25 results for "P6762"
Nam Muk Oh et al.
Colloids and surfaces. B, Biointerfaces, 101, 298-306 (2012-09-27)
Advanced materials that have controllable pH-responsive properties when submerged in the lysosome have a great potential in intracellular drug delivery. We developed novel poly(L-amino acid) nanogels that were prepared by a facile cross-linking of poly[L-aspartic acid-g-(3-diethylaminopropyl)]-b-poly(ethylene glycol)-maleimide [poly(L-Asp-g-DEAP)-b-PEG-Mal] and poly(L-aspartic...
Irina Marchenko et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(3), 599-605 (2012-08-21)
Enzyme-catalyzed degradation of CaCO₃-templated capsules is presented. We investigate a) biodegradable, b) mixed biodegradable/synthetic, and c) multicompartment polyelectrolyte multilayer capsules with different numbers of polymer layers. Using confocal laser scanning microscopy we observed the kinetics of the non-specific protease Pronase-induced...
Kyung Hyun Min et al.
Biomaterials, 33(23), 5788-5797 (2012-05-18)
A mineral (calcium phosphate, CaP)-reinforced core-shell-corona micelle was evaluated as a nanocarrier of doxorubicin (DOX) for cancer therapy. The polymer micelles of poly(ethylene glycol)-b-poly(L-aspartic acid)-b-poly(L-phenylalanine) (PEG-PAsp-PPhe) in the aqueous phase provided the three distinct functional domains: the hydrated PEG outer...
Min Xu et al.
Langmuir : the ACS journal of surfaces and colloids, 28(31), 11310-11318 (2012-07-10)
Cationic nanocarrier mediated intracellular therapeutic agent delivery acts as a double-edged sword: the carriers promote cellular uptake, but interact nonspecifically and strongly with negatively charged endogenic proteins and cell membranes, which results in aggregates and high cytotoxicity. The present study...
Tomohiro Hiraishi et al.
Applied microbiology and biotechnology, 91(4), 895-903 (2011-06-30)
Thermally synthesized poly(aspartate) (tPAA) shows potential for use in a wide variety of products and applications as a biodegradable replacement for non-biodegradable polycarboxylates, such as poly(acrylate). The tPAA molecule has unnatural structures, and the relationship between its biodegradability and structures...
Chao Li et al.
Bioconjugate chemistry, 23(9), 1832-1837 (2012-08-09)
Genome manipulation controlled by small metal complexes has attracted extensive interest because of their potential application in the fields of molecular biotechnology and drug development. However, their medicinal application is still limited due to the distinct toxicity of the free...
Wang Xiao et al.
Journal of biomedical materials research. Part A, 100(1), 149-154 (2011-10-15)
A new "plug and play" polymeric template with the driving force of host-guest interaction between β-CD and naphthalene-modified functional groups was designed and studied. Multiple functional groups can be loaded into the template directly and conveniently. Importantly, the "plug and...
Miklos Zrinyi et al.
Acta biomaterialia, 9(2), 5122-5131 (2012-09-15)
In the present paper we report for the first time the development of redox-responsive biocompatible polymer gels. Double cross-linked poly(aspartic acid) hydrogels were prepared using two different cross-linking agents simultaneously. One of the cross-linkers was diaminobutane (DAB), the other cystamine...
Anna Kubíčková et al.
Physical review letters, 108(18), 186101-186101 (2012-06-12)
Charge reversal as an extreme case of charge compensation is directly observed by capillary electrophoresis for a negatively charged peptide in aqueous solutions of trivalent cations. Atomistic and coarse-grained simulations provide molecular interpretation of this effect showing that it is...
Loredana E Nita et al.
Colloids and surfaces. B, Biointerfaces, 103, 544-549 (2012-12-25)
Pluronic F127/poly(aspartic acid) mixtures were investigated in dilute solutions by viscometry and dynamic light scattering. The two polymers were chosen due to well known applications in biomedical field, taking into account the final purpose (the use of the complex structure...
Jihui Tang et al.
Die Pharmazie, 67(9), 756-764 (2012-09-29)
A novel block copolymer containing two polymeric components, poly(L-aspartic acid)-b-poly (L-phenylalanine) (PAA-PPA), was synthesized and its potential for the preparation of copolymer micelles with a poorly water-soluble drug was investigated in this study. The chemical structure and physical properties of...
Xiaojuan Wang et al.
Colloids and surfaces. B, Biointerfaces, 86(1), 237-241 (2011-05-04)
A novel zwitterionic polypeptide derivative, denoted as His-PAsp/PAsp, was successfully synthesized by amidation of Poly (α,β-L-aspartic acid) with L-histidine methyl ester. Turbidity, zeta potential and ¹H NMR measurements were used to study the aggregation behaviors of His-PAsp/PAsp under different pH...
Jessica R Ray et al.
Environmental science & technology, 46(24), 13167-13175 (2012-11-17)
To better understand the transport of contaminants in aqueous environments, we need more accurate information about heterogeneous and homogeneous nucleation of iron(III) hydroxide nanoparticles in the presence of organics. We combined synchrotron-based grazing incidence small-angle X-ray scattering (GISAXS) and SAXS...
Ruijun Xing et al.
Nanoscale, 3(12), 4943-4945 (2011-11-09)
We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver...
Ying Xu et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 64(2), 423-430 (2011-11-22)
Polysuccinimide (abridged as PSI) was synthesized by urea and maleic anhydride. Aminobenzenesulfonic acid (ABSA) was introduced at different mole ratio to PSI to generate polyaspartic acid (abridged as PASP)/ABSA graft copolymer. The scale inhibition behavior of resultant PASP/ABSA copolymer was...
Mariano Licciardi et al.
Macromolecular bioscience, 11(3), 445-454 (2011-01-25)
A new PHEA-IB-PMANa(+) copolymer has been synthesized and its pH-induced self-assembly has been investigated in an aqueous medium. PHEA-IB-PMANa+ formed nanoparticles with diameters from 25 to 50 nm upon protonation of the carboxylic acid moieties dislocated along the grafted polymethacrylate sodium...
Marijana Zovko Končič et al.
Acta pharmaceutica (Zagreb, Croatia), 61(4), 465-472 (2011-12-29)
Two hydrosoluble conjugates of 17β-estradiol (ED) and estradiol-17β-valerate (EV) with polyaspartamide polymer were prepared and characterized. ED and EV were first chemically modified and bound to poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-aminoethyl-DL-aspartamide)] (PAHA), a hydrosoluble polyaspartamide-type copolymer bearing both hydroxyl and amino groups. ED was...
Sanzhong Xu et al.
Biomedical materials (Bristol, England), 6(3), 035002-035002 (2011-04-14)
Research in the field of orthopedic implantology is currently focused on developing methodologies to potentiate osseointegration and to expedite the reestablishment of full functionality. We have developed a simple biomimetic approach for preparing trace elements-codoped calcium phosphate (teCaP) coatings on...
Svetlana Zakharchenko et al.
Biomacromolecules, 12(6), 2211-2215 (2011-04-29)
We report an approach for the fabrication of fully biodegradable self-rolled tubes based on patterned polysuccinimide/polycaprolactone bilayers. These polymers are biocompatible, biodegradable, produced industrially, and are already approved for biomedical purposes. Both polycaprolactone and polysuccinimide are hydrophobic and intrinsically water-insoluble....
Wang Lin et al.
Langmuir : the ACS journal of surfaces and colloids, 27(19), 12090-12097 (2011-08-25)
A series of polyaspartamide derivatives were synthesized by grafting O-(2-aminoethyl)-O'-methylpoly(ethylene glycol) 5000 (MPEG), 1-(3-aminopropyl) imidazole (API), and cinnamate onto polysuccinimide (PSI) with the respective degrees of substitution adjusted by the feed molar ratio. The chemical structure of the prepared polymer...
Hyun Jin Kim et al.
Journal of drug targeting, 20(1), 33-42 (2011-11-10)
For systemic siRNA delivery into tumor tissues, a safe and efficient vehicle is strongly required. Therefore, we designed a block copolymer of detachable poly(ethylene glycol) (PEG) polycation bearing low pKa amines and hydrophobic moieties in the side chain to develop...
Tomoya Suma et al.
Biomaterials, 33(9), 2770-2779 (2011-12-28)
The delivery of siRNA therapeutics owes its success to the development of carrier systems with high efficacy and minimum toxicity. Here, cationic polyaspartamide derivatives with a regulated number and spacing of positively charged amino groups in the side chain were...
Hiroki Kimoto et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 27(11), 1157-1161 (2011-11-15)
Helix-coil transitions of poly α-aspartic acid (PASP) were studied by dc polarography in the presence of Zn(2+) as a marker attached to the polymer. The diffusion current (i(d)) of Zn(2+) declined markedly in the pH range of 3.5-7.4 due to...
Mo Dan et al.
Pharmaceutical research, 30(2), 552-561 (2012-10-20)
To develop cross-linked nanoassemblies (CNAs) as carriers for superparamagnetic iron oxide nanoparticles (IONPs). Ferric and ferrous ions were co-precipitated inside core-shell type nanoparticles prepared by cross-linking poly(ethylene glycol)-poly(aspartate) block copolymers to prepare CNAs entrapping Fe(3)O(4) IONPs (CNA-IONPs). Particle stability and...
Novel pH-sensitive zwitterionic poly(amino acid) derivatives for drug delivery.
Xiaojuan Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e93-e94 (2011-12-27)

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